{"id":1326808,"date":"2018-10-02T19:38:59","date_gmt":"2018-10-03T02:38:59","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=1326808"},"modified":"2018-10-02T19:38:59","modified_gmt":"2018-10-03T02:38:59","slug":"2018%e7%94%9f%e7%89%a9%e6%8a%80%e6%9c%af%e7%8c%9b%e5%85%ac%e5%8f%b8%e6%8f%ad%e6%99%93-%e5%9c%a3%e5%9c%b0%e4%ba%9a%e5%93%a5ansun%e5%88%97%e6%a6%9c%e9%a6%96%ef%bc%88%e5%9b%be%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/2018%e7%94%9f%e7%89%a9%e6%8a%80%e6%9c%af%e7%8c%9b%e5%85%ac%e5%8f%b8%e6%8f%ad%e6%99%93-%e5%9c%a3%e5%9c%b0%e4%ba%9a%e5%93%a5ansun%e5%88%97%e6%a6%9c%e9%a6%96%ef%bc%88%e5%9b%be%ef%bc%89\/.html","title":{"rendered":"2018\u201c\u751f\u7269\u6280\u672f\u731b\u516c\u53f8\u201d\u63ed\u6653 \u5723\u5730\u4e9a\u54e5AnSun\u5217\u699c\u9996\uff08\u56fe\uff09"},"content":{"rendered":"

\u533b\u836f\u89c2\u6f9c\/\u836f\u660e\u5eb7\u5fb7\u62a5\u9053<\/strong><\/span><\/p>\n

\u4eca\u65e5\uff0c\u4e1a\u754c\u77e5\u540d\u7684\u5e74\u5ea6\u201c\u751f\u7269\u6280\u672f\u731b\u516c\u53f8\u201d\uff08FierceBiotech\u2019s 2018 Fierce 15\uff09\u699c\u5355\u706b\u70ed\u51fa\u7089\uff0c15\u5bb6\u5bcc\u6709\u6f5c\u529b\u7684\u65b0\u9510\u516c\u53f8\u4e0a\u699c\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u5723\u5730\u4e9a\u54e5\u7684Ansun Biopharma \u5217\u4e8e\u699c\u9996\u3002\u5982\u516c\u5e03\u699c\u5355\u7684FierceBiotech\u6240\u8bf4\uff0c\u8fd915\u5bb6\u516c\u53f8\u8868\u73b0\u51fa\u4e86\u4ee4\u4eba\u4fe1\u670d\u7684\u51b3\u5fc3\u3001\u70ed\u5ff1\u548c\u79d1\u5b66\u57fa\u7840\uff0c\u5b83\u4eec\u503c\u5f97\u6301\u7eed\u5173\u6ce8\u3002<\/strong><\/p>\n

\u65b0\u9510\u540d\u79f0\uff1a<\/strong>Ansun Biopharma<\/p>\n

\u6210\u7acb\u5e74\u4efd\uff1a<\/strong>2002<\/p>\n

\u4e34\u5e8a\u4e13\u653b\uff1a<\/strong>\u547c\u5438\u9053\u75c5\u6bd2\u611f\u67d3<\/p>\n

Ansun Biopharma<\/a>\u516c\u53f8\u62e5\u6709\u6cbb\u7597\u75c5\u6bd2\u611f\u67d3\u7684\u4e00\u7cfb\u5217\u751f\u7269\u5236\u5242\u5728\u7814\u836f\u7269\u3002\u5176\u4e2d\uff0c\u201cfirst-in-class\u201d\u7597\u6cd5DAS181\u5df2\u7ecf\u5b8c\u62102\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u7528\u4e8e\u6cbb\u7597\u526f\u6d41\u611f\u75c5\u6bd2\u611f\u67d3\u3002DAS181\u662f\u4e00\u79cd\u5438\u5165\u5f0f\u7684\u91cd\u7ec4\u553e\u6db2\u9178\u9176\u878d\u5408\u86cb\u767d\uff0c\u5b83\u53ef\u4ee5\u5207\u65ad\u553e\u6db2\u9178\u53d7\u4f53\uff0c\u4ece\u800c\u963b\u65ad\u75c5\u6bd2\u5165\u4fb5\u547c\u5438\u9053\u5185\u58c1\u7ec6\u80de\u7684\u901a\u8def\u3002\u8fd9\u4e00\u4f5c\u7528\u673a\u5236\u4e0e\u73b0\u6709\u7684\u6297\u75c5\u6bd2\u7597\u6cd5\u4e0d\u540c\u3002FDA\u5df2\u7ecf\u6388\u4e88DAS181\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u3002<\/strong>\u9664\u4e86\u6cbb\u7597\u526f\u6d41\u611f\u75c5\u6bd2\u4ee5\u5916\uff0cDAS181\u53ef\u80fd\u5bf9\u6d41\u611f\u75c5\u6bd2\u611f\u67d3\u548c\u547c\u5438\u9053\u591a\u6838\u4f53\u75c5\u6bd2\uff0c\u4ee5\u53ca\u4eba\u7c7b\u504f\u80ba\u75c5\u6bd2\u7684\u611f\u67d3\u4e5f\u6709\u9884\u9632\u4f5c\u7528\u3002\u9664\u6b64\u4ee5\u5916\uff0cAnsun\u516c\u53f8\u8fd8\u67094\u4e2a\u5019\u9009\u836f\u7269\u5904\u4e8e\u4e34\u5e8a\u524d\u7814\u53d1\u9636\u6bb5\u3002<\/p>\n

\u65b0\u9510\u540d\u79f0\uff1a<\/strong>Arrakis Therapeutics<\/p>\n

\u6210\u7acb\u5e74\u4efd\uff1a<\/strong>2015<\/p>\n

\u4e34\u5e8a\u4e13\u653b\uff1a<\/strong>\u9776\u5411\u76ee\u524d\u96be\u4e8e\u6210\u836f\u7684RNA\u9776\u70b9\u7684\u5c0f\u5206\u5b50\u836f\u7269<\/p>\n

