{"id":1299652,"date":"2018-04-01T19:29:39","date_gmt":"2018-04-02T02:29:39","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=1299652"},"modified":"2018-04-01T19:29:39","modified_gmt":"2018-04-02T02:29:39","slug":"%e4%bb%96%e8%ae%a9%e6%96%b0%e8%8d%af%e8%b5%b7%e6%ad%bb%e5%9b%9e%e7%94%9f-%e4%b8%93%e8%ae%bfimpact%e9%a6%96%e5%b8%ad%e6%89%a7%e8%a1%8c%e5%ae%98john-hood%e5%8d%9a%e5%a3%ab","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/%e4%bb%96%e8%ae%a9%e6%96%b0%e8%8d%af%e8%b5%b7%e6%ad%bb%e5%9b%9e%e7%94%9f-%e4%b8%93%e8%ae%bfimpact%e9%a6%96%e5%b8%ad%e6%89%a7%e8%a1%8c%e5%ae%98john-hood%e5%8d%9a%e5%a3%ab\/.html","title":{"rendered":"\u4ed6\u8ba9\u65b0\u836f\u201c\u8d77\u6b7b\u56de\u751f\u201d- \u4e13\u8bbfImpact\u9996\u5e2d\u6267\u884c\u5b98John Hood\u535a\u58eb"},"content":{"rendered":"<div class=\"td-post-content\">\n<p><strong>\u7f16\u8005\u6309\uff1a<\/strong>\u8fd9\u662f\u4e00\u4f4d\u79d1\u5b66\u5bb6\u7684\u6210\u529f\u6545\u4e8b\u2014\u2014\u4ed6\u8ba9\u4e00\u79cd\u80fd\u633d\u6551\u60a3\u8005\u751f\u547d\u7684\u836f\u7269\u201c\u8d77\u6b7b\u56de\u751f\u201d\u3002\u4f20\u5947\u7ecf\u5386\u7684\u80cc\u540e\uff0c\u662f\u4ed6\u5bf9\u79d1\u5b66\u7eaf\u7cb9\u7684\u5949\u732e\u7cbe\u795e\u548c\u5bf9\u751f\u547d\u7684\u70ed\u5ff1\u3002<\/p>\n<p>John Hood\u535a\u58eb\u662fImpact Biomedicines\u9996\u5e2d\u6267\u884c\u5b98\uff0c\u8be5\u516c\u53f8\u4e8e2016\u5e74\u79cb\u5b63\u521b\u7acb\uff0c\u9996\u8f6e\u878d\u8d442200\u4e07\u7f8e\u5143\uff0c\u6700\u8fd1\u4ee570\u4ebf\u7f8e\u5143\u88abCelgene\u6536\u8d2d\u3002Celgene\u5bf9Impact\u7684\u65b0\u836ffedratinib\u975e\u5e38\u611f\u5174\u8da3\uff0c\u8fd9\u662f\u4e00\u79cd\u9ad8\u5ea6\u9009\u62e9\u6027\u7684\u53e3\u670d\u5c0f\u5206\u5b50JAK2\u6fc0\u9176\u6291\u5236\u5242\uff0c\u5df2\u88ab\u8bc1\u5b9e\u6709\u671b\u6210\u4e3a\u9aa8\u9ad3\u7ea4\u7ef4\u5316\u8840\u6db2\u764c\u7684\u6f5c\u5728\u6cbb\u7597\u836f\u7269\u3002<\/p>\n<p>Fedratinib\u662fHood\u535a\u58eb\u5728TargeGen\u516c\u53f8\u5de5\u4f5c\u671f\u95f4\u5171\u540c\u53d1\u73b0\u7684\u30022010\u5e74\uff0cTargeGen\u628a\u8be5\u4ea7\u54c1\u51fa\u552e\u7ed9\u4e86Sanofi\u3002\u7136\u800c\uff0c\u56e0\u4e34\u5e8a\u8bd5\u9a8c\u671f\u95f4\u53d1\u73b0\u4e86\u97e6\u5c3c\u514b\u8111\u75c5\uff08WE\uff09\uff0c\u7f8e\u56fdFDA\u8981\u6c42\u4e34\u5e8a\u8bd5\u9a8c\u6682\u7f13\u8fdb\u884c\uff0c\u4e8e\u662fSanofi\u7ec8\u6b62\u4e86\u5bf9fedratinib\u7684\u5f00\u53d1\u3002WE\u662f\u4e00\u79cd\u7ef4\u751f\u7d20B1\u7f3a\u4e4f\u7684\u6025\u6027\u795e\u7ecf\u75c5\u75c7\u3002<\/p>\n<p>\u4e8b\u5b9e\u4e0a\uff0c\u5728\u4e34\u5e8a\u8bd5\u9a8c\u671f\u95f4\uff0c\u8fd9\u79cd\u836f\u7269\u8ba9\u5f88\u591a\u60a3\u8005\u53d7\u76ca\u3002\u5728\u533b\u751f\u548c\u60a3\u8005\u7684\u6566\u4fc3\u4e0b\uff0cHood\u535a\u58eb\u8f9e\u53bb\u5de5\u4f5c\uff0c\u6295\u5165\u81ea\u5df1\u7684\u8d44\u91d1\uff0c\u91cd\u65b0\u83b7\u5f97\u4e86\u8be5\u836f\u7269\u7684\u8bb8\u53ef\u3002\u4ed6\u4e5f\u4e0d\u8d1f\u4f17\u671b\u5730\u8ba9\u8fd9\u6b3e\u66fe\u88ab\u6401\u7f6e\u7684\u65b0\u836f\u201c\u8d77\u6b7b\u56de\u751f\u201d\u2014\u20142017\u5e748\u6708\uff0cFDA\u53d6\u6d88\u4e86\u5bf9fedratinib\u7684\u4e34\u5e8a\u9650\u5236\u3002<\/p>\n<p>\u8fd1\u65e5\uff0c\u836f\u660e\u5eb7\u5fb7\u6218\u7565\u8ba1\u5212\u8d44\u6df1\u987e\u95eeRich Soll\u535a\u58eb\u4e0eHood\u535a\u58eb\u8fdb\u884c\u4e86\u4e00\u573a\u4e13\u8bbf\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0cRich Soll\u535a\u58eb\u66fe\u5728TargeGen\u4e0eHood\u535a\u58eb\u6709\u591a\u5e74\u7684\u540c\u4e8b\u4e4b\u8c0a\u3002\u4e0b\u9762\u5c31\u8ba9\u6211\u4eec\u58eb\u4e00\u8d77\u8d70\u8fd1Hood\u535a\u58eb\uff0c\u6765\u4e86\u89e3\u4ed6\u8dcc\u5b95\u8d77\u4f0f\u7684\u6545\u4e8b\uff0c\u4ee5\u53ca\u4ed6\u516c\u53f8\u540d\u79f0Impact\u7684\u6765\u7531\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-33396 td-animation-stack-type0-2\" src=\"http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-728.jpg\" sizes=\"auto, (max-width: 696px) 100vw, 696px\" srcset=\"http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-728.jpg 696w, http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-728-300x161.jpg 