{"id":1297520,"date":"2017-11-02T14:35:38","date_gmt":"2017-11-02T21:35:38","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=1297520"},"modified":"2017-11-02T14:35:38","modified_gmt":"2017-11-02T21:35:38","slug":"%e5%91%bd%e8%bf%90%e7%bb%99%e4%ba%86%e4%bb%96%e7%ac%ac%e4%ba%8c%e6%ac%a1%e6%9c%ba%e4%bc%9a%ef%bc%8c%e8%bf%99%e4%b8%80%e6%ac%a1%ef%bc%8c%e4%bb%96%e8%83%bd%e8%ae%a9%e6%96%b0%e8%8d%af%e9%a1%ba%e5%88%a9","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/%e5%91%bd%e8%bf%90%e7%bb%99%e4%ba%86%e4%bb%96%e7%ac%ac%e4%ba%8c%e6%ac%a1%e6%9c%ba%e4%bc%9a%ef%bc%8c%e8%bf%99%e4%b8%80%e6%ac%a1%ef%bc%8c%e4%bb%96%e8%83%bd%e8%ae%a9%e6%96%b0%e8%8d%af%e9%a1%ba%e5%88%a9\/.html","title":{"rendered":"\u547d\u8fd0\u7ed9\u4e86\u4ed6\u7b2c\u4e8c\u6b21\u673a\u4f1a\uff0c\u8fd9\u4e00\u6b21\uff0c\u4ed6\u80fd\u8ba9\u65b0\u836f\u987a\u5229\u4e0a\u5e02\u5417\uff1f"},"content":{"rendered":"<p><span style=\"color: #000080;\"><strong>\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053:<\/strong><\/span><\/p>\n<p>\u4e3a\u60a3\u8005\u5e26\u6765\u62ef\u6551\u751f\u547d\u7684\u65b0\u836f\u662f\u6bcf\u4e00\u540d\u7814\u53d1\u4eba\u5458\u7684\u68a6\u60f3\u3002<strong>\u5728\u68a6\u60f3\u7c89\u788e\u524d\uff0c\u7ea6\u7ff0\u00b7\u80e1\u5fb7\uff08John Hood\uff09\u79bb\u5b83\u66fe\u53ea\u6709\u4e00\u6b65\u4e4b\u9065\u3002<\/strong><\/p>\n<p><img decoding=\"async\" class=\"\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/FcLK21Ir4gP1r2hZ6PHHibMcAFbs1NVKjZwufFH4v3O9kSnEZpPXQiaF6j3Cic6DbbicXPPtPg9FticMbSugoqgfZWA\/640?wx_fmt=jpeg&amp;wxfrom=5&amp;wx_lazy=1\" data-s=\"300,640\" data-type=\"jpeg\" data-src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/FcLK21Ir4gP1r2hZ6PHHibMcAFbs1NVKjZwufFH4v3O9kSnEZpPXQiaF6j3Cic6DbbicXPPtPg9FticMbSugoqgfZWA\/0?wx_fmt=jpeg\" data-copyright=\"0\" data-ratio=\"0.5\" data-w=\"1280\" data-fail=\"0\" 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Blanda\uff09\u5c31\u662f\u4ece\u4e2d\u53d7\u76ca\u7684\u60a3\u8005\u4e4b\u4e00\u3002\u5979\u4e0e\u767d\u8840\u75c5\u6297\u4e89\u4e86\u591a\u5e74\uff0c\u5374\u57282008\u5e74\u7684\u4e00\u6b21\u68c0\u67e5\u4e2d\u542c\u5230\u4e86\u4e00\u4e2a\u574f\u6d88\u606f\u2014\u2014\u5979\u7684\u767d\u8840\u75c5\u51fa\u73b0\u6076\u5316\uff0c\u51fa\u73b0\u4e86\u9aa8\u9ad3\u7ea4\u7ef4\u5316\u75c7\u72b6\u3002\u5728\u5979\u7684\u9aa8\u9ad3\u91cc\uff0c\u75a4\u75d5\u7ec4\u7ec7\u75af\u72c2\u751f\u957f\uff0c\u4e25\u91cd\u5f71\u54cd\u4e86\u8840\u7ec6\u80de\u7684\u751f\u6210\u3002\u5f53\u65f6\uff0c\u6cbb\u7597\u8fd9\u79cd\u75be\u75c5\u7684\u6700\u4f73\u65b9\u6cd5\u662f\u9aa8\u9ad3\u79fb\u690d\uff0c\u4f46\u8fd9\u9700\u8981\u627e\u5230\u914d\u578b\u5408\u9002\u7684\u4f9b\u4f53\u3002\u5728\u8fd9\u65b9\u9762\uff0c\u7279\u857e\u838e\u6ca1\u6709\u8db3\u591f\u7684\u8fd0\u6c14\u3002<\/p>\n<p>\u4e3b\u6cbb\u533b\u751f\u5361\u5d14\u5965\u5a1c\u00b7\u8d3e\u7c73\u68ee\uff08Catriona