{"id":1346411,"date":"2018-10-29T19:09:13","date_gmt":"2018-10-30T02:09:13","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=1346411"},"modified":"2018-10-29T19:11:02","modified_gmt":"2018-10-30T02:11:02","slug":"%e8%8d%af%e6%98%8e%e5%ba%b7%e5%be%b7%e5%a4%b4%e6%9d%a1%ef%bc%9aucsd%e7%a7%91%e7%a0%94%e4%ba%ba%e5%91%98%e7%99%8c%e7%bb%86%e8%83%9e%e6%8a%97%e8%8d%af%e6%80%a7%e7%a0%94%e7%a9%b6%e5%88%8a%e4%ba%8e","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/%e8%8d%af%e6%98%8e%e5%ba%b7%e5%be%b7%e5%a4%b4%e6%9d%a1%ef%bc%9aucsd%e7%a7%91%e7%a0%94%e4%ba%ba%e5%91%98%e7%99%8c%e7%bb%86%e8%83%9e%e6%8a%97%e8%8d%af%e6%80%a7%e7%a0%94%e7%a9%b6%e5%88%8a%e4%ba%8e\/.html","title":{"rendered":"\u836f\u660e\u5eb7\u5fb7\u5934\u6761\uff1aUCSD\u79d1\u7814\u4eba\u5458\u764c\u7ec6\u80de\u6297\u836f\u6027\u7814\u7a76\u520a\u4e8e\u4eca\u300eNature\u300f\u5b50\u520a"},"content":{"rendered":"<p><span style=\"color: #000080;\"><strong>\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053<\/strong><\/span><\/p>\n<p>\u57fa\u4e8eDNA\u635f\u4f24\u673a\u5236\u7684\u5316\u7597\u548c\u653e\u7597\u662f\u764c\u75c7\u6700\u4e3b\u8981\u7684\u6cbb\u7597\u65b9\u5f0f\u4e4b\u4e00\u3002\u7136\u800c\uff0c\u764c\u75c7\u7ec6\u80de\u7684\u6297\u836f\u6027\u4f1a\u4e25\u91cd\u5f71\u54cd\u653e\u5316\u7597\u7684\u6548\u679c\u3002\u4eca\u65e5\uff0c\u300a\u81ea\u7136\u300b\u6742\u5fd7\u5b50\u520a\u300aNature Structural and Molecular Biology\u300b\u5728\u7ebf\u53d1\u8868\u4e86\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821\uff08UCSD\uff09\u674e\u8513\u9752\u535a\u58eb\u548cMichael David\u6559\u6388\u4f5c\u4e3a\u5171\u540c\u901a\u8baf\u4f5c\u8005\u7684\u4e00\u9879\u6700\u65b0\u7814\u7a76\uff0c<strong>\u63ed\u793a\u4e86\u764c\u75c7\u7ec6\u80de\u83b7\u5f97\u653e\u5316\u7597\u6297\u836f\u6027\u7684\u4e00\u4e2a\u5168\u65b0\u5206\u5b50\u673a\u5236\uff0c\u5e76\u63d0\u51fa\u4e86\u4e00\u4e2a\u6709\u6548\u7684\u9488\u5bf9\u6027\u836f\u7269\u7814\u53d1\u65b9\u6848\u3002<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-1346421\" src=\"https:\/\/www.sandiegochinesepress.com\/press\/wp-content\/uploads\/2018\/10\/643.jpg\" alt=\"\" width=\"781\" height=\"420\" srcset=\"https:\/\/www.sandiegochinesepress.com\/press\/wp-content\/uploads\/2018\/10\/643.jpg 781w, https:\/\/www.sandiegochinesepress.com\/press\/wp-content\/uploads\/2018\/10\/643-768x413.jpg 768w\" sizes=\"auto, (max-width: 781px) 100vw, 