300w, http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-728-600x322.jpg 600w\" width=\"696\" height=\"373\" \/><\/p>\n<section>\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\"><strong>\u836f\u660e\u5eb7\u5fb7\uff1a\u9996\u5148\uff0c\u6211\u4eec\u6765\u804a\u804aJAK2\u6291\u5236\u5242\u3002\u60a8\u80fd\u7b80\u5355\u63cf\u8ff0\u4e00\u4e0b\u5b83\u7684\u8fdb\u5316\u53f2\u548c\u4e34\u5e8a\u8bd5\u9a8c\u7684\u8fdb\u5c55\u5417\uff1f<\/strong><\/section>\n<section><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><strong>John Hood\u535a\u58eb\uff1a<\/strong>\u6b63\u5982\u60a8\u6240\u77e5\uff0cfedratinib\u662f\u6fc0\u9176JAK2\u7684\u9ad8\u5ea6\u9009\u62e9\u6027\u6291\u5236\u5242\u3002JAK\u5bb6\u65cf\u5bf9\u8eab\u4f53\u7684\u8bb8\u591a\u4e0d\u540c\u529f\u80fd\u90fd\u5f88\u91cd\u8981\u3002JAK2\u5bf9\u4e8e\u9a71\u52a8\u5e72\u7ec6\u80de\u53d8\u6210\u7ea2\u8840\u7403\u548c\u8840\u5c0f\u677f\u975e\u5e38\u91cd\u8981\uff0c\u5f53\u5b83\u53d1\u751f\u7a81\u53d8\u65f6\uff0c\u5b83\u4f1a\u9a71\u52a8\u8bb8\u591a\u9aa8\u9ad3\u589e\u751f\u6027\u80bf\u7624\uff08MPNs\uff09\uff0c\u5982\u771f\u6027\u7ea2\u7ec6\u80de\u589e\u591a\u75c7\uff0c\u539f\u53d1\u6027\u8840\u5c0f\u677f\u589e\u591a\u75c7\u548c\u9aa8\u9ad3\u7ea4\u7ef4\u5316\u3002\u5176\u4e2d\uff0c\u6700\u4e25\u91cd\u7684\u9884\u540e\u662f\u4e2d\u9ad8\u5ea6\u98ce\u9669\u6027\u9aa8\u9ad3\u7ea4\u7ef4\u5316\uff0c<strong>\u8fd9\u79cd\u75be\u75c5\u7684\u60a3\u8005\u4e00\u822c\u5728\u786e\u8bca\u540e\u53ea\u67092-3\u5e74\u7684\u751f\u5b58\u671f<\/strong>\u3002\u5927\u7ea6\u4e00\u534a\u7684\u9aa8\u9ad3\u7ea4\u7ef4\u5316\u60a3\u8005JAK2\uff08JAK V617F\uff09\u4e2d\u6709\u5355\u4e00\u7a81\u53d8\uff0c\u53e6\u670940\uff05\u7684\u7a81\u53d8\u662fMPL\u6216CALR\uff0c\u4ece\u800c\u5bfc\u81f4JAK2\u7684\u6fc0\u6d3b\u3002\u5728\u4efb\u4f55\u4e00\u79cd\u60c5\u51b5\u4e0b\uff0cJAK2\u6fc0\u6d3b\u90fd\u4f1a\u9020\u6210\u75be\u75c5\uff0c\u56e0\u6b64\u6291\u5236JAK2\u80fd\u591f\u6cbb\u7597\u75be\u75c5\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-33397 td-animation-stack-type0-2 aligncenter\" src=\"http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-729.jpg\" sizes=\"auto, (max-width: 339px) 100vw, 339px\" srcset=\"http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-729.jpg 339w, http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-729-203x300.jpg 203w, http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-729-284x420.jpg 284w\" width=\"339\" height=\"501\" \/><\/p>\n<p><strong>\u25b2\u9aa8\u9ad3\u589e\u751f\u6027\u80bf\u7624\uff08MPN\uff09\u7684\u7279\u5f81\u662fJAK2\uff0cMPL\u6216CALR\u7684\u7a81\u53d8\u3002\u5982\u56fe\u6240\u793a\uff0cJAK2\u7684\u7a81\u53d8\u6fc0\u6d3b\u662fMPN\u75be\u75c5\u7684\u4e3b\u8981\u9a71\u52a8\u56e0\u7d20\uff08\u56fe\u7247\u6765\u6e90\uff1aImpact Biomedicines\u5b98\u65b9\u7f51\u7ad9\uff09<\/strong><\/p>\n<section>\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\"><strong>\u836f\u660e\u5eb7\u5fb7\uff1aFedratinib\u7684\u72ec\u7279\u4e4b\u5904\u662f\u4ec0\u4e48\uff1f\u60a8\u5728\u8be5\u836f\u7269\u7684\u53d1\u73b0\u65b9\u9762\u626e\u6f14\u4e86\u4ec0\u4e48\u89d2\u8272\uff1f<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><strong>John Hood\u535a\u58eb\uff1a<\/strong>Fedratinib\u5728\u6240\u6709\u57fa\u4e8e\u4e34\u5e8a\u9009\u62e9\u800c\u88ab\u8bc4\u4f30\u7684\u6291\u5236\u5242\u4e2d\uff0c\u5bf9JAK2\u7684\u9009\u62e9\u6027\u662f\u6700\u9ad8\u7684\uff0c\u8fd9\u5f88\u91cd\u8981\u3002\u56e0\u4e3a\u5176\u4ed6JAKS\u8c03\u8282\u514d\u75ab\u529f\u80fd\uff0c\u56e0\u6b64\u6291\u5236\u53ef\u80fd\u5bfc\u81f4\u514d\u75ab\u6291\u5236\u548c\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\u2014\u2014\u8840\u5c0f\u677f\u751f\u6210\u51cf\u5c11\u5bfc\u81f4\u51fa\u8840\u3002\u86cb\u767d\u6fc0\u9176\u626b\u63cf\u8fdb\u4e00\u6b65\u589e\u5f3a\u4e86\u5b83\u7684\u9009\u62e9\u6027\uff0cflt3\u88ab\u786e\u8ba4\u4e3a\u552f\u4e00\u80fd\u88ab\u663e\u8457\u6291\u5236\u7684\u5176\u4ed6\u86cb\u767d\u6fc0\u9176\u3002<\/p>\n<p>\u8be5\u5316\u5408\u7269\u672c\u8eab\u5728TargeGen\u53