{"id":1301522,"date":"2018-08-03T17:29:21","date_gmt":"2018-08-04T00:29:21","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=1301522"},"modified":"2018-08-03T17:29:21","modified_gmt":"2018-08-04T00:29:21","slug":"%e8%8d%af%e6%98%8e%e5%ba%b7%e5%be%b7%ef%bc%9a%e8%8b%b1%e6%b4%be%e8%8d%af%e4%b8%9a%e5%ae%8c%e6%88%903000%e4%b8%87%e7%be%8e%e5%85%83c%e8%bd%ae%e8%9e%8d%e8%b5%84%ef%bc%81","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/%e8%8d%af%e6%98%8e%e5%ba%b7%e5%be%b7%ef%bc%9a%e8%8b%b1%e6%b4%be%e8%8d%af%e4%b8%9a%e5%ae%8c%e6%88%903000%e4%b8%87%e7%be%8e%e5%85%83c%e8%bd%ae%e8%9e%8d%e8%b5%84%ef%bc%81\/.html","title":{"rendered":"\u836f\u660e\u5eb7\u5fb7\uff1a\u82f1\u6d3e\u836f\u4e1a\u5b8c\u62103000\u4e07\u7f8e\u5143C\u8f6e\u878d\u8d44\uff01"},"content":{"rendered":"<p>2018\u5e748\u67083\u65e5\uff0c \u5357\u4eac\u82f1\u6d3e\u836f\u4e1a\uff08IMPACT Therapeutics\uff09\u5ba3\u5e03\u5df2\u6210\u529f\u5b8c\u62103000\u4e07\u7f8e\u5143 C \u8f6e\u878d\u8d44\u3002\u672c\u8f6e\u878d\u8d44\u7531<strong>\u5fb7\u8bda\u8d44\u672c\u9886\u6295\uff0c\u793c\u6765\u4e9a\u6d32\u57fa\u91d1\u8ddf\u6295<\/strong>\u3002\u7b79\u96c6\u7684\u8d44\u91d1\u5c06\u4e3b\u8981\u7528\u4e8e\u52a0\u901f\u63a8\u8fdb\u5177\u6709\u6700\u4f73\u540c\u7c7b\u836f\u6f5c\u529b\u7684<strong>PARP \u6291\u5236\u5242 IMP4297<\/strong>\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4ee5\u53ca\u5176\u5b83\u9879\u76ee\u3002<\/p>\n<p>\u82f1\u6d3e\u836f\u4e1a\u6210\u7acb\u4e8e2009\u5e746\u6708\uff0c\u81f4\u529b\u4e8e\u7814\u53d1\u5177\u6709\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684\u7528\u4e8e\u6cbb\u7597\u764c\u75c7\u7b49\u91cd\u5927\u75be\u75c5\u7684\u6700\u4f73\u540c\u7c7b\u836f (best-in-class)\u3002\u82f1\u6d3e\u836f\u4e1a\u65d7\u4e0b\u6ce8\u518c\u6709\u4e0a\u6d77\u745b\u6d3e\u836f\u4e1a\u548c\u6fb3\u5927\u5229\u4e9a\u82f1\u6d3e\u836f\u4e1a\u4e24\u4e2a\u5b50\u516c\u53f8\u3002\u82f1\u6d3e\u836f\u4e1a\u4ee5 <strong>DNA \u635f\u4f24\u5e94\u7b54<\/strong>(DNA Damage Response, DDR) \u4e3a\u91cd\u70b9\u9776\u6807\u642d\u5efa\u7814\u53d1\u5e73\u53f0\uff0c\u6784\u5efa\u72ec\u7279\u7684\u4ea7\u54c1\u7ba1\u7ebf\u30022015\u5e7412\u6708\uff0c\u82f1\u6d3e\u836f\u4e1a\u5b8c\u6210\u4e86B\u8f6e\u878d\u8d44\uff0c\u7531\u534e\u5cad\u8d44\u672c\u3001\u8d8a\u79c0\u4ea7\u4e1a\u57fa\u91d1\uff0c\u5143\u751f\u521b\u6295\u3001\u6d77\u90a6\u521b\u6295\u548c\u793c\u6765\u4e9a\u6d32\u57fa\u91d1\u5171\u540c\u53c2\u4e0e\uff0c\u878d\u8d44\u8fd11000\u4e07\u7f8e\u5143\u3002<\/p>\n<p><img decoding=\"async\" class=\"aligncenter\" src=\"http:\/\/5b0988e595225.cdn.sohucs.com\/images\/20180803\/04acc9c489474b668aee36f1b9da813d.png\" alt=\"\u82f1\u6d3e\u836f\u4e1a\u5b8c\u62103000\u4e07\u7f8e\u5143C\u8f6e\u878d\u8d44\uff0c\u5fb7\u8bda\u8d44\u672c\u9886\u6295\uff01-\u96ea\u82b1\u65b0\u95fb\" \/><\/p>\n<p>\u5176\u4e3b\u6253\u4ea7\u54c1 