{"id":1110382,"date":"2017-07-12T19:17:09","date_gmt":"2017-07-13T02:17:09","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=1110382"},"modified":"2017-07-12T20:09:43","modified_gmt":"2017-07-13T03:09:43","slug":"2017%e5%b9%b4%e7%be%8e%e5%9c%a3%e5%9c%b0%e4%ba%9a%e5%93%a5%e7%94%9f%e8%8d%af%e7%a7%91%e6%8a%80%e9%a2%86%e5%9f%9f%e6%8d%b7%e6%8a%a5%e9%a2%91%e4%bc%a0%ef%bc%88%e5%85%ab%ef%bc%89-sabpa","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/2017%e5%b9%b4%e7%be%8e%e5%9c%a3%e5%9c%b0%e4%ba%9a%e5%93%a5%e7%94%9f%e8%8d%af%e7%a7%91%e6%8a%80%e9%a2%86%e5%9f%9f%e6%8d%b7%e6%8a%a5%e9%a2%91%e4%bc%a0%ef%bc%88%e5%85%ab%ef%bc%89-sabpa\/.html","title":{"rendered":"2017\u5e74\u7f8e\u5723\u5730\u4e9a\u54e5\u751f\u836f\u79d1\u6280\u9886\u57df\u6377\u62a5\u9891\u4f20\uff08\u516b\uff09SABPA"},"content":{"rendered":"

2017\u5e74\u7f8e\u5723\u5730\u4e9a\u54e5\u751f\u836f\u79d1\u6280\u9886\u57df\u53c8\u6377\u62a5\u9891\u4f20\uff01Arena Pharmaceuticles \u7814\u53d1\u7684\u80ba\u52a8\u8109\u9ad8\u538b\u65b0\u836f\u559c\u83b72\u671f\u4e34\u5e8a\u6570\u636e\uff1b\u8bfa\u534e(Novartis)\u7684\u9996\u6b3eCAR-T\u7597\u6cd5CTL019 \u521a\u83b7\u5f97FDA\u7684\u6295\u7968\u8ba4\u53ef\u3002<\/strong><\/p>\n

\u8bf7\u770b\u836f\u660e\u5eb7\u5fb7\u7684\u8be6\u7ec6\u62a5\u9053\uff1a<\/p>\n

\u5f3a\u52bf\u53cd\u5f39\uff01\u80ba\u52a8\u8109\u9ad8\u538b\u65b0\u836f\u5c55\u73b02\u671f\u4e34\u5e8a\u79ef\u6781\u6570\u636e<\/span><\/strong><\/h4>\n

\u8fd1\u65e5\uff0cArena Pharmaceuticles\u5ba3\u5e03\u4e86\u6cbb\u7597\u80ba\u52a8\u8109\u9ad8\u538b(PAH)\u5728\u7814\u65b0\u836fralinepag\u7684\u79ef\u67812\u671f\u4e34\u5e8a\u5b9e\u9a8c\u7ed3\u679c\u3002\u5728\u8fd9\u9879\u9488\u5bf961\u4f8b\u60a3\u8005\u7684\u7814\u7a76\u4e2d\uff0c\u4e3b\u8981\u7597\u6548\u5206\u6790\u663e\u793a\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u80ba\u8840\u7ba1\u963b\u529b(PVR)\u76f8\u5bf9\u4e8e\u57fa\u7ebf\u6709\u7edf\u8ba1\u4e0a\u663e\u8457\u7684\u53d8\u5316\u3002<\/strong>Ralinepag\u8fd8\u663e\u8457\u63d0\u9ad8\u4e86\u60a3\u80056\u5206\u949f\u6b65\u884c\u8ddd\u79bb(6MWD)\u3002\u8fd9\u4e5f\u662f\u5728Arena Pharmaceuticles\u7684\u4e00\u6b3e\u80a5\u80d6\u75c7\u65b0\u836f\u4e34\u5e8a\u4e0d\u987a\u540e\uff0c\u5feb\u901f\u53d6\u5f97\u7684\u5f3a\u52bf\u53cd\u5f39\u3002<\/strong><\/p>\n