RNA\u662f\u4e00\u7c7b\u975e\u5e38\u96be\u4e8e\u6210\u836f\u7684\u9776\u70b9\uff0c\u56e0\u4e3a\u5b83\u4eec\u5f88\u5c0f\uff0c\u4e0d\u7a33\u5b9a\uff0c\u800c\u4e14\u7531\u540c\u6837\u7684\u6838\u82f7\u9178\u78b1\u57fa\u6784\u6210\u3002\u56e0\u6b64\u5f53Arrakis\u516c\u53f8\u5ba3\u5e03\u5b83\u7684\u76ee\u6807\u662f\u53d1\u73b0\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269\u65f6\uff0c\u5f88\u591a\u4eba\u8ba4\u4e3a\u8fd9\u662f\u4e0d\u53ef\u80fd\u5b8c\u6210\u7684\u4efb\u52a1\u3002Arrakis\u7684\u9ad8\u7ba1\u56e2\u961f\u90fd\u5728\u751f\u7269\u6280\u672f\u548c\u533b\u836f\u516c\u53f8\u4e2d\u79ef\u7d2f\u4e86\u8d85\u8fc720\u5e74\u7684\u7ecf\u9a8c\u3002\u4ed6\u4eec\u8ba4\u4e3a\u8fd9\u662f\u4e00\u4e2a\u80fd\u591f\u8fbe\u5230\u7684\u76ee\u6807\u3002\u4e3a\u6b64\uff0c\u4ed6\u4eec\u6539\u9020\u4e86\u5df2\u6709\u7684\u7528\u4e8e\u5f00\u53d1\u9776\u5411\u86cb\u767d\u8d28\u9776\u70b9\u7684\u836f\u7269\u7814\u53d1\u8fc7\u7a0b\uff0c\u8ba9\u8fd9\u4e9b\u8fc7\u7a0b\u53ef\u4ee5\u7528\u4e8e\u53d1\u73b0\u9776\u5411RNA\u7684\u9776\u70b9\u3002\u5173\u952e\u7684\u4e00\u70b9\u662fArrakis\u5229\u7528\u4e00\u7cfb\u5217\u8ba1\u7b97\u624b\u6bb5\u5efa\u7acb\u7684\u9776\u70b9\u53d1\u73b0\u5e73\u53f0\uff0c\u8ba9\u7814\u53d1\u4eba\u5458\u53ef\u4ee5\u9884\u6d4b\u54ea\u4e9bRNA\u5e8f\u5217\u548c\u7ed3\u6784\u4e0e\u7279\u5b9a\u751f\u7269\u5b66\u529f\u80fd\u76f8\u5173\uff0c\u4ece\u800c\u6307\u5bfc\u5b9e\u9a8c\u8bbe\u8ba1\u6765\u9a8c\u8bc1\u6f5c\u5728\u9776\u70b9\u3002<\/strong>\u8be5\u516c\u53f8\u57282017\u5e74\u521d\u5b8c\u6210\u6570\u989d\u4e3a3800\u4e07\u7684\u878d\u8d44\uff0c\u83b7\u5f97\u4e86\u8f89\u745e\uff08Pfizer\uff09\u548c\u65b0\u57fa\uff08Celgene\uff09\u7684\u652f\u6301\uff0c\u73b0\u5728\u8be5\u516c\u53f8\u6b63\u5728\u79ef\u6781\u53d1\u73b0\u5148\u5bfc\u5316\u5408\u7269\u3002<\/p>\n

\u76f8\u5173\u9605\u8bfb:<\/strong><\/p>\n

\u6df1\u5ea6\u957f\u6587\uff1a\u9776\u5411RNA\uff0c\u65b0\u9886\u57df\u5df2\u51c6\u5907\u8fce\u63a5\u7206\u53d1<\/a><\/p>\n

RNA\u7814\u53d1\u70ed\uff01\u8fd912\u5bb6\u516c\u53f8\u6b63\u5728\u63a8\u8fdb\u9776\u5411RNA\u7684\u5c0f\u5206\u5b50\u836f\u7269<\/a>
\n<\/strong><\/p>\n

\u65b0\u9510\u540d\u79f0\uff1a<\/strong>Beam Therapeutics<\/p>\n

\u6210\u7acb\u5e74\u4efd\uff1a<\/strong>2017<\/p>\n

\u4e34\u5e8a\u4e13\u653b\uff1a<\/strong>\u7531\u4e8e\u57fa\u56e0\u70b9\u7a81\u53d8\u5bfc\u81f4\u7684\u9057\u4f20\u75be\u75c5<\/p>\n

Beam Therapeutics<\/a>\u662f\u7531\u4e16\u754c\u9876\u5c16\u7684\u4e09\u540dCRISPR\u4e13\u5bb6\u521b\u5efa\u7684\uff0c\u4ed6\u4eec\u662f\u54c8\u4f5b\u5927\u5b66\u7684David Liu<\/strong>\u535a\u58eb\uff0c\u9ebb\u7701\u603b\u533b\u9662\u7684Keith Joung<\/strong>\u535a\u58eb\uff0c\u548cBroad\u7814\u7a76\u6240\u7684\u5f20\u950b<\/strong>\u535a\u58eb\u3002\u8be5\u516c\u53f8\u65e8\u5728\u5229\u7528\u57fa\u4e8eCRISPR\u7684\u78b1\u57fa\u7f16\u8f91\u6280\u672f\uff0c\u7cbe\u786e\u5730\u4fee\u6539\u57fa\u56e0\u7ec4\u4e2d\u5355\u4e2a\u78b1\u57fa\uff0c\u4ece\u800c\u6cbb\u7597\u7531\u4e8e\u5355\u4e2a\u57fa\u56e0\u70b9\u7a81\u53d8\u5bfc\u81f4\u7684\u9057\u4f20\u75be\u75c5\u3002\u8fd9\u7c7b\u9057\u4f20\u75be\u75c5\u5360\u4eba\u7c7b\u9057\u4f20\u75c5\u4e2d\u7684\u534a\u6570\u4ee5\u4e0a<\/strong>\u3002\u76ee\u524d\uff0c\u8be5\u516c\u53f8\u67098-10\u4e2a\u7814\u53d1\u9879\u76ee\uff0c\u9776\u5411\u591a\u4e2a\u4e0d\u540c\u7684\u57fa\u56e0\u9776\u70b9\u3002\u7814\u53d1\u4eba\u5458\u4e0d\u4f46\u5c1d\u8bd5\u5728\u4f53\u5916\u5bf9\u7ec6\u80de\u8fdb\u884c\u78b1\u57fa\u7f16\u8f91\uff0c\u4f7f\u5176\u6210\u4e3a\u6f5c\u5728\u7684\u7ec6\u80de\u7597\u6cd5\uff0c\u800c\u4e14\u5728\u4f7f\u7528\u7eb3\u7c73\u9897\u7c92\u6216AAV\u8f7d\u4f53\u5728\u773c\u775b\u3001\u808c\u8089\u3001\u76ae\u80a4\u3001\u548c\u809d\u810f\u7b49\u4e0d\u540c\u4f53\u5185\u7ec4\u7ec7\u4e2d\u8fdb\u884c\u78b1\u57fa\u7f16\u8f91\uff0c\u7ea0\u6b63\u57fa\u56e0\u7a81\u53d8\u3002<\/p>\n

\u65b0\u9510\u540d\u79f0\uff1a<\/strong>\u817e\u76db\u535a\u836f\uff08Brii Biosciences\uff09<\/p>\n

\u6210\u7acb\u5e74\u4efd\uff1a<\/strong>2018<\/p>\n

\u4e34\u5e8a\u4e13\u653b\uff1a<\/strong>\u5c06\u5177\u5907\u7a81\u51fa\u4e34\u5e8a\u610f\u4e49\u7684\u521b\u65b0\u836f\u7269\u5e26\u7ed9\u4e2d\u56fd\u60a3\u8005<\/p>\n

