\u7f8e\u56fd\u897f\u5cb8\u65f6\u95f410\u67081\u65e5\u665a\uff0c\u7f8e\u56fd\u79d1\u5b66\u5bb6\u8a79\u59c6\u65af\u2022\u827e\u5229\u68ee\uff08James P. Allison\uff09\u548c\u65e5\u672c\u79d1\u5b66\u5bb6\u672c\u5eb6\u4f51\uff08Tasuku Honjo\uff09\u83b7\u5f972018\u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\uff0c\u4ee5\u8868\u5f70\u4ed6\u4eec\u5728\u201c\u53d1\u73b0\u8d1f\u6027\u514d\u75ab\u8c03\u8282\u6cbb\u7597\u764c\u75c7\u7684\u7597\u6cd5\u201d\u6240\u505a\u51fa\u7684\u8d21\u732e\u3002<\/p>\n
\u4f5c\u4e3a\u5168\u7f8e\u751f\u7269\u533b\u836f\u7814\u53d1\u91cd\u5730\uff0c\u76ee\u524d\u7ea6\u6709\u5343\u4f59\u5bb6\u751f\u7269\u533b\u836f\u4f01\u4e1a\u548c\u591a\u6240\u7814\u7a76\u9662\u6821\u7684\u5723\u5730\u4e9a\u54e5\uff0c\u4eca\u5e74\u6b64\u8bfa\u8d1d\u5c14\u5956\u65b0\u95fb\u4f20\u51fa\u540e\uff0c\u5f15\u8d77\u4e86\u4eba\u4eec\u6781\u5927\u5173\u6ce8\u3002<\/p>\n
\u6839\u636e\u90ed\u660e\u535a\u58eb\u8f6c\u53d1\u7684\u6765\u81ea\u8036\u9c81\u5927\u5b66\u738b\u4fca\u535a\u58eb\u7684\u8bc4\u8bba\uff0c\u738b\u535a\u58eb\u8ba4\u4e3a\uff1a\u2026\u2026..1. \u5982\u679c\u662f\u56e0\u4e3a\u53d1\u73b0\u57fa\u56e0\u5f97\u5956\uff0c\u90a3\u53d1\u73b0 CTLA-4 \u7684\u662f Pierre Goldstein ,\u53d1\u73b0 PD1 \u7684\u662f Honjo, \u53d1\u73b0 PD-L1 \u7684\u662f\u9648\u6559\u6388\u3002\u800c PD-1 \u4e4b\u6240\u4ee5\u548c\u5176\u4ed6 immune inhibitory receptors , \u6bd4\u5982CTLA-4,LAG3\/Tim3 \u4e0d\u4e00\u6837\u7684\u5730\u65b9\uff0c\u662f\u5176\u914d\u4f53\u5728\u80bf\u7624\u5fae\u73af\u5883\u7684\u8c03\u63a7\u4f5c\u7528,\u8fd9\u70b9\u662f\u5176\u6700\u7279\u522b\u7684\u5730\u65b9\u30022. \u5982\u679c\u662f\u56e0\u4e3a\u53d1\u73b0\u65b0\u57fa\u56e0\/pathway \u5728\u80bf\u7624\u7684\u6cbb\u7597\u4f5c\u7528\u5f97\u5956\u3002\u90a3\u53d1\u73b0 CTLA-4 \u6297\u4f53\u80bf\u7624\u6cbb\u7597\u4f5c\u7528\u7684\u662f Allison, \u53d1\u73b0 PD-L1\/PD1 \u9014\u5f84\u6297\u4f53\u6cbb\u7597\u4f5c\u7528\u7684\u662f\u9648\u6559\u6388\uff0c\u8fd9\u70b9\u4ece\u6587\u7ae0\u548c\u4e13\u5229\u90fd\u6709\u5f88\u591a\u7684\u8bc1\u636e\u3002\u4e1c\u5927\u505a\u4e86\u4e00\u70b9\u70b9\u80bf\u7624\u7684\u5de5\u4f5c\uff0c\u6bd4\u9648\u6559\u6388\u90fd\u665a\uff0c\u800c\u4e14 Honjo \u53ea\u662f\u6302\u540d\uff0c\u8fd9\u4e9b\u5de5\u4f5c\u8fd8\u662f\u4e1c\u5927\u53e6\u4e00\u4e2a\u6559\u6388 Minato \u505a\u7684\u30023. \u771f\u6b63\u628a