<\/p>\n

\u80ba\u52a8\u8109\u9ad8\u538b\u662f\u4e00\u79cd\u7f55\u89c1\u7684\u3001\u5371\u53ca\u751f\u547d\u7684\u6e10\u8fdb\u5f0f\u6162\u6027\u75be\u75c5\uff0c\u5b83\u7684\u7279\u70b9\u662f\u52a8\u8109\u538b\u529b\u589e\u52a0\uff0c\u5c06\u8840\u6db2\u4ece\u5fc3\u810f\u8f93\u9001\u5230\u80ba\u90e8\u3002\u589e\u52a0\u7684\u538b\u529b\u4f1a\u4f7f\u5fc3\u810f\u53d7\u5230\u538b\u5236\uff0c\u4ece\u800c\u9650\u5236\u4f53\u529b\u6d3b\u52a8\uff0c\u5bfc\u81f4\u5fc3\u529b\u8870\u7aed\uff0c\u51cf\u5c11\u9884\u671f\u5bff\u547d\u3002\u76ee\u524d\u5bf9PAH\u6709\u56db\u79cd\u4e0d\u540c\u7684\u6cbb\u7597\u65b9\u6cd5\uff1a\u5185\u76ae\u7d20\u53d7\u4f53\u62ee\u6297\u5242\uff08endothelin receptor antagonists\uff0cERAs),\u3001\u78f7\u9178\u4e8c\u916f\u9176-5(PDE-5)\u6291\u5236\u5242\u3001\u524d\u5217\u73af\u7d20\uff08prostacyclin\uff09\u7c7b\u4f3c\u7269\u548c\u53ef\u6eb6\u7684\u9e1f\u82f7\u9178\u73af\u5316\u9176(SGc)\u523a\u6fc0\u3002\u73b0\u6709\u7684\u65b9\u6cd5\u5bf9\u6cbb\u7597PAH\u6709\u79ef\u6781\u7684\u4f5c\u7528\uff0c\u4f46\u5b83\u4eec\u5e76\u4e0d\u80fd\u6cbb\u6108\u8be5\u75be\u75c5\u3002\u800c\u4e14\u8bb8\u591a\u60a3\u8005\u5373\u4f7f\u63a5\u53d7\u6cbb\u7597\uff0c\u75c5\u60c5\u4ecd\u4f1a\u6301\u7eed\u53d1\u5c55\u3002<\/p>\n

Ralinepag(APD811)\u662f\u4e00\u79cd\u7531Arena\u81ea\u4e3b\u7814\u53d1\u7684\u836f\u7269\u3002\u4f5c\u4e3a\u65b0\u4e00\u4ee3\u957f\u6548\uff0c\u53e3\u670d\u7684\u524d\u5217\u73af\u7d20\u53d7\u4f53\u6fc0\u52a8\u5242\uff0cr<\/strong>alinepag\u5728\u8840\u7ba1\u8212\u5f20\u3001\u6291\u5236\u8840\u7ba1\u5e73\u6ed1\u808c\u7ec6\u80de\u589e\u6b96\u548c\u6291\u5236\u8840\u5c0f\u677f\u805a\u96c6\u7b49\u65b9\u9762\u7684\u836f\u6548\u826f\u597d\uff0c\u836f\u7269\u534a\u8870\u671f\u4e5f\u66f4\u957f\u3002\u8fd9\u4e9b\u7279\u70b9\u4f7f\u5176\u6210\u4e3a\u6cbb\u7597PAH\u7684\u6f5c\u5728\u540c\u7c7b\u6700\u4f73\uff08best-in-class\uff09\u836f\u7269\u3002<\/strong><\/p>\n

\"\"<\/a>\u25b2<\/strong>Ralinepag\u7684\u5206\u5b50\u7ed3\u6784\u5f0f\uff08\u56fe\u7247\u6765\u6e90\uff1aDrug Spider\uff09<\/strong><\/p>\n

