{"id":1375179,"date":"2018-12-03T20:25:09","date_gmt":"2018-12-04T04:25:09","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=1375179"},"modified":"2018-12-03T20:38:35","modified_gmt":"2018-12-04T04:38:35","slug":"%e8%8d%af%e6%98%8e%e5%ba%b7%e5%be%b7%e6%8a%a5%e9%81%93%ef%bc%9a%e3%80%90nature%e3%80%8f%e7%bb%bc%e8%bf%b0pd-1-pd-l1%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e7%96%97%e6%b3%95%e7%8e%b0%e7%8a%b6%e4%b8%8e","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/%e8%8d%af%e6%98%8e%e5%ba%b7%e5%be%b7%e6%8a%a5%e9%81%93%ef%bc%9a%e3%80%90nature%e3%80%8f%e7%bb%bc%e8%bf%b0pd-1-pd-l1%e8%82%bf%e7%98%a4%e5%85%8d%e7%96%ab%e7%96%97%e6%b3%95%e7%8e%b0%e7%8a%b6%e4%b8%8e\/.html","title":{"rendered":"\u836f\u660e\u5eb7\u5fb7\u62a5\u9053\uff1a\u3010Nature\u3011\u7efc\u8ff0PD-1\/PD-L1\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u73b0\u72b6\u4e0e\u524d\u666f"},"content":{"rendered":"

\u836f\u660e\u5eb7\u5fb7<\/span>\u7f16\u8bd1\u6574\u7406\uff08\u6765\u6e90\uff1aNature Reviews Drug Discovery)<\/p>\n

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\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u901a\u8fc7\u963b\u65adPD-1\u7b49\u514d\u75ab\u68c0\u67e5\u70b9\u4e0e\u914d\u4f53\u7ed3\u5408\uff0c\u6765\u6d88\u9664\u5bf9T\u7ec6\u80de\u6d3b\u6027\u7684\u6291\u5236\uff0c\u4ece\u800c\u63d0\u9ad8T\u7ec6\u80de\u6740\u4f24\u80bf\u7624\u7684\u80fd\u529b\u3002\u8fd9\u7c7b\u7597\u6cd5\u95ee\u4e16\u4ee5\u6765\u5df2\u88ab\u7528\u4e8e\u6cbb\u7597\u591a\u79cd\u764c\u75c7\uff0c\u5305\u62ec\u9ed1\u8272\u7d20\u7624\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u5934\u9888\u764c\u3001\u5bab\u9888\u764c\u7b49\u7b49\u3002\u4eca\u5e74\uff0c\u9488\u5bf9PD-1\/PD-L1\u7684\u836f\u7269\u6b63\u57282250\u9879\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8fdb\u884c\u8bc4\u4f30\uff0c\u6bd4\u53bb\u5e74\u589e\u52a0\u4e86748\u9879\u3002<\/strong>\u9886\u5934\u7684\u662f\u9ed8\u6c99\u4e1c\u7684pembrolizumab\uff08Keytruda\uff09\uff0c\u4eca\u5e74\u6709753\u9879\u4e34\u5e8a\u8bd5\u9a8c\uff1b\u7d27\u63a5\u5176\u540e\u7684\u662f\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u7684nivolumab\uff08Opdivo\uff09\uff0c\u6709639\u9879\u4e34\u5e8a\u8bd5\u9a8c\u3002\u8fd9\u4e9b\u4e34\u5e8a\u5b9e\u9a8c\u4e2d\u65e2\u6709\u5355\u72ec\u7528\u836f\uff0c\u4e5f\u6709\u7ec4\u5408\u7597\u6cd5\u7684\u7814\u7a76\u3002<\/p>\n