\u817e\u76db\u535a\u836f\u7684\u521b\u59cb\u4eba\u517c\u9996\u5e2d\u6267\u884c\u5b98\u6d2a\u5fd7\u535a\u58eb\u66fe\u7ecf\u662f\u845b\u5170\u7d20\u53f2\u514b\u516c\u53f8\uff08GSK\uff09\u7684\u9ad8\u7ea7\u526f\u603b\u88c1\u517c\u4f20\u67d3\u75c5\u90e8\u95e8\u7684\u8d1f\u8d23\u4eba\uff0c\u4ed6\u521b\u5efa\u817e\u76db\u535a\u836f\u7684\u76ee\u7684\u662f\u4e3a\u4e86\u5c06\u6700\u524d\u6cbf\u7684\u521b\u65b0\u836f\u5e26\u7ed9\u4e2d\u56fd\u60a3\u8005\u3002\u4eca\u5e74\u4e94\u6708\uff0c\u817e\u76db\u535a\u836f\u83b7\u5f97\u4e86\u5305\u62ecARCH Venture Partners\uff0c\u901a\u548c\u6bd3\u627f\uff0c\u7ea2\u6749\u8d44\u672c\u4e2d\u56fd\u57fa\u91d1\u7b49\u6295\u8d44\u65b92.6\u4ebf\u7f8e\u5143<\/a>\u7684\u652f\u6301\uff0c\u6b63\u5f0f\u6210\u7acb\u3002\u8be5\u516c\u53f8\u7684\u76ee\u6807\uff0c\u7528\u6d2a\u535a\u58eb\u7684\u8bdd\u6765\u8bf4\uff0c\u662f\u5f00\u53d1\u201c\u5177\u5907\u53d8\u9769\u6f5c\u529b\u7684\u836f\u7269\uff0c\u80fd\u591f\u89e3\u51b3\u4e2d\u56fd\u771f\u6b63\u7684\u672a\u6ee1\u8db3\u533b\u7597\u9700\u6c42<\/strong>\u201d\u3002\u76ee\u524d\uff0c\u8be5\u516c\u53f8\u7684\u76ee\u6807\u662f\u4f20\u67d3\u75c5\u9886\u57df\u3002\u817e\u76db\u535a\u836f\u4e0e\u7f8e\u56fd\u9886\u5148\u7684\u4f20\u67d3\u75c5\u521b\u65b0\u836f\u7814\u53d1\u516c\u53f8Vir Biotechnology\u5408\u4f5c\uff0c\u83b7\u5f97\u4e86\u591a\u8fbe4\u79cd\u9488\u5bf9\u4f20\u67d3\u75c5\u7684\u521b\u65b0\u836f\u5728\u5927\u4e2d\u534e\u533a\u7684\u72ec\u5bb6\u6743\u76ca\u3002\u540c\u65f6\u5b83\u4e0e\u963f\u91cc\u5df4\u5df4\u96c6\u56e2\u65d7\u4e0b\u963f\u91cc\u5065\u5eb7\uff08AliHealth\uff09\u5408\u4f5c\uff0c\u4f18\u5316\u4e34\u5e8a\u7814\u7a76\u548c\u5546\u4e1a\u63a8\u5e7f\u6d41\u7a0b\uff0c\u5e2e\u52a9\u60a3\u8005\u66f4\u5bb9\u6613\u83b7\u5f97\u6240\u9700\u7597\u6cd5\u3002\u5bf9\u4e8e\u6d2a\u535a\u58eb\u6765\u8bf4\uff0c\u5229\u7528\u4e2d\u56fd\u60a3\u8005\u7fa4\u7684\u5e9e\u5927\u57fa\u6570\uff0c\u8ba9\u60a3\u8005\u80fd\u591f\u4e70\u5f97\u8d77\u521b\u65b0\u836f\u4e5f\u662f\u8be5\u516c\u53f8\u7684\u91cd\u8981\u76ee\u6807<\/strong>\u3002<\/p>\n

\u76f8\u5173\u9605\u8bfb\uff1a\u65e9\u671f\u878d\u8d442.6\u4ebf\u7f8e\u5143\u60e0\u53ca\u4e2d\u56fd\u60a3\u8005\uff01\u4e13\u8bbf\u817e\u76db\u535a\u836fCEO\u6d2a\u5fd7\u535a\u58eb<\/strong><\/a><\/p>\n

\u65b0\u9510\u540d\u79f0\uff1a<\/strong>Compass Therapeutics<\/p>\n

\u6210\u7acb\u5e74\u4efd\uff1a<\/strong>2015<\/p>\n

\u4e34\u5e8a\u4e13\u653b\uff1a<\/strong>\u764c\u75c7\u548c\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u6297\u4f53\u7597\u6cd5<\/p>\n

Compass Therapeutics<\/a>\u516c\u53f8\u7814\u53d1\u7684\u6cbb\u7597\u6a21\u5f0f\u2014\u2014\u5355\u514b\u9686\u6297\u4f53\uff0c\u5df2\u7ecf\u662f\u533b\u7597\u9886\u57df\u4e45\u7ecf\u8003\u9a8c\u7684\u6cbb\u7597\u6a21\u5f0f\u3002\u800c\u8be5\u516c\u53f8\u7684\u72ec\u7279\u4e4b\u5904\u662f\u7814\u53d1\u6297\u4f53\u7597\u6cd5\u7684\u901f\u5ea6\u3002\u201c\u6211\u4eec\u7684\u6280\u672f\u5e73\u53f0\u80fd\u591f\u8ba9\u6211\u4eec\u6bcf\u4e2a\u6708\u5bf9\u4e24\u4e2a\u65b0\u9776\u70b9\u6210\u836f\uff0c\u4ece\u62ff\u5230\u6297\u539f\u5230\u4ea7\u751f\u5b8c\u5168\u4eba\u6e90\u5316\u7684\u5019\u9009\u7597\u6cd5\u53ea\u9700\u8981\u4e24\u4e2a\u6708\u3002<\/strong>\u201d\u8be5\u516c\u53f8\u7684\u9996\u5e2d\u6267\u884c\u5b98Tom Schuetz\u5148\u751f\u8bf4\u3002\u8fd9\u4e00\u6280\u672f\u8ba9Compass\u516c\u53f8\u80fd\u591f\u5feb\u901f\u53d1\u73b0\u5927\u91cf\u6297\u4f53\uff0c\u81ea\u4ece2015\u521b\u5efa\u4ee5\u6765\uff0c\u8be5\u516c\u53f8\u5df2\u7ecf\u5bf9\u514d\u75ab\u7a81\u89e6\uff08immunological synapse\uff09\u4e2d\u768430\u4e2a\u9776\u70b9\u6210\u836f\u3002\u8be5\u516c\u53f8\u7684\u6280\u672f\u5e73\u53f0\u80fd\u591f\u5c06\u4e24\u4e2a\u6216\u591a\u4e2a\u5355\u514b\u9686\u6297\u4f53\u3001\u6297\u4f53\u7247\u6bb5\u3001\u6216\u5176\u5b83\u751f\u7269\u5236\u5242\u8fde\u63a5\u5728\u4e00\u8d77\uff0c\u5f62\u6210\u5b9a\u5236\u7684\u53cc\u7279\u5f02\u6027\u6216\u591a\u7279\u5f02\u6027\u6297\u4f53\uff0c\u8fd9\u53ea\u9700\u8981\u51e0\u5206\u949f\u7684\u65f6\u95f4\u3002\u62e5\u670930\u591a\u4e2a\u65e9\u671f\u5019\u9009\u836f\u7269\uff0cCompass\u516c\u53f8\u8ba1\u5212\u4ece\u660e\u5e74\u5f00\u59cb\u5c06\u591a\u4e2a\u5019\u9009\u836f\u7269\u63a8\u5165\u4e34\u5e8a\u671f\u3002\u4ece2020\u5e74\u5f00\u59cb\uff0c\u6bcf\u5e74\u90fd\u5c06\u6709\u591a\u4e2a\u5019\u9009\u836f\u7269\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\u3002<\/p>\n

