{"id":1298899,"date":"2018-02-14T18:01:02","date_gmt":"2018-02-15T02:01:02","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=1298899"},"modified":"2018-02-14T18:01:02","modified_gmt":"2018-02-15T02:01:02","slug":"ucsd%e5%8d%8e%e8%a3%94%e5%ad%a6%e8%80%85%e5%b9%b2%e7%bb%86%e8%83%9e%e7%a0%94%e7%a9%b6%e6%96%b0%e7%aa%81%e7%a0%b4%e5%9c%a8%e3%80%8a%e7%a7%91%e5%ad%a6%e3%80%8b%e5%ad%90%e5%88%8a%e5%8f%91%e8%a1%a8","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/ucsd%e5%8d%8e%e8%a3%94%e5%ad%a6%e8%80%85%e5%b9%b2%e7%bb%86%e8%83%9e%e7%a0%94%e7%a9%b6%e6%96%b0%e7%aa%81%e7%a0%b4%e5%9c%a8%e3%80%8a%e7%a7%91%e5%ad%a6%e3%80%8b%e5%ad%90%e5%88%8a%e5%8f%91%e8%a1%a8\/.html","title":{"rendered":"UCSD\u534e\u88d4\u5b66\u8005\u5e72\u7ec6\u80de\u7814\u7a76\u65b0\u7a81\u7834\u5728\u300a\u79d1\u5b66\u300b\u5b50\u520a\u53d1\u8868\uff08\u56fe\uff09"},"content":{"rendered":"<h4 class=\"article-header-title\"><em><span style=\"color: #000080;\">\u836f\u660e\u5eb7\u5fb7\u4f20\u5a92\u62a5\u9053\uff1a<\/span><\/em><\/h4>\n<h5 class=\"article-header-title\" style=\"text-align: center;\"><strong>\u300a\u79d1\u5b66\u300b\uff08Science \uff09\u5b50\u520a\uff1a\u534e\u4eba\u5b66\u8005\u5e72\u7ec6\u80de\u7814\u7a76\u65b0\u7a81\u7834\uff0c\u5355\u4e00\u5206\u5b50\u5373\u53ef\u9ad8\u6548\u8bf1\u5bfc\u8840\u7ba1\u5173\u952e\u7ec6\u80de<\/strong><\/h5>\n<p>&nbsp;<\/p>\n<p>\u7531\u4e8e\u5728\u533b\u7597\u4e0a\u7684\u5de8\u5927\u6f5c\u529b\uff0c\u5e72\u7ec6\u80de\u6280\u672f\u5728\u8fd1\u5e74\u6765\u5f97\u5230\u4e86\u8bf8\u591a\u5173\u6ce8\u3002\u5982\u4eca\uff0c\u6211\u4eec\u5df2\u7ecf\u627e\u5230\u4e86\u5c06\u666e\u901a\u7ec6\u80de\u8bf1\u5bfc\u6210\u591a\u80fd\u5e72\u7ec6\u80de\u7684\u65b9\u6cd5\uff0c\u800c\u8fd9\u4e9b\u5e72\u7ec6\u80de\u4e5f\u6709\u5206\u5316\u6210\u4f17\u591a\u4e0d\u540c\u7c7b\u578b\u7ec6\u80de\u7684\u6f5c\u529b\u3002\u7136\u800c\uff0c\u5982\u4f55\u5c06\u8fd9\u4e9b\u5e72\u7ec6\u80de\u9009\u62e9\u6027\u5206\u5316\u6210\u7814\u7a76\u4eba\u5458\u60f3\u8981\u7684\u7ec6\u80de\uff0c\u4f9d\u7136\u662f\u4e00\u4e2a\u6709\u5f85\u89e3\u51b3\u7684\u95ee\u9898\u3002<\/p>\n<p><img