\u6b64\u6b212\u671f\u4e34\u5e8a\u8bd5\u9a8c\u662f\u4e00\u4e2a\u968f\u673a\u3001\u53cc\u76f2\u3001\u5b89\u6170\u5242\u63a7\u5236\u7684\u5242\u91cf\u8303\u56f4\u7684\u8bd5\u9a8c\u3002\u4e3b\u8981\u7597\u6548\u5206\u6790\u662f\u5728\u6cbb\u7597\u540e\u768422\u5468\u65f6\uff0c\u80ba\u8840\u7ba1\u963b\u529b(PVR)\u76f8\u5bf9\u4e8e\u57fa\u7ebf\u7684\u7edd\u5bf9\u53d8\u5316\u3002\u989d\u5916\u7684\u4e34\u5e8a\u7ec8\u70b9\u5305\u62ec6\u5206\u949f\u884c\u8d70\u6d4b\u8bd5\u3001\u663e\u793a\u4e34\u5e8a\u6076\u5316\u7684\u60a3\u8005\u7684\u6bd4\u4f8b\u3001\u4ee5\u53ca\u836f\u7269\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002\u7814\u7a76\u53d1\u73b0\uff0cralinepag\u63d0\u9ad8\u4e86PVR\u7684\u4e2d\u503c\u8fbe163.9 dyn.s.cm-5\uff0c\u800c\u5b89\u6170\u5242\u7ec4\u7531\u57fa\u7ebf\u6076\u5316\u4e860.7 dyn.s.cm-5(p=0.02)\u3002<\/strong>\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c\u670d\u7528Ralinepag\u7684\u60a3\u8005\u7684PVR\u5f97\u5230\u4e8629.8%\u7684\u6539\u5584\uff08P=0.03\uff09\uff0c\u800c\u4e0e\u57fa\u7ebf\u76f8\u6bd4\u4e5f\u670920.1%\u7684\u6539\u5584\u3002\u6b64\u5916\uff0c\u5728\u7814\u7a76\u4e2d\u89c2\u5bdf\u5230\u7684\u836f\u7269\u526f\u4f5c\u7528\u4e0e\u5176\u4ed6\u7684\u524d\u5217\u73af\u7d20\u7597\u6cd5\u4e00\u81f4\uff0c\u8be5\u516c\u53f8\u8ba1\u5212\u5728\u672a\u6765\u7684\u533b\u7597\u5927\u4f1a\u4e0a\u516c\u5e03\u5b8c\u6574\u7684\u7814\u7a76\u7ed3\u679c\u3002<\/p>\n

\u5bc6\u6b47\u6839\u5927\u5b66\uff08University of Michigan\uff09\u7684\u5fc3\u8840\u7ba1\u533b\u5b66\u6559\u6388\u3001\u80ba\u52a8\u8109\u9ad8\u538b\u9879\u76ee\u7684\u8d1f\u8d23\u4ebaVallerie McLaughlin\u535a\u58eb\u8bf4\uff1a\u201cPAH\u662f\u4e00\u79cd\u590d\u6742\u800c\u4e25\u91cd\u7684\u75be\u75c5\uff0c\u5c3d\u7ba1\u76ee\u524d\u6709\u6cbb\u7597\u624b\u6bb5\uff0c\u4f46\u9884\u540e\u8f83\u5dee\u3002\u9700\u8981\u65b0\u7684\u6cbb\u7597\u65b9\u6848\u6765\u63a7\u5236\u75c5\u4eba\u75c5\u60c5\u3002Ralinepag\u76842\u671f\u4e34\u5e8a\u7814\u7a76\u7684\u7ed3\u679c\u663e\u793a\u4e86PVR\u5728\u4e34\u5e8a\u610f\u4e49\u4e0a\u7684\u6539\u5584\uff0c\u8fd9\u662f\u4e00\u4e2a\u826f\u597d\u7684\u6cbb\u7597\u6307\u6807\u3002\u6211\u4eec\u76f8\u4fe1\u5b83\u80fd\u5728\u60a3\u8005\u8eab\u4e0a\u8d77\u5230\u79ef\u6781\u7684\u957f\u671f\u4e34\u5e8a\u6548\u679c\u3002\u201d<\/p>\n