PD1\/PDL1 \u8fde\u5728\u4e00\u8d77\uff0c\u53d1\u73b0 interaction \u7684\u4e0d\u662f Freeman\uff0c\u662f Clive wood\uff0c\u540e\u8005\u56e0\u4e3a\u79cd\u79cd\u539f\u56e0\uff0c\u5176\u8d21\u732e\u4e0d\u4e3a\u4eba\u6240\u77e5\u30024. \u5f97\u5956\u7406\u7531\u662f \u201dfor the discovery of cancer therapy on negative regulation of inhibitory pathways\u201d \u542c\u8d77\u6765\u6709\u70b9\u50cf\u7b2c\u4e8c\u70b9\uff0c\u4f46\u7ed9\u7684\u5374\u662f\u4e0d\u4f26\u4e0d\u7c7b\u7684\u4eba\u7269\u7ec4\u5408\u30025. \u5982\u679c\u662f\u8003\u8651\u5230\u7ed9\u7b2c\u4e09\u4e2a\u4eba\uff0c\u53ef\u80fd\u9020\u6210\u7ed9\u4e0d\u4e86 Freeman\uff0c\u6709\u51b2\u7a81\u3002\u4f46\u56e0\u4e3a\u53d1\u73b0 interaction \u7684\u662f Wood, \u6211\u89c9\u5f97\u51b2\u7a81\u5e94\u8be5\u4e0d\u5b58\u5728\u3002\u5f53\u7136\u4e5f\u6709\u670b\u53cb\u63d0\u5230\u53ef\u80fd\u662f\u6700\u8fd1\u745e\u5178\u4e2d\u56fd\u6e38\u5ba2\u4e8b\u4ef6\u7684\u5f71\u54cd\uff0c\u8fd9\u4e2a\u6709\u70b9\u626f\uff0c\u4f46\u662f\u4e5f\u4e0d\u662f\u6ca1\u53ef\u80fd\u30026. \u606d\u559c Allison \u548c Honjo\uff0c \u4ed6\u4eec\u90fd\u662f\u514d\u75ab\u9886\u57df\u7684\u5148\u9a71\u3002Allison codiscovered TCR, Honjo \u8fd8\u662f AID \u7684\u53d1\u73b0\u8005\u3002\u800c\u9648\u6559\u6388\u662f\u80bf\u7624\u514d\u75ab\u9886\u57df\u7684\u5148\u9a71\uff0c\u7ed9\u80bf\u7624\u514d\u75ab\u514d\u75ab\u8c03\u8282\u5206\u5b50\u7684\u5956\u4e0d\u7ed9\u9648\u6559\u6388\uff0c\u662f Nobel Prize Committe \u7684\u91cd\u5927\u5931\u8bef\u3002\u5f53\u5e74 TLR \u7684\u5956\u6f0f\u6389\u4e86\u540c\u5728\u8036\u9c81\u7684 Ruslan, DNA \u7ed3\u6784\u7684\u5956\u6f0f\u6389\u4e86\u5973\u6027\u79d1\u5b66\u5bb6 Franklin , \u4ed6\u4eec\u7684\u8d21\u732e\uff0c\u503c\u5f97\u79f0\u9053\u30027. \u7531\u8877\u611f\u8c22\u9648\u6559\u6388\u5728\u80bf\u7624\u514d\u75ab\u9886\u57df\u4e09\u5341\u5e74\u7684\u8e0f\u5b9e\u8f9b\u52e4\u7684\u8015\u8018\u3002\u4ed6\u662f\u8fd9\u4e2a\u9886\u57df\u771f\u6b63\u505a\u51fa\u6700\u6709\u521b\u9020\u5de5\u4f5c\u7684\u79d1\u5b66\u5bb6\u4e4b\u4e00\u3002\u4ece1992\u5e74\u7b2c\u4e00\u6b21\u628aB7\u5206\u5b50\u5f15\u5165\u80bf\u7624\u6cbb\u7597\uff0c\u5230\u53d1\u73b0 