{"id":1302247,"date":"2018-08-23T15:12:47","date_gmt":"2018-08-23T22:12:47","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=1302247"},"modified":"2018-08-23T15:24:52","modified_gmt":"2018-08-23T22:24:52","slug":"%e8%8d%af%e6%98%8e%e5%ba%b7%e5%be%b7%e5%a4%b4%e6%9d%a1%ef%bc%9a%e5%8e%89%e5%ae%b3%e4%ba%86%ef%bc%81%e4%bb%8a%e6%97%a5%e3%80%90nature%e3%80%91%e5%8f%91%e8%a1%a84%e7%af%87%e5%8d%8e%e4%ba%ba%e7%a0%94","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/%e8%8d%af%e6%98%8e%e5%ba%b7%e5%be%b7%e5%a4%b4%e6%9d%a1%ef%bc%9a%e5%8e%89%e5%ae%b3%e4%ba%86%ef%bc%81%e4%bb%8a%e6%97%a5%e3%80%90nature%e3%80%91%e5%8f%91%e8%a1%a84%e7%af%87%e5%8d%8e%e4%ba%ba%e7%a0%94\/.html","title":{"rendered":"\u836f\u660e\u5eb7\u5fb7\u5934\u6761\uff1a\u5389\u5bb3\u4e86\uff01\u4eca\u65e5\u3010Nature\u3011\u53d1\u88684\u7bc7\u534e\u4eba\u7814\u7a76\uff08\u56fe\uff09"},"content":{"rendered":"

\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053\uff1a<\/strong><\/p>\n

\u5bf9\u4e8e\u534e\u4eba\u5b66\u8005\u5728\u5b66\u672f\u754c\u505a\u51fa\u7684\u7a81\u7834\u6027\u7814\u7a76\uff0c\u6211\u4eec\u603b\u662f\u500d\u611f\u4eb2\u5207\u3002\u4eca\u65e5\uff0c\u5728\u9876\u5c16\u5b66\u672f\u671f\u520a\u300a\u81ea\u7136\u300b\u5728\u7ebf\u53d1\u8868\u7684\u591a\u7bc7\u6587\u7ae0\u4e2d\uff0c\u6211\u4eec\u5f88\u9ad8\u5174\u5730\u770b\u5230\uff0c\u67094\u7bc7\u751f\u7269\u533b\u836f\u9886\u57df\u7684\u7814\u7a76\u6765\u81ea\u4e8e\u534e\u4eba\u5b66\u8005\u7684\u8bfe\u9898\u7ec4\u3002\u5728\u8fd9\u7bc7\u6587\u7ae0\u91cc\uff0c\u6211\u4eec\u4e5f\u5c06\u4e3a\u5404\u4f4d\u8bfb\u8005\u4ecb\u7ecd\u8fd94\u7bc7\u8bba\u6587\u3002<\/p>\n