\"\"<\/a>\u25b2<\/strong>Arena\u516c\u53f8\u7814\u53d1\u90e8\u95e8\u7684\u6267\u884c\u526f\u603b\u88c1\uff0c\u9996\u5e2d\u533b\u7597\u5b98Preston Klassen\u535a\u58eb\uff08\u56fe\u7247\u6765\u6e90\uff1aSan Diego Business Journal\uff09<\/strong><\/p>\n

\u201cRalinepag\u5728\u8fd9\u98792\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684PAH\u60a3\u8005\u4e2d\u53d6\u5f97\u7684\u79ef\u6781\u6210\u679c\uff0c\u5bf9\u4e8e\u60a3\u6709\u8fd9\u79cd\u4e25\u91cd\u75be\u75c5\u7684\u60a3\u8005\u6765\u8bf4\u662f\u4e00\u4e2a\u91cd\u8981\u7684\u91cc\u7a0b\u7891\uff0c\u201dArena\u516c\u53f8\u7814\u53d1\u90e8\u95e8\u7684\u6267\u884c\u526f\u603b\u88c1\uff0c\u9996\u5e2d\u533b\u7597\u5b98Preston Klassen\u535a\u58eb\u8bf4\uff1a\u201c\u4ee4\u4eba\u5174\u594b\u7684\u662f\uff0c\u79ef\u6781\u7684\u975e\u4e34\u5e8a\u836f\u7406\u5b66\u8d44\u6599\u6b63\u8f6c\u53d8\u6210\u4e3a\u6f5c\u5728\u7684\u7b2c\u4e00\u79cd\u53e3\u670d\u524d\u5217\u73af\u7d20\u7597\u6cd5\uff0c\u4e0d\u9700\u8981\u518d\u7ecf\u8fc7\u590d\u6742\u6ce8\u5c04\u7597\u6cd5(IV)\uff0c\u9010\u6b65\u8fbe\u5230\u7a33\u5b9a\u6cbb\u7597\u7684\u6c34\u5e73\u3002\u8fd9\u4e9b\u6570\u636e\u8ba9\u6211\u4eec\u6709\u4fe1\u5fc3\u8fc5\u901f\u63a8\u8fdb\u52303\u671f\u4e34\u5e8a\u8bd5\u9a8c\u9879\u76ee\u4e2d\u53bb\u3002\u201d<\/p>\n

\u53c2\u8003\u8d44\u6599\uff1a<\/p>\n

[1] Arena Pharmaceuticals Reports Positive Topline Phase 2 Results for Ralinepag in Patients with Pulmonary Arterial Hypertension<\/p>\n

[2] San Diego’s Arena (ARNA) Soars as Phase II Hypertension Trial Data Wows<\/p>\n

CAR-T\u65e5 | \u56de\u987e\u8bfa\u534e\u9996\u6b3eCAR-T\u7597\u6cd5\u7684\u7814\u53d1\u4e4b\u8def<\/span><\/strong><\/h4>\n