\u65b0\u9510\u540d\u79f0\uff1a<\/strong>FLX Bio<\/p>\n

\u6210\u7acb\u5e74\u4efd\uff1a<\/strong>2015<\/p>\n

\u4e34\u5e8a\u4e13\u653b\uff1a<\/strong>\u80bf\u7624\u514d\u75ab\u7597\u6cd5<\/p>\n

\u80bf\u7624\u5fae\u73af\u5883\u901a\u5e38\u8d77\u5230\u6291\u5236\u514d\u75ab\u53cd\u5e94\u7684\u529f\u80fd\u3002FLX Bio<\/strong><\/a>\u7684\u5b97\u65e8\u662f\u81f4\u529b\u4e8e\u53d1\u73b0\u6539\u53d8\u80bf\u7624\u5fae\u73af\u5883\u7684\u66f4\u597d\u65b9\u6cd5\uff0c\u4ece\u800c\u8ba9\u514d\u75ab\u7cfb\u7edf\u80fd\u591f\u5168\u529b\u653b\u51fb\u80bf\u7624\u3002<\/strong>\u8be5\u516c\u53f8\u529b\u56fe\u83b7\u5f97\u8c03\u8282\u6027T\u7ec6\u80de\uff08Tregs\uff09\u548c\u9aa8\u9ad3\u7ec6\u80de\u7684\u8be6\u5c3d\u57fa\u56e0\u8868\u8fbe\u56fe\u8c31\uff0c\u5e76\u4e14\u4ece\u4e2d\u201c\u53d1\u73b0\u8ba9\u8fd9\u4e9b\u7ec6\u80de\u6539\u53d8\u80bf\u7624\u5fae\u73af\u5883\u7684\u5173\u952e\u8282\u70b9\u201d\uff0c\u8be5\u516c\u53f8\u7684\u9996\u5e2d\u6267\u884c\u5b98Brian Wong\u535a\u58eb\u8bf4\u3002FLX\u80fd\u591f\u901a\u8fc7\u9776\u5411\u8fd9\u4e9b\u8282\u70b9\u6765\u6539\u53d8Tregs\u548c\u5176\u5b83\u6291\u5236\u514d\u75ab\u53cd\u5e94\u7684\u7ec6\u80de\u7684\u529f\u80fd\u3002\u8be5\u516c\u53f8\u7684\u4e3b\u6253\u5019\u9009\u836f\u7269\u662f\u4e00\u79cd\u53e3\u670dCCR4\u6291\u5236\u5242\uff0c\u5b83\u88ab\u8bbe\u8ba1\u6210\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u80fd\u591f\u6291\u5236Tregs\u4f46\u662f\u4e0d\u4f1a\u5f71\u54cd\u5b83\u4eec\u5728\u5065\u5eb7\u7ec4\u7ec7\u4e2d\u7684\u529f\u80fd\u3002<\/p>\n

\u65b0\u9510\u540d\u79f0\uff1a<\/strong>Gossamer Bio<\/p>\n

\u6210\u7acb\u5e74\u4efd\uff1a<\/strong>2017<\/p>\n

\u4e34\u5e8a\u4e13\u653b\uff1a<\/strong>\u5173\u6ce8\u514d\u75ab\u5b66\u9886\u57df\uff0c\u5305\u62ec\u5728\u764c\u75c7\u3001\u8fc7\u654f\u548c\u708e\u75c7\u9886\u57df\u7684\u9002\u5e94\u75c7<\/p>\n

Gossamer Bio<\/a>\u516c\u53f8\u867d\u7136\u6210\u7acb\u4e0d\u4e45\uff0c\u4f46\u662f\u5df2\u7ecf\u5b8c\u6210\u603b\u8ba13.3\u4ebf\u7f8e\u5143\u7684A\u8f6e\u548cB\u8f6e\u878d\u8d44\u3002\u8be5\u516c\u53f8\u7684\u4e3b\u8981\u7814\u7a76\u65b9\u5411\u4e3a\u514d\u75ab\u5b66\u9886\u57df\uff0c\u76ee\u524d\u5728\u836f\u7269\u7814\u53d1\u7ba1\u7ebf\u4e2d\u5df2\u7ecf\u67095\u4e2a\u7814\u53d1\u9879\u76ee\uff0c\u5176\u4e2d3\u4e2a\u7814\u53d1\u9879\u76ee\u5df2\u7ecf\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\u3002\u4f8b\u5982\uff0c\u8be5\u516c\u53f8\u7684HIF-1\u03b1\u7a33\u5b9a\u5242\u76ee\u524d\u5728\u4e34\u5e8a1\u671f\u8bd5\u9a8c\u4e2d\u7528\u4e8e\u6cbb\u7597\u708e\u75c7\u6027\u80a0\u75c5\u3002Gossamer Bio\u516c\u53f8\u7684\u5176\u5b83\u7814\u7a76\u65b9\u5411\u5305\u62ec\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\uff0c\u80c3\u80a0\u9053\u75be\u75c5\u7b49\u7b49\u3002\u8be5\u516c\u53f8\u5c06\u4f7f\u7528\u83b7\u5f97\u7814\u53d1\u8bb8\u53ef\u7684\u65b9\u6cd5\u8fdb\u4e00\u6b65\u4e30\u5bcc\u7814\u53d1\u7ba1\u7ebf\u3002\u201c\u6211\u4eec\u4e0d\u662f\u5178\u578b\u7684\u53ea\u6709\u4e00\u4e24\u4e2a\u7814\u53d1\u9879\u76ee\u7684\u521d\u521b\u516c\u53f8\uff0c\u6211\u4eec\u6709\u5b8f\u5927\u7684\u613f\u666f\uff0c\u4e5f\u5f88\u9ad8\u5174\u6709\u548c\u6211\u4eec\u540c\u6837\u613f\u666f\u7684\u6295\u8d44\u4eba\u52a0\u5165\u3002\u201d\u8be5\u516c\u53f8\u7684\u9996\u5e2d\u6267\u884c\u5b98Sheila Gujrathi\u535a\u58eb\u8bf4\u3002<\/p>\n