d1\u73b0\u3002\u8fd9\u91cc\u6211\u4eec\u8fd8\u6709\u53e6\u5916\u4e00\u4e2a\u6545\u4e8b\u3002TargeGen\u662f\u5723\u5730\u4e9a\u54e5\u7684\u4e00\u5bb6\u751f\u7269\u6280\u672f\u516c\u53f8\uff0c\u6210\u7acb\u4e8e2001\u5e74\u3002\u6211\u9886\u5bfc\u4e86\u5927\u90e8\u5206\u751f\u7269\u5b66\u9879\u76ee\uff0c\u5176\u4e2d\u5305\u62ecJAK2\u6291\u5236\u5242\u9879\u76ee\u3002<\/p>\n<section>\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\"><strong>\u836f\u660e\u5eb7\u5fb7\uff1a\u60a8\u8ba9\u4eba\u4eec\u652f\u6301fedratinib\u7684\u7b56\u7565\u662f\u4ec0\u4e48\uff1f<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><strong>John Hood\u535a\u58eb\uff1a<\/strong>\u65e9\u671f\u9636\u6bb5\uff0c\u6211\u4eec\u4e0e\u5173\u952e\u610f\u89c1\u9886\u8896\uff08KOLs\uff09\u5bc6\u5207\u63a5\u89e6\uff0c\u542c\u53d6\u4ed6\u4eec\u7684\u610f\u89c1\uff0c\u4ee5\u5e2e\u52a9\u8bbe\u8ba1\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5e76\u4e14\u6211\u4eec\u4e5f\u4e0eKOLs\u5728\u4e34\u5e8a\u524d\u8fdb\u884c\u4e86\u5408\u4f5c\u3002\u5173\u4e8efedratinib\u7684\u7814\u7a76\u8bba\u6587\u7531\u6885\u5965\u8bca\u6240\uff08Mayo Clinic\uff09\u7684Ayalew Tefferi\u535a\u58eb\u3001Gary Gilliland\u535a\u58eb\u3001\u4ee5\u53caCatriona Jamieson\u533b\u751f\u7f16\u5199\u3002\u6240\u4ee5\uff0c\u6211\u4eec\u6709\u5f88\u591a\u4eba\u5728\u60a3\u8005\u4e4b\u524d\u5c31\u63a5\u89e6\u8fc7\u8fd9\u79cd\u5206\u5b50\u3002\u5728\u7814\u7a76\u8fdb\u7a0b\u4e2d\uff0c\u6211\u6709\u673a\u4f1a\u83b7\u5f97\u5927\u91cf\u4e0eKOLs\u5408\u4f5c\u7684\u7b2c\u4e00\u624b\u7ecf\u9a8c\uff0c\u80fd\u591f\u8bbe\u8ba1\u4e34\u5e8a\u65b9\u6848\uff0c\u5e76\u4e0e\u4ed6\u4eec\u4e00\u8d77\u505a\u8fdb\u4e00\u6b65\u7684\u65b9\u6848\u62d3\u5c55\u3002\u540c\u65f6\uff0c\u6211\u4eec\u662f\u4e00\u5bb6\u6709\u98ce\u9669\u6295\u8d44\u652f\u6301\u7684\u516c\u53f8\uff0c\u6240\u4ee5\u6211\u4eec\u975e\u5e38\u6709\u5174\u8da3\u4e0e\u5176\u4ed6\u516c\u53f8\u5efa\u7acb\u5408\u4f5c\uff0c\u5e2e\u52a9\u6211\u4eec\u5f00\u53d1\u5206\u5b50\u3002\u6700\u7ec8\uff0c\u6211\u4eec\u57282008\u5e74\u4e0eSanofi\u8ba2\u7acb\u4e86\u4e00\u4efd\u53e3\u5934\u534f\u8bae\u6765\u5f00\u53d1\u8fd9\u79cd\u5206\u5b50\u3002\u4ed6\u4eec\u5c06\u6536\u8d2dTargeGen\u4ee5\u83b7\u5f97\u8be5\u5316\u5408\u7269\u3002<\/p>\n<section>\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\"><strong>\u836f\u660e\u5eb7\u5fb7\uff1a\u8fd9\u9879\u4e34\u5e8a\u8bd5\u9a8c\u662f\u5982\u4f55\u8fdb\u884c\u7684\uff1f<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><strong>John Hood\u535a\u58eb\uff1a<\/strong>\u8fd9\u79cd\u5206\u5b50\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u786e\u5b9e\u8868\u73b0\u5f97\u5f88\u597d\uff1b\u5b83\u4e0d\u50cf\u5df2\u7ecf\u8bd5\u9a8c\u7684\u5176\u5b83\u5206\u5b50\u90a3\u6837\u4f1a\u4ea7\u751f\u514d\u75ab\u6291\u5236\u6216\u8840\u5c0f\u677f\u51cf\u5c11\u75c7\uff0c\u6240\u4ee5\u603b\u4f53\u4e0a\u5b89\u5168\u6027\u76f8\u5f53\u597d\u3002\u6b64\u5916\uff0c\u5b83\u5177\u6709\u6700\u9ad8\u7684\u521d\u6b21\u7f13\u89e3\u7387\uff0c\u5373\u813e\u810f\u5c3a\u5bf8\u51cf\u5c0f\uff0c\u8fd9\u5df2\u7ecf\u5728\u9aa8\u9ad3\u7ea4\u7ef4\u5316\u60a3\u8005\u8bd5\u9a8c\u4e2d\u5f97\u5230\u89c2\u5bdf\u3002\u66f4\u4ee4\u4eba\u5370\u8c61\u6df1\u523b\u7684\u662fJakarta2\u671f\u8bd5\u9a8c\uff0c<strong>\u8be5\u8bd5\u9a8c\u8bc1\u660e\u4e86fedratinib\u5bf9\u552f\u4e00\u83b7\u6279\u7684ruxolitinib\u7597\u6cd5\u4ea7\u751f\u8010\u836f\u7684\u60a3\u8005\u5177\u6709\u6d3b\u6027\uff0c\u7f13\u89e3\u7387\u572850-60\uff05\u4e4b\u95f4\u3002<\/strong>Ruxolitinib\u5728\u4e09\u4e2a\u4e0d\u540c\u8bd5\u9a8c\u4e2d\u7684\u4e3b\u8981\u7f13\u89e3\u7387\u7ea6\u4e3a32\uff05\uff0c\u800cfedratinib\u7684\u7f13\u89e3\u7387\u51e0\u4e4e\u662f\u8be5\u83b7\u6279\u7597\u6cd5\u7684\u4e24\u500d\u3002\u6240\u4ee5\u8fd9\u4e9b\u7f13\u89e3\u7387\u5bf9\u4e8e\u60a3\u8005\u6765\u8bf4\u662f\u5177\u6709\u6df1\u8fdc\u610f\u4e49\u7684\u3002<\/p>\n<section>\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\"><strong>\u836f\u660e\u5eb7\u5fb7\uff1a\u867d\u7136\u8fd9\u79cd\u836f\u7269\u5df2\u7ecf\u5728\u8bb8\u591a\u60a3\u8005\u4e2d\u88ab\u8bc1\u660e\u662f\u6210\u529f\u7684\uff0c\u4f46\u5b83\u9047\u5230\u4e86\u56f0\u96be\u3002\u60a8\u80fd\u7ed9\u6211\u4eec\u4ecb\u7ecd\u4e0b\u5417\uff1f<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><strong>John