{"id":1297414,"date":"2017-10-27T19:39:29","date_gmt":"2017-10-28T02:39:29","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=1297414"},"modified":"2017-10-27T19:39:29","modified_gmt":"2017-10-28T02:39:29","slug":"%e7%be%8e%e5%9b%bd%e5%8d%8e%e4%ba%ba%e7%a7%91%e5%ad%a6%e5%ae%b6%e5%bc%a0%e9%94%8b%ef%bc%9a%e7%bc%96%e8%be%91rna%e5%8f%af%e6%b2%bb%e7%96%97%e5%a4%9a%e7%a7%8d%e9%a1%bd%e7%96%be-%ef%bc%88%e5%9b%be","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/%e7%be%8e%e5%9b%bd%e5%8d%8e%e4%ba%ba%e7%a7%91%e5%ad%a6%e5%ae%b6%e5%bc%a0%e9%94%8b%ef%bc%9a%e7%bc%96%e8%be%91rna%e5%8f%af%e6%b2%bb%e7%96%97%e5%a4%9a%e7%a7%8d%e9%a1%bd%e7%96%be-%ef%bc%88%e5%9b%be\/.html","title":{"rendered":"\u7f8e\u56fd\u534e\u4eba\u79d1\u5b66\u5bb6\u5f20\u950b\uff1a\u7f16\u8f91RNA\u53ef\u6cbb\u7597\u591a\u79cd\u987d\u75be \uff08\u56fe\uff09"},"content":{"rendered":"
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\"\u7f8e\u56fd\u535a\u5fb7\u7814\u7a76\u6240\u534e\u4eba\u79d1\u5b66\u5bb6\u5f20\u950b\uff1a\u7f16\u8f91RNA\u53ef\u6cbb\u7597\u591a\u79cd\u987d\u75be\"<\/p>\n

\u3000\u3000\u4f5c\u4e3a\u9996\u4f4d\u5c06\u57fa\u56e0\u7f16\u8f91\u7cfb\u7edfCRISPR\u7528\u4e8e\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u7684\u5f00\u62d3\u8005\uff0c\u7f8e\u56fd\u535a\u5fb7\u7814\u7a76\u6240\u534e\u4eba\u79d1\u5b66\u5bb6\u5f20\u950b\u8fd1\u6765\u5bf9RNA\u7f16\u8f91\u4ea7\u751f\u4e86\u5174\u8da3\uff0c\u4e00\u6708\u5185\u8fde\u53d1\u4e24\u7bc7\u76f8\u5173\u8bba\u6587\u5728\u9876\u7ea7\u5b66\u672f\u671f\u520a\u3002<\/p>\n

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Cas13\u9176\u5bb6\u65cf\u6700\u8fd1\u53d7\u5f20\u950b\u56e2\u961f\u9752\u7750\u300210\u67084\u65e5\uff0c\u5728\u53d1\u8868\u4e8e\u300a\u81ea\u7136\u300b\u671f\u520a\u7684\u8bba\u6587\u4e0a\uff0c\u5f20\u950b\u56e2\u961f\u8bc1\u5b9e\u4e86\u53e6\u4e00\u79cd\u9176Cas13a\u80fd\u591f\u5728\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u4e2d\u7279\u5f02\u6027\u5730\u4e0b\u8c03\u5185\u6e90\u6027RNA\u548c\u62a5\u544aRNA\u7684\u6c34\u5e73\u3002<\/p>\n

\u201c\u57fa\u56e0\u7f16\u8f91\u7684\u9996\u8981\u76ee\u6807\u662f\u77eb\u6b63\u5bfc\u81f4\u75be\u75c5\u7684\u7a81\u53d8\u3002\u73b0\u5728\uff0c\u6211\u4eec\u5df2\u7ecf\u5f88\u64c5\u957f\u8ba9\u57fa\u56e0\u5931\u6d3b\uff0c\u4f46\u8981\u4fee\u590d\u5df2\u4e22\u5931\u7684\u86cb\u767d\u8d28\u529f\u80fd\u5219\u66f4\u5177\u6311\u6218\u5f97\u591a\u3002\u7f16\u8f91RNA\u8fd9\u4e00\u65b0\u6280\u80fd\u6253\u5f00\u4e86\u66f4\u591a\u7684\u53ef\u80fd\uff0c\u51e0\u4e4e\u53ef\u4ee5\u5728\u6240\u6709\u7ec6\u80de\u4e2d\u4fee\u590d\u86cb\u767d\u8d28\u529f\u80fd\uff0c\u6709\u52a9\u4e8e\u591a\u79cd\u75be\u75c5\u6cbb\u7597\u3002\u201d\u5f20\u950b\u8868\u793a\u3002<\/p>\n