\u8bfa\u534e(Novartis)\u7684\u9996\u6b3eCAR-T\u7597\u6cd5CTL019\u521a\u521a\u83b7\u5f97FDA\u7684\u6295\u7968\u8ba4\u53ef\uff0c\u8fd9\u6807\u5fd7\u7740\u5168\u7403\u7b2c\u4e00\u4e2aCAR-T\u7ec6\u80de\u7597\u6cd5\u6709\u671b\u572810\u6708\u524d\u83b7\u6279\u4e0a\u5e02<\/strong>\u3002\u81ea\u4ece2012\u5e74\u4e0e\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66(University of Pennsylvania) \u7b7e\u7f72\u5408\u4f5c\u534f\u8bae\u5f00\u53d1CAR-T\u7ec6\u80de\u7597\u6cd5\u4ee5\u6765\uff0c\u8bfa\u534e\u5728\u8fd9\u9879\u4ee3\u8868\u7740\u672a\u6765\u764c\u75c7\u7597\u6cd5\u91cd\u8981\u65b9\u5411\u4e4b\u4e00\u7684\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u4e0a\u505a\u51fa\u4e86\u5de8\u5927\u7684\u6295\u5165\u3002\u5982\u4ecaCTL019\u5373\u5c06\u4fee\u6210\u6b63\u679c\uff0c\u8ba9\u6211\u4eec\u56de\u987e\u4e00\u4e0b\u5b83\u7684\u7814\u53d1\u5386\u7a0b\u548c\u8bfa\u534e\u5bf9CAR-T\u7597\u6cd5\u7684\u671f\u5f85\u3002<\/p>\n

<\/p>\n

2012\u5e748\u6708<\/strong>\uff0c\u8bfa\u534e\u4e0e\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66\u8fbe\u6210\u5408\u4f5c\u534f\u8bae\uff0c\u83b7\u5f97\u6388\u6743\u5f00\u53d1\u57fa\u4e8e\u5bbe\u5927\u7814\u7a76\u6210\u679c\u7684CAR-T\u7ec6\u80de\u7597\u6cd5\u3002<\/strong>\u5bbe\u5927\u7684\u7814\u7a76\u56e2\u961f\u4e8e2011\u5e748\u6708\u5728\u300aThe New England Journal of Medicine\u300b\u548c\u300a\u79d1\u5b66\u300b\u5b50\u520a\u300aScience Translational Medicine\u300b\u6742\u5fd7\u4e0a\u53d1\u8868\u7684\u8bba\u6587\u7b2c\u4e00\u6b21\u663e\u793a\u51faCAR-T\u7ec6\u80de\u5728\u6cbb\u7597\u6162\u6027\u6dcb\u5df4\u6027\u767d\u8840\u75c5\u60a3\u8005(Chronic Lymphocytic Leukemia) \u7684\u663e\u8457\u7597\u6548<\/strong>\u3002\u5728CAR-T\u7ec6\u80de\u7597\u6cd5\u7684\u7814\u53d1\u521d\u671f\uff0c\u8bfa\u534e\u6210\u7acb\u4e86\u4e13\u95e8\u72ec\u7acb\u7684\u57fa\u56e0\u548c\u7ec6\u80de\u7597\u6cd5\u56e2\u961f(Gene and Cell Therapy Group) \u6765\u63a8\u8fdbCAR-T\u7ec6\u80de\u7597\u6cd5\u7684\u7814\u7a76\u3002\u540e\u6765\u6269\u5c55\u6210\u4e3a400\u4eba\u7684\u72ec\u7acb\u56e2\u961f\uff0c\u786e\u4fdd\u5f53\u65f6\u6280\u672f\u8fd8\u4e0d\u6210\u719f\u7684CAR-T\u7ec6\u80de\u7597\u6cd5\u5728\u7814\u53d1\u521d\u671f\u4e0d\u4f1a\u88ab\u6df9\u6ca1\u5728\u8bfa\u534e\u7684\u591a\u4e2a\u5176\u5b83\u9879\u76ee\u4e2d<\/strong>\uff0c\u8fd9\u4e5f\u662fCAR-T\u7ec6\u80de\u7597\u6cd5\u80fd\u591f\u5728\u836f\u7269\u7814\u53d1\u7ba1\u7ebf\u4e2d\u8fc5\u901f\u63a8\u8fdb\u7684\u4e00\u4e2a\u91cd\u8981\u539f\u56e0\u3002<\/p>\n

