{"id":1371299,"date":"2018-11-28T18:09:27","date_gmt":"2018-11-29T02:09:27","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=1371299"},"modified":"2018-11-29T18:32:37","modified_gmt":"2018-11-30T02:32:37","slug":"%e5%9f%ba%e5%9b%a0%e7%bc%96%e8%be%91%e6%8a%80%e6%9c%af%e5%8f%91%e6%98%8e%e4%ba%ba%e5%bc%a0%e5%b3%b0%ef%bc%9a%e5%9f%ba%e5%9b%a0%e7%bc%96%e8%be%91%e5%a9%b4%e5%84%bf%e6%98%af%e5%8d%b1%e9%99%a9%e7%9a%84","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/%e5%9f%ba%e5%9b%a0%e7%bc%96%e8%be%91%e6%8a%80%e6%9c%af%e5%8f%91%e6%98%8e%e4%ba%ba%e5%bc%a0%e5%b3%b0%ef%bc%9a%e5%9f%ba%e5%9b%a0%e7%bc%96%e8%be%91%e5%a9%b4%e5%84%bf%e6%98%af%e5%8d%b1%e9%99%a9%e7%9a%84\/.html","title":{"rendered":"\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u53d1\u660e\u4eba\u5f20\u5cf0\uff1a\u57fa\u56e0\u7f16\u8f91\u5a74\u513f\u662f\u5371\u9669\u7684\u76ee\u524d\u4e0d\u5e94\u7528\u4e8e\u4eba"},"content":{"rendered":"

\"\"<\/a><\/p>\n

\uff08\u56fe\uff09\u636e\u5e7f\u4e1c\u7701\u536b\u751f\u5065\u5eb7\u59d4\u5458\u4f1a\u5b98\u7f51\u6d88\u606f\uff0c11\u670827\u65e5\uff0c\u5e7f\u4e1c\u7701\u3001\u6df1\u5733\u5e02\u5df2\u6210\u7acb\u8054\u5408\u8c03\u67e5\u7ec4\uff0c\u5f00\u5c55\u5bf9\u201c\u6df1\u5733\u57fa\u56e0\u7f16\u8f91\u5a74\u513f\u4e8b\u4ef6\u201d\u7684\u5168\u9762\u8c03\u67e5\u3002<\/p>\n

\"\"<\/a><\/p>\n

\uff08\u56fe\uff09\u57fa\u56e0\u7f16\u8f91\u6280\u672fCRISPR\u53d1\u660e\u4eba\u5f20\u5cf0\u6559\u6388\u53d1\u8868\u5b8c\u6574\u58f0\u660e\uff1a\u57fa\u56e0\u7f16\u8f91\u5a74\u513f\u662f\u5371\u9669\u7684\uff0c\u76ee\u524d\u4e0d\u5e94\u7528\u4e8e\u4eba\u3002\u5168\u6587\u5982\u4e0b\uff08\u9644\u7ffb\u8bd1\u53c2\u8003\uff09\uff1a<\/p>\n

Although I appreciate the global threat posed by HIV, at this stage, the risks of editing embryos to knock out CCR5 seem to outweigh the potential benefits, not to mention that knocking out of CCR5 will likely render a person much more susceptible for West Nile Virus. Just as important, there are already common and highly-effective methods to prevent transmission of HIV from a parent to an unborn child.<\/em><\/p>\n

\u867d\u7136\u6211\u8ba4\u8bc6\u5230HIV\u75c5\u6bd2\u5bf9\u5168\u7403\u9020\u6210\u7684\u5a01\u80c1\uff0c\u4f46\u5728\u73b0\u9636\u6bb5\uff0c\u7f16\u8f91\u80da\u80ce\u4ee5\u6572\u9664CCR5\u7684\u98ce\u9669\u4f3c\u4e4e\u5927\u4e8e\u6f5c\u5728\u7684\u597d\u5904\uff0c\u66f4\u4e0d\u7528\u8bf4\u6572\u9664CCR5\u53ef\u80fd\u4f1a\u4f7f\u4e00\u4e2a\u4eba\u66f4\u5bb9\u6613\u611f\u67d3\u897f\u5c3c\u7f57\u6cb3\u75c5\u6bd2\u3002\u540c\u6837\u91cd\u8981\u7684\u662f\uff0c\u76ee\u524d\u5df2\u7ecf\u6709\u666e\u904d\u800c\u6709\u6548\u7684\u65b9\u6cd5\uff0c\u6765\u9632\u6b62\u827e\u6ecb\u75c5\u6bd2\u4ece\u7236\u6bcd\u4f20\u67d3\u7ed9\u672a\u51fa\u751f\u7684\u5b69\u5b50\u3002<\/p>\n

