{"id":1456786,"date":"2019-09-19T19:15:24","date_gmt":"2019-09-20T02:15:24","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=1456786"},"modified":"2019-09-19T19:22:06","modified_gmt":"2019-09-20T02:22:06","slug":"%e5%9c%a3%e5%9c%b0%e4%ba%9a%e5%93%a5%e7%94%9f%e7%89%a9%e6%8a%80%e6%9c%af%e5%85%ac%e5%8f%b8%e4%b8%ad%e5%a4%96%e4%ba%ba%e5%91%98%e7%a0%94%e5%8f%91%e9%9d%b6%e5%90%91%e6%b2%bb%e7%96%97%e6%9f%93%e8%89%b2","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/%e5%9c%a3%e5%9c%b0%e4%ba%9a%e5%93%a5%e7%94%9f%e7%89%a9%e6%8a%80%e6%9c%af%e5%85%ac%e5%8f%b8%e4%b8%ad%e5%a4%96%e4%ba%ba%e5%91%98%e7%a0%94%e5%8f%91%e9%9d%b6%e5%90%91%e6%b2%bb%e7%96%97%e6%9f%93%e8%89%b2\/.html","title":{"rendered":"\u5723\u5730\u4e9a\u54e5\u751f\u7269\u6280\u672f\u516c\u53f8\u4e2d\u5916\u4eba\u5458\u7814\u53d1\u9776\u5411\u6cbb\u7597\u67d3\u8272\u4f53\u5916DNA\uff08\u56fe\uff09"},"content":{"rendered":"

\u836f\u660e\u5eb7\u5fb7\u62a5\u9053\uff1a\u8fd9\u51e0\u5929\u5723\u5730\u4e9a\u54e5\u7684\u751f\u7269\u6280\u672f\u516c\u53f8 Boundless Bio\u540d\u58f0\u5927\u626c\u3002\u8be5\u516c\u53f8\u9996\u5e2d\u6267\u884c\u5b98 Zachary Hornby \u5148\u751f\u8c6a\u8fc8\u5730\u900f\u9732\uff1a\u516c\u53f8\u6380\u5f00\u4e86\u764c\u75c7\u6cbb\u7597\u7684\u7b2c\u56db\u6b21\u9769\u547d\u3002<\/p>\n

Hornsby \u6267\u884c\u5b98\u6240\u6307\u7684\u764c\u75c7\u6cbb\u7597\u7684\u524d\u4e09\u6b21\u9769\u547d\u5206\u522b\u662f\u4e0a\u4e16\u7eaa40\u5e74\u4ee3\u8bde\u751f\u7684\u5316\u7597\u3001\u4e0a\u4e16\u7eaa\u672b\u8bde\u751f\u7684\u9776\u5411\u7597\u6cd5\u3001\u548c\u8fd1\u4e9b\u5e74\u8bde\u751f\u7684\u514d\u75ab\u7597\u6cd5\u3002\u90a3\u80fd\u4e0e\u8fd9\u4e09\u5927\u9769\u547d\u76f8\u63d0\u5e76\u8bba\uff0c\u8be5\u6267\u884c\u5b98\u8c6a\u8fc8\u7684\u5e95\u6c14\u4ece\u54ea\u800c\u6765\uff1f<\/p>\n

\u4ed6\u7684\u56de\u7b54\u662f\u6211\u4eec\u7814\u53d1\u4e86\u201c\u67d3\u8272\u4f53\u5916DNA\u201d\uff08extrachromosomal DNA\uff0c\u7f29\u5199\u662fecDNA\uff09\u7684\u9776\u5411\u6cbb\u7597\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u56fe\u7247\u6765\u6e90\uff1aBoundless Bio\u5b98\u65b9\u7f51\u7ad9<\/p>\n

\u6ca1\u600e\u4e48\u542c\u8bf4\u8fc7\uff1f\u8fd9\u5c31\u5bf9\u4e86\u3002\u867d\u7136\u79d1\u5b66\u5bb6\u4eec\u65e9\u5728\u4e0a\u4e16\u7eaa70\u5e74\u4ee3\u5c31\u53d1\u73b0\u4e86\u8fd9\u4e9bDNA\u7684\u5b58\u5728\uff0c\u4f46\u76f4\u52302014\u5e74\uff0c\u4e00\u7bc7\u300a\u79d1\u5b66\u300b\u8bba\u6587\u624d\u63ed\u793a\u4e86\u5b83\u4eec\u4e0e\u80bf\u7624\u751f\u957f\u4e4b\u95f4\u7684\u5173\u8054\u3002<\/p>\n

