{"id":1300601,"date":"2018-06-08T18:10:36","date_gmt":"2018-06-09T01:10:36","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=1300601"},"modified":"2018-06-08T18:18:37","modified_gmt":"2018-06-09T01:18:37","slug":"%e8%8d%af%e6%98%8e%e5%ba%b7%e5%be%b7%e5%a4%b4%e6%9d%a1%ef%bc%9a%e7%be%8e%e3%80%90%e7%a7%91%e5%ad%a6%e3%80%91%e6%9c%9f%e5%88%8a%e5%90%8c%e6%97%b6%e5%88%8a%e7%99%bb%e7%be%8e%e5%8d%8e%e8%a3%94%e5%ad%a6","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/%e8%8d%af%e6%98%8e%e5%ba%b7%e5%be%b7%e5%a4%b4%e6%9d%a1%ef%bc%9a%e7%be%8e%e3%80%90%e7%a7%91%e5%ad%a6%e3%80%91%e6%9c%9f%e5%88%8a%e5%90%8c%e6%97%b6%e5%88%8a%e7%99%bb%e7%be%8e%e5%8d%8e%e8%a3%94%e5%ad%a6\/.html","title":{"rendered":"\u836f\u660e\u5eb7\u5fb7\u5934\u6761\uff1a\u7f8e\u3010\u79d1\u5b66\u3011\u671f\u520a\u540c\u65f6\u520a\u767b\u7f8e\u534e\u88d4\u5b66\u80056\u7bc7\u8bba\u6587 \uff01"},"content":{"rendered":"

\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053<\/strong><\/span><\/p>\n

\u5728\u8fd1\u65e5\u51fa\u7248\u7684\u300a\u79d1\u5b66\u300b\uff08Science) \u671f\u520a\u4e0a\uff0c\u6211\u4eec\u5f88\u9ad8\u5174\u5730\u770b\u52305\u7bc7\u6765\u81ea\u534e\u4eba\u5b66\u8005\u7684\u7814\u7a76\u8bba\u6587\u3002\u6b64\u5916\u5728\u7ebf<\/strong>\u300a\u79d1\u5b66\u300b<\/strong>\u53d1\u8868\u7684\u4e09\u7bc7\u91cc\uff0c\u6709\u4e00\u7bc7\u534e\u4eba\u5b66\u8005\u8bba\u6587\u3002\u5982\u4e0b\u6211\u4eec\u5c06\u9010\u4e00\u4ecb\u7ecd\u8fd9\u516d\u7bc7\u8bba\u6587\uff0c\u5176\u4e2d\u9996\u7bc7\u8bba\u6587\u6765\u81ea\u52a0\u5927\u5723\u5730\u4e9a\u54e5\u5206\u6821\u5b66\u8005\u5b59\u6b23\u6559\u6388<\/strong>\u3002<\/p>\n

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Pulmonary neuroendocrine cells amplify allergic asthma responses<\/strong><\/p>\n

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\u8bba\u6587\u5730\u5740\uff1ahttp:\/\/science.sciencemag.org\/content\/360\/6393\/eaan8546<\/p>\n

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A LIMA1<\/em> variant promotes low plasma LDL cholesterol and decreases intestinal cholesterol absorption<\/strong><\/p>\n

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\u8bba\u6587\u5730\u5740\uff1ahttp:\/\/science.sciencemag.org\/content\/360\/6393\/1087<\/p>\n

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Structure of the maize photosystem I supercomplex with light-harvesting complexes I and II<\/strong><\/p>\n