2016\u5e748\u6708\uff0c<\/strong>\u8bfa\u534e\u7684CAR-T\u7ec6\u80de\u7597\u6cd5\u6280\u672f\u5df2\u7ecf\u65e5\u6e10\u6210\u719f\u3002\u4e3a\u4e86\u66f4\u6709\u6548\u5730\u5229\u7528\u8bfa\u534e\u6574\u4f53\u7684\u7814\u53d1\u8d44\u6e90\uff0c\u6269\u5c55CAR-T\u7ec6\u80de\u7597\u6cd5\u7684\u9002\u7528\u8303\u56f4<\/strong>\uff0c\u8bfa\u534e\u5c06\u57fa\u56e0\u548c\u7ec6\u80de\u7597\u6cd5\u56e2\u961f\u6574\u5408\u5230\u8bfa\u534e\u7684\u7814\u53d1\u5927\u56e2\u961f\u4e2d\uff0c\u5e76\u4e14\u5168\u529b\u63a8\u52a8CTL019\u7597\u6cd5\u6cbb\u7597\u513f\u7ae5\u548c\u9752\u5c11\u5e74\u4e2d\u590d\u53d1\u548c\u96be\u6cbb\u578b\uff08r\/r\uff09B\u7ec6\u80de\u6025\u6027\u6dcb\u5df4\u6027\u767d\u8840\u75c5<\/strong>(ALL) \u7684\u7814\u53d1\u3002\u57282017\u5e743\u6708, FDA\u63a5\u53d7\u4e86CTL019\u7528\u4e8e\u4e0a\u8ff0\u9002\u5e94\u75c7\u7684\u751f\u7269\u5236\u5242\u8bb8\u53ef\u7533\u8bf7(BLA)\u5e76\u4e14\u9881\u53d1\u4e86\u4f18\u5148\u8bc4\u5ba1\u8d44\u683c\uff0c\u8bc4\u5ba1\u671f\u7f29\u77ed\u81f36\u4e2a\u6708\u3002<\/p>\n

<\/p>\n

\u25b2\u8bfa\u534e\u5168\u7403\u836f\u7269\u5f00\u53d1\u8d1f\u8d23\u4eba\u517c\u9996\u5e2d\u533b\u5b66\u5b98Vas Narasimhan\u535a\u58eb\u8ba4\u4e3a\u8bfa\u534e\u7684CAR-T\u7597\u6cd5\u8fd8\u6709\u591a\u4e2a\u524d\u8fdb\u65b9\u5411\uff08\u56fe\u7247\u6765\u6e90\uff1a\u8bfa\u534e\uff09<\/strong><\/p>\n

\u4f5c\u4e3a\u8bfa\u534e\u7684\u9996\u6b3eCAR-T\u7597\u6cd5\uff0cCTL019\u5df2\u83b7\u5f97\u4e86FDA\u59d4\u5458\u4f1a\u7684\u9ad8\u5ea6\u8ba4\u53ef\uff0c\u6709\u671b\u5373\u5c06\u83b7\u5f97FDA\u6279\u51c6\uff0c\u4f46\u662f\u8bfa\u534e\u5728CAR-T\u7ec6\u80de\u7597\u6cd5\u4e0a\u7684\u7814\u53d1\u8fdc\u8fdc\u6ca1\u6709\u7ed3\u675f\u3002\u8bfa\u534e\u5c06\u5728\u4ee5\u4e0b\u4e09\u4e2a\u65b9\u5411\u4e0a\u7ee7\u7eed\u63a8\u8fdb\u5bf9CAR-T\u7ec6\u80de\u7597\u6cd5\u7684\u8fdb\u4e00\u6b65\u7814\u7a76\uff1a<\/strong><\/p>\n

\u4e00\u3001\u5bf9CAR-T\u7ec6\u80de\u7597\u6cd5\u751f\u4ea7\u5de5\u827a\u6539\u8fdb\u548c\u521b\u65b0<\/strong><\/p>\n

