{"id":1299760,"date":"2018-04-10T19:16:36","date_gmt":"2018-04-11T02:16:36","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=1299760"},"modified":"2018-04-10T19:16:36","modified_gmt":"2018-04-11T02:16:36","slug":"%e9%98%bf%e6%96%af%e5%88%a9%e5%ba%b73-3%e4%ba%bf%e7%be%8e%e5%85%83%e6%94%b6%e8%8e%b7rna%e7%96%97%e6%b3%95%e6%b2%bb%e7%96%97nash","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/%e9%98%bf%e6%96%af%e5%88%a9%e5%ba%b73-3%e4%ba%bf%e7%be%8e%e5%85%83%e6%94%b6%e8%8e%b7rna%e7%96%97%e6%b3%95%e6%b2%bb%e7%96%97nash\/.html","title":{"rendered":"\u963f\u65af\u5229\u5eb73.3\u4ebf\u7f8e\u5143\u6536\u83b7RNA\u7597\u6cd5\u6cbb\u7597NASH"},"content":{"rendered":"<p><span style=\"color: #000080;\">\u836f\u660e\u5eb7\u5fb7\u62a5\u9053\uff1a<\/span><\/p>\n<p>\u4eca\u65e5\uff0c\u4f4d\u4e8e\u52a0\u5dde\u5723\u5730\u4e9a\u54e5\u7684Ionis Pharmaceuticals\u516c\u53f8\u5ba3\u5e03\u8be5\u516c\u53f8\u6388\u4e88\u963f\u65af\u5229\u5eb7(AstraZeneca)\u8fdb\u4e00\u6b65\u5f00\u53d1IONIS-AZ6-2.5-LRx\uff0c\u6cbb\u7597\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e(NASH)\u7684\u72ec\u5bb6\u6388\u6743\u3002Ionis\u516c\u53f8\u5c06\u4ece\u963f\u65af\u5229\u5eb7\u83b7\u5f973000\u4e07\u7f8e\u5143\u7684\u4ed8\u6b3e\uff0c\u5e76\u4e14\u6839\u636e\u836f\u7269\u5f00\u53d1\u8fc7\u7a0b\u4e2d\u7684\u91cc\u7a0b\u7891\u53ef\u80fd\u83b7\u5f97\u989d\u5916\u9ad8\u8fbe3\u4ebf\u7f8e\u5143\u7684\u4ed8\u6b3e\u3002\u963f\u65af\u5229\u5eb7\u5c06\u8d1f\u8d23\u8fd9\u4e00\u836f\u7269\u968f\u540e\u7684\u6240\u6709\u5f00\u53d1\u548c\u63a8\u5e7f\u8fc7\u7a0b\u3002<\/p>\n<p><img decoding=\"async\" src=\"http:\/\/med.sina.com\/files\/20180410\/jpg\/1523325347013.jpg\" alt=\"\" align=\"middle\" \/><\/p>\n<p>NASH\u662f\u975e\u9152\u7cbe\u6027\u8102\u80aa\u809d\u75c5(NAFLD)\u7684\u4e00\u79cd\uff0c\u5b83\u662f\u7531\u4e8e\u8102\u80aa\u5728\u809d\u810f\u4e2d\u79ef\u7d2f\u800c\u9020\u6210\u7684\u3002NASH\u60a3\u8005\u4e0d\u4f46\u8102\u80aa\u5728\u809d\u810f\u4e2d\u805a\u96c6\uff0c\u800c\u4e14\u5728\u809d\u810f\u4e2d\u51fa\u73b0\u708e\u75c7\u548c\u809d\u7ec6\u80de\u635f\u4f24\u3002\u8fd9\u79cd\u75be\u75c5\u6700\u7ec8\u53ef\u80fd\u5bfc\u81f4\u809d\u786c\u5316\u548c\u809d\u764c\u7684\u4ea7\u751f\u3002\u80a5\u80d6\u75c7\u30012\u578b\u7cd6\u5c3f\u75c5\u548c\u4ee3\u8c22\u7efc\u5408\u75c7\u60a3\u8005\u60a3\u4e0aNAFLD\u548cNASH\u7684\u98ce\u9669\u5347\u9ad8\uff0c\u4f46<strong>\u76ee\u524d\u8fd8\u6ca1\u6709FDA\u6279\u51c6\u7684\u6cbb\u7597NAFLD\u548cNASH\u7684\u