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\u5728\u690d\u7269\u7684\u5149\u5408\u4f5c\u7528\u91cc\uff0c\u5149\u7cfb\u7edfI\uff08PSI\uff09\u548c\u5149\u7cfb\u7edfII\uff08PSII\uff09\u662f\u6838\u5fc3\u3002\u5728\u9002\u5408\u7684\u6761\u4ef6\u4e0b\uff0cPSII\u7684\u201c\u5929\u7ebf\u201d\u2014\u2014\u6355\u5149\u590d\u5408\u7269II\u4f1a\u5f97\u5230\u78f7\u9178\u5316\uff0c\u5e76\u4e0ePSI\uff0c\u4ee5\u53ca\u6355\u5149\u590d\u5408\u7269I\u8fdb\u884c\u7ed3\u5408\u3002\u8fd9\u4e24\u79cd\u6355\u5149\u590d\u5408\u7269\u53ef\u5c06\u80fd\u91cf\u4f20\u9012\u7ed9PSI\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u4e2d\u56fd\u79d1\u5b66\u9662\u751f\u7269\u7269\u7406\u6240\u7684\u7ae0\u65b0\u653f\u6559\u6388\u4e0e\u674e\u6885\u6559\u6388\u56e2\u961f<\/strong>\u5229\u7528\u51b7\u51bb\u7535\u955c\u6280\u672f\uff0c\u89e3\u6790\u4e86\u7389\u7c73\u6355\u5149\u590d\u5408\u7269I\u548c\u6355\u5149\u590d\u5408\u7269II\u4e0ePSI\u7684\u7ed3\u5408\u7ed3\u6784\uff0c\u9610\u660e\u4e86\u6355\u5149\u590d\u5408\u7269II\u4e0ePSI\u7684\u8bc6\u522b\u4f4d\u70b9\u3002\u6b64\u5916\uff0c\u7814\u7a76\u4eba\u5458\u4eec\u8fd8\u53d1\u73b0\uff0cPSI\u7684\u4e9a\u57faPsaN\u4e0ePsaO\u5206\u522b\u53c2\u4e0e\u4e86\u5176\u4e0e\u4e24\u4e2a\u6355\u5149\u590d\u5408\u7269\u7684\u7ed3\u5408\uff0c\u800c\u6bcf\u4e00\u4e2a\u4e9a\u57fa\u90fd\u80fd\u901a\u8fc7\u4e00\u5bf9\u53f6\u7eff\u7d20\u5206\u5b50\uff0c\u5c06\u80fd\u91cf\u4f20\u7ed9PSI\u3002\u8fd9\u4e9b\u53d1\u73b0\u9610\u660e\u4e86\u5168\u65b0\u7684\u80fd\u91cf\u4f20\u9012\u8def\u5f84\uff0c\u8ba9\u6211\u4eec\u80fd\u66f4\u597d\u5730\u4e86\u89e3\u5149\u5408\u4f5c\u7528\u8fd9\u4e00\u91cd\u8981\u7684\u751f\u5316\u53cd\u5e94\u3002<\/strong><\/p>\n

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\u8bba\u6587\u5730\u5740\uff1ahttp:\/\/science.sciencemag.org\/content\/360\/6393\/1109<\/p>\n

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Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes<\/strong><\/p>\n

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\u25b2\u91d1\u6d77\u7fce\u6559\u6388\uff08\u524d\u6392\u5de6\u4e00\uff09<\/strong><\/p>\n