1\uff0cYueh-hsiu Chien\u8bfe\u9898\u7ec4<\/p>\n

A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes<\/p>\n

<\/p>\n

\u636e\u4f30\u8ba1\uff0c\u5168\u4e16\u754c\u6709\u56db\u5206\u4e4b\u4e00\u7684\u4eba\u53e3\u53ef\u80fd\u6709\u6f5c\u4f0f\u6027\u7ed3\u6838\u611f\u67d3\u3002\u5118\u7ba1\u5176\u4e2d\u4e0d\u523010%\u4f1a\u6700\u7ec8\u53d1\u75c5\uff0c\u4f46\u80ba\u7ed3\u6838\u4f9d\u7136\u662f\u5168\u4e16\u754c\u8303\u56f4\u5185\uff0c\u6700\u4e3a\u81f4\u547d\u7684\u4f20\u67d3\u75c5\u4e4b\u4e00\u3002\u4e0d\u5e78\u7684\u662f\uff0c\u6211\u4eec\u5bf9\u4e8e\u8fd9\u79cd\u75be\u75c5\u611f\u67d3\u80cc\u540e\u7684\u514d\u75ab\u56e0\u7d20\u5374\u77e5\u4e4b\u751a\u5c11\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u53f2\u4e39\u798f\u5927\u5b66\u7684Yueh-hsiu Chien\u6559\u6388\u8054\u624bPurvesh Khatri\u6559\u6388\uff0c\u505a\u4e86\u4e00\u9879\u5927\u89c4\u6a21\u7684\u7814\u7a76\u4e0e\u5206\u6790\u3002\u4ed6\u4eec\u53d1\u73b0\uff0c\u6f5c\u4f0f\u6027\u7ed3\u6838\u611f\u67d3\u4e0e\u589e\u5f3a\u7684\u7ec6\u80de\u6bd2\u6027\u53cd\u5e94\u6709\u5173\uff0c\u800c\u6301\u7eed\u7684\u708e\u75c7\u4f1a\u5f71\u54cd\u5230T\u7ec6\u80de\u4e0eB\u7ec6\u80de\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u5faa\u73af\u7684\u81ea\u7136\u6740\u624b\u7ec6\u80de\u6570\u91cf\u4e5f\u4e0e\u75be\u75c5\u7684\u8fdb\u5c55\u6709\u5173\uff0c\u8fd9\u4e9b\u7ec6\u80de\u7684\u6570\u91cf\u8d8a\u591a\uff0c\u75be\u75c5\u7684\u6d3b\u6027\u5c31\u8d8a\u4f4e\u3002\u7efc\u5408\u6765\u770b\uff0c\u7814\u7a76\u4eba\u5458\u6307\u51fa\u4ed6\u4eec\u7684\u53d1\u73b0\u4e3a\u80ba\u7ed3\u6838\u6f5c\u4f0f\u63d0\u4f9b\u4e86\u91cd\u8981\u7684\u75c5\u7406\u751f\u7406\u5b66\u6d1e\u89c1\uff0c\u5bfb\u627e\u5230\u4e86\u53ef\u80fd\u5f71\u54cd\u611f\u67d3\u9884\u540e\u7684\u5173\u952e\u56e0\u7d20\u3002<\/p>\n

<\/p>\n

\u76f8\u5173\u8bba\u6587\uff1aR Chowdhury et al., (2018) A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes, Nature, DOI: https:\/\/doi.org\/10.1038\/s41586-018-0439-x<\/p>\n

2\uff0c\u7ba1\u5764\u826f\u8bfe\u9898\u7ec4<\/p>\n

RAP2 mediates mechanoresponses of the Hippo pathway<\/p>\n

<\/p>\n

\u54fa\u4e73\u52a8\u7269\u7684\u7ec6\u80de\u5468\u56f4\uff0c\u5f80\u5f80\u662f\u5176\u4ed6\u7ec6\u80de\uff0c\u6216\u662f\u7ec6\u80de\u5916\u57fa\u8d28\u3002\u5b83\u4eec\u4e0d\u4ec5\u4e3a\u7ec6\u80de\u63d0\u4f9b\u4e86\u7ed3\u6784\u4e0a\u7684\u652f\u6491\uff0c\u8fd8\u80fd\u5f71\u54cd\u5230\u8bf8\u591a\u751f\u7269\u5b66\u8fdb\u7a0b\u3002\u5176\u4e2d\uff0cHippo\u901a\u8def\u7684\u6548\u5e94\u86cb\u767dYAP\u4e0eTAZ\u5c31\u53d7\u5230\u4e86\u76f8\u5e94\u7684\u8c03\u8282\uff0c\u4f1a\u6839\u636e\u7ec6\u80de\u5916\u57fa\u8d28\u7684\u521a\u6027\u7a0b\u5ea6\uff0c\u4ecb\u5bfc\u7ec6\u80de\u7684\u53cd\u5e94\u3002\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u6765\u81ea\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821\u7684\u7ba1\u5764\u826f\u6559\u6388\u8bfe\u9898\u7ec4\u53d1\u73b0\uff0cRAP2\u86cb\u767d\u662f\u8fd9\u6761\u901a\u8def\u91cc\u7684\u91cd\u8981\u7ec6\u80de\u5185\u4fe1\u53f7\u300c\u4f20\u611f\u5668\u300d\u3002\u4e00\u65e6\u6572\u9664RAP2\u86cb\u767d\uff0cYAP\u4e0eTAZ\u5c31\u65e0\u6cd5\u6839\u636e\u7ec6\u80de\u5916\u57fa\u8d28\u7684\u521a\u6027\u505a\u51fa\u53cd\u5e94\uff0c\u4f1a\u5bfc\u81f4\u5f02\u5e38\u7ec6\u80de\u751f\u957f\u3002\u7814\u7a76\u4eba\u5458\u540c\u6837\u9610\u660e\u4e86\u80cc\u540e\u7684\u751f\u7269\u5b66\u673a\u5236\u3002\u539f\u6765\uff0c\u7ec6\u80de\u5916\u57fa\u8d28\u7684\u521a\u6027\u5982\u679c\u8f83\u4f4e\uff0c\u5c31\u4f1a\u6fc0\u6d3bRAP2\uff0c\u4f7f\u5b83\u7ed3\u5408\u5230MAP4K4\u3001MAP4K6\u3001MAP4K7\u3001\u4ee5\u53caARHGAP29\u86cb\u767d\u4e0a\uff0c\u8fdb\u4e00\u6b65\u6fc0\u6d3bLATS1\u4e0eLATS2\uff0c\u5e76\u6291\u5236YAP\u4e0eTAZ\u3002\u8fd9\u9879\u91cd\u8981\u7684\u7814\u7a76\u8868\u660eRAP2\u662f\u4e00\u6b3e\u300c\u5206\u5b50\u5f00\u5173\u300d\uff0c\u80fd\u53c2\u4e0e\u673a\u68b0\u4fe1\u53f7\u7684\u4f20\u611f\u3002\u8fd9\u8ba9\u6211\u4eec\u5bf9\u4e8e\u76f8\u5173\u4fe1\u53f7\u901a\u8def\u7684\u7406\u89e3\uff0c\u53c8\u52a0\u6df1\u4e86\u4e00\u5c42\u3002<\/p>\n