836f\u7269<\/strong>\uff0c\u533b\u751f\u5bf9\u60a3\u8005\u7684\u5efa\u8bae\u901a\u5e38\u662f\u51cf\u80a5\u548c\u4fdd\u6301\u5065\u5eb7\u7684\u996e\u98df\u4e60\u60ef\u3002<\/p>\n<p>Ionis\u516c\u53f8\u5f00\u53d1\u7684<strong>IONIS-AZ6-2.5-LRx\u662f\u6291\u5236\u4e00\u4e2a\u672a\u62ab\u9732\u7684NASH\u9776\u70b9\u7684\u53cd\u4e49RNA\u7597\u6cd5<\/strong>\u3002\u8fd9\u4e00\u7597\u6cd5\u5e94\u7528\u4e86Ionis\u516c\u53f8\u6700\u65b0\u76842.5\u4ee3\u5316\u5b66\u4fee\u9970\u6280\u672f(Ionis\u2019 Generation 2.5 Chemistry)\u548c\u914d\u4f53\u590d\u5408\u53cd\u4e49(Ligand-Conjugated Antisense, LICA)\u6280\u672f\u3002<strong>\u4f7f\u75282.5\u4ee3\u5316\u5b66\u4fee\u9970\u6280\u672f\u7684\u53cd\u4e49\u836f\u7269\u4e0e2.0\u4ee3\u836f\u7269\u76f8\u6bd4\u836f\u6548\u53ef\u4ee5\u63d0\u9ad810\u500d<\/strong>\u3002\u540c\u65f6\uff0c2.5\u4ee3\u5316\u5b66\u4fee\u9970\u6280\u672f\u8ba9\u53cd\u4e49\u836f\u7269\u80fd\u591f\u6709\u6548\u5206\u5e03\u5230\u4eba\u4f53\u5185\u5305\u62ec\u809d\u810f\u3001\u80be\u810f\u3001\u80ba\u3001\u808c\u8089\u3001\u8102\u80aa\u3001\u80be\u4e0a\u817a\u548c\u5916\u5468\u795e\u7ecf\u7b49\u591a\u79cd\u7ec4\u7ec7\u4e2d\uff0c\u4ece\u800c\u6269\u5c55\u53cd\u4e49\u836f\u7269\u7684\u5e94\u7528\u8303\u56f4\u3002<\/p>\n<p>LICA\u6280\u672f\u5219\u901a\u8fc7\u5728\u53cd\u4e49\u836f\u7269\u4e0a\u6dfb\u52a0\u7279\u5b9a\u5316\u5b66\u7ed3\u6784\u6216\u8005\u5206\u5b50\uff0c\u589e\u5f3a\u836f\u7269\u5411\u7279\u5b9a\u7ec4\u7ec7\u7684\u8fd0\u9001\u3002Ionis\u516c\u53f8\u7684\u4e34\u5e8a1\u671f\u8bd5\u9a8c\u8868\u660e\uff0c<strong>\u589e\u5f3a\u9776\u5411\u809d\u810f\u8fd0\u9001\u7684LICA\u6280\u672f\u53ef\u4ee5\u5c06\u67d0\u4e9b\u53cd\u4e49\u836f\u7269\u7684\u836f\u6548\u589e\u5f3a30\u500d<\/strong>\u3002<\/p>\n<p><img decoding=\"async\" class=\"aligncenter\" src=\"http:\/\/med.sina.com\/files\/20180410\/jpg\/1523325148918.jpg\" alt=\"\" align=\"middle\" \/><\/p>\n<p>\u25b2Ionis Pharmaceuticals\u516c\u53f8\u9996\u5e2d\u8fd0\u8425\u5b98\u517c\u53cd\u4e49\u836f\u7269\u7814\u53d1\u548c\u8f6c\u5316\u836f\u7269\u9ad8\u7ea7\u526f\u603b\u88c1Brett P. Monia\u535a\u58eb\uff08\u56fe\u7247\u6765\u6e90\uff1aIonis