781px\" \/><\/p>\n<p>1998\u5e74\uff0c\u79d1\u5b66\u5bb6\u4eec\u53d1\u73b0\u4e86\u4e00\u4e2a\u65b0\u7684\u57fa\u56e0\u5bb6\u65cf\u3002\u56e0\u4e3a\u8be5\u57fa\u56e0\u5bb6\u65cf\u88ab\u7814\u7a76\u7684\u7b2c\u4e00\u4e2a\u57fa\u56e0\u6210\u5458\u7684\u8fc7\u91cf\u8868\u8fbe\u4f1a\u963b\u6b62\u7ec6\u80de\u5206\u88c2\uff0c\u8fd9\u4e2a\u57fa\u56e0\u5bb6\u65cf\u88ab\u547d\u540d\u4e3aSchlafen\uff08\u5fb7\u8bed\u201c\u6c89\u7761\u201d\u4e4b\u610f\uff09\u3002\u7136\u800c\uff0c\u8be5\u57fa\u56e0\u5bb6\u65cf\u6210\u5458\u7684\u751f\u7406\u548c\u7ec6\u80de\u529f\u80fd\u5374\u957f\u671f\u672a\u77e5\u3002<\/p>\n<p>2012\u5e74\uff0c\u674e\u8513\u9752\u535a\u58eb\u548cMichael David\u6559\u6388\u9996\u6b21\u5728\u300a\u81ea\u7136\u300b\u6742\u5fd7\u62a5\u9053\uff0c<strong>\u4eba\u7c7b<em>Schlafen 11<\/em>\u57fa\u56e0\u7f16\u7801\u7684\u86cb\u767d\u901a\u8fc7\u5bf9\u8f6c\u8fd0\u6838\u7cd6\u6838\u9178\uff08transfer RNA\uff0ctRNA\uff09\u7684\u8c03\u8282\uff0c\u6291\u5236\u4eba\u7c7b\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2HIV\u75c5\u6bd2\u86cb\u767d\u7684\u5408\u6210\uff0c\u4ece\u800c\u6291\u5236HIV\u75c5\u6bd2\u7684\u7e41\u6b96\u3002<\/strong>\u6709\u8da3\u7684\u662f\u5728\u540c\u5e74\uff0c\u4e24\u9879\u72ec\u7acb\u7814\u7a76\u53d1\u73b0\uff0c<em>Schlafen 11<\/em>\u57fa\u56e0\u7684\u8868\u8fbe\u662f\u51b3\u5b9a\u764c\u7ec6\u80de\u5316\u7597\u654f\u611f\u6027\u7684\u9996\u8981\u56e0\u7d20\uff0c\u8868\u660e\u8fd9\u4e00\u57fa\u56e0\u5bf9\u4e8e\u591a\u79cd\u75be\u75c5\u6709\u7740\u6f5c\u5728\u7684\u4f5c\u7528\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-1346414\" src=\"https:\/\/www.sandiegochinesepress.com\/press\/wp-content\/uploads\/2018\/10\/639.jpg\" alt=\"\" width=\"892\" height=\"282\" srcset=\"https:\/\/www.sandiegochinesepress.com\/press\/wp-content\/uploads\/2018\/10\/639.jpg 892w, https:\/\/www.sandiegochinesepress.com\/press\/wp-content\/uploads\/2018\/10\/639-768x243.jpg 768w\" sizes=\"auto, (max-width: 892px) 100vw, 892px\" \/><\/p>\n<p>\u5728\u4eca\u65e5\u53d1\u8868\u7684\u7814\u7a76\u4e2d\uff0c\u674e\u8513\u9752\u535a\u58eb\u548cMichael David\u6559\u6388\u8fdb\u4e00\u6b65\u9610\u660e\u4e86<em>Schlafen 11<\/em>\u57fa\u56e0\u5982\u4f55\u80fd\u5f71\u54cd\u764c\u75c7\u5316\u7597\u3002\u7c7b\u4f3c\u4e8e\u5bf9HIV\u75c5\u6bd2\u86cb\u767d\u5408\u6210\u7684\u6291\u5236\uff0c<strong>\u8be5\u57fa\u56e0\u7f16\u7801\u7684SLFN11\u86cb\u767d\u5728\u6fc0\u6d3b\u65f6\uff0c\u4f1a\u5bfc\u81f4\u7279\u5b9atRNA\u7684\u964d\u89e3\uff0c\u4ece\u800c\u6291\u5236\u5bf9DNA\u635f\u4f24\u4fee\u590d\u81f3\u5173\u91cd\u8981\u7684\u76f8\u5173\u86cb\u767d\u7684\u8868\u8fbe\u3002<\/strong>\u5728\u6b63\u5e38\u8868\u8fbeSLFN11\u86cb\u767d\u7684\u7ec6\u80de\u4e2d\uff0c\u4e25\u91cd\u7684DNA\u635f\u4f24\u4f1a\u9ad8\u5ea6\u6fc0\u6d3bSLFN11\u86cb\u767d\u7684\u529f\u80fd\uff0c\u6291\u5236\u635f\u4f24DNA\u7684\u4fee\u590d\uff0c\u4ece\u800c\u901a\u8fc7\u7ec6\u80de\u51cb\u4ea1\u6e05\u9664\u53d7\u635f\u7ec6\u80de\uff0c\u907f\u514d\u5728\u5927\u89c4\u6a21DNA\u4fee\u590d\u7684\u8fc7\u7a0b\u4e2d\u5f15\u5165DNA\u53d8\u5f02\u548c\u7ec6\u80de\u764c\u5316\u3002\u7136\u800c\u5728\u5927\u91cf\u7684\u764c\u75c7\u7ec6\u80de\u4e2d\uff0c<em>Schlafen 