4-BB, PD-L1\/PD1, B7-H2\/3\/4, VISTA(PD-1H), LIGHT,RELT, B7-H5\/CD28H\uff0c\u4ee5\u53ca\u540e\u7eed\u5f88\u591a\u65b0\u5206\u5b50\u65b0\u9014\u5f84\u7684\u6297\u80bf\u7624\u529f\u80fd\u3002\u6beb\u4e0d\u5938\u5f20\u7684\u8bb2\uff0c\u9648\u6559\u6388\u5960\u5b9a\u4e86\u80bf\u7624\u514d\u75ab\u514d\u75ab\u8c03\u8282\u5206\u5b50\u9886\u57df\u534a\u4e2a\u6c5f\u5c71\uff01\u8fd9\u70b9\u4e5f\u662f\u72ec\u4e00\u65e0\u4e8c\u7684\u3002\u8fd9\u4e9b\u8d21\u732e\u8fdc\u8fdc\u4e0d \u6b62PD1\/PDL1\uff0c\u62ef\u6551\u4e86\u65e0\u6570\u80bf\u7624\u60a3\u8005\uff0c\u4e5f\u8fdc\u8fdc\u5927\u4e8e\u8fd9\u4e2a\u5956\u672c\u8eab\u3002<\/p>\n
\u52a0\u5927\u5723\u5730\u4e9a\u54e5\u5206\u6821\u751f\u7269\u7cfb\u7684\u8292\u6e05\u535a\u58eb\u8868\u793a\uff1a\u6ca1\u6709PD-L1\u7684\u53d1\u73b0\u6839\u672c\u5c31\u8c08\u4e0d\u4e0a\u73b0\u5728\u8fd9\u4e48\u70ed\u7684\u80bf\u7624\u514d\u75ab\u5b66\u3002\u4ed6\u8ba4\u4e3a\u6ca1\u4eba\u8bf4PD-1\u7684\u8bba\u6587\u800c\u8d28\u7591Honjo\u3002\u6839\u636e\u8bba\u6587\u53d1\u8868\u7684\u65f6\u95f4\uff0c\u9648\u5217\u5e73\u6559\u6388\u5728\u81ea\u7136\u533b\u5b66\u520a\u7269\uff08Nature Medicine\uff09\u516c\u5f00\u7684\u6709\u5173PD-L1\u7684\u8bba\u6587\u662f\u57281999\u5e7412\u6708\uff0c\u800cHonjo\u76f8\u5173\u4e8eJ X Med\u7684\u8bba\u6587\u662f\u520a\u767b\u4e8e2000\u5e7410\u6708\u4efd\u3002<\/p>\n
\u5723\u5730\u4e9a\u54e5ProSci\u516c\u53f8CEO\u803f\u5cea\u5219\u8868\u793a\uff1aHonjo\uff0c Tasuku\u662f\u514d\u75ab\u5b66\u524d\u8f88\uff0c\u5728\u514d\u75ab\u5b66\u9886\u57df\u662f\u4eba\u4eba\u7686\u77e5\u7684\u91cd\u8981\u4eba\u7269\u3002<\/p>\n
Alan Paau\u535a\u58eb\u8ba4\u4e3a\uff1a\u3002\u3002\u3002\u3002\u3002\u3002\u9996\u5148\u53d1\u73b0\u4e86\u68c0\u67e5\u70b9. \u968f\u7740\u53d1\u73b0\u5b83\u7684\u914d\u4f53\u4e5f\u662f\u610f\u6599\u4e2d\u4e8b\u3002\u4e3a\u4ec0\u9ebd\u8c08PD-L1\u7684\u8bba\u6587 \u5462\uff1f\u800c\u4e14\u8fd9\u4e5f\u90fd\u662f1992\u591a\u5e74\u540e\u7684\u8ddf\u968f\u53d1\u73b0\u4e86 \u4e86\u3002\u8bfa\u8d1d\u5c14\u5956\u5bf9\u4e8e\u533b\u5b66\u6216\u690d\u7269\u5b66\u7684\u9009\u62e9\u6807\u51c6\uff0c\u662f\u6539\u53d8\u5f53\u65f6\u8303\u5f0f\u7684\u539f\u59cb\u53d1\u73b0\uff0c\u9020\u798f\u4eba\u7c7b\uff0c\u800c\u4e0d\u662f\u8c01\u5148\u53d1\u8868\u4e86\u4ec0\u4e48\u3002\u9648\u5217\u5e73\u6559\u6388\u7684\u8d21\u732e\u771f\u7684\u4e0d\u5c11\u3001\u4f46\u4e5f\u4e0d\u89c1\u5f97\u6bd4Allison \u6216 Honjo \u7684\u66f4\u4e3a\u91cd\u8981\u3002\u6258\u9a6c\u65af\u2022\u7231\u8fea\u751f\uff08Thomas