{"id":1456851,"date":"2019-09-23T04:24:36","date_gmt":"2019-09-23T11:24:36","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=1456851"},"modified":"2019-09-23T04:33:03","modified_gmt":"2019-09-23T11:33:03","slug":"%e7%be%8e%e7%a7%91%e5%ad%a6%e5%ae%b6%e5%8f%91%e7%8e%b0%e8%8d%af%e7%89%a9%e9%9d%b6%e5%90%91%e7%99%8c%e7%97%87%e8%bd%ac%e7%a7%bb%ef%bc%88%e5%9b%be%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/%e7%be%8e%e7%a7%91%e5%ad%a6%e5%ae%b6%e5%8f%91%e7%8e%b0%e8%8d%af%e7%89%a9%e9%9d%b6%e5%90%91%e7%99%8c%e7%97%87%e8%bd%ac%e7%a7%bb%ef%bc%88%e5%9b%be%ef%bc%89\/.html","title":{"rendered":"\u7f8e\u79d1\u5b66\u5bb6\u53d1\u73b0\u836f\u7269\u9776\u5411\u6cbb\u7597\u764c\u75c7\u8f6c\u79fb\uff08\u56fe\uff09"},"content":{"rendered":"

\u836f\u660e\u5eb7\u5fb7\u62a5\u9053<\/b>\uff1a\u764c\u75c7\u8f6c\u79fb\uff08cancer metastasis\uff09\u4e0e\u4e0d\u826f\u9884\u540e\u5bc6\u5207\u76f8\u5173\uff0c\u4e5f\u662f\u5bfc\u81f4\u764c\u75c7\u76f8\u5173\u6b7b\u4ea1\u7684\u9996\u8981\u539f\u56e0\u3002\u636e\u7edf\u8ba1\uff0c90%\u764c\u75c7\u60a3\u8005\u7684\u6b7b\u4ea1\u662f\u56e0\u4e3a\u75c5\u7076\u8f6c\u79fb\uff0c\u7136\u800c\u201c\u6ca1\u6709\u4e00\u4e2a\u83b7\u6279\u836f\u7269\u7279\u5f02\u6027\u9776\u5411\u764c\u75c7\u8f6c\u79fb\uff0c\u201d\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\uff08NIH\uff09\uff0c\u56fd\u5bb6\u8f6c\u5316\u79d1\u5b66\u4fc3\u8fdb\u4e2d\u5fc3\uff08NCATS\uff09\u7684Juan Jose Marugan\u535a\u58eb\uff08\u9898\u56fe\u8005\uff09\u8bf4\uff1a\u201c\u800c\u4e14\uff0c\u6211\u4eec\u5e76\u4e0d\u662f\u5b8c\u5168\u4e86\u89e3\u764c\u75c7\u8f6c\u79fb\u7684\u8fc7\u7a0b\u3002\u201d<\/p>\n

Marugan\u535a\u58eb\u548c\u4ed6\u7684\u540c\u4e8b\u81f4\u529b\u4e8e\u6539\u53d8\u8fd9\u4e2a\u73b0\u72b6\u3002\u4ed6\u4eec\u548c\u5176\u5b83\u5408\u4f5c\u4f19\u4f34\u4e00\u8d77\u53d1\u73b0\u4e86\u4e00\u79cd\u53eb\u505ametarrestin\u7684\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u5728\u591a\u79cd\u5b9e\u4f53\u7624\u6a21\u578b\u4e2d\u8868\u73b0\u51fa\u6291\u5236\u80bf\u7624\u8f6c\u79fb\u7684\u6548\u679c\u3002\u76ee\u524d\uff0c\u4ed6\u4eec\u6b63\u5728\u5c06\u8fd9\u6b3e\u5728\u7814\u5316\u5408\u7269\u63a8\u5411\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6cbb\u7597\u7684\u76ee\u6807\u662f\u201c\u764c\u75c7\u4e4b\u738b\u201d\u2014\u2014\u80f0\u817a\u764c\u3002\u800cMarugan\u535a\u58eb\u6240\u5728\u7684NCATS\u66f4\u662f\u81f4\u529b\u4e8e\u89e3\u51b3\u8f6c\u5316\u7814\u7a76\u4e2d\u7684\u201c\u75db\u70b9\u201d\uff0c\u63d0\u9ad8\u5c06\u7a81\u7834\u6027\u7814\u7a76\u8f6c\u5316\u6210\u7ed9\u60a3\u8005\u9020\u798f\u7597\u6cd5\u7684\u6548\u7387\u3002<\/p>\n