Given the current state of the technology, I\u2019m in favor of a moratorium on implantation of edited embryos, which seems to be the intention of the CCR5 trial, until we have come up with a thoughtful set of\u00a0safety requirements first.<\/em><\/p>\n

\u9274\u4e8e\u76ee\u524d\u7684\u6280\u672f\u6c34\u5e73\uff0c\u6211\u652f\u6301\u6682\u505c\u690d\u5165\u7ecf\u8fc7\u7f16\u8f91\u7684\u80da\u80ce\uff08\u8fd9\u4f3c\u4e4e\u662fCCR5\u8bd5\u9a8c\u7684\u610f\u56fe\uff09\uff0c\u76f4\u5230\u6211\u4eec\u5148\u63d0\u51fa\u4e00\u5957\u7ecf\u8fc7\u6df1\u601d\u719f\u8651\u7684\u5b89\u5168\u8981\u6c42\u3002<\/p>\n

Not only do I see this as risky, but I am also deeply concerned about the lack of transparency surrounding this trial. All medical advances, gene editing or otherwise and particularly those that impact vulnerable populations, should be cautiously and thoughtfully tested, discussed openly with patients, physicians, scientists, and other community members, and implemented in an equitable way.<\/em><\/p>\n

\u6211\u8ba4\u4e3a\u8fd9\u4e0d\u4ec5\u662f\u5371\u9669\u7684\uff0c\u800c\u4e14\u6211\u4e5f\u6df1\u5207\u62c5\u5fe7\u8fd9\u4e00\u8bd5\u9a8c\u7f3a\u4e4f\u900f\u660e\u5ea6\u7684\u95ee\u9898\u3002\u6240\u6709\u7684\u533b\u5b66\u8fdb\u6b65\u3001\u57fa\u56e0\u7f16\u8f91\u6216\u5176\u4ed6\u65b9\u9762\uff0c\u5c24\u5176\u662f\u90a3\u4e9b\u5f71\u54cd\u5f31\u52bf\u7fa4\u4f53\u7684\u8fdb\u6b65\uff0c\u90fd\u5e94\u8be5\u7ecf\u8fc7\u8c28\u614e\u548c\u6df1\u601d\u719f\u8651\u7684\u6d4b\u8bd5\uff0c\u4e0e\u60a3\u8005\u3001\u533b\u751f\u3001\u79d1\u5b66\u5bb6\u548c\u5176\u4ed6\u793e\u533a\u6210\u5458\u516c\u5f00\u8ba8\u8bba\uff0c\u5e76\u4ee5\u516c\u5e73\u7684\u65b9\u5f0f\u5b9e\u65bd\u3002<\/p>\n

In 2015, the international research community said it would be irresponsible to proceed with any germline editing without \u201cbroad societal consensus about the appropriateness of the proposed application.\u201d (This was the consensus statement from the 2015 International Summit on Human Gene Editing.)<\/em><\/p>\n

2015\u5e74\uff0c\u56fd\u9645\u7814\u7a76\u534f\u4f1a(international research community)\u66fe\u8868\u793a\uff0c\u5728\u201c\u793e\u4f1a\u5bf9\u6280\u672f\u7684\u5e94\u7528\u9002\u7528\u6027\u6ca1\u6709\u5e7f\u6cdb\u5171\u8bc6\u7684\u60c5\u51b5\u4e0b\u201d\u8fdb\u884c\u4efb\u4f55\u4eba\u7c7b\u80da\u80ce\u57fa\u56e0\u7f16\u8f91\u90fd\u662f\u4e0d\u8d1f\u8d23\u4efb\u7684\u3002(\u8fd9\u662f2015\u5e74\u4eba\u7c7b\u57fa\u56e0\u7f16\u8f91\u56fd\u9645\u5cf0\u4f1a\u7684\u5171\u8bc6\u58f0\u660e\u3002)<\/p>\n