\u4e0d\u5c11\u75c5\u539f\u4f53\u548c\u5bb3\u866b\u4f1a\u91ca\u653e\u51fa\u5c0fRNA\uff08sRNA\uff09\uff0c\u6291\u5236\u5bbf\u4e3b\u7ec6\u80de\u7684\u514d\u75ab\u3002\u4f46\u6709\u610f\u601d\u7684\u662f\uff0c\u5bbf\u4e3b\u4e5f\u4f1a\u5c06sRNA\u4f20\u7ed9\u75c5\u539f\u4f53\u548c\u5bb3\u866b\uff0c\u6291\u5236\u5b83\u4eec\u7684\u75c5\u539f\u6027\u3002<\/strong>\u5c3d\u7ba1\u6211\u4eec\u89c2\u5bdf\u5230\u4e86\u8bb8\u591asRNA\u7684\u8fd0\u8f93\u73b0\u8c61\uff0c\u4f46\u5173\u4e8e\u8fd9\u4e9bsRNA\u7684\u8fd0\u8f93\u673a\u7406\uff0c\u5c24\u5176\u662f\u4ece\u5bbf\u4e3b\u5230\u75c5\u539f\u4f53\u7684\u8fd0\u8f93\u673a\u7406\uff0c\u5374\u4e00\u76f4\u6ca1\u6709\u5f97\u5230\u9610\u660e\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u52a0\u5dde\u5927\u5b66\u6cb3\u6ee8\u5206\u6821\u7684\u91d1\u6d77\u7fce\u6559\u6388\u8bfe\u9898\u7ec4<\/strong>\u53d1\u73b0\uff0c\u62df\u5357\u82a5\u7ec6\u80de\u4f1a\u5206\u6ccc\u7c7b\u4f3c\u4e8e\u5916\u6ccc\u4f53\u7684\u56ca\u6ce1\uff0c\u5c06sRNA\u4f20\u8f93\u7ed9\u771f\u83cc\u75c5\u539f\u4f53Botrytis cinerea<\/em>\u3002\u8fd9\u4e9b\u542b\u6709sRNA\u7684\u56ca\u6ce1\u4f1a\u5728\u611f\u67d3\u4f4d\u70b9\u79ef\u805a\uff0c\u5e76\u88ab\u771f\u83cc\u7ec6\u80de\u6444\u5165\u3002\u8fd9\u4e9b\u8fdb\u5165\u771f\u83cc\u7684\u5bbf\u4e3bsRNA\u80fd\u6c89\u9ed8\u6389\u5173\u952e\u7684\u81f4\u75c5\u57fa\u56e0\uff0c\u4fdd\u62a4\u690d\u7269\u81ea\u5df1\u3002\u6362\u53e5\u8bdd\u8bf4\uff0c\u62df\u5357\u82a5\u6f14\u5316\u51fa\u4e86\u4e00\u7c7b\u4f9d\u8d56\u5916\u6ccc\u4f53\u7684RNA\u5e72\u6270\u673a\u5236\u4f5c\u4e3a\u81ea\u5df1\u7684\u514d\u75ab\u6b66\u5668\uff0c\u4e0e\u75c5\u539f\u4f53\u5c55\u5f00\u4e00\u573a\u201c\u519b\u5907\u7ade\u8d5b\u201d\u3002<\/strong><\/p>\n

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\u8bba\u6587\u5730\u5740\uff1ahttp:\/\/science.sciencemag.org\/content\/360\/6393\/1126<\/p>\n

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A selfish genetic element confers non-Mendelian inheritance in rice<\/strong><\/p>\n

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\u25b2\u9676\u5927\u4e91\u6559\u6388\uff08\u53f3\u4e09\uff09<\/strong><\/p>\n

\u81ea\u79c1\u7684\u57fa\u56e0\u662f\u4e00\u4e2a\u7ecf\u5178\u6982\u5ff5\u3002\u5728\u771f\u6838\u751f\u7269\u7684\u57fa\u56e0\u7ec4\u91cc\uff0c\u7814\u7a76\u4eba\u5458\u4eec\u4e5f\u786e\u5b9e\u53d1\u73b0\u4e86\u8bb8\u591a\u201c\u81ea\u79c1\u57fa\u56e0\u5143\u4ef6\u201d\uff0c\u4f46\u5b83\u4eec\u7684\u4f5c\u7528\u5374\u4e00\u76f4\u6ca1\u6709\u5f97\u5230\u9610\u660e\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u4e2d\u56fd\u519c\u4e1a\u79d1\u5b66\u9662\u7684\u4e13\u5bb6\u56e2\u961f\u53d1\u73b0\u4e86\u4e00\u79cd\u53eb\u505aqHMS7<\/em>\u7684\u57fa\u56e0\u4f4d\u70b9\uff0c\u5176\u5e26\u6709\u4e24\u4e2a\u7d27\u7d27\u76f8\u8fde\u7684\u57fa\u56e0ORF2<\/em>\u4e0eORF3<\/em>\u3002<\/strong>\u524d\u8005\u7f16\u7801\u4e00\u4e2a\u5177\u6709\u6bd2\u6027\u7684\u9057\u4f20\u5143\u4ef6\uff0c\u80fd\u4ee5\u6bcd\u4f53\u6548\u5e94\u5bfc\u81f4\u82b1\u7c89\u6b7b\u4ea1\uff1b\u800cORF3<\/em>\u5219\u7f16\u7801\u4e00\u4e2a\u89e3\u6bd2\u5242\uff0c\u4ee5\u914d\u5b50\u4f53\u6548\u5e94\u4fdd\u62a4\u914d\u5b50\u3002\u8fd9\u6837\u4e00\u6765\uff0c\u7f3a\u4e4fORF3<\/em>\u7684\u82b1\u7c89\u5c31\u4f1a\u88ab\u9009\u62e9\u6027\u5730\u79fb\u9664\uff0c\u4f7f\u5f97\u6c34\u7a3b\u7684\u540e\u4ee3\u4e0d\u9075\u5faa\u7ecf\u5178\u7684\u5b5f\u5fb7\u5c14\u9057\u4f20\u3002\u540e\u7eed\u7684\u5206\u6790\u8868\u660e\uff0cORF3<\/em>\u5148\u8d77\u4f5c\u7528\uff0cORF2<\/em>\u518d\u9010\u6e10\u529f\u80fd\u5316\u3002\u8fd9\u4e00\u7cfb\u7edf\u53ef\u80fd\u5bf9\u91ce\u751f\u7a3bOryza meridionalis<\/em> \/ \u4e9a\u6d32\u79cd\u690d\u7a3bO. sativa<\/em>\u7684\u5206\u5316\u548c\u7ef4\u6301\u5177\u6709\u4fc3\u8fdb\u4f5c\u7528\u3002<\/strong><\/p>\n