11<\/em>\u57fa\u56e0\u7684\u86cb\u767d\u8868\u8fbe\u88ab\u6c89\u9ed8\uff0c\u4f7f\u5f97\u8fd9\u4e9b\u764c\u7ec6\u80de\u62e5\u6709\u6bd4\u6b63\u5e38\u7ec6\u80de\u66f4\u5f3a\u7684DNA\u635f\u4f24\u4fee\u590d\u80fd\u529b\uff0c\u4ece\u800c\u83b7\u5f97\u5bf9\u653e\u5316\u7597\u7684\u6297\u836f\u6027\u3002<\/p>\n<p>\u201c<strong>\u6211\u4eec\u53d1\u73b0\uff0c\u8868\u8fbeSLFN11\u86cb\u767d\u7684\u764c\u75c7\u7ec6\u80de\u53d7\u5230\u5bfc\u81f4DNA\u635f\u4f24\u7684\u836f\u7269\u5904\u7406\u65f6\uff0cATR\u548cATM\u7684\u86cb\u767d\u8868\u8fbe\u4f1a\u88ab\u5f3a\u70c8\u6291\u5236\uff0c\u8fd9\u5c31\u662f\u8fd9\u4e9b\u764c\u75c7\u7ec6\u80de\u6b7b\u4ea1\u7684\u6839\u672c\u539f\u56e0<\/strong>\uff0c\u201dMichael David\u6559\u6388\u8bf4\uff1a\u201c\u800c\u5728\u90a3\u4e9b\u4e0d\u8868\u8fbeSLFN11\u86cb\u767d\u7684\u764c\u75c7\u7ec6\u80de\u91cc\uff0c\u4f60\u5c31\u770b\u4e0d\u5230\u5bf9ATR\u548cATM\u7684\u86cb\u767d\u8868\u8fbe\u7684\u6291\u5236\uff0c\u764c\u7ec6\u80de\u5c31\u4f1a\u6d3b\u4e0b\u6765\u3002\u201d<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-1346416 aligncenter\" src=\"https:\/\/www.sandiegochinesepress.com\/press\/wp-content\/uploads\/2018\/10\/640-3.jpg\" alt=\"\" width=\"576\" height=\"768\" srcset=\"https:\/\/www.sandiegochinesepress.com\/press\/wp-content\/uploads\/2018\/10\/640-3.jpg 576w, https:\/\/www.sandiegochinesepress.com\/press\/wp-content\/uploads\/2018\/10\/640-3-768x1024.jpg 768w\" sizes=\"auto, (max-width: 576px) 100vw, 576px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u25b2\u672c\u6587\u7684\u901a\u8baf\u4f5c\u8005\u4e4b\u4e00\u674e\u8513\u9752\u535a\u58eb\uff08\u56fe\u7247\u6765\u6e90\uff1aUCSD\uff09<\/strong><\/p>\n<p>\u5bf9SLFN11\u86cb\u767d\u529f\u80fd\u5206\u5b50\u673a\u5236\u7684\u8fdb\u4e00\u6b65\u7814\u7a76\u8868\u660e\uff0c<strong>SLFN11\u86cb\u767d\u529f\u80fd\u7684\u6fc0\u6d3b\u5f15\u8d77\u67d0\u4e9b\u7279\u5b9atRNA\u7684\u964d\u89e3\uff0c\u5305\u62ec\u6240\u6709\u4eae\u6c28\u9178(Leucine)\u548c\u4e1d\u6c28\u9178(Serine)\u7684tRNA\u3002<\/strong>\u548c\u5176\u4f59\u7684\u5927\u591a\u6570tRNA\u7684\u4e09\u53f6\u82dc\u84ff\u8349\u7ed3\u6784\u4e0d\u540c\uff0c\u5728\u539f\u6709\u7684\u53ef\u53d8\u73af\u7ed3\u6784\uff08variable loop\uff09\u7684\u4f4d\u7f6e\uff0c\u8fd9\u4e9b\u4eae\u6c28\u9178(Leucine)\u548c\u4e1d\u6c28\u9178(Serine)\u7684tRNA\u62e5\u6709\u4e00\u4e2a\u66f4\u957f\u7684\u53ef\u53d8\u67c4\u73af\u7ed3\u6784\uff08variable