\u65b0\u9510\u540d\u79f0\uff1a<\/strong>Jnana Therapeutics<\/p>\n

\u6210\u7acb\u5e74\u4efd\uff1a<\/strong>2017<\/p>\n

\u4e34\u5e8a\u4e13\u653b\uff1a<\/strong>\u53d1\u6398\u4ee3\u8c22\u7269\u8fd0\u8f93\u86cb\u767d\u7684\u6f5c\u529b\uff0c\u8fd9\u662f\u4e00\u7c7b\u5c1a\u672a\u88ab\u5145\u5206\u7814\u7a76\u7684\u819c\u86cb\u767d\u3002<\/p>\n

Jnana Therapeutics<\/a>\u516c\u53f8\u7684\u76ee\u6807\u662f\u5f00\u53d1\u80fd\u591f\u9776\u5411\u6eb6\u8d28\u8f7d\u4f53\uff08SLCs\uff09\u86cb\u767d\u5bb6\u65cf\u6210\u5458\u7684\u836f\u7269\u53d1\u73b0\u5e73\u53f0\u3002<\/strong>SLC\u86cb\u767d\u5bb6\u65cf\u4e2d\u6709400\u591a\u4e2a\u6210\u5458\uff0c\u4f46\u662f\u5176\u4e2d\u53ea\u6709\u5c11\u4e8e20\u4e2a\u6210\u5458\u662f\u5df2\u7ecf\u83b7\u5f97\u6279\u51c6\u7684\u836f\u7269\u7684\u9776\u70b9\u3002\u8fd9\u610f\u5473\u7740\u8fd9\u4e00\u86cb\u767d\u5bb6\u65cf\u8fd8\u6709\u5f88\u591a\u6f5c\u529b\u53ef\u4ee5\u53d1\u6398\u3002SLC\u86cb\u767d\u5bb6\u65cf\u662f\u4e00\u7c7b\u819c\u86cb\u767d\uff0c\u5b83\u4eec\u53ef\u4ee5\u8fd0\u9001\u6c28\u57fa\u9178\u3001\u6838\u82f7\u9178\u3001\u7cd6\u3001\u65e0\u673a\u79bb\u5b50\u548c\u5176\u5b83\u5c0f\u5206\u5b50\u4ee3\u8c22\u7269\u3002Jnana\u516c\u53f8\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u9879\u76ee\u5305\u62ec\u5355\u57fa\u56e0\u75be\u75c5\u548c\u708e\u75c7\u6027\u80a0\u75c5\u3002<\/p>\n

\u65b0\u9510\u540d\u79f0\uff1a<\/strong>Kallyope<\/p>\n

\u6210\u7acb\u5e74\u4efd\uff1a<\/strong>2015<\/p>\n

\u4e34\u5e8a\u4e13\u653b\uff1a<\/strong>\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\uff08CNS\uff09\u548c\u65b0\u9648\u4ee3\u8c22<\/p>\n

\u80a0\u8111\u8f74\u662f\u8fd1\u5e74\u6765\u975e\u5e38\u706b\u70ed\u7684\u7814\u7a76\u9886\u57df\u3002\u6700\u65b0\u7814\u7a76\u8868\u660e\u80a0\u9053\u548c\u8bf8\u5982\u5e15\u91d1\u68ee\u75c5\u548c\u766b\u75eb\u7b49\u795e\u7ecf\u75be\u75c5\u4e4b\u95f4\u6709\u7740\u5bc6\u5207\u7684\u8054\u7cfb\u3002Kallyope<\/a>\u516c\u53f8\u4f7f\u7528\u5305\u62ec\u5355\u7ec6\u80de\u6d4b\u5e8f\u3001\u5149\u9057\u4f20\u5b66\u3001\u5316\u5b66\u9057\u4f20\u5b66\u548c\u795e\u7ecf\u8ffd\u8e2a\uff08neural tracing\uff09\u7684\u9ad8\u79d1\u6280\u624b\u6bb5\uff0c\u5efa\u7acb\u8d77\u4e00\u4e2a\u80fd\u591f\u53d1\u73b0\u548c\u9a8c\u8bc1\u80a0\u8111\u56de\u8def\u7684\u7814\u53d1\u5e73\u53f0\u3002\u57fa\u4e8e\u8fd9\u4e9b\u80a0\u8111\u56de\u8def\u7684\u56fe\u8c31\uff0c\u8be5\u516c\u53f8\u529b\u56fe\u53d1\u73b0\u5728\u80a0\u9053\u8d77\u4f5c\u7528\uff0c\u5374\u80fd\u591f\u5f71\u54cd\u5927\u8111\u529f\u80fd\u7684\u836f\u7269\u3002<\/strong>\u201c\u6211\u4eec\u7684\u7b56\u7565\u662f\u4f7f\u7528\u53ea\u5728\u80a0\u9053\u8d77\u4f5c\u7528\u7684\u5206\u5b50\u6765\u9776\u5411\u80a0\u8111\u56de\u8def\u7684\u8d77\u70b9\uff0c\u201d\u8be5\u516c\u53f8\u7684\u9996\u5e2d\u6267\u884c\u5b98Nancy Thornberry\u5973\u58eb\u8bf4\uff1a\u201c\u8fd9\u662f\u4e00\u4e2a\u7597\u6cd5\u7684\u5d2d\u65b0\u601d\u8003\u65b9\u5f0f\u3002\u4f60\u53ef\u4ee5\u8bf4\u5b83\u662f\u4e00\u79cd\u66f4\u5b89\u5168\u7684\u5f71\u54cd\u5927\u8111\u7684\u9014\u5f84\u3002\u201d\u8be5\u516c\u53f8\u4eca\u5e74\u521a\u5b8c\u6210\u6570\u989d\u4e3a6600\u4e07\u7f8e\u5143\u7684B\u8f6e\u878d\u8d44\uff0c\u5c06\u63a8\u52a8\u4e3b\u6253\u7814\u53d1\u9879\u76ee\u8fdb\u5165\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n