Jamieson\uff09\u535a\u58eb\u5efa\u8bae\u5979\u5c1d\u8bd5\u4e34\u5e8a\u8bd5\u9a8c\uff0cfedratinib\u6210\u4e3a\u4e86\u7279\u857e\u838e\u7684\u9009\u62e9\u3002\u5f53\u65f6\uff0c\u8fd9\u6b3e\u5728\u7814\u65b0\u836f\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u62db\u52df\u60a3\u8005\u3002\u5361\u5d14\u5965\u5a1c\u4ecb\u7ecd\u8bf4\uff0c<strong>\u8fd9\u6b3e\u65b0\u836f\u80fd\u6291\u5236\u4eba\u4f53\u5185\u7a81\u53d8\u7684<em>JAK2<\/em>\u57fa\u56e0\uff0c\u4ece\u800c\u6291\u5236\u80bf\u7624\u7ec6\u80de\u7684\u751f\u957f\u3002<\/strong>\u5979\u5b9e\u9a8c\u5ba4\u5148\u524d\u8fdb\u884c\u7684\u4e0d\u5c11\u7814\u7a76\uff0c\u5df2\u7ecf\u8bc1\u5b9e\u4e86\u8fd9\u4e00\u6cbb\u7597\u601d\u8def\u7684\u53ef\u884c\u6027\u3002<\/p>\n<p><img decoding=\"async\" class=\"\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/FcLK21Ir4gP1r2hZ6PHHibMcAFbs1NVKjAJGVpF8gr4vgrv680CxPhGYBUdTlPAsurlX3LiaeFbbRJ3JH9yy1Olg\/640?wx_fmt=jpeg&amp;wxfrom=5&amp;wx_lazy=1\" data-s=\"300,640\" data-type=\"jpeg\" data-src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/FcLK21Ir4gP1r2hZ6PHHibMcAFbs1NVKjAJGVpF8gr4vgrv680CxPhGYBUdTlPAsurlX3LiaeFbbRJ3JH9yy1Olg\/0?wx_fmt=jpeg\" data-copyright=\"0\" data-ratio=\"0.5625\" data-w=\"800\" data-fail=\"0\" \/><\/p>\n<p><strong>\u25b2\u7279\u857e\u838e\uff08\u5de6\uff09\u4e0e\u5361\u5d14\u5965\u5a1c\uff08\u53f3\uff09\u5e26\u6765\u4e86\u4e00\u4e2a\u751f\u547d\u5947\u8ff9\uff08\u56fe\u7247\u6765\u6e90\uff1aSan Diego Union Tribune\uff09<\/strong><\/p>\n<p>\u7279\u857e\u838e\u522b\u65e0\u9009\u62e9\u3002\u201c\u6211\u6b63\u5904\u4e8e\u767d\u8840\u75c5\u5168\u9762\u7206\u53d1\u7684\u98ce\u53e3\u6d6a\u5c16\u201d\uff0c\u5979\u8bf4\u9053\u3002\u767d\u8840\u75c5\u5c06\u5979\u7684\u9020\u8840\u5e72\u7ec6\u80de\u6324\u51fa\u4e86\u9aa8\u9ad3\u5916\uff0c\u5f15\u8d77\u7684\u9ad3\u5916\u9020\u8840\u8ba9\u5979\u7684\u819d\u76d6\u80bf\u80c0\u4e0d\u582a\u3002<\/p>\n<p>\u8c01\u4e5f\u6ca1\u6709\u60f3\u5230\uff0cfedratinib\u7684\u6cbb\u7597\u6548\u679c\u7adf\u7136\u5982\u6b64\u51fa\u8272\uff01<strong>\u5728\u77ed\u77ed\u51e0\u4e2a\u6708\u91cc\uff0c\u7279\u857e\u838e\u7684\u75c5\u60c5\u51fa\u73b0\u4e86\u6781\u5927\u6539\u5584\u3002<\/strong>\u201c\u6211\u7684\u813e\u810f\u3001\u809d\u810f\u3001\u4e00\u5207\u90fd\u6062\u590d\u4e86\u6b63\u5e38\uff0c\u201d\u7