PARP \u6291\u5236\u5242 IMP4297\u6b63\u5728\u4e2d\u56fd\u548c\u6fb3\u5927\u5229\u4e9a\u540c\u65f6\u8fdb\u884c\u4e34\u5e8a\u8bd5\u9a8c\u3002\u4e34\u5e8a\u524d\u6570\u636e\u548c\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u663e\u793a\uff0c\u4e0e Olaparib \u53ca\u5176\u5b83\u5df2\u4e0a\u5e02\u7684 PARP \u6291\u5236\u5242\u76f8\u6bd4\uff0cIMP4297\u5728\u4e34\u5e8a\u4e0a\u53ef\u80fd\u6709\u66f4\u597d\u7684\u836f\u6548\u548c\u66f4\u4f4e\u7684\u6bd2\u6027\uff0c\u6709\u671b\u5f00\u53d1\u6210\u4e3a PARP \u6291\u5236\u5242\u6700\u4f73\u540c\u7c7b\u836f\u3002<\/p>\n<p>PARP \u6291\u5236\u5242\u662f\u9488\u5bf9\u6709 DNA \u4fee\u590d\u673a\u5236\u7f3a\u9677\uff0c\u7279\u522b\u662f\u6709 BRCA \u7a81\u53d8\u764c\u75c7\u7684\u7279\u6548\u9776\u5411\u836f\u7269\uff0c\u7ecf\u8fc7\u5927\u91cf\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u8bc1\u660e\u5b89\u5168\u6709\u6548\u3002\u76ee\u524d\u5df2\u67093\u4e2a PARP \u6291\u5236\u5242\u5728\u6d77\u5916\u6279\u51c6\u4e0a\u5e02\u3002\u82f1\u6d3e\u836f\u4e1a\u4e34\u5e8a I \u671f\u6570\u636e\u663e\u793a\uff0cIMP4297\u6709\u975e\u5e38\u597d\u7684\u5b89\u5168\u6027\u53ca\u5f88\u597d\u7684\u521d\u6b65\u836f\u6548\uff0c\u4e0e\u4e34\u5e8a\u524d\u6570\u636e\u4f53\u73b0\u7684\u9ad8\u836f\u6548\u548c\u5bbd\u6cbb\u7597\u7a97\u4e00\u81f4\u3002<\/p>\n<p><strong>\u82f1\u6d3e\u836f\u4e1a\u9ad8\u7ea7\u526f\u603b\u88c1\u517c\u9996\u5e2d\u6280\u672f\u5b98\u8521\u9042\u96c4\u535a\u58eb<\/strong>\u8868\u793a\uff1a\u201c\u76ee\u524d IMP4297\u4e34\u5e8a\u8bd5\u9a8c\u8fdb\u5c55\u987a\u5229\uff0c\u6570\u636e\u8d85\u51fa\u9884\u671f\uff0c\u5b8c\u5168\u53ef\u80fd\u5f00\u53d1\u6210\u4e3a\u4e00\u4e2a PARP \u6291\u5236\u5242\u6700\u4f73\u540c\u7c7b\u836f\u3002\u5fb7\u8bda\u548c\u793c\u6765\u8fd9\u4e9b\u77e5\u540d\u751f\u7269\u533b\u836f\u8d44\u672c\u7684\u8fdb\u5165\u548c\u652f\u6301\u5c06\u6781\u5927\u5730\u4fc3\u8fdb\u548c\u52a0\u5feb IMP4297\u7684\u4e34\u5e8a\u5f00\u53d1\uff0c\u4e3a\u53ca\u65f6\u53d6\u5f97\u5173\u952e\u4e34\u5e8a\u6570\u636e\u3001\u79ef\u6781\u63a8\u8fdb\u4ea7\u54c1\u4e0a\u5e02\u63d0\u4f9b\u4e86\u8d44\u91d1\u4fdd\u969c\u3002\u201d<\/p>\n<p><img decoding=\"async\" src=\"http:\/\/5b0988e595225.cdn.sohucs.com\/images\/20180803\/05bd67ee19ca4b58b9eec32b1e57b0f0.jpeg\" alt=\"\u82f1\u6d3e\u836f\u4e1a\u5b8c\u62103000\u4e07\u7f8e\u5143C\u8f6e\u878d\u8d44\uff0c\u5fb7\u8bda\u8d44\u672c\u9886\u6295\uff01-\u96ea\u82b1\u65b0\u95fb\" \/><\/p>\n<p>\u82f1\u6d3e\u836f\u4e1a\u9ad8\u7ea7\u526f\u603b\u88c1\u517c\u9996\u5e2d\u6280\u672f\u5b98\u8521\u9042\u96c4\u535a\u58eb\uff08\u56fe\u7247\u6765\u6e90\uff1a\u82f1\u6d3e\u836f\u4e1a\u5b98\u7f51\uff09<\/p>\n<p>\u793c\u6765\u4e9a\u6d32\u57fa\u91d1\u7ba1\u7406\u5408\u4f19\u4eba\u9648\u98de\u535a\u58eb\u8868\u793a\uff0c\u201c\u82f1\u6d3e\u836f\u4e1a\u7684\u53d1\u5c55\u6001\u52bf\u826f\u597d\u3001\u9879\u76ee\u8fdb\u5c55\u987a\u5229\uff0c\u5176\u4e3b\u6253\u4ea7\u54c1 