\u65b0\u9510\u540d\u79f0\uff1a<\/strong>Kronos Bio<\/p>\n

\u6210\u7acb\u5e74\u4efd\uff1a<\/strong>2017<\/p>\n

\u4e34\u5e8a\u4e13\u653b\uff1a<\/strong>\u764c\u75c7<\/p>\n

\u9ad8\u901a\u91cf\u7b5b\u9009\uff08HTS\uff09\u662f\u836f\u7269\u7814\u53d1\u9886\u57df\u7684\u5e38\u7528\u65b9\u6cd5\u3002\u901a\u5e38HTS\u4f7f\u7528\u5206\u79bb\u7684\u86cb\u767d\u4f5c\u4e3a\u836f\u7269\u9776\u70b9\uff0c\u7136\u540e\u4ece\u5316\u5408\u7269\u5e93\u4e2d\u7b5b\u9009\u80fd\u591f\u4e0e\u9776\u70b9\u7ed3\u5408\u7684\u836f\u7269\u3002\u800cKronos\u516c\u53f8<\/a>\u8bbe\u8ba1\u7684HTS\u548c\u4f20\u7edf\u65b9\u5f0f\u6070\u6070\u76f8\u53cd\uff0c\u5b83\u4f7f\u7528\u79f0\u4e3a\u5c0f\u5206\u5b50\u5fae\u9635\u5217\uff08small molecule microarray, SMM\uff09\u7684\u65b9\u6cd5\u5c06\u4e0a\u5343\u4e2a\u5c0f\u5206\u5b50\u5019\u9009\u5316\u5408\u7269\u6253\u5370\u5728\u7279\u5b9a\u8868\u9762\u4e0a\uff0c\u7136\u540e\u7528\u5b83\u6765\u7b5b\u9009\u53ef\u4ee5\u4e0e\u5c0f\u5206\u5b50\u7ed3\u5408\u7684\u86cb\u767d\u3002\u5173\u952e\u7684\u4e00\u70b9\u662f\u7b5b\u9009\u7684\u86cb\u767d\u4e0d\u9700\u8981\u5206\u79bb\u7eaf\u5316<\/strong>\uff0c\u4f60\u53ef\u4ee5\u7528SMM\u6765\u7b5b\u9009\u7ec6\u80de\u63d0\u53d6\u7269\u3002\u201c\u8fd9\u4e00\u6280\u672f\u7684\u4f18\u52bf\u5728\u4e8e\uff0c\u901a\u5e38\uff0c\u86cb\u767d\u4e0d\u662f\u5355\u72ec\u5b58\u5728\u7684\uff0c\u201d\u8be5\u516c\u53f8\u7684\u9996\u5e2d\u6267\u884c\u5b98Norbert Bischofberger\u5148\u751f\u8bf4\uff1a\u201c\u5b83\u4eec\u4e0e\u5176\u5b83\u86cb\u767d\u76f8\u7ed3\u5408\uff0c\u4e00\u65e6\u4f60\u628a\u5b83\u4eec\u4ece\u7ec6\u80de\u73af\u5883\u4e2d\u5206\u79bb\u51fa\u6765\uff0c\u86cb\u767d\u7684\u4e09\u7ea7\u7ed3\u6784\u4f1a\u6539\u53d8\u3002\u201dSMM\u80fd\u591f\u907f\u514d\u8fd9\u4e9b\u95ee\u9898\uff0c\u4ece\u800c\u53ef\u80fd\u53d1\u73b0\u901a\u5e38\u624b\u6bb5\u53d1\u73b0\u4e0d\u4e86\u7684\u7ed3\u5408\u5316\u5408\u7269\u3002<\/p>\n

\u65b0\u9510\u540d\u79f0\uff1a<\/strong>Pandion Therapeutics<\/p>\n

\u6210\u7acb\u5e74\u4efd\uff1a<\/strong>2017<\/p>\n

\u4e34\u5e8a\u4e13\u653b\uff1a<\/strong>\u514d\u75ab\u76f8\u5173\u75be\u75c5\uff0c\u4f8b\u5982\u708e\u75c7\u6027\u80a0\u75c5\uff0c1\u578b\u7cd6\u5c3f\u75c5\uff0c\u548c\u81ea\u8eab\u514d\u75ab\u6027\u809d\u3001\u80be\u548c\u76ae\u80a4\u75c5\u3002<\/p>\n

\u80bf\u7624\u7684\u4e00\u9879\u91cd\u8981\u80fd\u529b\u662f\u9003\u907f\u4eba\u4f53\u514d\u75ab\u7cfb\u7edf\u7684\u76d1\u6d4b\u548c\u653b\u51fb\u3002Pandion\u516c\u53f8<\/a>\u7684\u7814\u53d1\u7b56\u7565\u662f\u7814\u53d1\u7279\u522b\u7684\u7ec4\u7ec7\u7279\u5f02\u6027\u6297\u4f53\uff0c\u8fd9\u4e9b\u6297\u4f53\u80fd\u591f\u6a21\u62df\u80bf\u7624\u4e2d\u6291\u5236\u514d\u75ab\u7cfb\u7edf\u7684\u5206\u5b50\u7684\u80fd\u529b\uff0c\u4ece\u800c\u5728\u5c40\u90e8\u4fdd\u62a4\u7ec4\u7ec7\u6216\u5668\u5b98\u4e0d\u53d7\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u7684\u5f71\u54cd<\/strong>\u3002\u8be5\u516c\u53f8\u7684\u53cc\u7279\u5f02\u6027\uff08bi-specific\uff09\u6297\u4f53\u8ddf\u4f20\u7edf\u7684\u53cc\u7279\u5f02\u6027\u6297\u4f53\u4e0d\u540c\uff0c\u5b83\u7684\u5c3e\u90e8\uff08Y\u4e2d\u7684\u4e00\u7ad6\uff09\u80fd\u591f\u4e0e\u7279\u5b9a\u7ec4\u7ec7\u6216\u5668\u5b98\u7ed3\u5408\uff0c\u4f8b\u5982\u53d7\u5230\u708e\u75c7\u75be\u75c5\u5f71\u54cd\u7684\u809d\u810f\u3001\u80be\u810f\u6216\u76ae\u80a4\u3002\u800c\u6297\u4f53\u7684\u5934\u90e8\uff08Y\u4e2d\u7684V\uff09\u6784\u6210\u4e00\u4e2a\u4fdd\u62a4\u5c42\uff0c\u6291\u5236\u6fc0\u6d3b\u7684T\u7ec6\u80de\u5e76\u4e14\u6fc0\u6d3b\u8c03\u8282\u6027T\u7ec6\u80de\u3002\u8fd9\u79cd\u65b9\u6cd5\u80fd\u591f\u5c06\u514d\u75ab\u6291\u5236\u529f\u80fd\u63a7\u5236\u5728\u5c40\u90e8\u7ec4\u7ec7\uff0c\u4ece\u800c\u907f\u514d\u4e86\u5168\u8eab\u6027\u514d\u75ab\u6291\u5236\u836f\u7269\u7684\u526f\u4f5c\u7528\u3002<\/p>\n

\u65b0\u9510\u540d\u79f0\uff1a<\/strong>Quentis Therapeutics<\/p>\n

\u6210\u7acb\u5e74\u4efd\uff1a<\/strong>2015<\/p>\n

\u4e34\u5e8a\u4e13\u653b\uff1a<\/strong>\u6539\u53d8\u80bf\u7624\u5fae\u73af\u5883\uff0c\u5e2e\u52a9\u53d1\u73b0\u548c\u6cbb\u7597\u764c\u75c7\u3002<\/p>\n