279\u857e\u838e\u8bf4\uff1a\u201c\u6211\u8fd8\u91cd\u65b0\u5f00\u59cb\u4e86\u5de5\u4f5c\u201d\u3002\u63a5\u53d7\u4e34\u5e8a\u8bd5\u9a8c\u76845\u5e74\u91cc\uff0c\u7279\u857e\u838e\u7684\u751f\u547d\u91cd\u65b0\u71c3\u8d77\u4e86\u5e0c\u671b\u3002\u5979\u5f00\u59cb\u7545\u60f3\u672a\u6765\uff0c\u751a\u81f3\u60f3\u5230\u8981\u548c\u9ad8\u4e2d\u7684\u60c5\u4eba\u518d\u7eed\u524d\u7f18\uff0c\u8e0f\u5165\u5a5a\u59fb\u7684\u6bbf\u5802\u3002<\/p>\n<p>\u4f46\u610f\u5916\u603b\u662f\u6084\u7136\u800c\u81f3\u30022013\u5e74\uff0c\u8fd9\u4e00\u4e34\u5e8a\u8bd5\u9a8c\u88ab\u4e2d\u9014\u8170\u65a9\u3002\u7ef4\u7cfb\u7279\u857e\u838e\u751f\u547d\u7684\u552f\u4e00\u4e00\u6839\u7ebf\uff0c\u5c31\u8fd9\u6837\u65ad\u4e86\u3002<\/p>\n<section>\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\"><strong>\u795e\u79d8\u7684\u5e76\u53d1\u75c7<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\">\n<section class=\"\">\n<section class=\"\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p>\u51fa\u4e8efedratinib\u7b49\u4e00\u7cfb\u5217\u5728\u7814\u65b0\u836f\u7684\u6f5c\u529b\uff0c\u77e5\u540d\u836f\u4f01\u8d5b\u8bfa\u83f2\uff08Sanofi\uff09\u57282010\u5e74\u6536\u8d2d\u4e86TargeGen\uff0c\u5e76\u5c06fedratinib\u63a8\u8fdb\u5230\u4e86\u665a\u671f\u4e34\u5e8a\u9636\u6bb5\u3002\u7279\u857e\u838e\u53c2\u4e0e\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6b63\u662f\u5176\u5173\u952e\u4e34\u5e8a\u9879\u76ee\u4e4b\u4e00\u3002<strong>\u65b0\u836f\u7814\u53d1\u4eba\u5458\u5f88\u6b23\u6170\u5730\u770b\u5230\uff0c\u50cf\u7279\u857e\u838e\u8fd9\u6837\u7684\u60a3\u8005\u80fd\u591f\u4e00\u4e2a\u4e2a\u4ece\u767d\u8840\u75c5\u7684\u9b54\u722a\u4e0b\u9003\u8131\uff0c\u91cd\u65b0\u56de\u5230\u6b63\u5e38\u7684\u751f\u6d3b\u3002<\/strong>\u4e50\u89c2\u7684\u5206\u6790\u5e08\u4eec\u4e5f\u8ba4\u4e3a\uff0c\u8fd9\u6b3e\u65b0\u836f\u79bb\u4e0a\u5e02\u6216\u8bb8\u5df2\u7ecf\u4e0d\u8fdc\u4e86\u3002<\/p>\n<p>\u4f46\u665a\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6570\u636e\u5374\u6697\u793a\u4e86\u4e00\u4e9b\u5371\u9669\u7684\u526f\u4f5c\u7528\u3002\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u63a5\u53d7fedratinib\u6cbb\u7597\u7684\u4e00\u4e9b\u60a3\u8005\u51fa\u73b0\u4e86\u97e6\u5c3c\u514b\u8111\u75c5\uff08Wernicke\u2019s encephalopathy\uff09\u3002\u8fd9\u662f\u4e00\u79cd\u98ce\u9669\u6781\u9ad8\u7684\u7f55\u89c1\u795e\u7ecf\u75be\u75c5\uff0c\u5f80\u5f80\u4e0e\u7ef4\u751f\u7d20B1\u7f3a\u4e4f\u76f8\u5173\u3002\u60a3\u8005\u5927\u8111\u5185\u7684\u591a\u4e2a\u90e8\u5206\u4f1a\u51fa\u73b0\u75c5\u53d8\uff0c\u5e26\u6765\u5171\u6d4e\u5931\u8c03\u3001\u7cbe\u795e\u5f02\u5e38\u7b49\u795e\u7ecf\u7cfb\u7edf\u529f\u80fd\u969c\u788d\u3002<\/p>\n<p><img