IMP4297\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u53d6\u5f97\u4e86\u975e\u5e38\u597d\u7684\u4e34\u5e8a\u6570\u636e\u3002\u4f5c\u4e3a\u82f1\u6d3e\u836f\u4e1a\u524d\u4e24\u8f6e\u878d\u8d44\u7684\u6295\u8d44\u4eba\uff0c\u793c\u6765\u4e9a\u6d32\u57fa\u91d1\u5bf9\u62e5\u6709\u4f18\u79c0\u7ba1\u7406\u7ecf\u9a8c\u548c\u4e34\u5e8a\u5f00\u53d1\u5b9e\u529b\u7684\u82f1\u6d3e\u56e2\u961f\u5341\u5206\u770b\u597d\uff0c\u9009\u62e9\u7ee7\u7eed\u8ffd\u52a0\u6295\u8d44\u652f\u6301\uff0c\u5e76\u5c06\u4e0e\u82f1\u6d3e\u836f\u4e1a\u5728\u968f\u540e\u7684\u5feb\u901f\u63a8\u8fdb\u8fc7\u7a0b\u4e2d\u4fdd\u6301\u826f\u597d\u7684\u4e92\u52a8\u548c\u534f\u4f5c\u3002\u201d\u6b64\u524d\uff0c\u793c\u6765\u4e9a\u6d32\u57fa\u91d1\u66fe\u5206\u522b\u4e8e2014\u5e747\u6708\u548c2015\u5e7412\u6708\u53c2\u4e0e\u82f1\u6d3e\u836f\u4e1a A \u8f6e\u548c B \u8f6e\u878d\u8d44\u3002<\/p>\n<p>\u5fb7\u8bda\u521b\u59cb\u4eba\u517c\u8463\u4e8b\u957f\u5d14\u76f8\u6c11\u535a\u58eb\u8868\u793a\uff0c\u201c\u82f1\u6d3e\u836f\u4e1a\u7684 PARP \u6291\u5236\u5242\u9879\u76ee\u65e0\u8bba\u5728\u4e34\u5e8a\u524d\u7814\u7a76\uff0c\u8fd8\u662f\u5728\u65e9\u671f\u7684\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u90fd\u4f53\u73b0\u51fa\u6210\u4e3a\u6700\u4f73\u540c\u7c7b\u836f\u7684\u6f5c\u8d28\u3002\u540c\u65f6\uff0c\u82f1\u6d3e\u836f\u4e1a\u7684\u7814\u53d1\u7ba1\u7ebf\u5e03\u5c40\u6df1\u8fdc\uff0c\u5bf9\u5c0f\u5206\u5b50\u9776\u5411\u836f\u7684\u524d\u6cbf\u65b9\u5411\u89c1\u89e3\u72ec\u5230\u3002\u6211\u4eec\u5f88\u9ad8\u5174\u4e0e\u82f1\u6d3e\u836f\u4e1a\u8fd9\u6837\u5177\u6709\u672c\u571f\u7814\u53d1\u5b9e\u529b\u3001\u5bcc\u6709\u575a\u97e7\u5f00\u653e\u79d1\u7814\u7cbe\u795e\uff0c\u5e76\u4e14\u53ef\u4ee5\u53c2\u4e0e\u56fd\u9645\u7ade\u4e89\u7684\u4f01\u4e1a\u5408\u4f5c\u3002\u201d<\/p>\n<p><img decoding=\"async\" src=\"http:\/\/5b0988e595225.cdn.sohucs.com\/images\/20180803\/b846e84985b0447ab2d30126275c6298.jpeg\" alt=\"\u82f1\u6d3e\u836f\u4e1a\u5b8c\u62103000\u4e07\u7f8e\u5143C\u8f6e\u878d\u8d44\uff0c\u5fb7\u8bda\u8d44\u672c\u9886\u6295\uff01-\u96ea\u82b1\u65b0\u95fb\" \/><\/p>\n<p>\u82f1\u6d3e\u836f\u4e1a\u603b\u7ecf\u7406\u517c\u9996\u5e2d\u79d1\u5b66\u5b98\u7530\u91ce\u535a\u58eb\uff08\u56fe\u7247\u6765\u6e90\uff1a\u82f1\u6d3e\u836f\u4e1a\u5b98\u7f51\uff09<\/p>\n<p><strong>\u82f1\u6d3e\u836f\u4e1a\u603b\u7ecf\u7406\u517c\u9996\u5e2d\u79d1\u5b66\u5b98\u7530\u91ce\u535a\u58eb<\/strong>\u8868\u793a\uff1a\u201c\u82f1\u6d3e\u836f\u4e1a\u4ee5\u79d1\u5b66\u4e3a\u4e0a\uff0c\u4ee5\u56e2\u961f\u4e3a\u672c\uff0c\u7ecf\u8fc7\u8fd9\u4e9b\u5e74\u7684\u52aa\u529b\u7ec4\u5efa\u4e86\u4e00\u652f\u5e74\u8f7b\u3001\u9ad8\u6548\u3001\u5145\u6ee1\u671d\u6c14\u7684\u65b0\u836f\u7814\u53d1\u56e2\u961f\uff0c\u80fd\u591f\u4e3a\u516c\u53f8\u84ec\u52c3\u53d1\u5c55\u63d0\u4f9b\u6e90\u6e90\u4e0d\u65ad\u7684\u6d3b\u529b\u4e0e\u52a8\u529b\u3002\u8fd9\u6b21\u7b79\u96c6\u7684\u8d44\u91d1\u5c06\u4e3b\u8981\u7528\u6765\u5b8c\u6210 