<\/p>\n

\u8bba\u6587\u5730\u5740\uff1ahttp:\/\/science.sciencemag.org\/content\/360\/6393\/1130<\/p>\n

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6<\/strong><\/section>\n<\/section>\n<\/section>\n
<\/section>\n
\u5ed6\u8302\u5bcc\u6559\u6388\u3001Ailong Ke\u6559\u6388<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

Structure basis for RNA-guided DNA degradation by Cascade and Cas3<\/strong><\/p>\n

<\/p>\n

\u25b2\u5ed6\u8302\u5bcc\u6559\u6388\uff08\u5de6\uff09\u548cAilong Ke\u6559\u6388\uff08\u53f3\uff09<\/strong><\/p>\n

I\u7c7bCRISPR-Cas\u7cfb\u7edf\u4f1a\u5728RNA\u6307\u5bfc\u7684Cascade\u590d\u5408\u7269\uff0c\u4ee5\u53caCas3\u9176\u7684\u4f5c\u7528\u4e0b\uff0c\u884c\u4f7f\u5176\u7279\u6b8a\u7684\u9776\u70b9\u641c\u5bfb\u548c\u964d\u89e3\u529f\u80fd\u3002\u5728\u8fd9\u9879\u7814\u7a76\u91cc\uff0c\u54c8\u4f5b\u533b\u5b66\u9662\u7684\u5ed6\u8302\u5bcc\u6559\u6388\u4e0e\u5eb7\u5948\u5c14\u5927\u5b66\u7684Ailong Ke\u6559\u6388\u8054\u5408\u56e2\u961f<\/strong>\u5229\u7528\u51b7\u51bb\u7535\u955c\u6280\u672f\uff0c\u89e3\u6790\u4e863.7 \u00c5\u5206\u8fa8\u7387\u4e0b\u7684I-E\u7c7bCascade\/R-loop\/Cas3\u7ed3\u6784\u3002\u4ed6\u4eec\u53d1\u73b0\uff0cCas3\u80fd\u533a\u5206Cascade\u7684\u6784\u8c61\uff0c\u5e76\u53ea\u4f1a\u6355\u83b7\u5f62\u6210R-loop\u7684Cascade\uff0c\u4ee5\u907f\u514d\u5bf9\u90e8\u5206\u4e92\u8865\u7684\u9776\u70b9\u8fdb\u884c\u5207\u9664\u3002\u800c\u5176\u6838\u9178\u9176\u7ed3\u6784\u57df\u80fd\u62db\u52df\u975e\u9776\u70b9DNA\u94fe\uff08non-target strand DNA\uff09\uff0c\u5728\u5355\u94feDNA\u4e0a\u5207\u5f00\u4e00\u4e2a\u5c0f\u53e3\u3002\u6b64\u5916\uff0c\u4ed6\u4eec\u4e5f\u83b7\u5f97\u4e86\u53e6\u4e00\u4e2a\u57284.7 \u00c5\u5206\u8fa8\u7387\u4e0b\u7684\u7ed3\u6784\uff0c\u6355\u83b7\u5230\u4e86DNA\u5728\u5207\u5f00\u540e\u7684\u72b6\u6001\u3002\u5728\u8fd9\u4e2a\u7ed3\u6784\u91cc\uff0c\u88ab\u5207\u5f00\u7684\u975e\u9776\u70b9DNA\u94fe\u4f1a\u4ee5ATP\u4f9d\u8d56\u7684\u65b9\u5f0f\u88ab\u964d\u89e3\u3002\u8fd9\u4e9b\u7ed3\u6784\u80fd\u8ba9\u6211\u4eec\u66f4\u597d\u5730\u4e86\u89e3\u8fd9\u5957CRISPR-Cas\u7cfb\u7edf\u4e2d\uff0cRNA\u5982\u4f55\u6307\u5bfcDNA\u8fdb\u884c\u964d\u89e3\u3002<\/strong><\/p>\n