Edison\uff09\u66fe\u7ecf\u8bf4\u8fc7\uff1a\u201c\u4e00\u4e2a\u601d\u60f3\u7684\u4ef7\u503c\u5728\u4e8e\u4f7f\u7528\u5b83\u3002\u201d \u6216\u8005\u50cf\u6211\u4eec\u8fd9\u6837\u7684\u5916\u884c\u4eba\u4e5f\u5f00\u73a9\u7b11\u8bf4\u201c\u601d\u60f3\u662f\u4e00\u6bdb\u94b1\u4e00\u6253\u3002\u201d\uff0c\u5982\u679c\u5b83\u4eec\u6ca1\u6709\u88ab\u5f88\u597d\u5730\u5229\u7528\uff0c\u90a3\u4e48\u601d\u60f3\u5c31\u6ca1\u6709\u591a\u5927\u4ef7\u503c\uff01\u540c\u6837\u7684\u53d1\u73b0\u3002\u4e00\u4e2a\u4eba\u5fc5\u987b\u88ab\u62e5\u62a4\u3001\u4fc3\u8fdb\u6216\u66f4\u597d\u5730\u88ab\u652f\u6301\u5229\u7528\u548c\u53d1\u73b0\uff0c\u6765\u8bc1\u660e\u5b83\u5728\u9020\u798f\u4eba\u7c7b\u65b9\u9762\u7684\u4ef7\u503c\u3002\u6211\u8ba4\u4e3aAllison\u548cHonju\u90fd\u505a\u4e86\u5f88\u591a\uff0c\u5e94\u8be5\u795d\u8d3a\u3002\u9648\u6559\u6388\u4e5f\u5e94\u8be5\u8fd9\u4e48\u505a\uff01<\/p>\n
\u8ba8\u8bba\u4ecd\u5728\u7ee7\u7eed\u7740\u3002\u3002\u3002\u3002\u3002\u3002<\/p>\n
\u7f16\u540e\u8bed\uff1a\u5723\u5730\u4e9a\u54e5\u4e13\u4e1a\u4eba\u624d\u6d4e\u6d4e\uff0c\u4ed6\u4eec\u6709\u601d\u60f3\uff0c\u64c5\u957f\u601d\u8003\uff0c\u7ee7\u7eed\u53d1\u73b0\u3001\u5229\u7528\u3001\u521b\u65b0\u548c\u521b\u9020\u5bf9\u4eba\u7c7b\u6709\u76ca\u7684\u65b0\u4ef7\u503c\u3002<\/p>\n
\u9644\u8bfa\u8d1d\u5c14\u5956\u5c0f\u8d34\u58eb\uff1a<\/p>\n
1\u3001\u622a\u6b62\u52302017\u5e74\u5171\u9881\u53d1\u8fc7\u51e0\u6b21\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\uff1f<\/p>\n
\u4e00\u5171\u6709108\u6b21\uff0c\u4ece1901\u5e74\u8d77\uff0c\u5171\u67099\u5e74\u6ca1\u6709\u9881\u53d1\u3002<\/p>\n
2\u3001\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u66fe\u5355\u72ec\u9881\u53d1\u7ed9\u591a\u5c11\u4e2a\u4e2a\u4eba\uff0c\u66fe\u6709\u591a\u5c11\u6b21\u4e3a\u591a\u4eba\u5206\u4eab\uff1f<\/p>\n
\u5bf9\u4e8e\u5df2\u7ecf\u9881\u53d1\u7684\u8bfa\u8d1d\u5c14\u5956\uff0c\u5176\u4e2d\u670939\u6b21\u5355\u72ec\u9881\u53d1\u7ed9\u4e00\u4e2a\u4eba\uff1b32\u6b21\u7684\u8bfa\u5956\u75312\u4eba\u5206\u4eab\uff1b\u53e6\u5916\u670937\u6b21\u9881\u53d1\u7ed93\u4e2a\u4eba\u3002<\/p>\n
3\u3001\u4e00\u5171\u6709\u591a\u5c11\u4eba\u83b7\u5f97\u4e86\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\uff1f<\/p>\n
\u4ece1901\u5e74\u81f32017\u5e74\uff0c\u5171\u6709214\u4eba\u83b7\u5f97\u4e86\u6b21\u5956\u3002<\/p>\n
