{"id":1298695,"date":"2018-01-26T17:20:25","date_gmt":"2018-01-27T01:20:25","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=1298695"},"modified":"2018-01-26T17:34:31","modified_gmt":"2018-01-27T01:34:31","slug":"2018%ef%bc%9a%e5%9c%a3%e5%9c%b0%e4%ba%9a%e5%93%a5%e5%8d%8e%e4%ba%ba%e7%b2%be%e8%8b%b1%e5%8e%89%e5%ae%b3%e4%ba%86%ef%bc%81%ef%bc%88%e7%b3%bb%e5%88%97%e4%b8%80%ef%bc%89sabpa","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/2018%ef%bc%9a%e5%9c%a3%e5%9c%b0%e4%ba%9a%e5%93%a5%e5%8d%8e%e4%ba%ba%e7%b2%be%e8%8b%b1%e5%8e%89%e5%ae%b3%e4%ba%86%ef%bc%81%ef%bc%88%e7%b3%bb%e5%88%97%e4%b8%80%ef%bc%89sabpa\/.html","title":{"rendered":"2018\uff1a\u5723\u5730\u4e9a\u54e5\u534e\u4eba\u7cbe\u82f1\u5389\u5bb3\u4e86\uff01\uff08\u7cfb\u5217\u4e00\uff09SABPA"},"content":{"rendered":"<p><strong>\u836f\u660e\u5eb7\u5fb7\u4f20\u5a92\u62a5\u9053\uff1a<\/strong><\/p>\n<h4 class=\"news-title\" style=\"text-align: center;\"><span style=\"color: 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decoding=\"async\" src=\"http:\/\/med.sina.com\/files\/20180126\/jpg\/1516938728660.jpg\" alt=\"\" align=\"middle\" \/><\/p>\n<p>\u25b2ARS-1620\u7684\u4f5c\u7528\u673a\u7406\uff08\u56fe\u7247\u6765\u6e90\uff1a\u300a\u7ec6\u80de\u300b\uff09<\/p>\n<p>\u968f\u540e\uff0c\u7814\u7a76\u4eba\u5458\u4eec\u5206\u6790\u4e86ARS-1620\u7684\u6f5c\u5728\u8131\u9776\u6548\u5e94\u2014\u2014\u4f5c\u4e3a\u4e00\u6b3e\u5171\u4ef7\u6291\u5236\u5242\uff0c\u5982\u679c\u5b83\u80fd\u663e\u8457\u6291\u5236\u5176\u4ed6\u86cb\u767d\u7684\u529f\u80fd\uff0c\u5c31\u4f1a\u5e26\u6765\u610f\u6599\u4e4b\u5916\u7684\u526f\u4f5c\u7528\u3002\u5206\u6790\u8868\u660e\uff0cKRAS G12C\u662f\u5b83\u6700\u4e3b\u8981\u7684\u6291\u5236\u5bf9\u8c61\u3002<\/p>\n<p>\u6b64\u5916\uff0c\u7814\u7a76\u4eba\u5458\u4eec\u4e5f\u901a\u8fc7\u5206\u6790\u5168\u57fa\u56e0\u7ec4\u7684\u8868\u8fbe\u60c5\u51b5\uff0c\u786e\u8ba4\u4e86ARS-1620\u7684\u786e\u53ef\u4ee5\u6291\u5236KRAS\u7684\u4e0b\u6e38\u901a\u8def\u3002<\/p>\n<p>\u63a5\u4e0b\u6765\uff0c\u5c31\u662f\u6700\u4e3a\u4ee4\u4eba\u7d27\u5f20\u7684\u65f6\u523b\u4e86\u3002\u7814\u7a76\u4eba\u5458\u4eec\u8ba9\u5c0f\u9f20\u6a21\u578b\u901a\u8fc7\u53e3\u670d\u6444\u5165\u4e86ARS-1620\uff0c\u5e76\u5206\u6790\u5176\u8be5\u5206\u5b50\u5728\u4f53\u5185\u7684\u4e00\u7cfb\u5217\u6307\u6807\u3002\u4ed6\u4eec\u9ad8\u5174\u5730\u770b\u5230\uff0c\u8fd9\u6b3e\u5206\u5b50\u6709\u7740\u6781\u597d\u7684\u751f\u7269\u53ef\u5229\u7528\u6027\uff08bioavailability\uff09\uff0c\u5728\u8840\u6db2\u4e2d\u7684\u6d53\u5ea6\u4e5f\u5f88\u7a33\u5b9a\u3002\u5728\u80bf\u7624\u9644\u8fd1\uff0cARS-1620\u4e5f\u6709\u7740\u8f83\u597d\u7684\u5cf0\u503c\u6d53\u5ea6\u3002<\/p>\n<p><img