{"id":1452869,"date":"2019-04-24T13:59:34","date_gmt":"2019-04-24T20:59:34","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=1452869"},"modified":"2019-04-24T14:03:57","modified_gmt":"2019-04-24T21:03:57","slug":"%e4%bb%8a%e6%97%a5%e3%80%8a%e8%87%aa%e7%84%b6%e3%80%8b%e6%8a%a5%e9%81%93%ef%bc%9a%e5%8a%a0%e5%a4%a7%e5%9c%a3%e5%9c%b0%e4%ba%9a%e5%93%a5%e5%88%86%e6%a0%a1%e5%ad%a6%e8%80%85%e5%8f%91%e7%8e%b0%e6%8a%97","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/%e4%bb%8a%e6%97%a5%e3%80%8a%e8%87%aa%e7%84%b6%e3%80%8b%e6%8a%a5%e9%81%93%ef%bc%9a%e5%8a%a0%e5%a4%a7%e5%9c%a3%e5%9c%b0%e4%ba%9a%e5%93%a5%e5%88%86%e6%a0%a1%e5%ad%a6%e8%80%85%e5%8f%91%e7%8e%b0%e6%8a%97\/.html","title":{"rendered":"\u4eca\u65e5\u300a\u81ea\u7136\u300b\uff1a\u7ed9\u764c\u7ec6\u80de\u201c\u4e0a\u6237\u53e3\u201d\u52a0\u5927\u5723\u5730\u4e9a\u54e5\u5206\u6821\u5b66\u8005\u53d1\u73b0\u6297\u764c\u65b0\u8def\uff08\u56fe\uff09"},"content":{"rendered":"\n<p>\u4eba\u7c7b\u5bf9\u4e8e\u764c\u75c7\u7684\u8ba4\u77e5\u603b\u662f\u5448\u87ba\u65cb\u5f0f\u4e0a\u5347\u3002\u8fc7\u53bb\uff0c\u6211\u4eec\u7b80\u5355\u5730\u4ee5\u4e3a\u764c\u75c7\u6309\u53d1\u75c5\u90e8\u4f4d\u533a\u5206\uff0c\u957f\u5728\u80ba\u90e8\u7684\u90fd\u662f\u80ba\u764c\uff0c\u957f\u5728\u80c3\u90e8\u7684\u90fd\u662f\u80c3\u764c\u3002<strong>\u5728\u8fd9\u79cd\u7b80\u5355\u7c97\u66b4\u7684\u8ba4\u77e5\u4e0b\uff0c\u53ea\u8981\u662f\u540c\u4e00\u4e2a\u90e8\u4f4d\u7684\u764c\u75c7\uff0c\u533b\u751f\u4eec\u5f80\u5f80\u90fd\u4f1a\u91c7\u7528\u4e00\u5200\u5207\u7684\u6cbb\u7597\u65b9\u6848\u3002<\/strong><\/p>\n\n\n\n<p>\u800c\u968f\u7740\u4eba\u7c7b\u57fa\u56e0\u7ec4\u7684\u6d4b\u5e8f\u5b8c\u6210\uff0c\u6211\u4eec\u5728\u7cbe\u51c6\u533b\u5b66\u4e0a\u53d6\u5f97\u4e86\u5de8\u5927\u7684\u8fdb\u6b65\u3002\u73b0\u5728\u6211\u4eec\u77e5\u9053\uff0c<strong>\u5373\u4fbf\u662f\u540c\u4e00\u4e2a\u90e8\u4f4d\u7684\u764c\u75c7\uff0c\u80cc\u540e\u53ef\u80fd\u4e5f\u6709\u4e0d\u540c\u7684\u81f4\u764c\u7a81\u53d8\u3002<\/strong>\u5bf9\u6b64\uff0c\u6211\u4eec\u9700\u8981\u4f7f\u7528\u4e0d\u540c\u7684\u9776\u5411\u836f\u8fdb\u884c\u6cbb\u7597\u3002\u540c\u7406\uff0c<strong>\u75c5\u53d1\u4e8e\u4e0d\u540c\u90e8\u4f4d\u7684\u591a\u79cd\u764c\u75c7\uff0c\u80cc\u540e\u53ef\u80fd\u5e26\u6709\u76f8\u540c\u7684\u9057\u4f20\u53d8\u5f02\u3002<\/strong>\u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0c\u201c\u5e7f\u8c31\u201d\u6297\u764c\u836f\u53ef\u4ee5\u540c\u65f6\u5bf9\u591a\u79cd\u764c\u75c7\u8fdb\u884c\u6cbb\u7597\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_png\/UdvecgtVRYKuPR7fN6KVT53NcPdVtb4kiaY75QLNKTtwuSHE9jEJUEARTib2X4P7WbbicChXz19xRfTbeeXvX4hsg\/640?wx_fmt=png\" alt=\"\"\/><\/figure>\n\n\n\n<p>\u4eca\u65e5\uff0c\u9876\u5c16\u5b66\u672f\u671f\u520a\u300a\u81ea\u7136\u300b\u4e0a\u520a\u767b\u7684\u4e00\u9879\u7814\u7a76\uff0c\u5219\u8ba9\u6211\u4eec\u5bf9\u764c\u75c7\u7684\u8ba4\u77e5\u53c8\u6df1\u4e86\u4e00\u5c42\u2014\u2014<strong>\u75c5\u53d1\u4e8e\u4e0d\u540c\u90e8\u4f4d\u7684\u764c\u7ec6\u80de\uff0c\u53ef\u80fd\u4f1a\u5e26\u6709\u622a\u7136\u4e0d\u540c\u7684\u4ee3\u8c22\u901a\u8def\u3002<\/strong><strong>\u800c\u963b\u65ad\u8fd9\u4e9b\u4ee3\u8c22\u901a\u8def\uff0c\u5c31\u6709\u671b\u8ba9\u6211\u4eec\u5bf9\u8fd9\u4e9b\u764c\u75c7\u8fdb\u884c\u6cbb\u7597\u3002<\/strong><\/p>\n\n\n\n<p>\u8fd9\u9879\u7814\u7a76\u7531\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821\u7684Paul S. Mischel\u6559\u6388\u4e3b\u5bfc\uff0c\u4efb\u5175\u6559\u6388\u4e0eVineet Bafna\u6559\u6388\u56e2\u961f\u5171\u540c\u53c2\u4e0e\u5408\u4f5c\u3002\u7814\u7a76\u4e2d\uff0c\u79d1\u5b66\u5bb6\u4eec\u5c06\u76ee\u5149\u6295\u5411\u4e86\u4e00\u7c7b\u53eb\u505aNAD\u7684\u5c0f\u5206\u5b50\u4e0a\uff0c\u5b83\u5728\u6c27\u5316\u8fd8\u539f\u53cd\u5e94\u4e2d\u8d77\u5230\u4e86\u4f20\u9012\u7535\u5b50\u7684\u5173\u952e\u4f5c\u7528\uff0c\u662f\u7ec6\u80de\u4ee3\u8c22\u6240\u4e0d\u53ef\u6216\u7f3a\u7684\u3002<strong>\u5728\u54fa\u4e73\u52a8\u7269\u7ec6\u80de\u4e2d\uff0c\u4e00\u5171\u6709\u4e09\u79cd\u5408\u6210NAD\u7684\u4ee3\u8c22\u901a\u8def<\/strong>\uff0c\u800c\u4e0d\u540c\u7ec6\u80de\u9009\u62e9\u5177\u4f53\u901a\u8def\u7684\u673a\u5236\u5219\u5c1a\u6ca1\u6709\u5f97\u5230\u5f88\u597d\u7684\u9610\u660e\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/UdvecgtVRYKuPR7fN6KVT53NcPdVtb4kvpsGoAnP0AFXAOrtmQwvXcTbYlnruenfBJ7fChiajNvFh6xmib4m1U6Q\/640?wx_fmt=jpeg\" alt=\"\"\/><\/figure>\n\n\n\n<p><strong>\u25b2<\/strong><strong>\u672c\u7814\u7a76\u7684\u901a\u8baf\u4f5c\u8005Paul