\u6240\u4ee5\uff0c\u7a76\u7adf\u5565\u624d\u662fecDNA\uff1f\u6309\u7167\u5b9a\u4e49\uff0c\u8fd9\u6307\u7684\u662f\u72ec\u7acb\u4e8e\u67d3\u8272\u4f53\u5b58\u5728\u7684DNA\uff0c\u901a\u5e38\u662f\u73af\u5f62\u7ed3\u6784\uff0c\u6709\u70b9\u50cf\u7ec6\u83cc\u91cc\u7684\u8d28\u7c92\u3002\u8fd9\u4e9becDNA\u4e0a\u4e00\u822c\u6709\u591a\u6761\u5229\u4e8e\u7ec6\u80de\u751f\u5b58\u7684\u57fa\u56e0\u5b58\u5728\uff0c\u8fd9\u5176\u4e2d\u5c31\u5305\u62ec\u4e86\u81f4\u764c\u57fa\u56e0\u3002<\/p>\n

\"\"<\/a>\u56fe\u7247\u6765\u6e90\uff1aBoundless Bio\u5b98\u65b9\u7f51\u7ad9<\/p>\n

\u7531\u4e8e\u4e0d\u50cf\u67d3\u8272\u4f53\u90a3\u6837\u6709\u590d\u6742\u7684\u8f6c\u5f55\u8c03\u63a7\u673a\u5236\uff0c\u5b58\u5728\u4e8eecDNA\u4e0a\u7684\u57fa\u56e0\u4f1a\u5feb\u901f\u590d\u5236\uff0c\u9020\u6210\u7ec6\u80de\u5185\u7684\u81f4\u764c\u57fa\u56e0\u62f7\u8d1d\u6570\u98d9\u5347\u3002\u4e3a\u5565\u764c\u75c7\u90a3\u4e48\u96be\u6cbb\uff1f\u4e00\u4e9b\u79d1\u5b66\u5bb6\u8ba4\u4e3a\uff0c\u539f\u56e0\u6b63\u5728\u4e8e\u6b64\u3002<\/p>\n

\u6709\u4e00\u4e9b\u6743\u5a01\u7814\u7a76\u7684\u7ed3\u679c\u652f\u6301\u8fd9\u4e00\u89c2\u70b9\u3002\u57282017\u5e74\u53d1\u8868\u4e8e\u9876\u7ea7\u533b\u5b66\u671f\u520a\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\uff08NEJM\uff09\u7684\u4e00\u9879\u7814\u7a76\u4e2d\uff0c\u79d1\u5b66\u5bb6\u4eec\u53d1\u73b0\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\uff0c\u764c\u7ec6\u80de\u7684\u7a81\u53d8\u6570\u91cf\u662f\u591a\u662f\u5c11\uff0c\u5e76\u4e0d\u4f1a\u5f71\u54cd\u60a3\u8005\u7684\u9884\u540e\u3002\u76f8\u53cd\uff0c\u57fa\u56e0\u62f7\u8d1d\u6570\u53d8\u5316\u8d8a\u591a\u7684\u60a3\u8005\uff0c\u764c\u75c7\u5c31\u8d8a\u96be\u6cbb\uff0c\u4ed6\u4eec\u7684\u9884\u540e\u4e5f\u5c31\u8d8a\u5dee\u3002<\/p>\n

\"\"<\/a>\u56fe\u7247\u6765\u6e90\uff1a\u53c2\u8003\u8d44\u6599[2]<\/p>\n

\u56e0\u6b64\uff0cBoundless Bio\u76f8\u4fe1\u901a\u8fc7\u9776\u5411ecDNA\uff0c\u4ed6\u4eec\u80fd\u591f\u6709\u6548\u9488\u5bf9\u764c\u7ec6\u80de\u7684\u8010\u836f\u4e0e\u9003\u9038\uff0c\u6539\u53d8\u90a3\u4e9b\u96be\u6cbb\u764c\u75c7\u7684\u6cbb\u7597\u683c\u5c40\u3002Hornby\u5148\u751f\u900f\u9732\uff0cecDNA\u7684\u590d\u5236\u673a\u7406\u4e0e\u6b63\u5e38\u7684\u67d3\u8272\u4f53DNA\u6709\u7740\u4e9b\u8bb8\u4e0d\u540c\uff0c\u8fd9\u80fd\u8ba9\u79d1\u5b66\u5bb6\u4eec\u627e\u5230\u76f4\u63a5\u7279\u5f02\u6291\u5236ecDNA\u590d\u5236\u7684\u65b9\u6cd5\u3002\u4ed6\u4eec\u5728\u63a2\u7d22\u7684\u53e6\u4e00\u79cd\u65b9\u6cd5\uff0c\u5219\u662f\u6291\u5236ecDNA\u590d\u5236\u6240\u9700\u8981\u7684\u4ee3\u8c22\u901a\u8def\u3002<\/p>\n