\u4e0e\u5176\u5b83\u836f\u7269\u7597\u6cd5\u4e0d\u540c\uff0cCAR-T\u7ec6\u80de\u7597\u6cd5\u9700\u8981\u4ece\u60a3\u8005\u4f53\u5185\u6536\u96c6T\u7ec6\u80de\uff0c\u7136\u540e\u5728\u4f53\u5916\u6539\u826f\u3002\u8fd9\u4e00\u751f\u4ea7\u8fc7\u7a0b\u672c\u8eab\u5c31\u662f\u4e00\u4e2a\u5c16\u7aef\u79d1\u7814\u9879\u76ee\u3002\u201c\u6211\u4eec\u9700\u8981\u7ee7\u7eed\u6295\u5165\u4f18\u5316\u6211\u4eec\u7684\u751f\u4ea7\u5e73\u53f0\uff0c\u5728\u6269\u5c55\u9002\u5e94\u75c7\u7684\u540c\u65f6\u5c06\u8fd9\u4e00\u7597\u6cd5\u5e26\u7ed9\u66f4\u591a\u764c\u75c7\u60a3\u8005\uff0c\u201d\u8bfa\u534e\u7684\u5168\u7403\u836f\u7269\u5f00\u53d1\u8d1f\u8d23\u4eba\u517c\u9996\u5e2d\u533b\u5b66\u5b98 Vas Narasimhan\u535a\u58eb\u8bf4\u3002<\/p>\n

\u4e8c\u3001\u7ee7\u7eed\u5728\u8840\u6db2\u764c\u75c7\u4e2d\u5f00\u5c55\u7814\u7a76<\/strong><\/p>\n

\u8fc4\u4eca\u4e3a\u6b62\uff0cCAR-T\u7ec6\u80de\u7597\u6cd5\u5728\u6cbb\u7597\u8840\u6db2\u764c\u75c7\u4e0a\u7684\u7597\u6548\u662f\u6700\u597d\u7684\u3002\u8bfa\u534e\u5c06\u5f00\u5c55CAR-T\u7597\u6cd5\u4e0e\u5176\u5b83\u836f\u7269\u7684\u7ec4\u5408\u7597\u6cd5\u7814\u7a76\uff0c\u5e76\u4e14\u63a2\u7d22\u591a\u53d1\u6027\u9aa8\u9ad3\u7624(Multiple Myeloma)\u548c\u5176\u5b83\u7c7b\u578b\u7684\u8840\u6db2\u764c\u75c7\u80fd\u5426\u6210\u4e3aCAR-T\u7597\u6cd5\u7684\u9002\u5e94\u75c7\u3002<\/p>\n

\u4e09\u3001\u63a8\u8fdbCAR-T\u7597\u6cd5\u5bf9\u5b9e\u4f53\u7624\u7684\u6cbb\u7597<\/strong><\/p>\n

\u8fd9\u53ef\u80fd\u6700\u56f0\u96be\u7684\u4e00\u4e2a\u7814\u53d1\u65b9\u5411\uff0c\u56e0\u4e3a\u76ee\u524dCAR-T\u7597\u6cd5\u5bf9\u5b9e\u4f53\u7624\u7684\u7597\u6548\u5dee\u5f3a\u4eba\u610f\u3002\u8bfa\u534e\u5df2\u7ecf\u6784\u5efa\u4e86\u9776\u5411\u5375\u5de2\u764c\u548c\u5176\u5b83\u5b9e\u4f53\u7624\u7684CAR-T\u7597\u6cd5\uff0c\u5e76\u4e14\u6b63\u5728\u5c06\u8fd9\u4e9b\u7597\u6cd5\u63a8\u8fdb\u4e34\u5e8a\u8bd5\u9a8c\u3002\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7ed3\u679c\u5c06\u51b3\u5b9aCAR-T\u7597\u6cd5\u5728\u6cbb\u7597\u5b9e\u4f53\u7624\u65b9\u9762\u7684\u524d\u666f\u3002<\/p>\n