<\/p>\n

\u8bba\u6587\u5730\u5740\uff1ahttp:\/\/science.sciencemag.org\/content\/early\/2018\/06\/06\/science.aat0839<\/p>\n

\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u8fc7\u53bb\u6211\u4eec\u6781\u5c11\u770b\u5230\u540c\u671f\u300a\u79d1\u5b66\u300b\u6742\u5fd7\u4e0a\u80fd\u520a\u53d1\u5982\u6b64\u591a\u6765\u81ea\u534e\u4eba\u5b66\u8005\u7684\u7814\u7a76\u3002<\/strong>\u6211\u4eec\u671f\u5f85\u8fd9\u6837\u7684\u201c\u534e\u4eba\u65e5\u201d\u80fd\u5728\u4e0d\u4e45\u7684\u5c06\u6765\u53d8\u5f97\u8d8a\u6765\u8d8a\u666e\u904d\uff01<\/p>\n

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\u5386\u53f2\u4e0a\u7684\u201c\u534e\u4eba\u65e5\u201d<\/strong><\/p>\n

5.24.2018\uff1a4\u7bc7Nature<\/a><\/p>\n

4.5.2018\uff1a5\u7bc7Nature<\/a><\/p>\n

3.30.2018\uff1a4\u7bc7Cell<\/a><\/p>\n

10.12.2017\uff1a5\u7bc7Nature<\/a><\/p>\n

9.7.2017\uff1a4\u7bc7Nature<\/a><\/p>\n

7.28.2017\uff1a6\u7bc7Cell<\/a><\/p>\n

\u70b9\u51fb\u6587\u672b\u9605\u8bfb\u539f\u6587\uff0c\u5373\u53ef\u8bbf\u95ee\u300a\u79d1\u5b66\u300b\u6700\u65b0\u8bba\u6587\u5217\u8868\u3002<\/p>\n

\u672c\u6587\u5b66\u8005\u7167\u7247\u9664\u7279\u522b\u6ce8\u660e\u5916\uff0c\u5747\u6765\u81ea\u76f8\u5e94\u79d1\u7814\u9662\u6240\u5b98\u7f51\uff0c\u7814\u7a76\u56fe\u7247\u5747\u6765\u81ea\u300a\u79d1\u5b66\u300b\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u5728\u8fd1\u65e5\u51fa\u7248\u7684\u300a\u79d1\u5b66\u300b\u671f\u520a\u4e0a\uff0c\u6211\u4eec\u5f88\u9ad8\u5174\u5730\u770b\u52305\u7bc7\u6765\u81ea\u534e\u4eba\u5b66\u8005\u7684\u7814\u7a76\u8bba\u6587\u3002\u6b64\u5916\uff0c\u5728\u4eca\u5728\u8fd1\u65e5\u51fa\u7248\u7684\u300a\u79d1\u5b66\u300b\uff08Science) \u671f\u520a\u4e0a\uff0c\u6211\u4eec\u5f88\u9ad8\u5174\u5730\u770b\u52305\u7bc7\u6765\u81ea\u534e\u4eba\u5b66\u8005\u7684\u7814\u7a76\u8bba\u6587\u3002\u6b64\u5916\u5728\u7ebf\u300a\u79d1\u5b66\u300b\u53d1\u8868\u7684\u4e09\u7bc7\u91cc\uff0c\u6709\u4e00\u7bc7\u534e\u4eba\u5b66\u8005\u8bba\u6587…….<\/p>\n","protected":false},"author":3,"featured_media":1300603,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-1300601","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science_technology_education"],"_links":{"self":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1300601","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/comments?post=1300601"}],"version-history":[{"count":0,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1300601\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media\/1300603"}],"wp:attachment":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media?parent=1300601"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/categories?post=1300601"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/tags?post=1300601"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}