decoding=\"async\" class=\"\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_png\/FcLK21Ir4gP1r2hZ6PHHibMcAFbs1NVKjAc6ZAsiawpbbe0vARNtibuDCUibqvT4RrBLibyfoGSCoicwpAZu7Z8Kjz5Q\/640?wx_fmt=gif&amp;wxfrom=5&amp;wx_lazy=1\" data-type=\"gif\" data-src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_png\/FcLK21Ir4gP1r2hZ6PHHibMcAFbs1NVKjAc6ZAsiawpbbe0vARNtibuDCUibqvT4RrBLibyfoGSCoicwpAZu7Z8Kjz5Q\/0?wx_fmt=gif\" data-copyright=\"0\" data-ratio=\"0.6666666666666666\" data-w=\"600\" data-fail=\"0\" \/><\/p>\n<p><strong>\u25b2F<\/strong><strong>edratinib\u7684\u5206\u5b50\u7ed3\u6784\u5f0f\uff08\u56fe\u7247\u6765\u6e90\uff1aSelleck Chemicals\uff09<\/strong><\/p>\n<p>\u8003\u8651\u5230\u8fd9\u4e00\u75be\u75c5\u7684\u98ce\u9669\uff0c\u7f8e\u56fdFDA\u57282013\u5e74\u6682\u505c\u4e86\u8be5\u4e34\u5e8a\u8bd5\u9a8c\u7684\u8fdb\u884c\u3002<strong>\u8d5b\u8bfa\u83f2\u4ec5\u9694\u4e00\u4e2a\u5468\u672b\u5c31\u5f88\u5feb\u505a\u51fa\u4e86\u56de\u5e94\uff0c\u5e76\u51b3\u5b9a\u7ec8\u6b627\u9879\u6b63\u5728\u8fdb\u884c\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/strong>\u50cf\u7279\u857e\u838e\u8fd9\u6837\u539f\u672c\u5df2\u8ba9\u75c5\u60c5\u5f97\u5230\u63a7\u5236\u7684\u60a3\u8005\uff0c\u4e0d\u5f97\u4e0d\u91cd\u65b0\u5bfb\u627e\u65b0\u7684\u6cbb\u7597\u65b9\u6cd5\u3002<\/p>\n<p>\u8bb8\u591a\u4eba\u5e76\u6ca1\u6709\u627e\u5230\u89e3\u51b3\u65b9\u6848\u3002<strong>\u7279\u857e\u838e\u7684\u75c5\u60c5\u5f88\u5feb\u51fa\u73b0\u590d\u53d1\u548c\u6076\u5316\u30022016\u5e74\uff0c\u5979\u79bb\u5f00\u4e86\u4eba\u4e16\u3002<\/strong>\u5361\u5d14\u5965\u5a1c\u533b\u751f\u8bf4\uff0c\u8bb8\u591a\u5728\u7814\u836f\u7269\u90fd\u4f7f\u7528\u4e86\u7c7b\u4f3c\u7684\u673a\u5236\uff0c\u4f46\u5b83\u4eec\u4e0d\u5982fedratinib\u6709\u6548\u3002\u65e0\u6570\u533b\u751f\u4e0e\u60a3\u8005\u4eec\u8bf7\u6c42\u7ee7\u7eed\u63d0\u4f9b\u8fd9\u6b3e\u65b0\u836f\uff0c\u597d\u8ba9\u4ed6\u4eec\u7684\u751f\u547d\u5ef6\u7eed\u3002<\/p>\n<section>\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\"><strong>\u91cd\u65b0\u51fa\u53d1<\/strong><\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<section class=\"\">\n<section class=\"\">\n<section