stem-loop\uff09\uff0c\u4f7f\u5b83\u4eec\u7684\u4e8c\u7ea7\u7ed3\u6784\u770b\u8d77\u6765\u66f4\u50cf\u56db\u53f6\u82dc\u84ff\u8349\u3002\u201c<strong>\u8fd9\u53ef\u80fd\u5c31\u662fSLFN11\u86cb\u767d\u8bc6\u522b\u964d\u89e3\u8fd9\u4e9b\u7279\u5b9atRNA\u7684\u7ed3\u6784\u7279\u5f81<\/strong>\uff0c\u201d\u674e\u8513\u9752\u535a\u58eb\u89e3\u91ca\u8bf4\uff1a\u201c\u8fd9\u5176\u4e2d\u6709\u4e00\u4e2a\u7279\u6b8a\u7684\u4eae\u6c28\u9178\u8f6c\u8fd0\u6838\u7cd6\u6838\u9178 (Leucine transfer RNA)\uff0ctRNA-Leu-TAA\uff0c\u5b83\u7684\u8868\u8fbe\u6c34\u5e73\u975e\u5e38\u4f4e\uff0c\u540c\u65f6\u5b83\u53c8\u88ab\u5728ATR\u548cATM\u7684\u86cb\u767d\u5408\u6210\u4e2d\u5927\u91cf\u4f7f\u7528\u3002\u8fd9\u5c31\u4f7f\u5f97ATR\u548cATM\u7684\u86cb\u767d\u5408\u6210\u5bf9\u56e0\u4e3aSLFN11\u529f\u80fd\u6fc0\u6d3b\u800c\u5f15\u8d77\u7684\u8fd9\u79cd\u4eae\u6c28\u9178\u8f6c\u8fd0\u6838\u7cd6\u6838\u9178(tRNA-Leu-TAA)\u7684\u964d\u89e3\u6781\u7aef\u654f\u611f\u3002\u201d<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-1346415\" src=\"https:\/\/www.sandiegochinesepress.com\/press\/wp-content\/uploads\/2018\/10\/641-2.jpg\" alt=\"\" width=\"708\" height=\"488\" \/><\/p>\n<p><strong>\u25b2tRNA\u7684\u4e0d\u540c\u7ed3\u6784\u6216\u8bb8\u662fSLFN11\u86cb\u767d\u7684\u4f5c\u7528\u5173\u952e\uff08\u56fe\u7247\u6765\u6e90\uff1ahttp:\/\/gtrnadb.ucsc.edu\/\uff09<\/strong><\/p>\n<p>\u66f4\u6df1\u5165\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u7edd\u5927\u591a\u6570\u548cDNA\u635f\u4f24\u4fee\u590d\u6709\u5173\u7684\u86cb\u767d\u7684\u5408\u6210\u90fd\u9ad8\u5ea6\u4f9d\u8d56\u4e8e\u8fd9\u79cd\u7a00\u6709\u7684\u4eae\u6c28\u9178\u8f6c\u8fd0\u6838\u7cd6\u6838\u9178(tRNA-Leu-TAA)\u3002\u674e\u8513\u9752\u535a\u58eb\u53d1\u660e\u4e86\u4e00\u79cd\u4f7f\u7528\u7279\u6b8a\u7684\u53cd\u4e49\u5be1\u6838\u82f7\u9178(antisense oligonucleotide)\u6765\u6291\u5236\u8fd9\u79cd\u4eae\u6c28\u9178\u8f6c\u8fd0\u6838\u7cd6\u6838\u9178(tRNA-Leu-TAA)\u8868\u8fbe\u7684\u65b9\u6cd5\uff0c\u4ece\u800c\u6291\u5236\u8fd9\u4e9b\u548cDNA\u635f\u4f24\u4fee\u590d\u76f8\u5173\u86cb\u767d\u7684\u5408\u6210\uff0c\u8fbe\u5230\u514b\u670d\u8fd9\u4e9b\u764c\u75c7\u7ec6\u80de\u5bf9\u653e\u5316\u7597\u6297\u836f\u6027\u7684\u76ee\u7684\u3002\u548c\u5176\u4ed6\u9488\u5bf9\u5355\u4e00\u9776\u6807\u7684\u836f\u7269\u76f8\u6bd4\uff0c<strong>\u8fd9\u79cd\u65b0\u7684\u6cbb\u7597\u9014\u5f84\u9488\u5bf9\u6574\u4e2aDNA\u635f\u4f24\u4fee\u590d\u673a\u5236\uff0c\u6240\u4ee5\u764c\u75c7\u7ec6\u80de\u51e0\u4e4e\u6ca1\u6709\u4ea7\u751f\u6297\u836f\u6027\u7684\u53ef\u80fd\u3002<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-1346413 