{"id":1299270,"date":"2018-03-05T20:11:19","date_gmt":"2018-03-06T04:11:19","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=1299270"},"modified":"2018-03-05T20:11:19","modified_gmt":"2018-03-06T04:11:19","slug":"%e5%af%bb%e6%89%be%e5%88%9b%e6%96%b0%e9%9d%b6%e7%82%b9%ef%bc%8c%e6%96%b0%e5%9f%ba%e4%b8%8evividion%e8%be%be%e9%80%be%e4%ba%bf%e7%be%8e%e5%85%83%e5%90%88%e4%bd%9c%e5%9b%be%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/%e5%af%bb%e6%89%be%e5%88%9b%e6%96%b0%e9%9d%b6%e7%82%b9%ef%bc%8c%e6%96%b0%e5%9f%ba%e4%b8%8evividion%e8%be%be%e9%80%be%e4%ba%bf%e7%be%8e%e5%85%83%e5%90%88%e4%bd%9c%e5%9b%be%ef%bc%89\/.html","title":{"rendered":"\u5bfb\u627e\u521b\u65b0\u9776\u70b9\uff0c\u65b0\u57fa\u4e0eVividion\u8fbe\u903e\u4ebf\u7f8e\u5143\u5408\u4f5c(\u56fe\uff09"},"content":{"rendered":"<div class=\"td-post-content\">\n<p>\u4f4d\u4e8e\u7f8e\u56fd\u5723\u5730\u4e9a\u54e5\u7684Vividion Therapeutics\u516c\u53f8\u5ba3\u5e03\u4e0eCelgene\uff08\u65b0\u57fa\uff09\u516c\u53f8\u8fbe\u6210\u6218\u7565\u7814\u53d1\u5408\u4f5c\u534f\u8bae\u3002<strong>\u8fd9\u4e00\u591a\u5e74\u5408\u4f5c\u5173\u7cfb\u5c06\u7740\u91cd\u5229\u7528Vividion\u7684\u836f\u7269\u5f00\u53d1\u5e73\u53f0\u6765\u5f00\u53d1\u9776\u5411\u764c\u75c7\u3001\u708e\u75c7\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u521b\u65b0\u5c0f\u5206\u5b50\u836f\u7269\u3002<\/strong>Vividion\u516c\u53f8\u7684\u7279\u957f\u662f\u5b83\u7684\u521b\u65b0\u86cb\u767d\u7ec4\u5b66\u548c\u5316\u5b66\u836f\u7269\u5f00\u53d1\u5e73\u53f0\u3002\u672c\u6b21\u5408\u4f5c\u534f\u8bae\u529b\u56fe\u63a8\u52a8\u5f71\u54cd\u6cdb\u7d20\u86cb\u767d\u9176\u4f53(ubiquitin protease)\u7cfb\u7edf\u7684\u521b\u65b0\u5c0f\u5206\u5b50\u7684\u7814\u53d1\uff0c\u4ece\u800c\u901a\u8fc7\u8c03\u8282\u7279\u5b9a\u86cb\u767d\u6c34\u5e73\u6765\u83b7\u5f97\u6cbb\u7597\u6548\u679c\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-32038 td-animation-stack-type0-2 aligncenter\" src=\"http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-32.png\" width=\"288\" height=\"171\" \/><\/p>\n<p>Vividion\u516c\u53f8\u7684\u836f\u7269\u7814\u53d1\u5e73\u53f0\u662f\u57fa\u4e8e\u8be5\u516c\u53f8\u7684\u79d1\u5b66\u521b\u59cb\u4eba\uff0c\u7f8e\u56fdScripps\u7814\u7a76\u6240(Scripps Research Institute)\u7684\u591a\u540d\u4e13\u5bb6\u5728\u5316\u5b66\u751f\u7269\u5b66\u548c\u5408\u6210\u5316\u5b66\u65b9\u9762\u7684\u7814\u7a76\uff0c\u5176\u4e2d\u5305\u62ec<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDA5NTIxNQ==&amp;mid=2649955968&amp;idx=1&amp;sn=91b5a93313a89515d8ef6a9bb41d43b3&amp;chksm=82e99800b59e1116765e83b00352d16ea6151b2716e212e1a50a8110c6950f7c26c818fe114f&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener\">\u4f59\u91d1\u6743\u6559\u6388<\/a>\u7684\u7814\u7a76\u6210\u679c\u3002<strong>\u8be5\u5e73\u53f0\u80fd\u591f\u8ba9\u86cb\u767d\u4e0e\u836f\u7269\u7684\u76f8\u4e92\u4f5c\u7528\u5728\u81ea\u7136\u751f\u7269\u7cfb\u7edf\u4e2d\u88ab\u51c6\u786e\u6d4b\u91cf\uff0c\u800c\u4e14\u8fd9\u79cd\u6d4b\u91cf\u65b9\u6cd5\u53ef\u4ee5\u540c\u65f6\u7814\u7a76\u591a\u79cd\u86cb\u767d\u3002\u800c\u4f20\u7edf\u7684\u836f\u7269\u7814\u53d1\u8fc7\u7a0b\u9700\u8981\u5bf9\u86cb\u767d\u8fdb\u884c\u63d0\u7eaf\u5e76\u4e14\u6bcf\u6b21\u53ea\u80fd\u7814\u7a76\u4e00\u4e2a\u86cb\u767d\u3002<\/strong>\u8fd9\u4e00\u5e73\u53f0\u7684\u53e6\u4e00\u4e2a\u4f18\u52bf\u662f\u53ef\u4ee5\u5728\u6d3b\u7ec6\u80de\u73af\u5883\u4e0b\u53d1\u73b0\u86cb\u767d\u8868\u9762\u539f\u5148\u5728\u63d0\u7eaf\u72b6\u6001\u4e0b\u65e0\u6cd5\u53d1\u73b0\u7684\u6210\u836f\u9776\u70b9\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-32039 td-animation-stack-type0-2\" src=\"http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-136.jpg\" sizes=\"auto, (max-width: 