Hood\u535a\u58eb\uff1a<\/strong>2013\u5e74\uff0c\u4e00\u540d\u6cd5\u56fd\u60a3\u8005\u5728\u670d\u7528\u8be5\u836f\u7269\u6570\u5468\u540e\uff0c\u51fa\u73b0\u4e86\u4e00\u79cd\u88ab\u79f0\u4e3aWE\u7684\u75c5\u75c7\u3002\u4efb\u4f55\u65f6\u5019\uff0c\u51fa\u73b0\u4e0e\u7814\u7a76\u836f\u7269\u76f8\u5173\u7684\u526f\u4f5c\u7528\uff0c\u90fd\u662f\u975e\u5e38\u53ef\u6015\u7684\u3002\u73b0\u5b9e\u60c5\u51b5\u662f\uff0c\u8fd9\u662f\u4e00\u79cd\u7ef4\u751f\u7d20B1\u7f3a\u4e4f\u75c7\uff0c\u5bfc\u81f4\u8111\u80bf\u80c0\uff0c\u6df7\u6c8c\u548c\u884c\u8d70\u56f0\u96be\u3002\u60a3\u8005\u901a\u8fc7\u8865\u5145\u7ef4\u751f\u7d20B1\uff08\u786b\u80fa\u7d20\uff09\u53ef\u4ee5\u9884\u9632\u3001\u6cbb\u7597\u548c\u9006\u8f6c\u75c5\u75c7\u3002WE\u5927\u7ea6\u53d1\u751f\u57281.2\uff05\u7684\u666e\u901a\u4eba\u7fa4\u4e2d\uff0c\u800c\u5176\u5728fedratinib\u7684\u8bd5\u9a8c\u4e2d\u53d1\u751f\u7684\u6b21\u6570\u8981\u5c11\u5f97\u591a\u3002<\/p>\n<p>\u4f46\u5728\u8fd9\u4e2a\u75c5\u4f8b\u53d1\u73b0\u65f6\uff0c\u5df2\u7ecf\u6709\u8fd11000\u540d\u60a3\u8005\u63a5\u53d7\u4e86\u8be5\u836f\u7269\u7684\u6cbb\u7597\u3002Sanofi\u56de\u987e\u6027\u5206\u6790\u4e86\u4e34\u5e8a\u8d44\u6599\uff0c\u5e76\u786e\u5b9a\u4e868\u4f8b\u6709WE\u795e\u7ecf\u75c7\u72b6\u7684\u60a3\u8005\u3002\u7f8e\u56fdFDA\u968f\u5373\u5ba3\u5e03\u8be5\u4e34\u5e8a\u8bd5\u9a8c\u6682\u7f13\u8fdb\u884c\uff0c\u5e76\u63d0\u51fa\u76f8\u5173\u5efa\u8bae\uff0c\u4f46Sanofi\u51b3\u5b9a\u7ec8\u6b62\u5bf9fedratnib\u7684\u8fdb\u4e00\u6b65\u5f00\u53d1\u3002Sanofi\u6536\u96c6\u4e86160\u540d\u60a3\u8005\u7684\u786b\u80fa\u7d20\u6570\u636e\uff0c\u53d1\u73b0\u8fd9\u4e9b\u6570\u636e\u662f\u6b63\u5e38\u7684\u3002\u6bcb\u5eb8\u7f6e\u7591\uff0c\u6301\u7eed\u63a5\u53d7fedratinib\u6210\u529f\u6cbb\u7597\u7684\u60a3\u8005\u4e0d\u5f97\u4e0d\u653e\u5f03\u8be5\u836f\u7269\uff0c\u91cd\u56de\u6807\u51c6\u7597\u6cd5\u3002\u7ed3\u679c\uff0c\u5927\u591a\u6570\u60a3\u8005\u7684\u6cbb\u7597\u4ee5\u5931\u8d25\u800c\u544a\u7ec8\u3002<\/p>\n<section>\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\"><strong>\u836f\u660e\u5eb7\u5fb7\uff1a\u63a5\u4e0b\u6765\u53d1\u751f\u4e86\u4ec0\u4e48\uff1f<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><strong>John Hood\u535a\u58eb\uff1a<\/strong>\u60a3\u8005\u8bd5\u56fe\u627e\u56defedratinib\uff0c\u56e0\u4e3a\u4ed6\u4eec\u90fd\u51e0\u4e4e\u5944\u5944\u4e00\u606f\uff0c\u56e0\u800c\u4ed6\u4eec\u52aa\u529b\u63a2\u5bfb\u80fd\u591f\u8ba9\u4ed6\u4eec\u5f97\u5230\u8be5\u836f\u7269\u7684\u7a81\u7834\u53e3\u3002\u56e0\u4e3a\u6211\u57281\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u53d1\u6325\u4e86\u91cd\u8981\u4f5c\u7528\uff0c\u56e0\u800c\u533b\u751f\u53ca\u60a3\u8005\u76f4\u63a5\u627e\u5230\u4e86\u6211\u3002\u8fd9\u4e9b\u60a3\u8005\u548c\u533b\u751f\u7684\u6700\u521d\u8981\u6c42\u662f\u5145\u5206\u5229\u7528\u73b0\u6709\u836f\u7269\u7684\u6709\u9650\u4f9b\u5e94\uff1b\u4f46\u4e0d\u5e78\u7684\u662f\uff0c\u6211\u7684\u8fd9\u9879\u52aa\u529b\u6ca1\u6709\u53d6\u5f97\u6210\u529f\u3002<\/p>\n<p>\u5305\u62ecMoshe Talpaz\u5148\u751f\uff0cClaire Harrison\u5973\u58eb\u548cCatriona Jamieson\u5973\u58eb\u5728\u5185\u7684\u8bb8\u591a\u533b\u751f\u90fd\u6566\u4fc3\u6211\u7ee7\u7eed\u52aa\u529b\u3002\u5bf9\u6211\u800c\u8a00\uff0c\u8fd9\u4e2a\u51b3\u5b9a\u6027\u7684\u65f6\u523b\u6765\u81ea\u5723\u5730\u4e9a\u54e5\u60a3\u8005Theresa\u5973\u58eb\uff0c\u6211\u901a\u8fc7\u5979\u7684\u533b\u751fCatriona