aligncenter\" src=\"https:\/\/www.sandiegochinesepress.com\/press\/wp-content\/uploads\/2018\/10\/642.jpg\" alt=\"\" width=\"614\" height=\"378\" \/><\/p>\n<p><strong>\u25b2\u5728\u7ec6\u80de\u5b9e\u9a8c\u4e2d\uff0c\u8fd9\u4e00\u7597\u6cd5\u6548\u679c\u826f\u597d\uff08\u56fe\u7247\u6765\u6e90\uff1a\u674e\u8513\u9752\u535a\u58eb\u4f9b\u56fe\uff09<\/strong><\/p>\n<p><strong>\u5728\u7ec6\u80de\u5b9e\u9a8c\u4e2d\uff0c\u8fd9\u4e00\u6838\u82f7\u9178\u7597\u6cd5\u53d6\u5f97\u4e86\u4f18\u79c0\u7684\u6210\u7ee9<\/strong>\u2014\u2014\u901a\u8fc7\u4f7f\u7528\u7279\u6b8a\u7684\u53cd\u4e49\u5be1\u6838\u82f7\u9178(antisense oligonucleotide)\u6765\u6291\u5236\u4eae\u6c28\u9178\u8f6c\u8fd0\u6838\u7cd6\u6838\u9178tRNA-Leu-TAA\u7684\u8868\u8fbe\uff0c\u4e0d\u8868\u8fbeSLFN11\u86cb\u767d\u7684\u80f0\u817a\u764c\u7ec6\u80de\u5bf9\u5316\u7597\u7684\u6297\u836f\u6027\u4e5f\u80fd\u88ab\u514b\u670d\uff0c\u8fdb\u5165\u7ec6\u80de\u51cb\u4ea1\u3002<\/p>\n<p>\u672c\u9879\u7814\u7a76\u7684\u53e6\u4e00\u4f4d\u5171\u540c\u4f5c\u8005\uff0c\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821\u533b\u5b66\u9662\u8363\u8a89\u9000\u4f11\u6559\u6388\uff0c\u7f8e\u56fd\u6587\u7406\u79d1\u5b66\u9662\u9662\u58eb\u738b\u6620\u771f\uff08Jean Y.J. Wang\uff09\u6559\u6388\u6307\u51fa\uff0c<strong>\u4e86\u89e3\u764c\u75c7\u7ec6\u80de\u5728DNA\u53d7\u635f\u7684\u60c5\u51b5\u4e0b\u5982\u4f55\u907f\u514d\u6b7b\u4ea1\uff0c\u6709\u52a9\u4e8e\u7814\u53d1\u65b0\u7684\u6cbb\u7597\u624b\u6bb5\u6765\u4fc3\u8fdb\u653e\u5316\u7597\u5bf9\u764c\u75c7\u7684\u6cbb\u7597\u6548\u679c\u3002<\/strong>\u201c\u8fd9\u9879\u7814\u7a76\u6210\u679c\u8868\u660e\u53ef\u4ee5\u901a\u8fc7\u4e24\u4e2a\u9014\u5f84\u6765\u4fc3\u8fdbDNA\u635f\u4f24\u836f\u7269\u5bf9\u764c\u75c7\u7ec6\u80de\u7684\u6740\u4f24\u30021\uff09\u6291\u5236ATR\u86cb\u767d\u6fc0\u9176\u7684\u6d3b\u6027\u30022\uff09\u6291\u5236tRNA\u3002\u540c\u65f6\uff0c\u8fd9\u9879\u7814\u7a76\u7b2c\u4e00\u6b21\u53d1\u73b0\u5e76\u62a5\u9053\u4e86DNA\u53d7\u635f\u7ec6\u80de\u7684\u5b58\u6d3b\u53d6\u51b3\u4e8etRNA\u7684\u8c03\u8282\uff0c\u5bf9\u7ec6\u80deDNA\u635f\u4f24\u53cd\u5e94\u7684\u57fa\u7840\u7814\u7a76\u5177\u6709\u91cd\u8981\u7684\u5b66\u672f\u610f\u4e49\u3002\u201d<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-1346412\" src=\"https:\/\/www.sandiegochinesepress.com\/press\/wp-content\/uploads\/2018\/10\/644.jpg\" alt=\"\" width=\"478\" height=\"538\" \/><\/p>\n<p><strong>\u25b2\u672c\u6587\u7684\u901a\u8baf\u4f5c\u8005\u4e4b\u4e00Michael David\u6559\u6388\uff08\u56fe\u7247\u6765\u6e90\uff1aUCSD\uff09<\/strong><\/p>\n<p>Michael