S. Mischel\u6559\u6388\uff08\u56fe\u7247\u6765\u6e90\uff1a<\/strong><strong>Paul S. Mischel\u6559\u6388\u5b9e\u9a8c\u5ba4\u5b98\u7f51\uff09<\/strong><\/p>\n\n\n\n<p>\u4e3a\u4e86\u7814\u7a76\u764c\u7ec6\u80de\u4f1a\u9009\u62e9\u54ea\u4e00\u6761NAD\u5408\u6210\u901a\u8def\uff0c\u7814\u7a76\u56e2\u961f\u505a\u4e86\u4e00\u573a\u5927\u89c4\u6a21\u7684\u5206\u6790\u3002\u4ed6\u4eec<strong>\u5206\u6790\u4e867000\u591a\u4e2a\u6765\u81ea\u80bf\u7624\u7684\u6837\u672c\uff0c\u4ee5\u53ca2600\u591a\u4e2a\u6765\u81ea\u6b63\u5e38\u7ec4\u7ec7\u7684\u6837\u672c\uff0c\u6d89\u53ca\u7684\u7ec4\u7ec7\u7c7b\u578b\u9ad8\u8fbe19\u79cd\u3002<\/strong>\u7136\u540e\uff0c\u4ed6\u4eec\u5e94\u7528\u6570\u5b66\u5efa\u6a21\uff0c\u5e76\u5728\u7ec6\u80de\u5b9e\u9a8c\u548c\u5c0f\u9f20\u5b9e\u9a8c\u4e2d\u9a8c\u8bc1\u5047\u8bbe\uff0c\u60f3\u8981\u603b\u7ed3\u51fa\u7279\u5b9a\u7684\u89c4\u5f8b\uff0c\u63a2\u7d22\u764c\u7ec6\u80de\u9009\u62e9NAD\u5408\u6210\u901a\u8def\u7684\u79d8\u5bc6\uff0c\u4ece\u800c\u5bfb\u627e\u6f5c\u5728\u7684\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n\n\n\n<p><strong>\u8c01\u4e5f\u6ca1\u6709\u60f3\u5230\uff0c\u764c\u7ec6\u80de\u5c45\u7136\u5728\u8fd9\u4e2a\u751f\u6b7b\u6538\u5173\u7684\u95ee\u9898\u4e0a\u5077\u8d77\u4e86\u61d2\u2026\u2026<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_png\/UdvecgtVRYKuPR7fN6KVT53NcPdVtb4kOAUvFmWIfRcaBz5Nia7rlrEPOqoD9fnbRp35TTfoSP86epndonsfDLA\/640?wx_fmt=png\" alt=\"\"\/><\/figure>\n\n\n\n<p><strong>\u25b2<\/strong><strong>\u6b63\u5e38\u7ec6\u80de\u5185\u7684\u4e0d\u540cNAD\u5408\u6210\u901a\u8def\uff08\u56fe\u7247\u6765\u6e90\uff1a\u53c2\u8003\u8d44\u6599[1]<\/strong><strong>\uff09<\/strong><\/p>\n\n\n\n<p>\u5728\u6b63\u5e38\u7ec6\u80de\u4e2d\uff0c\u4e00\u79cd\u53eb\u505aNAPRT\u7684\u9176\u662f\u5408\u6210NAD\u7684\u5173\u952e\u3002\u7814\u7a76\u4eba\u5458\u4eec\u53d1\u73b0\uff0c<strong>\u5982\u679c\u4e00\u7c7b\u6b63\u5e38\u7ec4\u7ec7\u91cc\uff0cNAPRT\u7684\u8868\u8fbe\u6c34\u5e73\u8f83\u9ad8\uff0c\u6765\u81ea\u8fd9\u79cd\u7ec4\u7ec7\u7684\u764c\u7ec6\u80de\uff0c\u5c31\u4f1a\u5927\u91cf\u8868\u8fbe\u8fd9\u79cd\u9176\u3002<\/strong>\u8fd9\u4f7f\u5f97\u8fd9\u4e9b\u764c\u7ec6\u80de\u51e0\u4e4e\u5b8c\u5168\u4f9d\u8d56\u4e8e\u8fd9\u4e00\u6761\u5408\