\u764c\u75c7\u8f6c\u79fb\u2014\u2014\u590d\u6742\u800c\u672a\u88ab\u6f84\u6e05\u7684\u8fc7\u7a0b<\/strong><\/p>\n

\u764c\u75c7\u8f6c\u79fb\u662f\u4e00\u4e2a\u590d\u6742\u7684\u591a\u6b65\u8fc7\u7a0b\u3002\u6700\u521d\uff0c\u764c\u7ec6\u80de\u53d8\u5f97\u5177\u6709\u4fb5\u88ad\u6027\uff0c\u80fd\u591f\u7a81\u7834\u4e0a\u76ae\u7ec4\u7ec7\u5f62\u6210\u7684\u5c4f\u969c\uff0c\u4fb5\u5165\u5230\u8840\u7ba1\u4e2d\uff08intravasation\uff09\u3002\u5728\u968f\u7740\u8840\u5faa\u73af\u8f6c\u79fb\u5230\u8eab\u4f53\u5176\u5b83\u90e8\u4f4d\u540e\uff0c\u4ed6\u4eec\u8fd8\u9700\u8981\u79bb\u5f00\u8840\u5faa\u73af\uff0c\u4fb5\u5165\u5230\u8fdc\u7aef\u7ec4\u7ec7\u4e2d\uff08extravasation\uff09\u3002\u764c\u75c7\u8f6c\u79fb\u5e76\u4e0d\u662f\u5728\u6240\u6709\u7ec4\u7ec7\u4e2d\u53d1\u751f\uff0c\u4ee5\u5f80\u7814\u7a76\u8868\u660e\u4eba\u4f53\u4e2d\u7279\u5b9a\u7ec4\u7ec7\u7684\u73af\u5883\u66f4\u5229\u4e8e\u8f6c\u79fb\u7684\u764c\u7ec6\u80de\u7684\u751f\u5b58\u548c\u5b9a\u690d\u3002\u8fd9\u4e9b\u8f6c\u79fb\u764c\u7ec6\u80de\u9002\u5408\u751f\u5b58\u7684\u73af\u5883\u79f0\u4e3a\u8f6c\u79fb\u524d\u751f\u5883\uff08pre-metastatic niches\uff09\u3002\u5728\u8f6c\u79fb\u524d\u751f\u5883\u4e2d\u5b58\u6d3b\u4e0b\u6765\u7684\u764c\u7ec6\u80de\u53ef\u80fd\u4f1a\u6f5c\u4f0f\u5f88\u957f\u65f6\u95f4\uff0c\u7136\u540e\u5728\u7279\u5b9a\u56e0\u7d20\u7684\u523a\u6fc0\u4e0b\uff0c\u764c\u7ec6\u80de\u6269\u589e\u5e76\u4e14\u6210\u4e3a\u8f6c\u79fb\u5b9a\u690d\uff08metastatic colonization\uff09\u3002<\/p>\n