1080px) 100vw, 1080px\" srcset=\"http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-136.jpg 1080w, http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-136-300x169.jpg 300w, http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-136-768x432.jpg 768w, http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-136-1024x576.jpg 1024w, http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-136-600x338.jpg 600w, http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-136-696x392.jpg 696w, http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-136-1068x601.jpg 1068w, http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-136-746x420.jpg 746w\" width=\"1080\" height=\"608\" \/><\/p>\n<p>\u25b2<strong>Vividion\u7684\u6280\u672f\u5e73\u53f0\uff08\u56fe\u7247\u6765\u6e90\uff1aVividion\u5b98\u65b9\u7f51\u7ad9\uff09<\/strong><\/p>\n<p>\u6839\u636e\u5408\u4f5c\u534f\u8bae\uff0cVividion\u516c\u53f8\u5c06\u627f\u62c5\u6700\u521d\u5148\u5bfc\u5316\u5408\u7269\u7684\u5f00\u53d1\u548c\u9a8c\u8bc1\u5de5\u4f5c\uff0c\u800cCelgene\u516c\u53f8\u6709\u6743\u5728\u7814\u7a76\u6027\u65b0\u836f(investigational new drug, IND)\u7533\u8bf7\u9636\u6bb5\u52a0\u5165\u8fd9\u4e9b\u9879\u76ee\u7684\u7814\u53d1\u8fc7\u7a0b\u3002Vividion\u4eceCelgene\u83b7\u5f97\u4e86<strong>1.01\u4ebf\u7f8e\u5143\u7684\u9884\u5148\u4ed8\u6b3e<\/strong>\u3002<\/p>\n<p>\u201cVividion\u6784\u5efa\u4e86\u4e00\u4e2a\u771f\u6b63\u524d\u6cbf\u7684\u836f\u7269\u7814\u53d1\u5e73\u53f0\uff0c\u5b83\u80fd\u591f\u52a0\u5feb\u836f\u7269\u7814\u53d1\u7684\u901f\u5ea6\uff0c\u6269\u5c55\u53ef\u6210\u836f\u7684\u86cb\u767d\u7ec4\u8303\u56f4\uff0c\u5e76\u4e14\u653b\u514b\u9ad8\u96be\u5ea6\u9776\u70b9\uff0c\u201dCelgene\u516c\u53f8\u7684\u7814\u7a76\u4e0e\u65e9\u671f\u5f00\u53d1\u603b\u88c1<a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDA5NTIxNQ==&amp;mid=2649964194&amp;idx=1&amp;sn=8897b1117bf420b036ca06d6363c449a&amp;chksm=82e9b822b59e3134bbe83f61c28c1caa3ef9387bab8faee570e23ea837168a1eb3e7cecf4031&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener\">Rupert Vessey\u535a\u58eb<\/a>\u8bf4\uff1a\u201c\u8fd9\u4e00\u5408\u4f5c\u8ba9\u6211\u4eec\u4e24\u5bb6\u516c\u53f8\u80fd\u591f\u8fd0\u7528\u4e00\u79cd\u7efc\u5408\u3001\u5feb\u901f\u7684\u836f\u7269\u7814\u53d1\u624b\u6bb5\u6765\u5f00\u53d1\u5bf9\u60a3\u8005\u5177\u6709\u91cd\u5927\u5f71\u54cd\u7684\u591a\u4e2a\u9886\u57df\u4e2d\u7684first-in-class\u836f\u7269\u3002\u201d<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-32040 td-animation-stack-type0-2\" src=\"http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-137.jpg\" sizes=\"auto, (max-width: 934px) 100vw, 934px\" srcset=\"http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-137.jpg 934w, http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-137-300x202.jpg 300w, http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-137-768x518.jpg 768w, http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-137-600x405.jpg 600w, http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-137-696x469.jpg 696w, http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-137-623x420.jpg 623w\" width=\"934\" height=\"630\" \/><\/p>\n<p><strong>\u25b2Celgene\u7814\u7a76\u4e0e\u65e9\u671f\u5f00\u53d1\u603b\u88c1Rupert