It is my hope that the upcoming summit will serve as a forum for deeper conversations about the implications of this news and provide guidance on how we as a global society can best benefit from gene editing.<\/em><\/p>\n

\u6211\u5e0c\u671b\uff0c\u5373\u5c06\u53ec\u5f00\u7684\u5cf0\u4f1a\u5c06\u6210\u4e3a\u5c31\u8fd9\u4e00\u6d88\u606f\u7684\u5f71\u54cd\u8fdb\u884c\u66f4\u6df1\u5165\u8ba8\u8bba\u7684\u8bba\u575b\uff0c\u5e76\u4e3a\u6211\u4eec\u4f5c\u4e3a\u4e00\u4e2a\u5168\u7403\u6027\u793e\u4f1a\u5982\u4f55\u4ece\u57fa\u56e0\u7f16\u8f91\u4e2d\u83b7\u5f97\u6700\u5927\u5229\u76ca\u63d0\u4f9b\u6307\u5bfc\u3002<\/p>\n

\u79d1\u6280\u90e8\u660e\u4ee4\u7981\u6b62\u201c\u57fa\u56e0\u7f16\u8f91\u5a74\u513f\u201d| \u56db\u95ee\u201c\u57fa\u56e0\u7f16\u8f91\u201d<\/strong><\/span><\/p>\n

\u65b0\u4eac\u62a5\u5feb\u8baf\uff08\u8bb0\u8005 \u6768\u783a\uff09<\/strong>11 \u6708 27 \u65e5\uff0c\u5357\u65b9\u79d1\u6280\u5927\u5b66\u5b66\u8005\u8d3a\u5efa\u594e\u76f8\u5173\u4e8b\u4ef6\u6301\u7eed\u53d1\u9175\uff0c\u8ba9\u5728\u9999\u6e2f\u4e3e\u884c\u7684\u7b2c\u4e8c\u5c4a\u56fd\u9645\u4eba\u7c7b\u57fa\u56e0\u7ec4\u7f16\u8f91\u5cf0\u4f1a\u53d7\u5230\u5e7f\u6cdb\u5173\u6ce8\u3002<\/p>\n

\u4f1a\u4e0a\uff0c\u57fa\u56e0\u7f16\u8f91\u9886\u57df\u6743\u5a01\u3001CRISPR-CAS9\u57fa\u56e0\u7f16\u8f91\u7597\u6cd5\u9886\u57df\u6700\u91cd\u5927\u7684\u89c4\u5219\u5236\u5b9a\u8005\u4e4b\u4e00\u2014\u5f20\u5cf0\uff08Feng Zhang\uff09\u5728\u53d1\u8868\u4e3b\u9898\u53d1\u8a00\u540e\uff0c\u63a5\u53d7\u4e86\u65b0\u4eac\u62a5\u8bb0\u8005\u7684\u72ec\u5bb6\u4e13\u8bbf\uff0c\u5e76\u5c31\u8206\u8bba\u548c\u884c\u4e1a\u5173\u6ce8\u7684\u8bf8\u591a\u7591\u95ee\u4f5c\u51fa\u4e86\u56de\u5e94\u3002<\/p>\n