\u548c\u6b64\u524dCRISPR\u7cfb\u7edf\u7528\u4e8e\u7f16\u8f91DNA\u4e0d\u540c\uff0c\u5f20\u950b\u56e2\u961f\u5728\u666e\u96f7\u6c83\u6c0f\u7ec6\u83cc\uff08Prevotella\uff09\u4e2d\u627e\u5230\u4e86PspCas13b\u9176\u3002\u8fd9\u662fCas13\u9176\u5bb6\u65cf\u4e2d\u80fd\u4f7fRNA\u5931\u53bb\u6d3b\u6027\u7684\u201c\u4f7c\u4f7c\u8005\u201d\uff0c\u662f\u6f5c\u5728\u7684RNA\u201c\u526a\u5200\u201d\u3002<\/p>\n

\u4f46\u5f20\u950b\u56e2\u961f\u8d4b\u4e88PspCas13b\u7684\u201c\u4f7f\u547d\u201d\u4e0d\u662f\u53bb\u8ba9RNA\u5931\u6d3b\uff0c\u76f8\u53cd\u7684\uff0c\u4ed6\u4eec\u8bbe\u8ba1\u4e86PspCas13b\u7684\u201c\u53d8\u4f53\u201d\u3002\u8fd9\u4e2a\u201c\u53d8\u4f53\u201d\u5931\u53bb\u4e86\u201c\u526a\u5200\u201d\u7684\u529f\u80fd\uff0c\u4f46\u4f1a\u7262\u7262\u5730\u7ed3\u5408\u5728\u7279\u5b9a\u7684RNA\u7247\u6bb5\u4e0a\u3002\u540c\u65f6\uff0cPspCas13b\u201c\u53d8\u4f53\u201d\u7684\u642d\u6863\u2014\u2014ADAR2\u86cb\u767d\u4f1a\u5c06\u8be5\u7247\u6bb5\u4e0a\u7684\u817a\u560c\u5464\u6838\u82f7\uff08A\uff09\u66ff\u6362\u6210\u6b21\u9ec4\u560c\u5464\u6838\u82f7\uff08I\uff09\u3002<\/p>\n

\u4e3a\u4f55\u8981\u505a\u6b64\u66ff\u6362\uff1f\u539f\u6765\uff0c\u9e1f\u560c\u5464\u6838\u82f7\uff08G\uff09\u7a81\u53d8\u4e3a\u817a\u560c\u5464\u6838\u82f7\uff08A\uff09\u65f6\u6709\u53d1\u751f\uff0c\u800c\u8fd9\u88ab\u8ba4\u4e3a\u548c\u675c\u6c0f\u808c\u8425\u517b\u4e0d\u826f\u75c7\u3001\u5e15\u91d1\u68ee\u75c5\u7b49\u75be\u75c5\u5bc6\u5207\u76f8\u5173\u3002<\/p>\n

\u4eba\u7c7b\u7684\u5f88\u591a\u75be\u75c5\u4fe1\u606f\u90fd\u7f16\u7801\u5728DNA\u8fd9\u4e2a\u201c\u751f\u547d\u811a\u672c\u201d\u4e0a\u3002\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u7684\u51fa\u73b0\u4f7f\u5f97\u79d1\u5b66\u5bb6\u6709\u4e86\u4fee\u6539DNA\u7684\u53ef\u80fd\uff0c\u7ed9\u6cbb\u6108\u75be\u75c5\u5e26\u6765\u5e0c\u671b\u3002\u4f46\u7531\u4e8e\u57fa\u56e0\u627f\u8f7d\u7740\u751f\u547d\u6700\u6839\u6e90\u7684\u4fe1\u606f\uff0c\u5bf9DNA\u8fdb\u884c\u7f16\u8f91\u6709\u7740\u5b89\u5168\u548c\u4f26\u7406\u4e0a\u7684\u987e\u8651\u3002<\/p>\n