\u4eca\u65e5\u8bfa\u534e\u53d6\u5f97\u7684\u6210\u7ee9\uff0c\u65e0\u7591\u662f\u7ec6\u80de\u7597\u6cd5\u5386\u53f2\u4e0a\u7684\u4e00\u4e2a\u91cc\u7a0b\u7891<\/strong>\u3002\u6211\u4eec\u795d\u613f\u66f4\u591a\u7ec6\u80de\u7597\u6cd5\u80fd\u5728\u672a\u6765\u53d6\u5f97\u5168\u65b0\u7a81\u7834\uff0c\u9020\u798f\u5e7f\u5927\u60a3\u8005\uff01<\/p>\n

\u53c2\u8003\u8d44\u6599\uff1a<\/p>\n

[1] Novartis drug development chief outlines CAR-T research commitment<\/p>\n

[2] University of Pennsylvania and Novartis Form Alliance to Expand Use of Personalized T Cell Therapy for Cancer Patients<\/p>\n

[3] Novartis announces first CAR-T cell therapy BLA for pediatric and young adult patients with r\/r B-cell ALL granted FDA Priority Review<\/p>\n

\uff08\u6765\u6e90\uff1a\u836f\u660e\u5eb7\u5fb7\uff09<\/p>\n

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\u94fe\u63a5\uff1a2017\u5e74\u7f8e\u5723\u5730\u4e9a\u54e5\u751f\u836f\u79d1\u6280\u9886\u57df\u6377\u62a5\u9891\u4f20\uff08\u4e00\uff09<\/a><\/strong>
\n \u94fe\u63a5\uff1a2017\u5e74\u7f8e\u5723\u5730\u4e9a\u54e5\u751f\u836f\u79d1\u6280\u9886\u57df\u6377\u62a5\u9891\u4f20\uff08\u4e8c\uff09<\/a><\/strong>
\n \u94fe\u63a5\uff1a2017\u5e74\u7f8e\u5723\u5730\u4e9a\u54e5\u751f\u836f\u79d1\u6280\u9886\u57df\u6377\u62a5\u9891\u4f20\uff08\u4e09\uff09<\/a><\/strong>
\n \u94fe\u63a5\uff1a2017\u5e74\u7f8e\u5723\u5730\u4e9a\u54e5\u751f\u836f\u79d1\u6280\u9886\u57df\u6377\u62a5\u9891\u4f20\uff08\u56db\uff09<\/a><\/strong>
\n \u94fe\u63a5\uff1a2017\u5e74\u7f8e\u5723\u5730\u4e9a\u54e5\u751f\u836f\u79d1\u6280\u9886\u57df\u6377\u62a5\u9891\u4f20\uff08\u4e94\uff09<\/a><\/strong>
\n \u94fe\u63a5\uff1a2017\u5e74\u7f8e\u5723\u5730\u4e9a\u54e5\u751f\u836f\u79d1\u6280\u9886\u57df\u6377\u62a5\u9891\u4f20\uff08\u516d\uff09<\/a><\/strong>
\n \u94fe\u63a5\uff1a2017\u5e74\u7f8e\u5723\u5730\u4e9a\u54e5\u751f\u836f\u79d1\u6280\u9886\u57df\u6377\u62a5\u9891\u4f20\uff08\u4e03\uff09<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

2017\u5e74\u7f8e\u5723\u5730\u4e9a\u54e5\u751f\u836f\u79d1\u6280\u9886\u57df\u53c8\u6377\u62a5\u9891\u4f20\uff01Arena Pharmaceuticles \u7814\u53d1\u7684\u80ba\u52a8\u8109\u9ad8\u538b\u65b0\u836f\u559c\u83b72\u671f\u4e34\u5e8a\u6570\u636e\uff1b\u8bfa\u534e(Novartis)\u7684\u9996\u6b3eCAR-T\u7597\u6cd5CTL019 \u521a\u83b7\u5f97FDA\u7684\u6295\u7968\u8ba4\u53ef……<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[34],"class_list":["post-1110382","post","type-post","status-publish","format-standard","hentry","category-headline","tag-featured-2"],"_links":{"self":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1110382","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/comments?post=1110382"}],"version-history":[{"count":0,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1110382\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media?parent=1110382"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/categories?post=1110382"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/tags?post=1110382"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}