Vessey\u535a\u58eb\u57282018\u836f\u660e\u5eb7\u5fb7\u5168\u7403\u8bba\u575b\u4e0a\u7545\u8c08<\/strong><strong><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDA5NTIxNQ==&amp;mid=2649969282&amp;idx=2&amp;sn=0cb0d6dbb04f19f156a696bdf0ec687c&amp;chksm=82e9d402b59e5d14995d8736d80211244b21baeb85608d462c1220960f1171f20d726bf2e836&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener\">\u5982\u4f55\u5bfb\u627e\u4e0b\u4e00\u4e2a\u91cd\u78c5\u7a81\u7834<\/a><\/strong><\/p>\n<p>\u201c\u6211\u4eec\u975e\u5e38\u9ad8\u5174\u80fd\u591f\u4e0eCelgene\u8fd9\u6837\u5168\u7403\u9886\u5148\u7684\u533b\u7597\u521b\u65b0\u516c\u53f8\u5408\u4f5c\u3002\u6211\u4eec\u72ec\u7279\u7684\u836f\u7269\u7814\u53d1\u80fd\u529b\u5c06\u5f00\u62d3\u548c\u6269\u5c55\u65b0\u7684\u533b\u7597\u53ef\u80fd\uff0c\u201dVividion\u516c\u53f8\u7684\u9996\u5e2d\u6267\u884c\u5b98Diego Miralles\u535a\u58eb\u8bf4\uff1a\u201c<strong>\u6211\u4eec\u7684\u72ec\u521b\u836f\u7269\u7b5b\u9009\u6280\u672f\u80fd\u591f\u4e3a\u8fc4\u4eca\u4e3a\u6b62\u65e0\u6cd5\u6210\u836f\u7684\u9776\u70b9\u53d1\u73b0\u5148\u5bfc\u5316\u5408\u7269\u5e76\u4e14\u8fdb\u4e00\u6b65\u63a8\u52a8\u5bf9\u5b83\u4eec\u7684\u5316\u5b66\u6539\u9020<\/strong>\u3002\u8fd9\u5c06\u9769\u65b0\u548c\u52a0\u5feb\u5c0f\u5206\u5b50\u836f\u7269\u7814\u53d1\u7684\u6a21\u5f0f\u3002\u201d<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-32042 td-animation-stack-type0-2\" src=\"http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-138.jpg\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" srcset=\"http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-138.jpg 640w, http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-138-300x169.jpg 300w, http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-138-600x338.jpg 600w\" width=\"640\" height=\"360\" \/><\/p>\n<p><strong>\u25b2Vividion\u516c\u53f8\u7684\u9996\u5e2d\u6267\u884c\u5b98Diego Miralles\u535a\u58eb\u57282017\u836f\u660e\u5eb7\u5fb7\u5168\u7403\u8bba\u575b\u4e0a\u5206\u4eab<\/strong><a href=\"http:\/\/mp.weixin.qq.com\/s?__biz=MzAwMDA5NTIxNQ==&amp;mid=2649958553&amp;idx=1&amp;sn=b2eef3efaf3fbcca327c5c976d40288a&amp;chksm=82e9ae19b59e270fa3898966e56d1f29bed645b193edabedf9bd43555d2a67e3b968a22d0958&amp;scene=21#wechat_redirect\" target=\"_blank\" rel=\"noopener\"><strong>\u7cbe\u51c6\u533b\u5b66\u7684\u672a\u6765<\/strong><\/a><\/p>\n<p>\u53c2\u8003\u8d44\u6599\uff1a<\/p>\n<p>[1] Vividion Therapeutics Announces Strategic Research Collaboration with Celgene Corporation to Discover Therapies Against Transformative, First-in-Class Targets<\/p>\n<p>[2] Vividion Therapeutics \u5b98\u7f51<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u4f4d\u4e8e\u7f8e\u56fd\u5723\u5730\u4e9a\u54e5\u7684Vividion Therapeutics\u516c\u53f8\u5ba3\u5e03\u4e0eCelgene\uff08\u65b0\u57fa\uff09\u516c\u53f8\u8fbe\u6210\u6218\u7565\u7814\u53d1\u5408\u4f5c\u534f\u8bae\u3002\u8fd9\u4e00\u591a\u5e74\u5408\u4f5c\u5173\u7cfb\u5c06\u7740\u91cd\u5229\u7528Vividion\u7684\u836f\u7269\u5f00\u53d1\u5e73\u53f0\u6765\u5f00\u53d1\u9776\u5411\u764c\u75c7\u3001\u708e\u75c7\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u521b\u65b0\u5c0f\u5206\u5b50\u836f\u7269&#8230;..<\/p>\n","protected":false},"author":3,"featured_media":1299271,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-1299270","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science_technology_education"],"_links":{"self":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1299270","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/comments?post=1299270"}],"version-history":[{"count":0,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1299270\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media\/1299271"}],"wp:attachment":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media?parent=1299270"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/categories?post=1299270"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/tags?post=1299270"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}