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\u4ece\u5f00\u53d1\u836f\u7269\u7684\u56fd\u5bb6\u548c\u5730\u533a\u6765\u770b\uff0c\u7f8e\u56fd\u4f9d\u7136\u5728\u7ec6\u80de\u57fa\u56e0\u7597\u6cd5\u9886\u57df\u5e26\u5934\uff0c\u5171\u6709345\u9879\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5176\u4e2dCAR-T\u7ea6\u5360\u534a\u6570\uff1b\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u4e2d\u56fd\u4e5f\u5728\u7ec6\u80de\u57fa\u56e0\u7597\u6cd5\u9886\u57df\u53d1\u5c55\u58ee\u5927\uff0c\u4f4d\u4e8e\u4e16\u754c\u7b2c\u4e8c\uff0c\u5176\u4e2d\u7ea63\/4\u662fCAR-T\u3002\u5176\u4e2d\uff0c\u4e00\u4e9b\u4e2d\u56fd\u81ea\u4e3b\u539f\u521b\u7684\u672c\u571fPD-1\/PD-L1\u836f\u7269\u5373\u5c06\u5728\u4e2d\u56fd\u83b7\u6279\uff0c\u4f30\u8ba1\u4f1a\u5bf9\u4e16\u754c\u5176\u4ed6\u5730\u533a\u4e5f\u4ea7\u751f\u5f71\u54cd\uff0c\u975e\u5e38\u503c\u5f97\u671f\u5f85\u3002<\/strong><\/p>\n

\u76f8\u5173\u9605\u8bfb\uff1a<\/strong>Nature\u7efc\u8ff0\uff1a\u5168\u7403\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u6709\u54ea\u51e0\u5927\u8d8b\u52bf\uff1f<\/a><\/p>\n

\u53c2\u8003\u8d44\u6599<\/p>\n

1. New Report Charts Dramatic Growth in the Global Clinical Trial Landscape for PD-1\/L1 Immune Checkpoint Inhibitors, retrieved 2018\/11\/30, https:\/\/www.cancerresearch.org\/news\/2018\/pd-1-l1-checkpoint-inhibitor-landscape-analysis<\/p>\n

2.\u00a0Landscape of Immuno-Oncology Drug Development, retrieved 2018\/11\/30, from https:\/\/www.cancerresearch.org\/scientists\/clinical-accelerator\/landscape-of-immuno-oncology-drug-development<\/p>\n

3. The number of I\/O cancer drugs in the clinic continues to swell at an explosive pace \u2014 offering new hope, fresh concerns, retrieved 2018\/11\/30, https:\/\/endpts.com\/the-number-of-new-i-o-cancer-drugs-in-the-clinic-continues-to-swell-at-an-explosive-pace-offering-new-hope-fresh-concerns\/<\/p>\n

4. Jun Tang et al., The clinical trial landscape for PD1\/ PDL1 immune checkpoint inhibitors, Nature Reviews Drug Discovery, 2018, doi:10.1038\/nrd.2018.210<\/p>\n

\u672c\u6587\u6765\u81ea\u836f\u660e\u5eb7\u5fb7\u5fae\u4fe1\u56e2\u961f\uff0c\u6b22\u8fce\u8f6c\u53d1\u5230\u670b\u53cb\u5708\uff0c\u8c22\u7edd\u8f6c\u8f7d\u5230\u5176\u4ed6\u5e73\u53f0\uff1b\u5982\u6709\u5f00\u8bbe\u767d\u540d\u5355\u9700\u6c42\uff0c\u8bf7\u5728\u6587\u7ae0\u5e95\u90e8\u7559\u8a00\uff1b\u5982\u6709\u5176\u4ed6\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u8054\u7cfbwuxi_media@wuxiapptec.com<\/p>\n","protected":false},"excerpt":{"rendered":"

\u836f\u660e\u5eb7\u5fb7\u7f16\u8bd1\u6574\u7406\uff08\u6765\u6e90\uff1aNature Reviews Drug Discovery) \u8fd1\u5e74\u6765\uff0c\u7531\u4e8e\u514d\u75ab\u7597\u6cd5\u5728\u80bf … \u7ee7\u7eed\u9605\u8bfb\u836f\u660e\u5eb7\u5fb7\u62a5\u9053\uff1a\u3010Nature\u3011\u7efc\u8ff0PD-1\/PD-L1\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u73b0\u72b6\u4e0e\u524d\u666f<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":1375184,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-1375179","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science_technology_education"],"_links":{"self":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1375179","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/comments?post=1375179"}],"version-history":[{"count":0,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1375179\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media\/1375184"}],"wp:attachment":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media?parent=1375179"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/categories?post=1375179"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/tags?post=1375179"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}