Pharmaceuticals\u5b98\u65b9\u7f51\u7ad9\uff09<\/p>\n<p>\u201c2.5\u4ee3\u5316\u5b66\u4fee\u9970\u548cLICA\u6280\u672f\u7ed3\u5408\u5728\u4e00\u8d77\uff0c\u8ba9\u6211\u4eec\u80fd\u591f\u5f00\u53d1\u51fa\u5177\u5907\u9ad8\u4eb2\u548c\u529b\u5e76\u4e14\u53ef\u4ee5\u6709\u6548\u9776\u5411\u7279\u5b9a\u7ec6\u80de\u7684\u836f\u7269\u3002<strong>\u8fd9\u8ba9\u6211\u4eec\u53ef\u4ee5\u4f7f\u7528\u5f88\u4f4e\u5242\u91cf\u7684\u836f\u7269\uff0c\u5e76\u4e14\u4e0d\u9700\u8981\u7ecf\u5e38\u65bd\u836f\uff0c\u751a\u81f3\u8ba9\u53e3\u670d\u65bd\u836f\u6210\u4e3a\u53ef\u80fd<\/strong>\uff0c\u201dIonis\u516c\u53f8\u7684\u9996\u5e2d\u8fd0\u8425\u5b98\u517c\u53cd\u4e49\u836f\u7269\u7814\u53d1\u548c\u8f6c\u5316\u836f\u7269\u9ad8\u7ea7\u526f\u603b\u88c1Brett P. Monia\u535a\u58eb\u8bf4\uff1a\u201c\u963f\u65af\u5229\u5eb7\u5728\u836f\u7269\u7814\u53d1\u8fc7\u7a0b\u4e2d\u63d0\u4f9b\u4e86\u5173\u4e8eNASH\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u548c\u5f00\u53d1\u65b9\u9762\u7684\u4e13\u957f\uff0c\u8fd9\u662f\u8fd9\u4e00\u7814\u53d1\u9879\u76ee\u80fd\u591f\u53d6\u5f97\u5feb\u901f\u8fdb\u5c55\u7684\u91cd\u8981\u539f\u56e0\u3002\u6211\u4eec\u671f\u5f85\u963f\u65af\u5229\u5eb7\u5c06\u8fd9\u4e00\u9879\u76ee\u8fc5\u901f\u63a8\u8fdb\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5e76\u6700\u7ec8\u63a8\u5411\u5e02\u573a\u3002\u201d<\/p>\n<p>\u53c2\u8003\u8d44\u6599\uff1a<\/p>\n<p>[1] Ionis and AstraZeneca Advance New Drug for NASH<\/p>\n<p>[2] Ionis Pharmaceuticals \u5b98\u7f51<\/p>\n<p>[3] Nonalcoholic Fatty Liver Disease &amp; NASH<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4eca\u65e5\uff0c\u4f4d\u4e8e\u52a0\u5dde\u5723\u5730\u4e9a\u54e5\u7684Ionis Pharmaceuticals\u516c\u53f8\u5ba3\u5e03\u8be5\u516c\u53f8\u6388\u4e88\u963f\u65af\u5229\u5eb7(AstraZeneca)\u8fdb\u4e00\u6b65\u5f00\u53d1IONIS-AZ6-2.5-LRx\uff0c\u6cbb\u7597\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e(NASH)\u7684\u72ec\u5bb6\u6388\u6743&#8230;..<\/p>\n","protected":false},"author":3,"featured_media":1299762,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-1299760","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science_technology_education"],"_links":{"self":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1299760","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/comments?post=1299760"}],"version-history":[{"count":0,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1299760\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media\/1299762"}],"wp:attachment":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media?parent=1299760"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/categories?post=1299760"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/tags?post=1299760"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}