\u5bf9\u4e8e\u8d3a\u5efa\u594e\u76f8\u5173\u4e8b\u4ef6\uff0c\u5f20\u5cf0\u8ba4\u4e3a\u79d1\u5b66\u548c\u533b\u5b66\u7684\u7ed3\u5408\u80fd\u4f7f\u6cbb\u7597\u75be\u75c5\u53d8\u5f97\u66f4\u52a0\u5feb\u901f\u3001\u6709\u6548\u662f\u4f7f\u4eba\u4eec\u5bf9\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u611f\u5230\u5174\u594b\u7684\u539f\u56e0\u3002\u5f20\u5cf0\u5411\u65b0\u4eac\u62a5\u8bb0\u8005\u8868\u793a\uff0c\u201c\u73b0\u5728\u5c31\u5728\u4eba\u8eab\u4e0a\u8fdb\u884c\u5b9e\u9a8c\u662f\u4e0d\u5e94\u8be5\u7684\uff0c\u201d\u5f20\u5cf0\u8868\u793a\uff0c\u57fa\u56e0\u7f16\u8f91\u4f5c\u4e3a\u4e00\u9879\u65b0\u6280\u672f\uff0c\u5e94\u8be5\u8fdb\u4e00\u6b65\u901a\u8fc7\u5927\u91cf\u7684\u5b9e\u9a8c\u548c\u8f83\u957f\u65f6\u95f4\u7684\u53cd\u590d\u8bba\u8bc1\uff0c\u5728\u73b0\u9636\u6bb5\u4e0d\u5e94\u8be5\u88ab\u5e94\u7528\u4e8e\u4eba\u3002<\/p>\n

\u6b64\u524d\uff0c\u4e2d\u56fd\u77e5\u8bc6\u754c\u8d28\u7591\u8d3a\u5efa\u594e\u76f8\u5173\u9879\u76ee\u7684\u6709\u5229\u6027\uff0c\u8ba4\u4e3a\u901a\u8fc7\u5bf9\u7cbe\u6db2\u5145\u5206\u6d17\u6da4\uff0c\u8fdb\u884c\u5782\u76f4\u4e0a\u7684\u963b\u65ad\u5b8c\u5168\u6709\u5e0c\u671b\u8ba9\u540e\u4ee3\u907f\u514d\u5782\u76f4\u611f\u67d3HIV\uff0c\u76f8\u5173\u6280\u672f\u4e5f\u6bd4\u8f83\u6210\u719f\u3002\u4e3a\u6b64\u4e13\u95e8\u53bb\u505a\u57fa\u56e0\u7f16\u8f91\uff0c\u5e76\u5c06\u8fd9\u79cd\u5b9e\u9a8c\u6027\u7684\u6280\u672f\u76f4\u63a5\u8fd0\u7528\u4e8e\u4eba\u4f53\uff0c\u5728\u6ca1\u6709\u786e\u5207\u83b7\u76ca\u7684\u60c5\u51b5\u4e0b\uff0c\u8981\u5192\u5f88\u5927\u98ce\u9669\uff0c\u8fd9\u662f\u5bf9\u60a3\u8005\u672c\u8eab\u5229\u76ca\u548c\u540e\u4ee3\u5229\u76ca\u7684\u4e00\u79cd\u635f\u4f24\u3002<\/p>\n

\u5bf9\u6b64\uff0c\u5f20\u5cf0\u5e76\u672a\u76f4\u63a5\u8868\u793a\u8d5e\u540c\uff0c\u4ed6\u8ba4\u4e3a\u75be\u75c5\u7684\u89e3\u51b3\u53ef\u80fd\u4f1a\u5b58\u5728\u66f4\u591a\u65b9\u6848\uff0c\u5bf9\u4e8e\u901a\u8fc7\u57fa\u56e0\u7f16\u8f91\u7684\u65b9\u5f0f\u6765\u5e2e\u52a9\u5a74\u513f\u62b5\u6297HIV\u7406\u8bba\u4e0a\u6709\u6548\u6027\u66f4\u9ad8\uff0c\u4e5f\u76f8\u5bf9\u66f4\u5b89\u5168\u3002<\/p>\n

\u4f46\u5f20\u5cf0\u540c\u65f6\u5f3a\u8c03\uff0c\u6211\u4eec\u5728\u63a2\u7d22\u5176\u4ed6\u89e3\u51b3\u65b9\u6848\u7684\u540c\u65f6\uff0c\u5e94\u8be5\u901a\u8fc7\u5b9e\u9a8c\u8fdb\u884c\u66f4\u591a\u7684\u7814\u7a76\uff0c\u53cd\u590d\u8bc1\u660e\u6280\u672f\u7684\u5176\u53ef\u884c\u6027\u548c\u5b89\u5168\u6027\uff0c\u7136\u540e\u518d\u8fdb\u884c\u5b9e\u65bd\u3002<\/p>\n