u6210\u901a\u8def\u6765\u4ea7\u751fNAD\u3002\u5206\u6790\u8868\u660e\uff0c\u524d\u5217\u817a\u764c\u3001\u5375\u5de2\u764c\u3001\u80f0\u817a\u764c\u3001\u80c3\u80a0\u9053\u764c\u75c7\u7b49\uff0c\u90fd\u5b58\u5728\u8fd9\u4e00\u73b0\u8c61\u3002<\/p>\n\n\n\n<p>\u4e0e\u4e4b\u76f8\u53cd\uff0c\u5982\u679c\u67d0\u79cd\u6b63\u5e38\u7ec4\u7ec7\u672c\u8eab\u7684NAPRT\u8868\u8fbe\u91cf\u4e0d\u9ad8\uff0c\u6765\u6e90\u4e8e\u8fd9\u7c7b\u7ec4\u7ec7\u7684\u764c\u7ec6\u80de\u5c31\u4f1a\u4f9d\u8d56\u5176\u4ed6\u7684NAD\u5408\u6210\u901a\u8def\u6765\u751f\u5b58\u3002<\/p>\n\n\n\n<p>\u8fd9\u662f\u4ec0\u4e48\u6982\u5ff5\u5462\uff1f\u7b80\u5355\u8bb2\uff0c\u666e\u901a\u7ec6\u80de\u80fd\u4ece3\u79cdNAD\u5408\u6210\u901a\u8def\u91cc\u9009\u62e9\u4e00\u79cd\u4f7f\u7528\uff0c\u800c\u201c\u5077\u61d2\u201d\u7684\u764c\u7ec6\u80de\u5219\u4f1a\u76ef\u7740\u4e00\u6761\u901a\u8def\u4e0d\u653e\u3002<strong>\u5982\u679c\u7ed9\u764c\u7ec6\u80de\u201c\u4e0a\u6237\u53e3\u201d\uff0c\u627e\u5230\u5b83\u4eec\u7684\u6765\u6e90\uff0c\u5e76\u6291\u5236\u764c\u7ec6\u80de\u5185\u7684\u8fd9\u6761NAD\u5408\u6210\u901a\u8def\uff0c\u5c31\u80fd\u6740\u6b7b\u764c\u7ec6\u80de\u3002<\/strong>\u7406\u8bba\u4e0a\u8bf4\uff0c\u7531\u4e8e\u53ef\u4ee5\u9009\u62e9\u5176\u4ed6\u901a\u8def\uff0c\u666e\u901a\u7ec6\u80de\u53d7\u5230\u7684\u6f5c\u5728\u5f71\u54cd\u4f1a\u6bd4\u8f83\u6709\u9650\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/mmbiz.qpic.cn\/mmbiz_png\/UdvecgtVRYKuPR7fN6KVT53NcPdVtb4kZzSj6jVQWBI0C6X3ia9tznuWcxAnkUDiaG1uuXqsZRfm2cxdqY7VTDQA\/640?wx_fmt=png\" alt=\"\"\/><\/figure>\n\n\n\n<p><strong>\u25b2<\/strong><strong>\u5728\u7ec6\u80de\u5b9e\u9a8c\u548c\u5c0f\u9f20\u5b9e\u9a8c\u4e2d\uff0c\u8fd9\u79cd\u6cbb\u7597\u601d\u8def\u5f97\u5230\u4e86\u68c0\u9a8c\uff08\u56fe\u7247\u6765\u6e90\uff1a\u53c2\u8003\u8d44\u6599[1]<\/strong><strong>\uff09<\/strong><\/p>\n\n\n\n<p>\u4e3a\u4e86\u9a8c\u8bc1\u8fd9\u4e00\u60f3\u6cd5\uff0c\u7814\u7a76\u4eba\u5458\u4eec\u4f7f\u7528\u4e86\u4e00\u79cd\u6291\u5236\u5242\uff0c\u6765\u6291\u5236\u7279\u5b9aNAD\u5408\u6210\u901a\u8def\u3002\u7ec6\u80de\u5b9e\u9a8c\u8868\u660e\uff0c<strong>\u5b83\u7684\u786e\u53ef\u4ee5\u51cf\u5c11NAD\u7684\u5408\u6210\uff0c\u5e76\u6291\u5236\u764c\u7ec6\u80de\u7cfb\u7684\u751