<\/p>\n

\u76f8\u5173\u8bba\u6587\uff1aZ Meng et al., (2018) RAP2 mediates mechanoresponses of the Hippo pathway, Nature, DOI: https:\/\/doi.org\/10.1038\/s41586-018-0444-0<\/p>\n

3\uff0c\u674e\u4f1f\u3001\u5218\u5149\u6167\u3001\u80e1\u5b9d\u6d0b\u8bfe\u9898\u7ec4<\/p>\n

SIRT6 deficiency results in developmental retardation in cynomolgus monkeys<\/p>\n

<\/p>\n

\u5728\u556e\u9f7f\u7c7b\u52a8\u7269\u4e2d\uff0cSIRT6\u662f\u4e00\u6b3e\u4e0e\u957f\u5bff\u6709\u5173\u7684\u86cb\u767d\u3002\u4f46\u5b83\u5728\u7075\u957f\u7c7b\u52a8\u7269\u91cc\u7684\u751f\u7269\u5b66\u529f\u80fd\uff0c\u5374\u4e00\u76f4\u6ca1\u6709\u5f97\u5230\u9610\u660e\u3002\u5728\u672c\u7bc7\u8bba\u6587\u91cc\uff0c\u6765\u81ea\u4e2d\u79d1\u9662\u65d7\u4e0b\u591a\u4e2a\u673a\u6784\u7684\u674e\u4f1f\u3001\u5218\u5149\u6167\u3001\u80e1\u5b9d\u6d0b\u8bfe\u9898\u7ec4\u8054\u5408\u5728\u98df\u87f9\u7334\u6a21\u578b\u4e2d\uff0c\u5229\u7528\u57fa\u4e8eCRISPR-Cas9\u7684\u65b9\u6cd5\uff0c\u5b9e\u73b0\u4e86SIRT6\u7684\u5168\u6572\u9664\u3002\u7814\u7a76\u8868\u660e\uff0c\u8fd9\u4e9b\u7f3a\u5c11SIRT6\u7684\u7334\u5b50\u4f1a\u5728\u51fa\u751f\u6570\u5c0f\u65f6\u540e\u6b7b\u4ea1\uff0c\u4e14\u6709\u4e25\u91cd\u7684\u53d1\u80b2\u8fdf\u7f13\u73b0\u8c61\u3002\u5728\u795e\u7ecf\u7cfb\u7edf\u91cc\uff0cSIRT6\u7684\u7f3a\u5931\u4f1a\u6fc0\u6d3b\u975e\u7f16\u7801RNA H19\uff08\u672c\u8eab\u80fd\u6291\u5236\u53d1\u80b2\uff09\uff0c\u4ece\u800c\u5ef6\u7f13\u795e\u7ecf\u5143\u7684\u5206\u5316\u3002\u8fd9\u4e00\u53d1\u73b0\u5728\u4eba\u7c7b\u7ec6\u80de\u6a21\u578b\u4e2d\u4e5f\u5f97\u5230\u4e86\u91cd\u8907\u3002\u8fdb\u4e00\u6b65\u53d1\u73b0\u8868\u660e\uff0cSIRT6\u7684\u7f3a\u4e4f\u4f1a\u5728H19\u7684\u5370\u8bb0\u8c03\u63a7\u533a\u57df\u5bfc\u81f4\u7ec4\u86cb\u767d\u7684\u8fc7\u5ea6\u4e59\u91af\u5316\uff0c\u4e0a\u8c03H19\u3002\u8fd9\u4e00\u53d1\u73b0\u8868\u660eSIRT6\u53c2\u4e0e\u5230\u4e86\u975e\u4eba\u7075\u957f\u7c7b\u52a8\u7269\u7684\u53d1\u80b2\u4e2d\uff0c\u5bf9\u4eba\u7c7b\u7684\u56f4\u4ea7\u671f\u81f4\u6b7b\u7efc\u5408\u5fb5\u7b49\u75be\u75c5\u6709\u671b\u5e26\u6765\u65b0\u7684\u7406\u89e3\u3002<\/p>\n