decoding=\"async\" class=\"aligncenter\" src=\"http:\/\/www.bio360.net\/storage\/image\/2018\/02\/gPgzYfHoy9GLy5oNzqdBXNAVzO6TYNzmj2jMSiKo.png\" alt=\"QQ \u622a\u56fe 20180214113626\" \/><\/p>\n<p>\u25b2\u672c\u7814\u7a76\u7684\u901a\u8baf\u4f5c\u8005 Jonathan Lin \u6559\u6388\uff08\u56fe\u7247\u6765\u6e90\uff1a\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821\uff09<\/p>\n<p>\u4eca\u65e5\uff0c\u300a\u79d1\u5b66\u300b\u5b50\u520a\u300aScience Signaling\u300b\u520a\u767b\u4e86\u4e00\u7bc7\u6765\u81ea\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821\uff08UCSD\uff09\u7684\u7814\u7a76\u3002\u534e\u4eba\u5b66\u8005 Jonathan Lin \u6559\u6388\u4e0e\u4ed6\u7684\u56e2\u961f\u610f\u5916\u53d1\u73b0\uff0c\u4e00\u79cd\u5206\u5b50\u53ef\u4ee5\u5c06\u5e72\u7ec6\u80de\u8bf1\u5bfc\u6210\u4e3a\u8840\u7ba1\u3002\u8fd9\u6709\u671b\u7528\u4e8e\u4e2d\u98ce\u6216\u662f\u5fc3\u810f\u75c5\u7684\u7ec6\u80de\u7597\u6cd5\u3002<\/p>\n<p>Jonathan Lin \u6559\u6388\u4ee5\u9610\u660e ATF6 \u57fa\u56e0\u4e0e\u9057\u4f20\u5b66\u773c\u75c5\u4e4b\u95f4\u7684\u5173\u7cfb\u800c\u77e5\u540d\u3002Lin \u6559\u6388\u7684\u56e2\u961f\u66fe\u53d1\u73b0\uff0c\u5982\u679c\u60a3\u8005\u7684 ATF6 \u57fa\u56e0\u53d1\u751f\u7a81\u53d8\uff0c\u60a3\u8005\u773c\u5e95\u9ec4\u6591\u533a\u4e2d\u5fc3\u5c0f\u7a9d\uff08fovea\uff09\u5c31\u4f1a\u51fa\u73b0\u5f02\u5e38\uff0c\u800c\u8fd9\u4e00\u533a\u57df\u5bf9\u4e8e\u89c6\u89c9\u7684\u6e05\u6670\u5ea6\u81f3\u5173\u91cd\u8981\u3002\u56e0\u6b64\uff0c\u8fd9\u4e9b\u60a3\u8005\u81ea\u51fa\u751f\u8d77\uff0c\u89c6\u89c9\u5c31\u6781\u53d7\u5f71\u54cd\u3002\u66f4\u7cdf\u7cd5\u7684\u662f\uff0c\u8fd9\u79cd\u9057\u4f20\u75c5\u65e0\u836f\u53ef\u6cbb\u3002<\/p>\n<p>\u51e0\u5e74\u524d\uff0cLin \u6559\u6388\u7684\u56e2\u961f\u8868\u660e ATF6 \u86cb\u767d\u662f\u4e00\u6b3e\u8f6c\u5f55\u56e0\u5b50\uff0c\u80fd\u63a7\u5236\u57fa\u56e0\u7684\u201c\u5f00\u201d\u548c\u201c\u5173\u201d\u3002\u5728\u5e72\u7ec6\u80de\u7684\u53d1\u80b2\u4e2d\uff0c\u8fd9\u4e00\u86cb\u767d\u5904\u4e8e\u81ea\u7136\u201c\u5f00\u542f\u201d\u72b6\u6001\u3002\u56e0\u6b64\uff0c\u5b83\u7684\u7a81\u53d8\u4f1a\u5f15\u8d77\u4e00\u7cfb\u5217\u4e25\u91cd\u540e\u679c\uff0c\u5305\u62ec\u89c6\u89c9\u7684\u635f\u5bb3\u3002<\/p>\n<p><img