\u963b\u788d\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u5b8c\u5168\u53d1\u6325\u529f\u6548\u7684\u4e00\u4e2a\u91cd\u8981\u539f\u56e0\u662f\u80bf\u7624\u7684\u5fae\u73af\u5883\uff0c\u5b83\u80fd\u591f\u6291\u5236\u514d\u75ab\u53cd\u5e94\uff0c\u50cf\u201c\u62a4\u57ce\u6cb3\u201d\u4e00\u6837\u4fdd\u62a4\u80bf\u7624\u8fd9\u5ea7\u201c\u57ce\u5821\u201d\u4e0d\u53d7\u4fb5\u72af\u3002\u800cQuentis\u516c\u53f8<\/a>\u627e\u5230\u4e86\u4e00\u6761\u6539\u53d8\u80bf\u7624\u5fae\u73af\u5883\u7684\u72ec\u7279\u65b9\u6cd5\u3002\u8be5\u516c\u53f8\u7684\u9776\u70b9\u662f\u5185\u8d28\u7f51\uff08ER\uff09\u5e94\u6fc0\u4fe1\u53f7\u901a\u8def\u4e2d\u540d\u4e3aIRE1\u03b1\u7684\u86cb\u767d\u3002\u8be5\u516c\u53f8\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u6572\u9664IRE1<\/em>\u57fa\u56e0\u80fd\u591f\u589e\u5f3aT\u7ec6\u80de\u529f\u80fd\uff0c\u548c\u63d0\u9ad8\u89e6\u53d1\u514d\u75ab\u53cd\u5e94\u7684\u6811\u7a81\u72b6\u7ec6\u80de\u7684\u529f\u80fd\uff0c\u4ece\u800c\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\u7f29\u5c0f\u80bf\u7624\u4f53\u79ef\u3002\u8be5\u516c\u53f8\u7684\u4e3b\u6253\u4ea7\u54c1\u662f\u4e00\u6b3eIRE1\u03b1\u6291\u5236\u5242\uff0c\u5e0c\u671b\u5b83\u80fd\u591f\u91cd\u65b0\u7f16\u7a0b\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u51e0\u79cd\u4e0d\u540c\u7ec6\u80de\u7c7b\u578b\uff0c\u589e\u5f3a\u514d\u75ab\u7cfb\u7edf\u6740\u4f24\u80bf\u7624\u7684\u80fd\u529b\u3002<\/strong><\/p>\n

\u65b0\u9510\u540d\u79f0\uff1a<\/strong>Rallybio<\/p>\n

\u6210\u7acb\u5e74\u4efd\uff1a<\/strong>2018<\/p>\n

\u4e34\u5e8a\u4e13\u653b\uff1a<\/strong>\u7f55\u89c1\u75c5<\/p>\n

\u7531\u524d\u5927\u578b\u533b\u836f\u516c\u53f8\u7814\u53d1\u9ad8\u7ba1\u638c\u8235\u7684Rallybio<\/a>\u7684\u7814\u53d1\u91cd\u70b9\u662f\u7f55\u89c1\u75c5\uff0c\u4f46\u662f\u5b83\u6ca1\u6709\u66f4\u8be6\u7ec6\u7684\u7279\u5b9a\u7814\u53d1\u65b9\u5411\u3002\u8be5\u516c\u53f8\u7684\u7406\u5ff5\u662f\u8ba9\u79d1\u5b66\u53d1\u73b0\u5f15\u5bfc\u836f\u7269\u7814\u53d1\uff0c\u4e0d\u4e3a\u81ea\u5df1\u8bbe\u7f6e\u4eba\u4e3a\u7684\u9650\u5236\u3002<\/strong>\u81ea\u4ece\u5728\u4eca\u5e744\u6708\u5b8c\u6210A\u8f6e\u878d\u8d44\u4e4b\u540e\uff0c\u8be5\u516c\u53f8\u7684\u7814\u53d1\u548c\u7ba1\u7406\u56e2\u961f\u5728\u5bf9\u4e0d\u540c\u516c\u53f8\u7684\u8d85\u8fc7100\u4e2a\u5019\u9009\u836f\u7269\u8fdb\u884c\u5c3d\u804c\u8c03\u67e5\uff0c\u529b\u56fe\u4ece\u4e2d\u53d1\u73b0\u6f5c\u5728\u7684\u7814\u53d1\u673a\u4f1a\u3002\u8be5\u516c\u53f8\u5c06\u91c7\u7528\u8d2d\u4e70\u7814\u53d1\u8bb8\u53ef\u7684\u65b9\u6cd5\u83b7\u5f97\u7814\u53d1\u9879\u76ee\uff0c\u5e76\u4e14\u5229\u7528\u9ad8\u7ba1\u5728\u4e1a\u754c\u7684\u7ecf\u9a8c\u548c\u4eba\u8109\u627e\u5bfb\u5408\u4f5c\u4f19\u4f34\u8fdb\u884c\u8fdb\u4e00\u6b65\u7814\u53d1\u548c\u751f\u4ea7\u5de5\u4f5c\u3002\u8fd9\u662f\u4e00\u5bb6\u5229\u7528\u5927\u578b\u533b\u836f\u516c\u53f8\u7684\u7814\u53d1\u7ecf\u9a8c\u6765\u9a71\u52a8\u521b\u65b0\u7684\u521d\u521b\u516c\u53f8\u3002<\/p>\n

\u65b0\u9510\u540d\u79f0\uff1a<\/strong>Senti Biosciences<\/p>\n

\u6210\u7acb\u5e74\u4efd\uff1a<\/strong>2016<\/p>\n

\u4e34\u5e8a\u4e13\u653b\uff1a<\/strong>\u764c\u75c7\u548c\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5<\/p>\n