Jamieson\u5973\u58eb\u8ba4\u8bc6\u5979\u3002Theresa\u5973\u58eb\u63a5\u53d7\u4e86fedratinib\u4e94\u5e74\u534a\u7684\u6cbb\u7597\uff0c\u53d1\u73b0\u5979\u7684\u9aa8\u9ad3\u7ea4\u7ef4\u5316\u4ece3\u7ea7\uff08\u4e25\u91cd\u7a0b\u5ea6\u4ee50-4\u7ea7\u8bc4\u4f30\uff0c3\u7ea7\u4e3a\u975e\u5e38\u4e25\u91cd\uff09\u4e00\u8def\u964d\u4f4e\u52300\u7ea7\uff1b\u5979\u7684\u813e\u810f\u5927\u5c0f\u5b8c\u5168\u6b63\u5e38\u3002\u53ea\u8981\u5979\u670d\u7528\u8be5\u836f\u7269\uff0c\u5c31\u80fd\u8fc7\u6b63\u5e38\u7684\u751f\u6d3b\uff0c\u6ca1\u6709\u75be\u75c5\u75c7\u72b6\u3002\u4f46\u4e0d\u4e45\u540e\uff0c\u56e0\u4e3a\u6ca1\u6709\u8fd9\u79cd\u836f\u7269\uff0c\u5979\u5c31\u5f00\u59cb\u53d1\u75c5\uff0cruxolitinib\u7684\u6cbb\u7597\u5bf9\u5979\u6ca1\u6709\u6548\u679c\u3002\u6211\u4eec\u7aed\u5c3d\u5168\u529b\u53bb\u83b7\u53d6fedratinib\uff0c\u4f46\u4e0d\u5e78\u7684\u662f\uff0c\u6ca1\u6709\u53ca\u65f6\u62ff\u5230\u3002\u4e0d\u4e45\uff0c\u5979\u53bb\u4e16\u4e86\u3002Moshe Taplaz\u533b\u751f\u670911\u4f4d\u60a3\u8005\u53c2\u4e0e\u4e86fedratinib\u76841\u671f\u548c2\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4ed6\u4eec\u90fd\u5bf9\u6cbb\u7597\u4ea7\u751f\u4e34\u5e8a\u7f13\u89e3\uff0c\u4f46\u81ea\u836f\u7269\u88ab\u53d6\u6d88\u540e\uff0c\u5168\u90e8\u90fd\u53bb\u4e16\u4e86\u3002<\/p>\n<section>\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\"><strong>\u836f\u660e\u5eb7\u5fb7\uff1a\u60a8\u5982\u4f55\u4eceSanofi\u62ff\u56de\u8be5\u836f\u7269\uff0c\u5e76\u8bf7FDA\u89e3\u9664\u4e34\u5e8a\u9650\u5236\uff1f<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><strong>John Hood\u535a\u58eb\uff1a<\/strong>\u533b\u751f\u4eec\u4e0d\u65ad\u6566\u4fc3\u6211\u62ff\u56defedratinib\u7684\u8bb8\u53ef\uff0c\u56e0\u4e3a\u8fd9\u662f\u4e00\u79cd\u975e\u5e38\u597d\u7684\u836f\u7269\uff0c\u5bf9\u5f88\u591a\u4eba\u90fd\u6709\u5e2e\u52a9\u3002\u60a3\u8005\u5728\u505c\u836f\u524d\u957f\u8fbe5\u5e74\u7684\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u90fd\u6709\u6301\u7eed\u7684\u7f13\u89e3\u3002\u4e0d\u5c11\u60a3\u8005\u90fd\u56e0\u4e3a\u8fd9\u4e2a\u75be\u75c5\u800c\u53bb\u4e16\uff0c\u5982\u679c\u4ed6\u4eec\u80fd\u591f\u6301\u7eed\u670d\u7528\u8fd9\u79cd\u836f\u7269\uff0c\u5176\u7ed3\u679c\u53ef\u80fd\u4f1a\u4e0d\u540c\u3002<strong>\u6211\u89c9\u5f97\u6709\u4e49\u52a1\uff0c\u5b9e\u9645\u4e0a\u662f\u9053\u4e49\u4e0a\u7684\u8d23\u4efb\uff0c\u7ee7\u7eed\u4e3a\u60a3\u8005\u63d0\u4f9b\u8fd9\u79cd\u836f\u7269\u3002\u8fd9\u662f\u505a\u6b63\u786e\u7684\u4e8b\u3002<\/strong>\u6211\u7684\u59bb\u5b50\u4e5f\u8d5e\u540c\u6211\u7684\u51b3\u5b9a\u3002<\/p>\n<p>\u4e3a\u4e86\u62ff\u56de\u8fd9\u79cd\u836f\u7269\uff0c\u6211\u57282016\u5e743\u6708\u8f9e\u804c\uff0c\u81ea\u5df1\u6295\u516525\u4e07\u7f8e\u5143\u3002\u7531\u4e8e\u7279\u5b9a\u7684\u5546\u4e1a\u8003\u8651\uff0c\u6211\u4e0d\u5f97\u4e0d\u5728120\u5929\u5185\u7b79\u96c6\u81f3\u5c11500\u4e07\u7f8e\u5143\u3002\u4e3a\u4e86\u8fd9\u4e00\u4e8b\u4e1a\u7684\u6210\u529f\uff0c\u6211\u5f97\u5230\u4e86Medicxi\uff08\u6bd4\u5229\u65f6\u4e4b\u5916\uff09\u7684\u652f\u6301\uff0c\u4ed6\u4eec\u552f\u4e00\u7684\u8981\u6c42\u662f\u4ed6\u4eec\u60f3\u8981\u6295\u51651500\u4e07\u7f8e\u5143\u800c\u4e0d\u662f500\u4e07\u7f8e\u5143\uff0c\u4ee5\u4fbf\u5728\u516c\u53f8\u83b7\u5f97\u5408\u7406\u7684\u6240\u6709\u6743\u6bd4\u4f8b\u3002<\/p>\n<p>\u6211\u4eec\u641c\u5bfb\u4e86\u4e0e\u4e34\u5e8a\u6682\u7f13\u76f8\u5173\u7684\u8bd5\u9a8c\u6570\u636e\uff0c<strong>\u5e76\u5f97\u51fa\u7ed3\u8bba\uff1a\u795e\u7ecf\u7cfb\u7edf\u7684\u7ed3\u679c\u4e0e\u836f\u7269\u65e0\u5173\u3002<\/strong>\u6211\u4eec\u57282017\u5e74\u5411FDA\u5448\u62a5\u4e86\u6211\u4eec\u7684\u5206\u6790\u7ed3\u679c\uff0c\u6700\u7ec8\u5f97\u4ee5\u89e3\u9664\u4e34\u5e8a\u9650\u5236\uff0c\u6211\u4eec\u4e5f\u8fdb\u4e00\u6b65\u5b8c\u5584\u4e86\u98ce\u9669\u7f13\u89e3\u63aa\u65bd\u3002<strong>FDA\u8868\u793a\uff0c2013\u5e74\u7684\u53cc\u76f2\u3001\u8bbe\u7f6e\u5b89\u6170\u5242\u5bf9\u7167\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7f13\u89e3\u7387\u975e\u5e38\u9ad8\uff0c\u5b83\u7684\u7ed3\u679c\u8db3\u591f\u7528\u4e8e\u65b0\u836f\u7533\u8bf7\uff08NDA\uff09\uff0c<\/strong><strong>\u76ee\u524d\u4ecd\u7136\u6709\u6548\u3002<\/strong>\u6240\u4ee5\uff0c\u6211\u4eec\u6709\u4e86\u4e00\u4e2a\u53ef\u4ee5\u5728\u6ca1\u6709\u4efb\u4f55\u989d\u5916\u4e34\u5e8a\u7814\u7a76\u7684\u60c5\u51b5\u4e0b\u63d0\u4ea4NDA\u7684\u836f\u7269\uff0c\u8fd9\u79cd\u836f\u7269\u5177\u6709\u660e\u786e\u7684\u7597\u6548\u4e14\u5bf9\u60a3\u8005\u5b89\u5168\u3002\u5b83\u4e0d\u4f1a\u6291\u5236\u514d\u75ab\u7cfb\u7edf\uff0c\u5e76\u4e14\u4e0d\u4f1a\u635f\u5bb3\u8840\u5c0f\u677f\u8ba1\u6570\u3002<\/p>\n<section>\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\"><strong>\u836f\u660e\u5eb7\u5fb7\uff1a\u4e4b\u540e\uff0cImpact