decoding=\"async\" src=\"http:\/\/www.bio360.net\/storage\/image\/2018\/02\/FNkqqlWqmfdjGfonmP1jFud2PRDVLNNvVSB3y00x.png\" alt=\"QQ \u622a\u56fe 20180214113647\" \/><\/p>\n<p>\u25b2ATF6 \u5f97\u5230\u6fc0\u6d3b\u7684\u5e72\u7ec6\u80de\u6b63\u5728\u5f62\u6210\u8840\u7ba1\uff08\u56fe\u7247\u6765\u6e90\uff1aUC San Diego Health\uff09<\/p>\n<p>\u8fd9\u9879\u7814\u7a76\u520a\u767b\u540e\uff0c\u7acb\u523b\u5728\u60a3\u8005\u7fa4\u4f53\u4e2d\u9020\u6210\u4e86\u53cd\u54cd\u3002Lin \u6559\u6388\u79f0\uff0c\u5168\u7403\u5404\u5730\u6709\u7c7b\u4f3c\u89c6\u89c9\u969c\u788d\u7684\u60a3\u8005\u7eb7\u7eb7\u8054\u7cfb\u4ed6\u7684\u5b9e\u9a8c\u5ba4\uff0c\u60f3\u4e86\u89e3\u81ea\u5df1\u662f\u5426\u5e26\u6709 ATF6 \u57fa\u56e0\u7a81\u53d8\u3002\u53e6\u5916\uff0c\u4e3a\u4e86\u4e86\u89e3\u548c\u6539\u5584\u81ea\u5df1\u7684\u75c5\u60c5\uff0c\u8fd9\u4e9b\u60a3\u8005\u4e5f\u4e3b\u52a8\u7533\u8bf7\u53c2\u4e0e\u540e\u7eed\u7684\u7814\u7a76\u3002<\/p>\n<p>Lin \u6559\u6388\u56e2\u961f\u7684\u6700\u65b0\u7814\u7a76\u6b63\u662f\u57fa\u4e8e\u548c\u60a3\u8005\u4eec\u7684\u5408\u4f5c\u3002\u5728\u7ebd\u7ea6\uff0c\u6709\u4e00\u4e2a\u5bb6\u5ead\u9971\u53d7\u9057\u4f20\u6027\u773c\u75be\u56f0\u6270\u2014\u2014\u4ed6\u4eec\u6709\u4e09\u4e2a\u5b69\u5b50\u7684 ATF6 \u57fa\u56e0\u90fd\u7f3a\u4e4f\u5b8c\u6574\u7684\u529f\u80fd\u3002\u4e3a\u4e86\u4e86\u89e3\u80fd\u5426\u6fc0\u6d3b\u8fd9\u4e9b\u57fa\u56e0\uff0c\u7814\u7a76\u4eba\u5458\u4eec\u63d0\u53d6\u4e86\u4ed6\u4eec\u7684\u8868\u76ae\u7ec6\u80de\uff0c\u8ba9\u5b83\u4eec\u201c\u8fd4\u8001\u8fd8\u7ae5\u201d\uff0c\u53d8\u6210\u4e86\u8bf1\u5bfc\u591a\u80fd\u5e72\u7ec6\u80de\u3002\u968f\u540e\uff0c\u7814\u7a76\u4eba\u5458\u4eec\u4e0e\u540c\u5904\u52a0\u5dde\u5723\u5730\u4e9a\u54e5\u7684 Scripps \u7814\u7a76\u6240\u5408\u4f5c\uff0c\u5bfb\u627e\u80fd\u5728\u5e72\u7ec6\u80de\u4e2d\u6fc0\u6d3b ATF6 \u7684\u5206\u5b50\u3002<\/p>\n<p>Scripps \u7814\u7a76\u6240\u7684\u79d1\u5b66\u5bb6\u4eec\u4ece\u6570\u767e\u4e07\u4e2a\u5316\u5b66\u5206\u5b50\u4e2d\u8fdb\u884c\u5927\u89c4\u6a21\u7684\u7b5b\u9009\uff0c\u5e76\u4f7f\u7528\u673a\u5668\u4eba\u6280\u672f\uff0c\u6d4b\u8bd5\u8fd9\u4e9b\u5206\u5b50\u80fd\u5426\u987a\u5229\u6fc0\u6d3b