class=\"\"><\/section>\n<\/section>\n<\/section>\n<\/section>\n<p>\u60a3\u8005\u7684\u9700\u6c42\u4f20\u5230\u4e86\u7ea6\u7ff0\u7684\u8033\u6735\u91cc\u3002\u4f5c\u4e3afedratinib\u7684\u5171\u540c\u53d1\u660e\u4eba\u4e4b\u4e00\uff0c\u7ea6\u7ff0\u5728\u8d5b\u8bfa\u83f2\u6536\u8d2dTargeGen\u524d\uff0c\u5c31\u79bb\u5f00\u4e86\u8fd9\u5bb6\u516c\u53f8\u3002\u4e0e\u51e0\u540d\u670b\u53cb\u4e00\u9053\uff0c\u4ed6\u5171\u540c\u521b\u7acb\u4e86\u4e00\u5bb6\u540d\u4e3aSamumed\u7684\u751f\u7269\u6280\u672f\u65b0\u9510\uff0c\u51fa\u4efb\u9996\u5e2d\u79d1\u5b66\u5b98\u4e00\u804c\u3002\u5728\u90a3\u91cc\uff0c\u7ea6\u7ff0\u4e0e\u56e2\u961f\u5c06\u591a\u6b3e\u5019\u9009\u65b0\u836f\u5e26\u5230\u4e86\u665a\u671f\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\uff0c\u5e76\u5e2e\u52a9Samumed\u6210\u4e3a\u4e00\u5bb6\u201c\u72ec\u89d2\u517d\u201d\u3002<\/p>\n<p>\u4f46\u4ed6\u4e00\u76f4\u6ca1\u6709\u5fd8\u8bb0\u66fe\u7ecf\u4e3afedratinib\u503e\u6ce8\u7684\u5fc3\u8840\uff0c\u800c\u4ece\u7279\u857e\u838e\u4e0e\u5361\u5d14\u5965\u5a1c\u90a3\u91cc\u542c\u5230\u7684\u6545\u4e8b\u4e5f\u8ba9\u4ed6\u96be\u8fc7\u3002\u201c<strong>\u57282013\u5e74\u7ec8\u6b62\u5f00\u53d1fedratinib\u7684\u51b3\u5b9a\u8ba9\u8bb8\u591a\u60a3\u8005\u5fc3\u788e\u3002<\/strong>\u5f53\u65f6\uff0c\u4ed6\u4eec\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u53d6\u5f97\u4e86\u975e\u5e38\u79ef\u6781\u7684\u7f13\u89e3\u3002\u5bf9\u8fd9\u4e9b\u60a3\u8005\u6765\u8bf4\uff0c\u80fd\u591f\u4f7f\u7528\u7684\u6cbb\u7597\u65b9\u6848\u975e\u5e38\u6709\u9650\u3002\u5bf9\u4e8e\u5927\u90e8\u5206\u60a3\u8005\u6765\u8bf4\uff0c\u9664\u4e86fedratinib\u4e4b\u5916\uff0c\u51e0\u4e4e\u6ca1\u6709\u5176\u4ed6\u6709\u6548\u7684\u836f\u7269\u3002\u201d\u7ea6\u7ff0\u8bf4\u9053\u3002<\/p>\n<p><img decoding=\"async\" class=\"\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_png\/FcLK21Ir4gP1r2hZ6PHHibMcAFbs1NVKjucxT08gFADeicUhPE3XibTpdqv8xnDrANedrKrZM0PFXTLxbDtianuMYw\/640?wx_fmt=png&amp;wxfrom=5&amp;wx_lazy=1\" data-s=\"300,640\" data-type=\"png\" data-src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_png\/FcLK21Ir4gP1r2hZ6PHHibMcAFbs1NVKjucxT08gFADeicUhPE3XibTpdqv8xnDrANedrKrZM0PFXTLxbDtianuMYw\/0?wx_fmt=png\" data-copyright=\"0\" data-ratio=\"0.5122950819672131\" data-w=\"732\" data-fail=\"0\" 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Biomedicines\u7684\u65b0\u9510\u3002\u800c\u4ed6\u4eec\u7684\u76ee\u7684\uff0c\u5c31\u662f\u53d6\u56defedratinib\u7684\u5f00\u53d1\u8bb8\u53ef\uff0c\u5c06\u5b83\u63a8\u8fdb\u4e0a\u5e02\u3002<\/p>\n<p>\u4e0e\u8d5b\u8bfa\u83f2\u7684\u6c9f\u901a\u975e\u5e38\u987a\u5229\u3002<strong>Impact\u83b7\u5f97\u4e86fedratinib\u5728\u5168\u7403\u7684\u5f00\u53d1\u4e0e\u5546\u4e1a\u5316\u6743\u76ca\uff0c\u8d5b\u8bfa\u83f2\u6ca1\u6709\u5411Impact\u6536\u53d6\u4efb\u4f55\u5148\u671f\u4ed8\u6b3e\u3002<\/strong>\u800c\u4e3a\u4e86\u7ee7\u7eed\u5f00\u53d1fedratinib\uff0cImpact\u8058\u8bf7\u4e86\u4e00\u6279\u5177\u6709\u4e30\u5bcc\u7ecf\u9a8c\u7684\u65b0\u836f\u7814\u53d1\u4eba\u5458\uff0c\u5176\u4e2d\u5305\u62ec\u4e86\u6765\u81ea\u4e8eTargeGen\u7684\u539f\u59cb\u5f00\u53d1\u56e2\u961f\u6210\u5458\u3002\u8fd9\u597d\u4f3c\u6700\u521d\u68a6\u60f3\u7684\u518d\u805a\u9996\u3002<\/p>\n<p><img