\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0cBoundless Bio\u7684\u7ba1\u7406\u56e2\u961f\u5728\u4e1a\u5185\u6210\u540d\u5df2\u4e45\u3002\u5176\u9996\u5e2d\u6267\u884c\u5b98\u7684Hornby\u5148\u751f\u66fe\u62c5\u4efb\u8457\u540d\u751f\u7269\u6280\u672f\u516c\u53f8Ignyta\u7684\u9996\u5e2d\u8fd0\u8425\u5b98\uff0c\u800c\u8463\u4e8b\u4f1a\u4e3b\u5e2dJonathan Lim\u535a\u58eb\u4e5f\u66fe\u662fIgnyta\u7684\u9996\u5e2d\u6267\u884c\u5b98\u3002\u8fd9\u5bb6\u65b0\u9510\u516c\u53f8\u4e8e2017\u5e74\u88ab\u7f57\u6c0f\uff08Roche\uff09\u4ee517\u4ebf\u7f8e\u5143\u7684\u9ad8\u4ef7\u6536\u8d2d\uff0c\u5176\u5e26\u6765\u7684entrectinib\u4e5f\u5df2\u4e8e\u4eca\u5e74\u83b7\u6279\u4e0a\u5e02\u3002<\/p>\n

\"\"<\/a><\/p>\n

Ignyta\u56e2\u961f\u7684Hornby\u5148\u751f\uff08\u5de6\uff09\u4e0eLim\u535a\u58eb\uff08\u53f3\uff09\uff08\u56fe\u7247\u6765\u6e90\uff1a\u53c2\u8003\u8d44\u6599[3]\uff09<\/p>\n

\u5728\u4eca\u65e5\u95ea\u4eae\u767b\u573a\u4e4b\u9645\uff0cBoundless Bio\u4e5f\u5ba3\u5e03\u83b7\u5f97\u4e864600\u4e07\u7f8e\u5143\u7684A\u8f6e\u878d\u8d44\uff0c\u77e5\u540d\u98ce\u6295\u673a\u6784ARCH Venture Partners\u4e0eCity Hill Ventures\u5171\u540c\u9886\u6295\u3002<\/p>\n

\u6211\u4eec\u4e5f\u671f\u5f85\u5728\u8d44\u672c\u7684\u52a9\u529b\u4e0b\uff0c\u9776\u5411ecDNA\u7684\u6297\u764c\u7597\u6cd5\u80fd\u591f\u5b8c\u6210\u6982\u5ff5\u9a8c\u8bc1\uff0c\u65e9\u65e5\u4e3a\u96be\u6cbb\u7684\u764c\u75c7\u75c5\u60a3\u9020\u798f\u3002<\/p>\n

\u53c2\u8003\u8d44\u6599\uff1a
\n[1] Boundless Bio Launches to Deliver Transformative Therapies to Patients with Difficult-to-Treat Cancers Driven by Extrachromosomal DNA, Retrieved September 19, 2019, from https:\/\/www.businesswire.com\/news\/home\/20190919005166\/en\/Boundless-Bio-Launches-Deliver-Transformative-Therapies-Patients
\n[2] Mariam Jamal-Hanjani et al., (2019), Tracking the Evolution of Non\u2013Small-Cell Lung Cancer, NEJM, DOI: 10.1056\/NEJMoa1616288
\n[3] Boundless Bio\u5b98\u65b9\u7f51\u7ad9, Retrieved September 19, 2019, from https:\/\/boundlessbio.com\/<\/p>\n

\uff08\u836f\u660e\u5eb7\u5fb7\u62a5\u9053 \u7f8e\u56fd\u534e\u6587\u7f51 \u5723\u5730\u4e9a\u54e5\u534e\u6587\u7f51\u7f16\u53d1 USChinesePress.com SanDiegoChinesePress.com)<\/p>\n","protected":false},"excerpt":{"rendered":"

\u8fd9\u51e0\u5929\u5723\u5730\u4e9a\u54e5\u7684\u751f\u7269\u6280\u672f\u516c\u53f8 Boundless Bio\u540d\u58f0\u5927\u626c\u3002\u8be5\u516c\u53f8\u9996\u5e2d\u6267\u884c\u5b98 Zachary Hornby \u5148\u751f\u8c6a\u8fc8\u5730\u900f\u9732……..<\/p>\n","protected":false},"author":3,"featured_media":1456788,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-1456786","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science_technology_education"],"_links":{"self":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1456786","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/comments?post=1456786"}],"version-history":[{"count":0,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1456786\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media\/1456788"}],"wp:attachment":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media?parent=1456786"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/categories?post=1456786"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/tags?post=1456786"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}