<\/p>\n

\u76f8\u5173\u8bba\u6587\uff1aW Zhang et al., (2018) SIRT6 deficiency results in developmental retardation in cynomolgus monkeys, Nature, DOI: https:\/\/doi.org\/10.1038\/s41586-018-0437-z<\/p>\n

4\uff0c\u5f90\u83f2\u8bfe\u9898\u7ec4<\/p>\n

Crystal structure of the Frizzled 4 receptor in a ligand-free state<\/p>\n

<\/p>\n

FZD\u662f\u4e00\u7c7bG\u86cb\u767d\u5076\u8054\u53d7\u4f53\uff08GPCR\uff09\uff0c\u5728Wnt\u4fe1\u53f7\u901a\u8def\u4e2d\u6709\u91cd\u8981\u7684\u751f\u7406\u4f5c\u7528\u3002\u4f5c\u4e3a\u8fd9\u6761\u901a\u8def\u91cc\u7684\u5173\u952e\u86cb\u767d\u4e4b\u4e00\uff0c\u7406\u89e3FZD\u7684\u7ed3\u6784\uff0c\u5bf9\u4e8e\u57fa\u7840\u7814\u7a76\uff0c\u6216\u662f\u4e34\u5e8a\u8f6c\u5316\u6765\u8bf4\uff0c\u90fd\u6709\u6781\u5927\u7684\u610f\u4e49\u3002\u5728\u8fd9\u9879\u7814\u7a76\u91cc\uff0c\u6765\u81ea\u4e0a\u6d77\u79d1\u6280\u5927\u5b66\u7684\u5f90\u83f2\u8bfe\u9898\u7ec4\u63ed\u793a\u4e86\u4eba\u7c7bFZD4\u86cb\u767d\u5728\u6ca1\u6709\u914d\u4f53\u7684\u60c5\u51b5\u4e0b\uff0c\u5176\u8de8\u819c\u533a\u57df\u7684\u539f\u5b50\u89e3\u6790\u5ea6\u7ed3\u6784\u3002\u8be5\u7ed3\u6784\u8868\u660e\uff0c\u5176VI\u53f7\u87ba\u65cb\u66f4\u77ed\uff0c\u4e5f\u66f4\u7d27\u5b9e\uff0c\u4e0e\u5176\u4ed6\u5df2\u62a5\u5bfc\u7684GPCR\u90fd\u4e0d\u4e00\u6837\u3002\u8fd9\u5e26\u6765\u4e86\u4e00\u4e2a\u6781\u4e3a\u72ed\u7a84\u548c\u9ad8\u5ea6\u4eb2\u6c34\u7684\u300c\u53e3\u888b\u300d\uff0c\u4f7f\u4f20\u7edf\u7684GPCR\u914d\u4f53\u4e0d\u9002\u5408\u4e0e\u5176\u7ed3\u5408\u3002\u540e\u7eed\u7814\u7a76\u53d1\u73b0\uff0c\u8fd9\u4e2a\u300c\u53e3\u888b\u300d\u5728\u6240\u6709\u7684FZD\u86cb\u767d\u4e2d\u90fd\u4fdd\u5b88\u5b58\u5728\uff0c\u8fd9\u4ece\u4e00\u5b9a\u7a0b\u5ea6\u89e3\u91ca\u4e86\u4e3a\u4f55\u4e4b\u524d\u96be\u4ee5\u5f00\u53d1\u9488\u5bf9FZD\u7684\u914d\u4f53\u3002\u540e\u7eed\u7684\u7814\u7a76\u53c8\u5728VII\u53f7\u87ba\u65cb\u91cc\u627e\u5230\u4e86\u4e24\u4e2a\u548cFZD4\u6fc0\u6d3b\u76f8\u5173\u7684\u7f20\u7ed3\u3002\u8fd9\u4e9b\u53d1\u73b0\u5747\u8868\u660e\uff0cFZD\u86cb\u767d\u5728\u6f14\u5316\u7684\u9053\u8def\u4e0a\uff0c\u53d1\u5c55\u51fa\u4e86\u5168\u65b0\u7684\u914d\u4f53\u7ed3\u5408\u4e0e\u6fc0\u6d3b\u673a\u5236\u3002<\/p>\n