Biomedicines\u7684\u4e1a\u52a1\u8fc5\u901f\u53d1\u5c55\uff0c\u5305\u62ec\u4e0eCelgene\u7684\u5408\u4f5c\u3002\u90a3\u662f\u5982\u4f55\u53d1\u751f\u7684\uff1f<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><strong>John Hood\u535a\u58eb\uff1a<\/strong>\u6b63\u5982\u60a8\u6240\u77e5\u9053\u7684\uff0c\u5bf9\u4e8e\u90a3\u4e9b\u80fd\u591f\u8fc5\u901f\u4e0a\u5e02\u7684\u836f\u7269\u4f1a\u6709\u5f88\u591a\u5e02\u573a\u9700\u6c42\uff0c\u6240\u4ee5\u4e00\u65e6\u4e34\u5e8a\u9650\u5236\u88ab\u89e3\u9664\uff0c\u4e00\u4e9b\u516c\u53f8\u5bf9\u8fd9\u79cd\u4ea7\u54c1\u8868\u73b0\u51fa\u7684\u9ad8\u5ea6\u5174\u8da3\u5e76\u4e0d\u4ee4\u4eba\u60ca\u8bb6\u3002\u5728\u6211\u4eec\u770b\u6765\uff0cCelgene\u662f\u8840\u6db2\u5b66\u548c\u80bf\u7624\u5b66\u65b9\u9762\u663e\u800c\u6613\u89c1\u7684\u5408\u4f5c\u4f19\u4f34\uff1b\u4ed6\u4eec\u64c5\u957f\u8fd9\u4e2a\u9886\u57df\uff0c\u5e76\u4e13\u6ce8\u4e8e\u60a3\u8005\u3002\u6211\u4eec\u516d\u4e2a\u4eba\u7684\u516c\u53f8\u5728\u4e00\u4f4d\u94f6\u884c\u5bb6\u7684\u5e2e\u52a9\u4e0b\uff0c\u572812\u6708\u4e0b\u65ec\u4e0eCelgene\u5c31\u4e00\u822c\u6761\u6b3e\u8fbe\u6210\u4e86\u534f\u8bae\u3002\u5c31\u5728\u6469\u6839\u5927\u901a\u533b\u7597\u5065\u5eb7\u5e74\u4f1a\uff08JP Morgan Healthcare Conference\uff0cJPM\uff09\u7684\u524d\u4e00\u5929\uff0c\u6211\u4eec\u7b7e\u7f72\u4e86\u534f\u8bae\uff0c\u5e76\u5728JPM\u7684\u9996\u65e5\u5ba3\u5e03\u4e86\u6211\u4eec\u7684\u5408\u4f5c\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-33398 td-animation-stack-type0-2 aligncenter\" src=\"http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-202.png\" sizes=\"auto, (max-width: 314px) 100vw, 314px\" srcset=\"http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-202.png 314w, http:\/\/www.wuximediaglobal.com\/wp-content\/uploads\/2018\/03\/4ffce04d92a4d6cb21c1494cdfcd6dc1-202-300x154.png 300w\" width=\"314\" height=\"161\" \/><\/p>\n<section>\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\"><strong>\u836f\u660e\u5eb7\u5fb7\uff1a\u8fd9\u662f\u4e00\u4e2a\u975e\u5e38\u611f\u4eba\u3001\u4e14\u9f13\u821e\u4eba\u5fc3\u7684\u6545\u4e8b\u3002\u6211\u8bb0\u5f97\uff0c\u8fd9\u4e2a\u6545\u4e8b\u540e\u6765\u88ab\u8fc5\u901f\u4f20\u64ad\u5f00\u3002<\/strong><\/section>\n<section><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><strong>John Hood\u535a\u58eb\uff1a<\/strong>\u6700\u521dCatriona\u5973\u58eb\u4ee5\u53ca\u5176\u4ed6\u4e00\u4e9b\u533b\u751f\u548c\u60a3\u8005\u662f\u57282016\u5e743\u6708\u5e95\u5f00\u59cb\u8054\u7cfb\u6211\u7684\uff0c\u6211\u4eec\u4e8e2016\u5e7410\u6708\u7ed3\u675f\u4e86\u878d\u8d44\uff0c\u6240\u4ee5\u8fd9\u603b\u5171\u662f7\u4e2a\u6708\u7684\u65f6\u95f4\u3002\u4f46\u4e0eSanofi\u548cTargeGen\u7684\u8c08\u5224\u82b1\u8d39\u4e86\u51e0\u4e2a\u6708\u7684\u65f6\u95f4\uff0c\u6240\u4ee5\u6211\u4eec\u771f\u6b63\u5f00\u59cb\u662f\u57285\u6708\u4efd\u5de6\u53f3\u3002\u7136\u540e\uff0c\u6211\u57286\u6708\u4efd\u548c\u4e8c\u5341\u4e2a\u591a\u4e2a\u56e2\u4f53\u8fdb\u884c\u4ea4\u8c08\uff0c\u5e76\u57287\u6708\u62168\u6708\u5de6\u53f3\u4e0eMedicxi\u4ea4\u6d41\u3002\u4e4b\u540e30\u5929\u5185\uff0c\u6211\u4eec\u7b7e\u7f72\u4e86\u610f\u5411\u4e66\uff0c\u523010\u6708\u4efd\uff0c\u6211\u4eec\u6709\u4e86\u73b0\u91d1\u6d41\u3002<\/p>\n<p>\u6211\u4e5f\u610f\u8bc6\u5230\uff0c\u8fd8\u6709\u5f88\u591a\u62e5\u62a4\u8005\u548c\u8fd9\u4e2a\u9886\u57df\u7684KOL\u652f\u6301\u8fd9\u4efd\u4e8b\u4e1a\uff0c\u4ed6\u4eec\u662fClaire Harrison\u5973\u58eb\uff0cMoshe Talpaz\u5148\u751f\uff0cAnn Brazeau\u5973\u58eb\u548cCatriona