decoding=\"async\" class=\"aligncenter\" src=\"http:\/\/med.sina.com\/files\/20180126\/jpg\/1516938739756.jpg\" alt=\"\" align=\"middle\" \/><\/p>\n<p>\u25b2ARS-1620\u5728\u4f53\u5185\u6709\u6548\u51cf\u5c11\u7684KRAS G12C\u80bf\u7624\u7684\u4f53\u79ef\uff08\u56fe\u7247\u6765\u6e90\uff1a\u300a\u7ec6\u80de\u300b\uff09<\/p>\n<p>\u8fd9\u4e9b\u51fa\u8272\u7684\u5c5e\u6027\uff0c\u80fd\u5426\u8ba9ARS-1620\u5728\u4f53\u5185\u8d77\u5230\u6291\u5236\u80bf\u7624\u751f\u957f\u7684\u4f5c\u7528\u5462\uff1f\u7814\u7a76\u4eba\u5458\u5728\u5c0f\u9f20\u7684\u80bf\u7624\u6a21\u578b\u4e2d\u8fdb\u4e00\u6b65\u6d4b\u8bd5\u4e86ARS-1620\u7684\u6548\u679c\uff0c\u800c\u7ed3\u679c\u8ba9\u4eba\u611f\u5230\u6b23\u559c\uff01\u5728\u4e24\u4e2a\u4e0d\u540c\u7684\u6d53\u5ea6\u4e0b\uff0cARS-1620\u90fd\u80fd\u663e\u8457\u7f29\u5c0fKRAS G12C\u80bf\u7624\u7684\u4f53\u79ef\uff0c\u800c\u4e14\u7f29\u5c0f\u7684\u5e45\u5ea6\u4e0e\u7528\u836f\u91cf\u76f8\u5173\u3002\u6b64\u5916\uff0c\u53e6\u4e00\u79cdKRAS\u7a81\u53d8\uff08KRAS G12V\uff09\u7684\u80bf\u7624\u5219\u6ca1\u6709\u53d7\u8be5\u5206\u5b50\u7684\u5f71\u54cd\uff0c\u4f53\u73b0\u4e86\u8be5\u5206\u5b50\u7684\u7279\u5f02\u6027\u3002<\/p>\n<p>\u5728\u591a\u4e2aKRAS G12C\u80bf\u7624\u6a21\u578b\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u4eec\u6210\u529f\u91cd\u590d\u4e86\u8fd9\u4e00\u7ed3\u679c\u2014\u2014ARS-1620\u5728\u4f53\u5185\u5b9e\u9a8c\u4e2d\u5747\u80fd\u663e\u8457\u7f29\u5c0f\u80bf\u7624\u7684\u4f53\u79ef\uff0c\u4e14\u5f70\u663e\u51fa\u4e86\u826f\u597d\u7684\u9009\u62e9\u6027\u3002<\/p>\n<p><img decoding=\"async\" src=\"http:\/\/med.sina.com\/files\/20180126\/jpg\/1516938752165.jpg\" alt=\"\" align=\"middle\" \/><\/p>\n<p>\u25b2\u8be5\u7814\u7a76\u7684\u56fe\u793a\uff08\u56fe\u7247\u6765\u6e90\uff1a\u300a\u7ec6\u80de\u300b\uff09<\/p>\n<p>\u201c\u8fd9\u4e9b\u5c0f\u9f20\u4f53\u5185\u5b9e\u9a8c\u7684\u6570\u636e\u8868\u660e\uff0cARS-1620\u5728\u591a\u4e2a\u6a21\u578b\u4e2d\u90fd\u5177\u6709\u7597\u6548\u3002\u8fd9\u6709\u671b\u8f6c\u5316\u4e3a\u65b0\u7684\u7597\u6cd5\uff0c\u9020\u798f\u90a3\u4e9b\u7f79\u60a3KRAS G12C\u7684\u764c\u75c7\u60a3\u8005\uff0c\u201d\u8be5\u7814\u7a76\u7684\u901a\u8baf\u4f5c\u8005\u5218\u5f02\u535a\u58eb\u8bf4\u9053\uff1a\u201c\u6211\u611f\u8c22\u53c2\u4e0e\u8fd9\u9879\u7814\u7a76\u7684\u6240\u6709\u79d1\u7814\u4eba\u5458\u3002\u4ed6\u4eec\u7684\u667a\u6167\u4e0e\u52aa\u529b\u8ba9\u8fd9\u9879\u7a81\u7834\u6210\u4e3a\u4e86\u53ef\u80fd\u3002\u201d<\/p>\n<p>\u6211\u4eec\u795d\u8d3a\u8fd9\u652f\u56e2\u961f\u5728\u8bbe\u8ba1\u9488\u5bf9KRAS\u7a81\u53d8\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5242\u4e0a\u53d6\u5f97\u7a81\u7834\uff0c\u4e5f\u795d\u613f\u8fd9\u6b3e\u5206