IMP4297\u7684\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u540c\u65f6\u5145\u5b9e\u516c\u53f8\u7684\u7814\u53d1\u7ba1\u7ebf\u3002\u5fb7\u8bda\u8d44\u672c\u662f\u56fd\u9645\u77e5\u540d\u7684\u3001\u4e13\u95e8\u6295\u8d44\u751f\u7269\u533b\u836f\u4ea7\u4e1a\u7684\u6295\u8d44\u516c\u53f8\uff0c\u4ed6\u4eec\u7684\u52a0\u5165\u4f7f\u6211\u4eec\u66f4\u6709\u4fe1\u5fc3\u3002\u793c\u6765\u4e9a\u6d32\u57fa\u91d1\u5bf9\u6211\u4eec\u7684\u518d\u6b21\u6295\u8d44\u65e2\u662f\u5bf9\u516c\u53f8\u5df2\u6709\u6210\u7ee9\u7684\u80af\u5b9a\uff0c\u4e5f\u662f\u5bf9\u516c\u53f8\u524d\u666f\u7684\u770b\u597d\u3002\u6211\u4eec\u611f\u8c22\u8fd9\u4e24\u5bb6\u77e5\u540d\u6295\u8d44\u4f01\u4e1a\u5bf9\u82f1\u6d3e\u836f\u4e1a\u7684\u652f\u6301\uff0c\u5e76\u671f\u5f85\u4eca\u540e\u957f\u671f\u5408\u4f5c\uff0c\u5171\u540c\u4e3a\u80bf\u7624\u60a3\u8005\u7814\u53d1\u51fa\u66f4\u5b89\u5168\u3001\u66f4\u6709\u6548\u7684\u65b0\u836f\u3002\u201d<\/p>\n<p>\u6d88\u606f\u6765\u6e90\uff1a\u836f\u660e\u5eb7\u5fb7<\/p>\n<p>\uff08\u7f8e\u56fd\u534e\u6587\u7f51 \u5723\u5730\u4e9a\u54e5\u534e\u6587\u7f51\u00a0 \u534e\u6587\u98ce\u91c7\u7f16\u53d1 USChinesePress.com SanDiegoChinesePress.com)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>2018\u5e748\u67083\u65e5\uff0c \u5357\u4eac\u82f1\u6d3e\u836f\u4e1a\uff08IMPACT Therapeutics\uff09\u5ba3\u5e03\u5df2\u6210\u529f\u5b8c\u62103000\u4e07\u7f8e\u5143 C \u8f6e\u878d\u8d44\u3002\u672c\u8f6e\u878d\u8d44\u7531\u5fb7\u8bda\u8d44\u672c\u9886\u6295\uff0c\u793c\u6765\u4e9a\u6d32\u57fa\u91d1\u8ddf\u6295&#8230;&#8230;<\/p>\n","protected":false},"author":3,"featured_media":1301523,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-1301522","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science_technology_education"],"_links":{"self":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1301522","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/comments?post=1301522"}],"version-history":[{"count":0,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1301522\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media\/1301523"}],"wp:attachment":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media?parent=1301522"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/categories?post=1301522"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/tags?post=1301522"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}