Jamieson\u5973\u58eb\u7b49\u7b49\u3002Catriona\u5973\u58eb\u4e5f\u6210\u4e3a\u6211\u4eec\u516c\u53f8\u7684\u5171\u540c\u521b\u59cb\u4eba\u3002\u4ed6\u4eec\u5728\u4e0e\u540c\u4e8b\u548c\u60a3\u8005\u4f1a\u9762\u65f6\u7684\u5021\u8bae\u786e\u5b9e\u4fc3\u4f7f\u8be5\u836f\u7269\u5feb\u901f\u88ab\u63a5\u53d7\u3002\u5728TargeGen\u89e3\u6563\u4e4b\u540e\uff0c\u4e8b\u60c5\u653e\u7f13\u4e86\u3002\u5c3d\u7ba1\u5982\u6b64\uff0c\u4ed6\u4eec\u4f9d\u65e7\u5bf9\u8fd8\u5728\u5b9e\u9a8c\u5ba4\u4e2d\u7684\u8fd9\u79cd\u836f\u7269\u5145\u6ee1\u4fe1\u5fc3\uff0c\u76f4\u5230\u4ed6\u4eec\u5728\u60a3\u8005\u8eab\u4e0a\u770b\u5230\u7597\u6548\u3002<\/p>\n<p>\u6211\u66fe\u4ee5\u4e3a\u6211\u4eec\u4f1a\u975e\u5e38\u987a\u5229\u5730\u83b7\u5f97FDA\u7684\u7eff\u706f\u653e\u884c\u3002\u7136\u800c\uff0cCMC\uff08\u5316\u5b66\u3001\u751f\u4ea7\u3001\u63a7\u5236\uff09\u5f00\u53d1\u53d7\u5230\u9650\u5236\uff0c\u8981\u5728\u5723\u5730\u4e9a\u54e5\u627e\u5230\u5177\u6709\u4e34\u5e8a\u665a\u671f\/\u4e0a\u5e02\u7ecf\u9a8c\u7684\u4eba\u5458\u4e5f\u53d7\u5230\u9650\u5236\u3002\u4e8e\u662f\uff0c\u6211\u505a\u51fa\u7684\u4e00\u4e2a\u51b3\u5b9a\uff1a\u53bb\u627e\u5bf9\u8fd9\u4e2a\u9879\u76ee\u719f\u6089\u548c\u6709\u7ecf\u9a8c\u7684\u56e2\u961f\u2014\u2014\u836f\u660e\u5eb7\u5fb7\u3002\u663e\u800c\u6613\u89c1\uff0c\u6211\u4eec\u9700\u8981Sanofi\u4e4b\u5916\u7684\u4e00\u4e2a\u5c0f\u7ec4\u8fdb\u884cCMC\u5f00\u53d1\u3002\u800c\u5bf9\u4e8e\u4e00\u4e9b\u4f9b\u5e94\u5546\u6765\u8bf4\uff0c\u539f\u6750\u6599\u7684\u83b7\u53d6\u9700\u898112\u523014\u4e2a\u6708\u7684\u65f6\u95f4\u3002\u800c\u836f\u660e\u5eb7\u5fb7\u5728\u4e0d\u52304\u4e2a\u534a\u6708\u7684\u65f6\u95f4\u91cc\u5b8c\u6210\u4e86\u6574\u4e2a\u9879\u76ee\uff0c\u90fd\u5728GMP\u89c4\u8303\u4e0b\u5b8c\u6210\u4e86\u6574\u4e2a\u5de5\u827a\u6d41\u7a0b\uff0c\u63d0\u524d\u4e00\u4e2a\u6708\u4ea4\u4ed869\u516c\u65a4\u539f\u6750\u6599\uff0c\u800c\u4e0d\u662f50\u516c\u65a4\uff0c\u4e14\u7eaf\u5ea6\u6781\u9ad8\u3002<\/p>\n<section>\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\"><strong>\u836f\u660e\u5eb7\u5fb7\uff1a\u611f\u8c22\u60a8\u7684\u9009\u62e9\u3002\u4e8b\u5b9e\u4e0a\uff0c\u4e3aTargeGen\u9879\u76ee\u5b8c\u6210\u539f\u59cb\u6676\u4f53\u7ed3\u6784\u7684Crelux\uff0c\u73b0\u5df2\u662f\u836f\u660e\u5eb7\u5fb7\u7684\u5b50\u516c\u53f8\u4e86\u3002\u800c\u60a8\u4e5f\u4ece\u79d1\u5b66\u5bb6\u8f6c\u53d8\u4e3a\u5177\u6709\u5f88\u5927\u5f71\u54cd\u529b\u7684\u4f01\u4e1a\u5bb6\uff0c\u80fd\u6982\u8ff0\u4e00\u4e0b\u60a8\u7684\u5386\u53f2\u5e76\u63cf\u8ff0\u4e00\u4e0b\u5f71\u54cd\u60a8\u4e8b\u4e1a\u7684\u56e0\u7d20\u5417\uff1f<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><strong>John Hood\u535a\u58eb\uff1a<\/strong>\u6211\u5728\u5fb7\u514b\u8428\u65af\u5dde\u7684\u7267\u573a\u957f\u5927\uff0c\u5c31\u8bfb\u4e8e\u516c\u7acb\u5b66\u6821\u3002\u5728\u5fb7\u514b\u8428\u65afA&amp;M\u5927\u5b66\uff08Texas A&amp;M University\uff09\u83b7\u5f97\u535a\u58eb\u5b66\u4f4d\u4e4b\u540e\uff0c\u6211\u4f5c\u4e3a\u535a\u58eb\u540e\u7814\u7a76\u5458\u4e0eDave Cheresh\u535a\u58eb\u4e00\u8d77\u5728Scripps\u7814\u7a76\u6240\u5de5\u4f5c\u3002\u6211\u8d1f\u8d23\u521b\u5efa\u81ea\u5df1\u7684\u9879\u76ee\u3002\u6211\u4e3a\u57fa\u56e0\u9012\u9001\u9879\u76ee\u5f00\u53d1\u4e86\u76f8\u5f53\u6570\u91cf\u7684\u5316\u5b66\u7ec4\u6210\u3002Scripps\u7814\u7a76\u6240\u662f\u4e00\u4e2a\u76f8\u5f53\u72ec\u7279\u7684\u5730\u65b9\uff0c\u56e0\u4e3a\u90a3\u91cc\u65e2\u6709\u4f1f\u5927\u7684\u751f\u7269\u5b66\u5bb6\uff0c\u53c8\u6709\u4ee4\u4eba\u60ca\u53f9\u7684\u5316\u5b66\u90e8\u95e8\u3002\u57fa\u56e0\u9012\u9001\u7684\u7814\u7a76\u4f7fTargeGen\u5f97\u4ee5\u521b\u7acb\u3002\u8fd9\u662f\u4e00\u4e2a\u5f00\u62d3\u773c\u754c\u7684\u5730\u65b9\uff0c\u5e76\u53ef\u4ee5\u628a\u5b66\u672f\u9879\u76ee\u8f6c\u5316\u4e3a\u5546\u4e1a\u6210\u679c\u548c\u5e94\u7528\u3002<\/p>\n<section>\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\"><strong>\u836f\u660e\u5eb7\u5fb7\uff1a\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u60a8\u8ba4\u4e3a\u60a8\u804c\u4e1a\u751f\u6daf\u4e2d\u6700\u663e\u8457\u7684\u6210\u5c31\u662f\u4ec0\u4e48\uff1f<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><strong>John