David\u6559\u6388\u8fdb\u4e00\u6b65\u6307\u51fa\uff0c\u7c7b\u4f3c\u7684\u6cbb\u7597\u65b9\u6cd5\u4e5f\u6709\u5f88\u5927\u6f5c\u529b\u53ef\u4ee5\u88ab\u7528\u4e8e\u6cbb\u7597HIV\u548c\u5176\u4ed6\u9ad8\u5ea6\u4f9d\u8d56\u8fd9\u79cd\u4eae\u6c28\u9178\u8f6c\u8fd0\u6838\u7cd6\u6838\u9178(tRNA-Leu-TAA)\u8fdb\u884c\u86cb\u767d\u5408\u6210\u7684\u75c5\u6bd2\uff0c\u5e76\u6709\u6548\u9632\u6b62\u6297\u836f\u75c5\u6bd2\u682a\u7684\u4ea7\u751f\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c<strong>\u76ee\u524d\u591a\u79cd\u53cd\u4e49\u5be1\u6838\u82f7\u9178(antisense oligonucleotide)\u7c7b\u578b\u7684\u836f\u7269\u5df2\u7ecf\u88ab\u7f8e\u56fdFDA\u6279\u51c6\u6cbb\u7597\u5305\u62ec\u810a\u9ad3\u6027\u808c\u8089\u840e\u7f29\u75c7\u5728\u5185\u7684\u591a\u79cd\u75be\u75c5\uff0c\u8fd9\u4e00\u7c7b\u578b\u7684\u836f\u7269\u5176\u6f5c\u529b\u4e5f\u4e3a\u4eba\u6240\u770b\u597d\u3002<\/strong><\/p>\n<p>\u53c2\u8003\u8d44\u6599\uff1a<\/p>\n<p>1 Li, M. et al. Codon-usage-based inhibition of HIV protein synthesis by human schlafen 11. Nature 491, 125-128, doi:10.1038\/nature11433 (2012).<\/p>\n<p>2 Barretina, J. et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 483, 603-607, doi:10.1038\/nature11003 (2012).<\/p>\n<p>3 Zoppoli, G. et al. Putative DNA\/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents. Proc Natl Acad Sci U S A 109, 15030-15035, doi:10.1073\/pnas.1205943109 (2012).<\/p>\n<p>\uff08\u836f\u660e\u5eb7\u5fb7\u7a3f\/\u56fe\uff09<\/p>\n<section class=\"\">\n<section>\n<section>\n<section>\n<section class=\"\">\n<section>\n<section>\u00a0<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>\u57fa\u4e8eDNA\u635f\u4f24\u673a\u5236\u7684\u5316\u7597\u548c\u653e\u7597\u662f\u764c\u75c7\u6700\u4e3b\u8981\u7684\u6cbb\u7597\u65b9\u5f0f\u4e4b\u4e00\u3002\u7136\u800c\uff0c\u764c\u75c7\u7ec6\u80de\u7684\u6297\u836f\u6027\u4f1a\u4e25\u91cd\u5f71\u54cd\u653e\u5316\u7597\u7684\u6548\u679c\u3002\u4eca\u65e5\uff0c\u300a\u81ea\u7136\u300b\u6742\u5fd7\u5b50\u520a\u300aNature Structural and Molecular Biology\u300b&#8230;&#8230;<\/p>\n","protected":false},"author":3,"featured_media":1346416,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-1346411","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-headline"],"_links":{"self":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1346411","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/comments?post=1346411"}],"version-history":[{"count":0,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1346411\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media\/1346416"}],"wp:attachment":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media?parent=1346411"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/categories?post=1346411"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/tags?post=1346411"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}