4\u3001\u83b7\u5f97\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u7684\u4eba\u6709\u65e0\u51fa\uff08\u661f\uff09\u751f\uff08\u5ea7\uff09\u5171\u6027\u5462\uff1f<\/p>\n
\u636e\u7edf\u8ba1\uff0c\u8bfa\u8d1d\u5c14\u5956\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u7684\u83b7\u5f97\u8005\uff0c\u7edd\u5927\u591a\u6570\u90fd\u662f\u516d\u6708\u51fa\u751f\u3002<\/p>\n
5\u3001\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u83b7\u5f97\u8005\u7684\u5e73\u5747\u5e74\u9f84\u662f\u591a\u5c11\uff1f<\/p>\n
\u4ed6\u4eec\u7684\u5e73\u5747\u5e74\u9f84\u4e3a58\u5c81\u3002<\/p>\n
6\u3001\u5e74\u7eaa\u6700\u8f7b\u7684\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u83b7\u5f97\u8005\u662f\u8c01\uff1f<\/p>\n
1923\u5e74\uff0c\u5e74\u4ec532\u5c81\u7684Frederick G. Banting\u83b7\u5f97\u4e86\u5f53\u5e74\u7684\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u3002<\/p>\n
7\u3001\u90a3\u4e48\u6700\u957f\u5e74\u7eaa\u7684\u6b64\u9879\u8bfa\u5956\u83b7\u5f97\u8005\u662f\u8c01\uff1f<\/p>\n
1966\u5e74\uff0c87\u5c81\u9ad8\u9f84\u7684Peyton Rous\u83b7\u5f97\u4e86\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u3002<\/p>\n
8\u3001\u6709\u591a\u5c11\u5973\u6027\u83b7\u5f97\u4e86\u6b21\u5956<\/p>\n
\u5728214\u4f4d\u83b7\u5956\u8005\u4e2d\uff0c\u4ec5\u670912\u4f4d\u5973\u6027\uff0c\u5305\u542b2015\u5e74\u4e2d\u56fd\u83b7\u5956\u8005\u5c60\u5466\u5466\u3002<\/p>\n
9\u3001\u8fc4\u4eca\u4e3a\u6b62\u8fd8\u672a\u6709\u8fc7\u66fe\u4e24\u6b21\u83b7\u6b64\u6b8a\u8363\u7684\u83b7\u5956\u8005\u3002<\/p>\n
10\u3001\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u8fd8\u672a\u9881\u53d1\u7ed9\u5df2\u6545\u5b66\u8005\u3002<\/p>\n
11\u3001\u66fe\u67092\u5bf9\u592b\u59bb\u30012\u5bf9\u7236\u5b50\u30011\u5bf9\u5144\u5f1f\u5173\u7cfb\u7684\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u83b7\u5f97\u8005\u3002<\/p>\n
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14\u3001\u63d0\u540d\u6700\u591a\u6b21\u6570\u7684Sigmund Freud\uff0c\u66fe32\u6b21\u83b7\u5f97\u8bfa\u5956\u63d0\u540d\uff0c\u4f46\u4ece\u672a\u83b7\u5956\u3002<\/p>\n
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\uff08\u7f8e\u56fd\u534e\u6587\u7f51 \u5723\u5730\u4e9a\u54e5\u534e\u6587\u7f51 \u534e\u6587\u98ce\u91c7\u7f16\u53d1 \u7f51\u7edc\u622a\u56fe USChinesePress.com SanDiegoChinesePress.com\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"
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