Hood\u535a\u58eb\uff1a<\/strong>\u8ba9FDA\u91cd\u65b0\u8ba4\u53ef\u8fd9\u79cd\u836f\u7269\u662f\u4e00\u4e2a\u6311\u6218\u3002\u5b83\u66fe\u88ab\u6401\u7f6e\uff0c\u800c\u6211\u4eec\u8fd9\u6837\u4e00\u4e2a\u5c0f\u56e2\u4f53\u8ba9FDA\u91cd\u65b0\u8003\u8651\u6211\u4eec\u7684\u8bd5\u9a8c\u6570\u636e\u5e76\u4ed4\u7ec6\u5ba1\u67e5\u3002\u8bf7FDA\u53c2\u4e0e\u5e76\u8046\u542c\u6211\u4eec\u7684\u62a5\u544a\u662f\u6211\u751f\u547d\u4e2d\u6700\u5feb\u4e50\u7684\u65f6\u523b\u3002\u5f53\u4e34\u5e8a\u9650\u5236\u5ba3\u5e03\u88ab\u53d6\u6d88\u65f6\uff0c\u6211\u5f53\u65f6\u7684\u5fc3\u60c5\u5c31\u597d\u50cf\u662f5\u5c81\u65f6\u8fc7\u5723\u8bde\u8282\u3002<\/p>\n<section>\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\"><strong>\u836f\u660e\u5eb7\u5fb7\uff1a\u8fd9\u662f\u5426\u662f\u53e6\u5916\u4e00\u79cd\u4fe1\u5fc3\u7684\u8868\u793a\uff0c\u5373\u6fc0\u9176\u6291\u5236\u5242\u53ef\u8d85\u8d8a\u764c\u75c7\u6216\u80bf\u7624\u5b66\u7684\u5e94\u7528\uff1f<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><strong>John Hood\u535a\u58eb\uff1a<\/strong>\u5f53\u7136\uff0c\u6211\u8ba4\u4e3a\u8fd9\u662f\u53e6\u5916\u4e00\u4e2a\u5145\u6ee1\u673a\u9047\u7684\u9886\u57df\u3002\u4e8b\u5b9e\u4e0a\uff0c\u5c31\u5de5\u4f5c\u6c34\u51c6\u548c\u7cbe\u51c6\u533b\u836f\u6c34\u5e73\u800c\u8a00\uff0c\u80bf\u7624\u5b66\uff0c\u6216\u662f\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u9886\u57df\u5728\u8bb8\u591a\u65b9\u9762\u90fd\u5904\u4e8e\u9886\u5148\u5730\u4f4d\u3002<\/p>\n<section>\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\"><strong>\u836f\u660e\u5eb7\u5fb7\uff1a\u90a3\u4e48\u63a5\u4e0b\u6765\u5462\uff1f<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><strong>John Hood\u535a\u58eb\uff1a<\/strong>\u6211\u8981\u786e\u4fddCelgene\u7684NDA\u5f97\u5230\u53d7\u7406\uff0c\u6240\u4ee5\u6211\u5728\u672a\u6765\u51e0\u4e2a\u6708\u5c06\u4e0e\u4ed6\u4eec\u5408\u4f5c\u3002\u8fd8\u6709\u5176\u4ed6\u4e00\u4e9b\u8ba9\u6211\u5f88\u5174\u594b\u7684\u516c\u53f8\uff0c\u6211\u5df2\u7ecf\u6709\u4e00\u4e9b\u60f3\u6cd5\u4e0e\u4ed6\u4eec\u5408\u4f5c\u3002<\/p>\n<section>\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\">\n<section class=\"\"><strong>\u836f\u660e\u5eb7\u5fb7\uff1a\u60a8\u60f3\u5bf9\u90a3\u4e9b\u6b63\u5728\u8003\u8651\u4ece\u4e8b\u533b\u7597\u5065\u5eb7\u884c\u4e1a\u548c\u836f\u7269\u53d1\u73b0\u7684\u5e74\u8f7b\u4eba\u8bf4\u4e9b\u4ec0\u4e48\uff1f<\/strong><\/section>\n<section><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p><strong>John Hood\u535a\u58eb\uff1a<\/strong>\u6ca1\u6709\u4ec0\u4e48\u6bd4\u4f60\u5de5\u4f5c\u7684\u7ec8\u6781\u76ee\u6807\u662f\u62ef\u6551\u751f\u547d\u66f4\u6709\u4ef7\u503c\u7684\u4e86\u3002\u6211\u8ba4\u4e3a\uff0c\u5982\u679c\u4f60\u80fd\u89e3\u51b3\u591a\u7ef4\u96be\u9898\u2014\u2014\u836f\u7269PK\u3001\u5b89\u5168\u6027\u3001\u4ee5\u53ca\u6295\u8d44\u8005\u2014\u2014\u90a3\u4e48\u4f60\u4f1a\u6709\u673a\u4f1a\u6210\u5c31\u4e00\u756a\u5927\u4e8b\u4e1a\u3002<\/p>\n<p>\uff08\u836f\u660e\u5eb7\u5fb7\u4f20\u5a92\uff09<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>John Hood\u535a\u58eb\u662fImpact Biomedicines\u9996\u5e2d\u6267\u884c\u5b98\uff0c\u8be5\u516c\u53f8\u4e8e2016\u5e74\u79cb\u5b63\u521b\u7acb\uff0c\u9996\u8f6e\u878d\u8d442200\u4e07\u7f8e\u5143\uff0c\u6700\u8fd1\u4ee570\u4ebf\u7f8e\u5143\u88abCelgene\u6536\u8d2d\u3002Celgene\u5bf9Impact\u7684\u65b0\u836ffedratinib\u975e\u5e38\u611f\u5174\u8da3&#8230;&#8230;<\/p>\n","protected":false},"author":3,"featured_media":1299653,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-1299652","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science_technology_education"],"_links":{"self":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1299652","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/comments?post=1299652"}],"version-history":[{"count":0,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1299652\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media\/1299653"}],"wp:attachment":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media?parent=1299652"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/categories?post=1299652"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/tags?post=1299652"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}