decoding=\"async\" class=\"\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_png\/FcLK21Ir4gP1r2hZ6PHHibMcAFbs1NVKj2RXIDvbL8SGm8tEOibDkE5IYkIdkJKgeRX1KR52ZsdX9ogbkXUN7tdg\/640?wx_fmt=png&amp;wxfrom=5&amp;wx_lazy=1\" data-s=\"300,640\" data-type=\"png\" data-src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_png\/FcLK21Ir4gP1r2hZ6PHHibMcAFbs1NVKj2RXIDvbL8SGm8tEOibDkE5IYkIdkJKgeRX1KR52ZsdX9ogbkXUN7tdg\/0?wx_fmt=png\" data-copyright=\"0\" data-ratio=\"1.4788069073783359\" data-w=\"1911\" data-fail=\"0\" \/><\/p>\n<p><strong>\u25b2Fedratinib\u7684\u4f5c\u7528\u673a\u7406<\/strong><strong>\uff08\u56fe\u7247\u6765\u6e90\uff1aImpact\u5b98\u65b9\u7f51\u7ad9\uff09<\/strong><\/p>\n<p>\u7ea6\u7ff0\u548c\u4ed6\u7684\u56e2\u961f\u540c\u65f6\u4e5f\u83b7\u5f97\u4e86fedratinib\u7684\u6700\u65b0\u4e34\u5e8a\u6570\u636e\uff0c\u8fd9\u5305\u62ec\u4e8618\u9879\u4e0d\u540c\u7684\u7814\u7a76\uff0c\u6d89\u53ca\u5230877\u540d\u60a3\u8005\u3002\u5728\u4e00\u9879\u540d\u4e3aJAKARTA-1\u7684\u5168\u74033\u671f\u5173\u952e\u4e34\u5e8a\u8bd5\u9a8c\u91cc\uff0cfedratinib\u572824\u5468\u7684\u6cbb\u7597\u540e\uff0c\u663e\u8457\u51cf\u5c11\u4e86\u60a3\u8005\u813e\u810f\u5c3a\u5bf8\u3002<strong>\u572836%\u7684\u53d7\u8bd5\u8005\u4e2d\uff0c\u51cf\u5c11\u7684\u5e45\u5ea6\u8d85\u8fc7\u4e8650%\uff08p&lt;0.0001\uff09\u3002\u8fd9\u8fbe\u5230\u4e86\u4e3b\u8981\u4e34\u5e8a\u7ec8\u70b9\u548c\u6b21\u8981\u4e34\u5e8a\u7ec8\u70b9\u3002<\/strong>\u5728\u968f\u540e\u8fdb\u884c\u7684\u4e00\u9879\u540d\u4e3aJAKARTA-2\u7684\u4e34\u5e8a\u8bd5\u9a8c\u91cc\uff0c\u7814\u7a76\u4eba\u5458\u8fdb\u4e00\u6b65\u5206\u6790\u4e86\u5bf9\u73b0\u6709\u7597\u6cd5\u4ea7\u751f\u8010\u53d7\u7684\u60a3\u8005\uff0c\u662f\u5426\u4e5f\u80fd\u4ecefedratinib\u7684\u6cbb\u7597\u4e2d\u53d7\u76ca\u3002\u7ed3\u679c\u8868\u660e\uff0cfedratinib\u540c\u6837\u8ba955%\u7684\u60a3\u8005\u51fa\u73b0\u4e8635%\u4ee5\u4e0a\u7684\u813e\u810f\u5c3a\u5bf8\u7f29\u5c0f\u3002<strong>\u8fd9\u8868\u660e\u5bf9\u4e8e\u73b0\u6709\u7597\u6cd5\u4e0d\u8d77\u53cd\u5e94\u7684\u60a3\u8005\uff0cfedratinib\u6709\u671b\u6210\u4e3a\u4ed6\u4eec\u7684\u65b0\u798f\u97f3\uff01<\/strong><\/p>\n<p>\u53e6\u4e00\u65b9\u9762\uff0c\u5361\u5d14\u5965\u5a1c\u4e5f\u5728\u5206\u6790\u4e3a\u4f55\u60a3\u8005\u4f1a\u51fa\u73b0\u