\u5bf9\u4e8e\u5982\u4f55\u80fd\u591f\u8bc1\u660e\u8fd9\u5bf9\u53cc\u80de\u80ce\u5a74\u513f\u80fd\u591f\u5929\u7136\u62b5\u6297\u827e\u6ecb\u75c5\u7684\u95ee\u9898\uff0c\u5f20\u5cf0\u79f0\uff0c\u53ef\u4ee5\u901a\u8fc7\u4ece\u5a74\u513f\u4f53\u5185\u62bd\u8840\uff0c\u5e76\u5c06\u5176\u4e0eHIV\u75c5\u6bd2\u7ed3\u5408\uff0c\u89c2\u5bdf\u662f\u5426\u4f1a\u88abHIV\u611f\u67d3\u6765\u5224\u65ad\u3002<\/p>\n

\u6709\u5173\u4e2d\u56fd\u5730\u533a\u76f8\u5173\u653f\u7b56\u6cd5\u89c4\u7a7a\u767d\u7684\u95ee\u9898\uff0c\u5f20\u5cf0\u8868\u793a\uff0c\u653f\u5e9c\u5e94\u8be5\u51fa\u53f0\u5b8c\u5584\u7684\u6574\u4f53\u67b6\u6784\uff0c\u5e76\u7531\u6307\u5b9a\u90e8\u95e8\u8d1f\u8d23\u5b8c\u5584\u3002\uff08\u65b0\u4eac\u62a5\u8bb0\u8005 \u6768\u783a\u00a0 \u7f16\u8f91 \u6881\u7f18 \u6821\u5bf9 \u674e\u94ed\uff09<\/p>\n

\"\"<\/a><\/p>\n

\u6863\u6848\uff1a\u5f20\u950b\uff0c\u7537\uff0c1982\u5e74\u51fa\u751f\u4e8e\u6cb3\u5317\u77f3\u5bb6\u5e84\uff0c\u65af\u5766\u798f\u5927\u5b66\u5316\u5b66\u53ca\u751f\u7269\u5de5\u7a0b\u535a\u58eb\uff0c\u662f\u5f53\u4eca\u6700\u4e3a\u4eba\u6240\u5173\u6ce8\u7684\u534e\u4eba\u751f\u7269\u5b66\u5bb6\u3002\u4ed6\u6700\u8457\u540d\u7684\u5de5\u4f5c\u662f\u57fa\u56e0\u4fee\u9970\u6280\u672fCRISPR-Cas9\u7684\u53d1\u5c55\u548c\u5e94\u7528\uff0c\u7387\u5148\u83b7\u5f97\u4e86\u7f8e\u56fd\u4e13\u5229\u3002 2016\u5e749\u670821\u65e5\uff0c\u5165\u9009\u5f15\u6587\u6842\u51a0\u5956\u5316\u5b66\u9886\u57df\u7684\u83b7\u5956\u540d\u5355\u00a0\u00a0\u30022017\u5e74\u664b\u5347\u4e3a\u7f8e\u56fd\u9ebb\u7701\u7406\u5de5\u5b66\u9662\u7406\u5b66\u9662\u7ec8\u8eab\u6559\u6388\u00a0\u30022017\u5e748\u670815\u65e5\uff0c\u5f20\u950b\u83b7\u963f\u5c14\u4f2f\u5c3c\u751f\u7269\u533b\u5b66\u5956\uff0c\u6210\u4e3a\u5386\u53f2\u4e0a\u7b2c\u4e8c\u540d\u83b7\u5f97\u6b64\u5956\u9879\u7684\u534e\u4eba\u5b66\u8005\u3002\u00a0<\/sup>2018\u5e744\u6708\uff0c\u83b7\u5f97\u7f8e\u56fd\u4eba\u6587\u4e0e\u79d1\u5b66\u5b66\u9662\u9662\u58eb\u3002\uff08\u6765\u6e90\uff1a\u767e\u5ea6\u767e\u79d1\uff09<\/p>\n

\"\"<\/a><\/p>\n

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