RNA\u7f16\u8f91\u6709\u6240\u4e0d\u540c\u3002RNA\u662f\u4ee5DNA\u5355\u94fe\u4e3a\u6a21\u677f\u7684\u9057\u4f20\u4fe1\u606f\u8f7d\u4f53\u3002DNA\u53d1\u51fa \u201c\u9519\u8bef\u6307\u4ee4\u201d\uff0c\u7ecfRNA\u8f6c\u5f55\uff0c\u7ffb\u8bd1\u7ed9\u86cb\u767d\u8d28\u5e76\u6267\u884c\u529f\u80fd\uff0c\u624d\u6709\u75be\u75c5\u7684\u8868\u73b0\u3002\u82e5\u4e2d\u9014\u62e6\u622a\uff0c\u77eb\u6b63RNA\u4e0a\u7684\u9519\u8bef\u4fe1\u606f\uff0c\u8ba9\u86cb\u767d\u8d28\u63a5\u6536\u5230\u6b63\u786e\u7684\u4fe1\u606f\uff0c\u53ef\u8d77\u5230\u6cbb\u7597\u6548\u679c\u3002<\/p>\n

\"\"<\/a><\/p>\n

DNA\u4e0eRNA\u4e4b\u95f4\u7684\u5173\u7cfb\u3002<\/p>\n

\u3000\u3000\u5b89\u5168\u548c\u7075\u6d3b\u662f\u201cREPAIR\u201d\u7684\u4f18\u52bf\u3002\u201cREPAIR\u65e0\u9700\u7be1\u6539\u57fa\u56e0\u7ec4\u5c31\u53ef\u4ee5\u4fee\u590d\u7a81\u53d8\u3002\u800c\u4e14RNA\u4f1a\u81ea\u52a8\u964d\u89e3\uff0c\u5bf9\u5b83\u7684\u4fee\u6539\u6216\u662f\u53ef\u9006\u7684\u3002\u201d\u5f20\u950b\u5b9e\u9a8c\u5ba4\u5b66\u751f\u3001\u8be5\u8bba\u6587\u7684\u5171\u540c\u7b2c\u4e00\u4f5c\u8005David Cox\u8868\u793a\u3002<\/p>\n

\u4e3a\u4e86\u8ba9\u201cREPAIR\u201d\u66f4\u52a0\u6210\u719f\uff0c\u5f20\u950b\u56e2\u961f\u5bf9\u5176\u8fdb\u884c\u4e86\u4f18\u5316\uff0c\u8bbe\u8ba1\u51fa\u201cREPAIR2\u201d\u7248\u672c\uff0c\u5c06\u5728\u8f6c\u5f55\u7ec4\u4e2d\u53ef\u68c0\u6d4b\u5230\u7684\u8131\u9776\u6b21\u6570\u4ece1.8\u4e07\u6b21\u964d\u81f320\u6b21\u3002\u636e\u4ecb\u7ecd\uff0c\u201cREPAIR2\u201d\u5bf9\u76ee\u6807RNA\u7684\u7f16\u8f91\u6548\u7387\u4e3a20%-40%\uff0c\u6700\u9ad8\u8fbe\u523051%\u3002<\/p>\n

\u4e3a\u9a8c\u8bc1\u201cREPAIR\u201d\u7cfb\u7edf\u5728\u75be\u75c5\u6cbb\u7597\u4e0a\u7684\u6f5c\u529b\uff0c\u5f20\u950b\u56e2\u961f\u4eba\u5de5\u5408\u6210\u4e86\u4f1a\u9020\u6210\u8303\u79d1\u5c3c\u8d2b\u8840\u548cX\u8fde\u9501\u6027\u80be\u6e90\u6027\u5c3f\u5d29\u75c7\u7684\u7a81\u53d8\uff0c\u5e76\u5c06\u8fd9\u4e9b\u7a81\u53d8\u5f15\u81f3\u4eba\u4f53\u7ec6\u80de\u4e2d\uff0c\u6700\u540e\u6210\u529f\u901a\u8fc7\u201cREPAIR\u201d\u5728RNA\u5c42\u6b21\u4e0a\u4fee\u590d\u4e86\u81f4\u75c5\u7a81\u53d8\u3002<\/p>\n