97e6\u5c3c\u514b\u8111\u75c5\u8fd9\u6837\u602a\u5f02\u7684\u526f\u4f5c\u7528\u3002\u4ed6\u4eec\u53d1\u73b0\uff0c<strong>\u5728\u63a5\u53d7\u6cbb\u7597\u65f6\uff0c\u7531\u4e8e\u75be\u75c5\u5e26\u6765\u7684\u538b\u529b\uff0c\u764c\u75c7\u60a3\u8005\u5f80\u5f80\u4f1a\u51fa\u73b0\u8425\u517b\u4e0d\u826f\uff0c\u800c\u8fd9\u662f\u97e6\u5c3c\u514b\u8111\u75c5\u51fa\u73b0\u7684\u539f\u56e0\u3002<\/strong>\u4e4b\u524d\uff0c\u7814\u7a76\u4eba\u5458\u6ca1\u6709\u68c0\u67e5\u60a3\u8005\u7684\u8425\u517b\u60c5\u51b5\uff0c\u56e0\u6b64\u5bfc\u81f4\u4e86\u4e00\u7cfb\u5217\u526f\u4f5c\u7528\u7684\u8bde\u751f\u3002\u5982\u4eca\uff0c\u6211\u4eec\u6709\u671b\u907f\u514d\u526f\u4f5c\u7528\u7684\u518d\u6b21\u4ea7\u751f\u3002<\/p>\n<p><img decoding=\"async\" class=\"\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/FcLK21Ir4gP1r2hZ6PHHibMcAFbs1NVKjCQEE5yAW6r3LXcRqFgZEll3prWy387eDsPwP0Qic5Wjq3NZdj4JuN4A\/640?wx_fmt=jpeg&amp;wxfrom=5&amp;wx_lazy=1\" data-s=\"300,640\" data-type=\"jpeg\" data-src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/FcLK21Ir4gP1r2hZ6PHHibMcAFbs1NVKjCQEE5yAW6r3LXcRqFgZEll3prWy387eDsPwP0Qic5Wjq3NZdj4JuN4A\/0?wx_fmt=jpeg\" data-copyright=\"0\" data-ratio=\"0.30859375\" data-w=\"1280\" data-fail=\"0\" \/><\/p>\n<p><strong>\u25b2Fedratinib\u540c\u65f6\u4e5f\u6709\u671b\u7528\u4e8e\u5176\u4ed6\u75be\u75c5\u7684\u6cbb\u7597<\/strong><strong>\uff08\u56fe\u7247\u6765\u6e90\uff1aImpact\u5b98\u65b9\u7f51\u7ad9\uff09<\/strong><\/p>\n<p>\u201c\u7531\u4e8e\u9aa8\u9ad3\u7ea4\u7ef4\u5316\u6709\u7740\u975e\u5e38\u9ad8\u7684\u533b\u7597\u9700\u6c42\uff0cImpact\u56e2\u961f\u5b8c\u6210\u4e86\u5bf9\u73b0\u6709\u6570\u636e\u7684\u8be6\u7ec6\u68c0\u67e5\u3002<strong>\u6211\u5f88\u9ad8\u5174\u5730\u5ba3\u5e03\uff0cFDA\u5df2\u7ecf\u5141\u8bb8\u4e34\u5e8a\u8bd5\u9a8c\u7ee7\u7eed\u8fdb\u884c\u4e0b\u53bb<\/strong>\uff0c\u201d\u7ea6\u7ff0\u5174\u594b\u5730\u8bf4\u9053\uff1a\u201c\u5728\u9aa8\u9ad3\u7ea4\u7ef4\u5316\u5916\uff0cImpact\u4e5f\u5e0c\u671b\u80fd\u5bfb\u627efedratinib\u7684\u5176\u4ed6\u4e34\u5e8a\u5e94\u7528\uff0c\u8ba9\u5b83\u6210\u4e3a\u540c\u7c7b\u6700\u4f73\uff08best-in-class\uff09\u7684JAK2\u6fc0\u9176\u6291\u5236\u5242\u3002\u201d<\/p>\n<p>\u91cd\u89c1fedratinib\u4e0a\u5e02\u66d9\u5149\u7684Impact\u5f97\u5230\u4e86\u4e1a\u5185\u7684\u4e00\u81f4\u770b\u597d\u300210\u670813\u65e5\uff0c\u5b83\u83b7\u5f97\u4e862200\u4e07\u7f8e\u5143\u7684\u6295\u8d44\u3002\u4ec5\u57282\u5468\u540e\uff0cImpact\u5ba3\u5e03\uff0c\u5f53\u8f6e\u878d\u8d44\u4e00\u5171\u83b7\u5f97\u4e869000\u4e07\u7f8e\u5143\u3002<\/p>\n<p>\u7ea6\u7ff0\u76f8\u4fe1\uff