\u6cbb\u7597\u764c\u75c7\u7684CAR-T\u7ec6\u80de\u7597\u6cd5\u5728\u8fd1\u51e0\u5e74\u6765\u53ef\u4ee5\u8bf4\u65e5\u6e10\u6210\u719f\uff0c\u4f46\u662f\u8fd9\u4e9b\u7597\u6cd5\u4ecd\u7136\u53ef\u80fd\u89e6\u53d1\u96be\u4e8e\u9884\u6d4b\u548c\u63a7\u5236\u7684\u540e\u679c\u3002\u60a3\u8005\u53ef\u80fd\u53d1\u751f\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\uff0c\u80bf\u7624\u53ef\u80fd\u901a\u8fc7\u6297\u539f\u9003\u9038\uff08antigen escape\uff09\u7684\u65b9\u5f0f\u8eb2\u907f\u514d\u75ab\u7cfb\u7edf\u7684\u8fdb\u653b\u3002Senti\u516c\u53f8<\/strong><\/a>\u7684\u89e3\u51b3\u65b9\u6cd5\u662f\u5229\u7528\u5408\u6210\u751f\u7269\u5b66\uff0c\u5728CAR-T\u7597\u6cd5\u4e2d\u52a0\u5165\u5408\u6210\u57fa\u56e0\u56de\u8def\uff0c\u8fd9\u4e9b\u5408\u6210\u57fa\u56e0\u56de\u8def\u80fd\u591f\u8ba9\u7ec6\u80de\u611f\u77e5\u5468\u56f4\u73af\u5883\u5e76\u4e14\u505a\u51fa\u9002\u5e94\u6027\u53cd\u5e94\uff0c\u4ece\u800c\u8ba9\u5b83\u4eec\u80fd\u591f\u62e5\u6709\u66f4\u597d\u7684\u5b89\u5168\u6027\u548c\u7597\u6548\u3002<\/strong>\u4f8b\u5982\uff0c\u201c\u5728\u6211\u4eec\u7684\u5b9e\u4f53\u7624\u9879\u76ee\u4e2d\uff0c\u6211\u4eec\u53ef\u4ee5\u901a\u8fc7\u5408\u6210\u751f\u7269\u5b66\uff0c\u8bbe\u8ba1\u51fa\u80fd\u591f\u5b9a\u4f4d\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u7684\u7ec6\u80de\u7597\u6cd5\uff0c\u800c\u4e0d\u8ba9\u5b83\u4eec\u5728\u8eab\u4f53\u7684\u5faa\u73af\u7cfb\u7edf\u4e2d\u81ea\u7531\u6d41\u52a8\u3002\u201d\u8be5\u516c\u53f8\u7684\u521b\u59cb\u4eba\u548c\u9996\u5e2d\u6267\u884c\u5b98Tim Lu<\/strong>\u535a\u58eb\u8bf4\u3002\u8fd9\u4e9b\u5408\u6210\u57fa\u56e0\u56de\u8def\u53ef\u4ee5\u5e2e\u52a9CAR-T\u7ec6\u80de\u611f\u77e5\u8d8b\u5411\u56e0\u5b50\uff0c\u6216\u8005\u8c03\u8282\uff0c\u751a\u81f3\u5b8c\u5168\u5173\u95ed\u5b83\u4eec\u7684\u529f\u80fd\u3002Senti\u516c\u53f8\u5df2\u7ecf\u6784\u5efa\u4e86\u4e00\u4e2a\u80fd\u591f\u8fc5\u901f\u8bbe\u8ba1\u3001\u642d\u5efa\u548c\u68c0\u6d4b\u57fa\u56e0\u56de\u8def\u7684\u7ec6\u80de\u5de5\u7a0b\u5b66\u6280\u672f\u5e73\u53f0\u3002\u8be5\u516c\u53f8\u9884\u8ba1\u5728\u660e\u5e74\u521d\u516c\u5e03\u7b2c\u4e00\u4e2a\u7814\u53d1\u5019\u9009\u836f\u7269\u3002<\/p>\n

\u65b0\u9510\u540d\u79f0\uff1a<\/strong>Tmunity Therapeutics<\/p>\n

\u6210\u7acb\u5e74\u4efd\uff1a<\/strong>2015<\/p>\n

\u4e34\u5e8a\u4e13\u653b\uff1a<\/strong>\u764c\u75c7T\u7ec6\u80de\u514d\u75ab\u7597\u6cd5<\/p>\n

Tmunity<\/strong><\/a>\u516c\u53f8\u5c06\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66CAR-T\u7597\u6cd5\u4e13\u5bb6\u4eec\u7684\u4e13\u957f\u548c1.35\u4ebf\u7f8e\u5143\u7684\u65e9\u671f\u878d\u8d44\u7ed3\u5408\u5728\u4e00\u8d77\uff0c\u529b\u56fe\u540c\u65f6\u8fdb\u884c\u591a\u4e2a\u7814\u53d1\u9879\u76ee\uff0c\u7814\u53d1\u521b\u65b0CAR-T\u548cTCR\u7ec6\u80de\u7597\u6cd5\uff0c\u6cbb\u7597\u591a\u79cd\u5b9e\u4f53\u7624\u3002<\/strong>CAR-T\u7597\u6cd5\u867d\u7136\u5728\u6cbb\u7597\u8840\u764c\u65b9\u9762\u6548\u679c\u663e\u8457\uff0c\u4f46\u662f\u5728\u6cbb\u7597\u5b9e\u4f53\u7624\u65b9\u9762\u76ee\u524d\u4ecd\u7136\u9762\u4e34\u6311\u6218\u3002Tmunity\u516c\u53f8\u7684\u79d1\u5b66\u521b\u59cb\u4eba\u5305\u62ecCarl June<\/strong>, Bruce Levine, Yangbing Zhao, Anne Chew\u548cJim Riley\u535a\u58eb\uff0c\u8fd9\u4e00\u56e2\u961f\u5728\u7814\u53d1\u7ec6\u80de\u7597\u6cd5\u4e0a\u62e5\u6709\u4e16\u754c\u9876\u5c16\u7684\u7ecf\u9a8c\u548c\u4e13\u957f\u3002\u8be5\u516c\u53f8\u76ee\u524d\u6709\u4e24\u4e2a\u7814\u53d1\u9879\u76ee\u8fdb\u5165\u4e34\u5e8a\u671f\uff0c\u5176\u4e2d\u4e00\u6b3eCAR-T\u7597\u6cd5\u7528\u4e8e\u6cbb\u7597\u524d\u5217\u817a\u764c\uff0c\u800c\u53e6\u4e00\u6b3eCRISPR\u7f16\u8f91\u7684TCR\u7597\u6cd5\u65e8\u5728\u6cbb\u7597\u9aa8\u9ad3\u7624\uff0c\u9ed1\u8272\u7d20\u7624\u548c\u8089\u7624\u3002\u6b64\u5916\uff0c\u8be5\u516c\u53f8\u8fd8\u67095\u4e2aCAR-T\u7814\u53d1\u9879\u76ee\u548c2\u4e2aTCR\u7814\u53d1\u9879\u76ee\u5904\u4e8e\u4e34\u5e8a\u524d\u7814\u53d1\u9636\u6bb5\u3002Tmunity\u516c\u53f8\u7684\u76ee\u6807\u662f\u6bcf\u5e74\u5f00\u53d1\u51fa\u4e24\u4e2a\u8fbe\u5230IND\u9636\u6bb5\u7684\u7814\u53d1\u9879\u76ee\u3002<\/p>\n

\u6211\u4eec\u795d\u8d3a\u8fd915\u5bb6\u516c\u53f8\u5165\u9009\u699c\u5355\uff0c\u5e76\u671f\u5f85\u5b83\u4eec\u65e9\u65e5\u4e3a\u5168\u7403\u60a3\u8005\u5e26\u6765\u66f4\u591a\u521b\u65b0\u7597\u6cd5\uff0c\u9020\u798f\u4eba\u7c7b\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"

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