\u63a5\u4e0b\u6765\uff0c\u5f20\u950b\u56e2\u961f\u8868\u793a\u5c06\u7ee7\u7eed\u4ece\u81ea\u7136\u754c\u5bfb\u627e\u7ebf\u7d22\uff0c\u8bbe\u8ba1\u5176\u4ed6\u9644\u4ef6\uff0c\u9002\u7528\u4e8e\u66f4\u591a\u7c7b\u578b\u7684\u6838\u82f7\u9178\u4fee\u590d\u3002\uff08PENGBAI \u8bb0\u8005\uff1a\u738b\u76c8\u9896)<\/p>\n

\"\"<\/a><\/p>\n

\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u56fe\u4e3a\u4e0d\u4e45\u524d\u4e3a\u5f20\u950b\uff08\u53f3\u4e00\uff09\u62ff\u4e0b\u201c\u8bfa\u5956\u98ce\u5411\u6807\u201d\u963f\u5c14\u4f2f\u5c3c\u5956\uff0c\u4e3a\u7b2c\u4e8c\u4f4d\u534e\u4eba\u5f97\u4e3b\u3002<\/p>\n

\u4e2a\u4eba\u6863\u6848\uff1a\u5f20\u950b\uff08\u7f8e\u56fd\u9ebb\u7701\u7406\u5de5\u5b66\u9662\u534e\u4eba\u79d1\u5b66\u5bb6\uff09\uff0c\u7537\uff0c1982\u5e74\u51fa\u751f\u4e8e\u6cb3\u5317\u77f3\u5bb6\u5e84\uff0c\u7f8e\u56fd\u9ebb\u7701\u7406\u5de5\u5b66\u9662\u535a\u58eb\uff0c\u662f\u5f53\u4eca\u6700\u4e3a\u4eba\u6240\u5173\u6ce8\u7684\u534e\u4eba\u751f\u7269\u5b66\u5bb6\u4e4b\u4e00\u3002\u4ed6\u6700\u8457\u540d\u7684\u5de5\u4f5c\u662f\u57fa\u56e0\u4fee\u9970\u6280\u672fCRISPR-Cas9\u7684\u53d1\u5c55\u548c\u5e94\u7528\uff0c\u7387\u5148\u83b7\u5f97\u4e86\u7f8e\u56fd\u4e13\u5229\uff0c\u5e76\u88ab\u89c6\u4e3a\u8bfa\u8d1d\u5c14\u5956\u7684\u70ed\u95e8\u4eba\u9009\u4e4b\u4e00\u00a0\u3002<\/span><\/p>\n

\n
2016\u5e749\u670821\u65e5\uff0c\u5165\u9009\u5f15\u6587\u6842\u51a0\u5956\u5316\u5b66\u9886\u57df\u7684\u83b7\u5956\u540d\u5355\u30022017\u5e74\u664b\u5347\u4e3a\u7f8e\u56fd\u9ebb\u7701\u7406\u5de5\u5b66\u9662\u7406\u5b66\u9662\u7ec8\u8eab\u6559\u6388\u30022017\u5e748\u670815\u65e5\uff0c\u5f20\u950b\u83b7\u963f\u5c14\u4f2f\u5c3c\u751f\u7269\u533b\u5b66\u5956\uff0c\u6210\u4e3a\u5386\u53f2\u4e0a\u7b2c\u4e8c\u540d\u83b7\u5f97\u6b64\u5956\u9879\u7684\u534e\u4eba\u5b66\u8005\u3002(\u767e\u5ea6\u767e\u79d1\uff09<\/div>\n<\/div>\n<\/div>\n
<\/div>\n<\/div>\n
\u6d88\u606f\u53c2\u8003\uff1a<\/div>\n
http:\/\/www.thepaper.cn\/newsDetail_forward_1765409<\/div>\n
<\/div>\n<\/div>\n

\uff08\u7f8e\u56fd\u534e\u6587\u7f51 \u5723\u5730\u4e9a\u54e5\u534e\u6587\u7f51 \u534e\u6587\u98ce\u91c7\u7efc\u5408\u7f16\u53d1 \u7f51\u7edc\u622a\u56fe US Chinese Press\uff0cSan Diego Chinese Press\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"

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