0c\u5728\u73b0\u6709\u7684\u6570\u636e\u4e0b\uff0cImpact\u6709\u671b\u5728\u8fd1\u671f\u9012\u4ea4fedratinib\u7684\u65b0\u836f\u7533\u8bf7\u3002\u201c\u6211\u4eec\u6b63\u5728\u4e0eFDA\u8fdb\u884c\u534f\u5546\u3002\u201d\u7ea6\u7ff0\u8bf4\u3002<strong>\u65e0\u8bba\u662f\u5bf9\u4ed6\uff0c\u8fd8\u662f\u5bf9\u4e8e\u65e0\u6570\u7f79\u60a3\u9aa8\u9ad3\u7ea4\u7ef4\u5316\u7684\u60a3\u8005\uff0c\u4ed6\u4eec\u8ddd\u79bb\u68a6\u60f3\u7684\u5b9e\u73b0\uff0c\u4ece\u672a\u5982\u6b64\u63a5\u8fd1\u3002<\/strong><\/p>\n<p>\u53c2\u8003\u8d44\u6599\uff1a<\/p>\n<p>[1] Abandoned blood cancer drug resurrected by San Diego startup<\/p>\n<p>[2] Fighting patient, fighting doctor<\/p>\n<p>[3] Four years after it imploded at Sanofi, John Hood is resurrecting the myelofibrosis drug fedratinib<\/p>\n<p>[4] Impact\u5b98\u65b9\u7f51\u7ad9<\/p>\n<p>[5] Impact bags $22M to save ex-Sanofi drug from trial limbo<\/p>\n<p><a href=\"https:\/\/www.sandiegochinesepress.com\/press\/wp-content\/uploads\/2017\/10\/02.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-large wp-image-1297432\" src=\"https:\/\/www.sandiegochinesepress.com\/press\/wp-content\/uploads\/2017\/10\/02-576x162.gif\" alt=\"\" width=\"474\" height=\"133\" \/><\/a> <a href=\"https:\/\/www.sandiegochinesepress.com\/press\/wp-content\/uploads\/2017\/10\/0.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-large wp-image-1297433\" src=\"https:\/\/www.sandiegochinesepress.com\/press\/wp-content\/uploads\/2017\/10\/0-576x115.gif\" alt=\"\" width=\"474\" height=\"95\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e3a\u60a3\u8005\u5e26\u6765\u62ef\u6551\u751f\u547d\u7684\u65b0\u836f\u662f\u6bcf\u4e00\u540d\u7814\u53d1\u4eba\u5458\u7684\u68a6\u60f3\u3002\u5728\u68a6\u60f3\u7c89\u788e\u524d\uff0c\u7ea6\u7ff0\u00b7\u80e1\u5fb7\uff08John Hood\uff09\u79bb\u5b83\u66fe\u53ea\u6709\u4e00\u6b65\u4e4b\u9065&#8230;..<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-1297520","post","type-post","status-publish","format-standard","hentry","category-science_technology_education"],"_links":{"self":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1297520","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/comments?post=1297520"}],"version-history":[{"count":0,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1297520\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media?parent=1297520"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/categories?post=1297520"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/tags?post=1297520"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}