ATF6\u3002\u5927\u89c4\u6a21\u7b5b\u9009\u7684\u7ed3\u679c\u627e\u5230\u4e86 10 \u4e2a\u770b\u4e0a\u53bb\u201c\u5f88\u6709\u6f5c\u529b\u201d\u7684\u5206\u5b50\uff0c\u4ed6\u4eec\u88ab\u9001\u5f80 Lin \u6559\u6388\u7684\u5b9e\u9a8c\u5ba4\uff0c\u7b49\u5f85\u4e0b\u4e00\u6b65\u5206\u6790\u3002<\/p>\n<p><img decoding=\"async\" class=\"aligncenter\" src=\"http:\/\/www.bio360.net\/storage\/image\/2018\/02\/L204v5lWNUlsCe285xRW5CBXFsC02Nh1xY4b82bj.png\" alt=\"QQ \u622a\u56fe 20180214113714\" \/><\/p>\n<p>\u25b2AA147 \u7684\u5206\u5b50\u7ed3\u6784\u5f0f\uff08\u56fe\u7247\u6765\u6e90\uff1a\u300aScience Signaling\u300b\uff09<\/p>\n<p>\u201c\u6211\u4eec\u4e0d\u786e\u5b9a\u80fd\u627e\u5230\u4ec0\u4e48\uff0c\u201dLin \u6559\u6388\u8bf4\u9053\uff1a\u201c\u6211\u4eec\u53ea\u662f\u5e0c\u671b\u6709\u4e00\u4e2a\u5206\u5b50\u80fd\u8d77\u5230\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u7684\u79ef\u6781\u6548\u679c\u3002\u201d<\/p>\n<p>\u7136\u800c\u7ed3\u679c\u8ba9\u79d1\u5b66\u5bb6\u5927\u4e3a\u6b23\u559c\u3002\u4ed6\u4eec\u53d1\u73b0\uff0c\u4e00\u79cd\u53eb\u505a AA147 \u7684\u5206\u5b50\u80fd\u5728\u5e72\u7ec6\u80de\u4e2d\u663e\u8457\u6fc0\u6d3b ATF6\uff0c\u5e76\u4e14\u6539\u53d8\u7ec6\u80de\u7684\u5206\u5316\u9014\u5f84\u3002\u5728 AA147 \u7684\u4f5c\u7528\u4e0b\uff0c\u5e72\u7ec6\u80de\u4e3b\u8981\u5206\u5316\u4e3a\u4e86\u5185\u76ae\u7ec6\u80de\uff0c\u8fd9\u662f\u7ec4\u6210\u8840\u7ba1\u7684\u5173\u952e\u7ec6\u80de\u3002<\/p>\n<p><img decoding=\"async\" src=\"http:\/\/www.bio360.net\/storage\/image\/2018\/02\/AdN5M0Lw0TfzLN9xEfQqos5iqCBT6JsmU4uKrlJm.png\" alt=\"QQ \u622a\u56fe 20180214113734\" \/><\/p>\n<p>\u25b2\u672c\u7814\u7a76\u7684\u56fe\u793a\uff08\u56fe\u7247\u6765\u6e90\uff1a\u300aScience Signaling\u300b\uff09<\/p>\n<p>\u201c\u901a\u5e38\u6765\u8bf4\uff0c\u5e72\u7ec6\u80de\u80fd\u5206\u5316\u6210\u8bb8\u591a\u4e0d\u540c\u7684\u7ec6\u80de\u7c7b\u578b\uff0c\u4f46\u5f88\u96be\u8ba9\u5b83\u4eec\u4ea7\u751f\u5927\u91cf\u7279\u5b9a\u7684\u7ec6\u80de\u7c7b\u578b\uff0c\u201dLin \u6559\u6388\u8bf4\u9053\uff1a\u201c\u7136\u800c\u7ecf\u8fc7 AA147 \u7684\u5904\u7406\uff0c\u57f9\u517b\u76bf\u4e2d\u5927\u7ea6 