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\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053<\/b>\uff1a\u8bfa\u548c\u8bfa\u5fb7\uff08Novo Nordisk\uff09\u516c\u53f8\u6628\u65e5\u5ba3\u5e03\uff0c\u7f8e\u56fdFDA\u6279\u51c6\u4e86\u516c\u53f8\u4ea7\u54c1\uff0c\u53e3\u670d\u7d22\u9a6c\u9c81\u80bd\uff08oral semaglutide\uff0c\u5546\u54c1\u540dRybelsus\uff09\u4e0a\u5e02\uff0c\u4e0e\u996e\u98df\u548c\u953b\u70bc\u76f8\u7ed3\u5408\uff0c\u6539\u55842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u8840\u7cd6\u63a7\u5236\u3002\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21\u7684\u7d22\u9a6c\u9c81\u80bd\u836f\u7247\u662f\u7b2c\u4e00\u6b3e\u83b7\u5f97FDA\u6279\u51c6\u7684\u53e3\u670d\u80f0\u9ad8\u8840\u7cd6\u7d20\u6837\u80bd-1\u53d7\u4f53\u6fc0\u52a8\u5242\uff08GLP-1RA\uff09\u3002\u5b83\u7684\u51fa\u73b0\u6253\u7834\u4e862\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u6bcf\u5929\u6216\u6bcf\u5468\u9700\u8981\u63a5\u53d7GLP-1RA\u6ce8\u5c04\u7684\u683c\u5c40\uff0c\u4e3a\u4ed6\u4eec\u63a7\u5236\u8840\u7cd6\u63d0\u4f9b\u4e86\u4fb5\u5165\u6027\u66f4\u5c0f\u7684\u4fbf\u6377\u6cbb\u7597\u9009\u62e9\u3002\u201c\u80fd\u591f\u7528\u6bcf\u65e5\u670d\u7528\u4e00\u6b21\u7684\u5c0f\u836f\u7247\u9012\u9001GLP-1\u8fd9\u4e00\u751f\u7269\u5236\u5242\u7684\u7597\u6548\uff0c\u662f\u975e\u5e38\u72ec\u7279\u7684\u6210\u5c31\uff0c\u201d\u8bfa\u548c\u8bfa\u5fb7\u516c\u53f8\u7684\u9996\u5e2d\u79d1\u5b66\u5b98Mads Krogsgaard Thomsen\u535a\u58eb\u8bf4\uff1a\u201c\u5b83\u6709\u70b9\u50cf\u4e00\u4e2a\u5723\u676f\uff08holy grail\uff09\u3002\u201d\u4eca\u5929\uff0c\u836f\u660e\u5eb7\u5fb7\u5185\u5bb9\u56e2\u961f\u5c06\u4e0e\u8bfb\u8005\u56de\u987e\u8bfa\u548c\u8bfa\u5fb7\u6458\u5f97\u53e3\u670dGLP-1RA\u201c\u5723\u676f\u201c\u7684\u5386\u7a0b\u3002<\/p>\n

GLP-1\uff0c\u63a7\u5236\u8840\u7cd6\u7684\u80a0\u4fc3\u80f0\u5c9b\u7d20<\/strong><\/p>\n

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\n<\/a>\"\"<\/a>\u25b2\u53e3\u670d\u7d22\u9a6c\u9c81\u80bd\u5728\u80c3\u90e8\u88ab\u5438\u6536\uff08\u56fe\u7247\u6765\u6e90\uff1a\u53c2\u8003\u8d44\u6599[3]\uff09<\/p>\n

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\u53c2\u8003\u8d44\u6599\uff1a
\n[1] FDA approves first oral GLP-1 treatment for type 2 diabetes. Retrieved September 19, 2019, from https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-first-oral-glp-1-treatment-type-2-diabetes
\n[2] Sharma et al., (2018). Recent updates on GLP-1 agonists: Current advancements & challenges. Biomedicine & Pharmacotherapy, https:\/\/doi.org\/10.1016\/j.biopha.2018.08.088
\n[3] Knudsen and Lau. (2019). The Discovery and Development of Liraglutide and Semaglutide. Front. Endocrinol., https:\/\/doi.org\/10.3389\/fendo.2019.00155.
\n[4] Andersen et al., (2018). Glucagon-like peptide 1 in health and disease. Nature Reviews Endocrinology, https:\/\/doi.org\/10.1038\/s41574-018-0016-2
\n[5] Novo Nordisk Investor Presentation, First Quarter of 2019. Retrieved September 20, 2019, from https:\/\/www.novonordisk.com\/content\/dam\/Denmark\/HQ\/investors\/irmaterial\/investor_presentations\/2019\/20190503_Q1%202019%20roadshow%20presentation.pdf
\n[6] Rybelsus\u00ae (semaglutide tablets), the first GLP-1 in a tablet approved in the US. Retrieved September 20, 2019, from https:\/\/www.novonordisk.com\/content\/Denmark\/HQ\/www-novonordisk-com\/en_gb\/home\/media\/news-details.2172050.html<\/p>\n","protected":false},"excerpt":{"rendered":"

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