\u5b50\u80fd\u5728\u63a5\u4e0b\u6765\u7684\u4e00\u7cfb\u5217\u8bd5\u9a8c\u4e2d\u8d70\u5f97\u66f4\u8fdc\uff0c\u65e9\u65e5\u9020\u798f\u60a3\u8005\uff01<\/p>\n<p>\u7f16\u8005\u9644\uff1a\u5218\u5f02\uff0c\u5317\u5927\u751f\u726985\u7ea7\uff0c\u76ee\u524d\u4e3a\u6e90\u6cc9(Wellspring)\u751f\u7269\u6280\u672f\u516c\u53f8\u9996\u5e2d\u79d1\u5b66\u5b98\u517c\u8054\u5408\u521b\u59cb\u4eba\u3002\u4e5f\u4e3a<span class=\"st\">\u7f8e\u4e2d\u751f\u7269\u533b\u5b66\u4e0e\u5236\u836f\u534f\u4f1a<\/span>\uff08SABPA\uff09\u8d1f\u8d23\u4eba\u4e4b\u4e00\u3002<\/p>\n<p>\u53c2\u8003\u8d44\u6599\uff1a<\/p>\n<p>[1] Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor<\/p>\n<p>[2] Kura Oncology\u5b98\u65b9\u7f51\u7ad9<\/p>\n<p>[3] http:\/\/www.chinanews.com\/lxsh\/2013\/05-07\/4792884.shtml<\/p>\n<p><a href=\"https:\/\/www.sandiegochinesepress.com\/press\/wp-content\/uploads\/2018\/01\/0.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-1298593\" src=\"https:\/\/www.sandiegochinesepress.com\/press\/wp-content\/uploads\/2018\/01\/0.gif\" alt=\"\" width=\"600\" height=\"120\" \/><\/a> <a href=\"https:\/\/www.sandiegochinesepress.com\/press\/wp-content\/uploads\/2018\/01\/02.gif\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-1298592\" src=\"https:\/\/www.sandiegochinesepress.com\/press\/wp-content\/uploads\/2018\/01\/02.gif\" alt=\"\" width=\"600\" height=\"169\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5728\u764c\u75c7\u7814\u7a76\u9886\u57df\uff0cKRAS\u662f\u6700\u4e3a\u77e5\u540d\u7684\u81f4\u764c\u57fa\u56e0\u4e4b\u4e00\uff1a\u79d1\u5b66\u5bb6\u4eec\u65e9\u5c31\u53d1\u73b0\uff0c\u5728\u591a\u79cd\u4eba\u7c7b\u764c\u75c7\u91cc\uff0c\u8fd9\u4e2a\u57fa\u56e0\u90fd\u53d1\u751f\u4e86\u7a81\u53d8\u3002\u7136\u800c\u51e0\u5341\u5e74\u6765\uff0c\u7ecf\u8fc7\u6570\u4ee3\u7814\u53d1\u4eba\u5458\u7684\u4e0d\u61c8\u52aa\u529b&#8230;&#8230;<\/p>\n","protected":false},"author":3,"featured_media":1298696,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-1298695","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-headline"],"_links":{"self":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1298695","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/comments?post=1298695"}],"version-history":[{"count":0,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1298695\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media\/1298696"}],"wp:attachment":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media?parent=1298695"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/categories?post=1298695"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/tags?post=1298695"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}