f\u957f\u3002<\/strong>\u800c\u8fd9\u4e9b\u6291\u5236\u5242\u5bf9\u4e8e\u4e0d\u91c7\u7528\u8fd9\u6761\u901a\u8def\u7684\u6b63\u5e38\u7ec6\u80de\uff0c\u5176\u5f71\u54cd\u51e0\u4e4e\u53ef\u4ee5\u5ffd\u7565\u4e0d\u8ba1\u3002<\/p>\n\n\n\n<p><strong>\u5728\u5c0f\u9f20\u7684\u5375\u5de2\u764c\u6a21\u578b\u4e2d\uff0c\u8fd9\u4e00\u6cbb\u7597\u601d\u8def\u7684\u53ef\u884c\u6027\u4e5f\u540c\u6837\u5f97\u5230\u4e86\u786e\u8ba4\u3002<\/strong>\u63a5\u53d7\u6cbb\u7597\u7684\u5c0f\u9f20\uff0c\u5176\u80bf\u7624\u5185\u7684NAD\u6c34\u5e73\u51fa\u73b0\u4e0b\u964d\uff0c\u80bf\u7624\u751f\u957f\u4e5f\u5f97\u5230\u4e86\u6291\u5236\u3002<\/p>\n\n\n\n<p>\u201c\u6211\u4eec\u7684\u5de5\u4f5c\u5728\u4e0d\u540c\u80bf\u7624\u7c7b\u578b\u4e2d\uff0c\u627e\u5230\u4e86\u80bf\u7624\u7ec6\u80de\u7279\u5f02\u7684NAD\u4ee3\u8c22\u901a\u8def\uff0c\u5e76\u80fd\u5bf9\u5176\u8fdb\u884c\u9776\u5411\u3002\u8fd9\u4e3a\u5c06\u6765<strong>\u5177\u6709\u7279\u5f02\u6027\u3001\u9009\u62e9\u6027\u3001\u4e0d\u5f71\u54cd\u6b63\u5e38\u7ec4\u7ec7\u3001\u4e14\u6709\u5de8\u5927\u6f5c\u529b\u7684\u764c\u75c7\u6cbb\u7597\u65b9\u6cd5\u5960\u5b9a\u4e86\u57fa\u7840<\/strong>\u3002\u201d\u672c\u7814\u7a76\u7684\u901a\u8baf\u4f5c\u8005Mischel\u6559\u6388\u70b9\u8bc4\u9053\u3002<\/p>\n\n\n\n<p>\u6211\u4eec\u795d\u8d3a\u6240\u6709\u53c2\u4e0e\u672c\u7814\u7a76\u7684\u79d1\u5b66\u5bb6\u80fd\u591f\u505a\u51fa\u8fd9\u4e00\u91cd\u8981\u53d1\u73b0\uff0c\u4e5f\u671f\u5f85\u5c0f\u9f20\u7814\u7a76\u7684\u7ed3\u679c\u80fd\u5728\u4eba\u7c7b\u60a3\u8005\u4e2d\u5f97\u5230\u91cd\u590d\uff0c\u65e9\u65e5\u4e3a\u60a3\u8005\u5e26\u6765\u5168\u65b0\u7684\u6cbb\u7597\u65b9\u6848\uff01<\/p>\n\n\n\n<p>\u53c2\u8003\u8d44\u6599\uff1a<\/p>\n\n\n\n<p>[1] Sudhir Chowdhry et al., (2019), NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodeling, Nature, https:\/\/doi.org\/10.1038\/s41586-019-1150-2<\/p>\n\n\n\n<p>[2] Exposing cancer&#8217;s metabolic addictions, Retrieved April 24, 2019, from https:\/\/www.eurekalert.org\/pub_releases\/2019-04\/uoc&#8211;ecm042219.php<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8fd9\u9879\u7814\u7a76\u7531\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821\u7684Paul S. 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