70% \u7684\u7ec6\u80de\u8f6c\u5316\u6210\u4e86\u5185\u76ae\u7ec6\u80de\uff0c\u800c\u5b83\u4eec\u53ef\u4ee5\u5f62\u6210\u8840\u7ba1\u3002\u8fd9\u662f\u6211\u6240\u77e5\u9053\u80fd\u7528\u5b9e\u9a8c\u65b9\u6cd5\u5236\u9020\u8840\u7ba1\u6700\u9ad8\u6548\u7684\u65b9\u6cd5\u3002\u201d<\/p>\n<p>\u5c3d\u7ba1\u53d6\u5f97\u4e86\u51fa\u8272\u7684\u5b9e\u9a8c\u7ed3\u679c\uff0cLin \u6559\u6388\u4f9d\u65e7\u4fdd\u6301\u7740\u8c28\u614e\u3002\u4ed6\u8bf4\uff0c\u8fd9\u5e76\u4e0d\u4ee3\u8868 AA147 \u5df2\u7ecf\u6210\u4e3a\u4e86\u4e00\u6b3e\u771f\u6b63\u7684\u836f\u7269\u3002\u9996\u5148\uff0c\u8fd9\u4e9b\u7ed3\u679c\u53ea\u5728\u5b9e\u9a8c\u5ba4\u7684\u57f9\u517b\u76bf\u4e2d\u5f97\u5230\u4e86\u91cd\u590d\uff1b\u5176\u6b21\uff0c\u7814\u7a76\u4eba\u5458\u4f7f\u7528\u7684 AA147 \u6d53\u5ea6\u4e5f\u5f88\u9ad8\u3002\u4e3a\u4e86\u68c0\u9a8c\u8fd9\u6b3e\u836f\u7269\u7684\u4e34\u5e8a\u4ef7\u503c\uff0c\u6211\u4eec\u9700\u8981\u5bf9\u5b83\u8fdb\u884c\u4f18\u5316\uff0c\u964d\u4f4e\u6240\u9700\u7684\u5242\u91cf\uff0c\u5e76\u901a\u8fc7\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u9a8c\u8bc1\u5b83\u7684\u5b89\u5168\u6027\u4e0e\u6709\u6548\u6027\u3002<\/p>\n<p>\u800c\u5173\u4e8e\u56e2\u961f\u7684\u6700\u65b0\u53d1\u73b0\uff0cLin \u6559\u6388\u8ba4\u4e3a\uff0c\u8fd9\u63d0\u4f9b\u4e86\u5173\u4e8e ATF6 \u529f\u80fd\u7684\u91cd\u8981\u4fe1\u606f\uff0c\u6709\u52a9\u4e8e\u8ba9\u6211\u4eec\u7406\u89e3\u5b83\u7684\u5931\u6d3b\u5982\u4f55\u5f15\u8d77\u773c\u75be\u3002\u6b64\u5916\uff0c\u8fd9\u4e2a\u53d1\u73b0\u4e5f\u6709\u671b\u5e94\u7528\u5230\u5176\u4ed6\u548c\u8840\u7ba1\u76f8\u5173\u7684\u75be\u75c5\u4e2d\u3002<\/p>\n<p>\u70b9\u51fb\u6587\u672b\u201c\u9605\u8bfb\u539f\u6587\u201d\uff0c\u5373\u53ef\u8bbf\u95ee\u539f\u59cb\u8bba\u6587\u9875\u9762\u3002<\/p>\n<p>\u53c2\u8003\u8d44\u6599\uff1a<\/p>\n<p>[1] In effort to treat rare blinding disease, researchers turn stem cells into blood vessels<\/p>\n<p>[2] The unfolded protein response regulator ATF6 promotes mesodermal differentiation<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4eca\u65e5\uff0c\u300a\u79d1\u5b66\u300b\u5b50\u520a\u300aScience 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