<\/p>\n

\u76f8\u5173\u8bba\u6587\uff1aS Yang et al., (2018) Crystal structure of the Frizzled 4 receptor in a ligand-free state, Nature, DOI: https:\/\/doi.org\/10.1038\/s41586-018-0447-x<\/p>\n

\u6211\u4eec\u5411\u8fd9\u4e9b\u5e26\u6765\u91cd\u78c5\u5b66\u672f\u7a81\u7834\u7684\u79d1\u5b66\u5bb6\u4eec\u518d\u6b21\u8868\u793a\u795d\u8d3a\uff01<\/p>\n

\u5386\u53f2\u4e0a\u7684\u201c\u534e\u4eba\u65e5\u201d<\/strong><\/p>\n

7.19.2018\uff1a4\u7bc7Cell
\n<\/a><\/p>\n

6.7.2018\uff1a6\u7bc7Science<\/a><\/p>\n

5.24.2018\uff1a4\u7bc7Nature<\/a><\/p>\n

4.5.2018\uff1a5\u7bc7Nature<\/a><\/p>\n

3.30.2018\uff1a4\u7bc7Cell<\/a><\/p>\n

10.12.2017\uff1a5\u7bc7Nature<\/a><\/p>\n

9.7.2017\uff1a4\u7bc7Nature<\/a><\/p>\n

7.28.2017\uff1a6\u7bc7Cell<\/a><\/p>\n

\u672c\u6587\u5b66\u8005\u7167\u7247\u9664\u7279\u522b\u6ce8\u660e\u5916\uff0c\u5747\u6765\u81ea\u76f8\u5e94\u79d1\u7814\u9662\u6240\u5b98\u7f51\uff0c\u7814\u7a76\u56fe\u7247\u5747\u6765\u81ea\u300a\u81ea\u7136\u300b\u3002<\/p>\n

\u672c\u6587\u6765\u81ea\u836f\u660e\u5eb7\u5fb7\u5fae\u4fe1\u56e2\u961f\uff0c\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u8f6c\u8f7d\u5230\u5176\u4ed6\u5e73\u53f0\u3002\u5982\u6709\u5f00\u8bbe\u767d\u540d\u5355\u9700\u6c42\uff0c\u8bf7\u5728\u6587\u7ae0\u5e95\u90e8\u7559\u8a00\u3002\u5982\u6709\u5176\u4ed6\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u8054\u7e6bwuxi_media@wuxiapptec.com\u3002<\/p>\n

\u764c\u75c7\u7a81\u7834<\/p>\n

\u6297\u764c\u75ab\u82d7 | \u764c\u75c7\u5730\u56fe | KRAS | \u9152\u7cbe | CAR-T 2.0 | \u5355\u7ec6\u80deCAR-T |<\/p>\n

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\u539f\u6587\u7f51\u5740\uff1ahttps:\/\/read01.com\/O34g26z.html<\/p>\n

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