\u7279\u5f02\u6027\u9776\u5411\u764c\u75c7\u8f6c\u79fb\u610f\u5473\u7740\u53ef\u4ee5\u9776\u5411\u8fd9\u4e00\u590d\u6742\u8fc7\u7a0b\u4e2d\u7684\u591a\u4e2a\u8282\u70b9\u3002\u7531\u4e8e\u764c\u7ec6\u80de\u53d1\u751f\u8f6c\u79fb\u7684\u7b2c\u4e00\u6b65\u662f\u53d8\u5f97\u5177\u6709\u4fb5\u88ad\u6027\uff0c\u8fd9\u4e2a\u8fc7\u7a0b\u4e5f\u6210\u4e3a\u79d1\u5b66\u5bb6\u7814\u7a76\u7684\u91cd\u5fc3\u4e4b\u4e00\u3002\u5df2\u6709\u7814\u7a76\u8868\u660e\uff0c\u591a\u79cd\u80bf\u7624\u7ec6\u80de\u5185\u5728\u7684\u53d8\u5316\u53ef\u4ee5\u5bfc\u81f4\u5b83\u4eec\u4fb5\u88ad\u6027\u7684\u589e\u5f3a\uff0c\u5305\u62ec\u4e0a\u76ae\u95f4\u5145\u8d28\u8f6c\u5316\uff08epithelial-mesenchymal transition, EMT\uff09\u3001\u86cb\u767d\u9176\u7684\u751f\u6210\u548c\u8fc1\u79fb\u80fd\u529b\u7684\u589e\u5f3a\u3002<\/p>\n

\"\"<\/a>\u25b2\u764c\u75c7\u8f6c\u79fb\u7684\u591a\u4e2a\u6b65\u9aa4\uff08\u56fe\u7247\u6765\u6e90\uff1a\u53c2\u8003\u8d44\u6599[1]\uff09<\/p>\n

\u7136\u800c\uff0c\u7531\u4e8e\u8f6c\u79fb\u764c\u7ec6\u80de\u7684\u57fa\u56e0\u4e0d\u7a33\u5b9a\u6027\uff0c\u5728\u5927\u591a\u6570\u764c\u75c7\u7c7b\u578b\u4e2d\uff0c\u53ef\u80fd\u4e0d\u5b58\u5728\u4e00\u4e2a\u63a7\u5236\u764c\u75c7\u8f6c\u79fb\u7684\u4e3b\u5bfc\u4fe1\u53f7\u901a\u8def\u3002\u6211\u4eec\u5bf9\u764c\u75c7\u8f6c\u79fb\u7684\u4e86\u89e3\u8fd8\u8fdc\u8c08\u4e0d\u4e0a\u5b8c\u5907\u3002Marugan\u535a\u58eb\u8868\u793a\uff0c\u6211\u4eec\u77e5\u9053\u4e0e\u4e0a\u76ae\u95f4\u5145\u8d28\u8f6c\u5316\u8fc7\u7a0b\u76f8\u5173\u7684\u4e00\u4e9b\u673a\u5236\uff0c\u548c\u4e0e\u8fd9\u4e00\u8fc7\u7a0b\u76f8\u5173\u7684\u57fa\u672c\u53d7\u4f53\u548c\u56e0\u5b50\u3002\u4f46\u662f\uff0c\u8fd9\u4e9b\u77e5\u8bc6\u5c1a\u4e14\u4e0d\u8db3\u4ee5\u4e3a\u5f00\u53d1\u9776\u5411\u764c\u75c7\u8f6c\u79fb\u63d0\u4f9b\u4e00\u4e2a\u201c\u5168\u666f\u56fe\u201d\u3002<\/p>\n

\u53e6\u8f9f\u8e4a\u5f84\uff0c\u4f7f\u7528\u8868\u578b\u7b5b\u9009\u53d1\u73b0\u65b0\u6cbb\u7597\u6027\u5206\u5b50<\/strong><\/p>\n

\u65e2\u7136\u65e0\u6cd5\u9488\u5bf9\u7279\u5b9a\u5206\u5b50\u9776\u70b9\u8fdb\u884c\u836f\u7269\u5f00\u53d1\uff0cMarugan\u535a\u58eb\u7684\u56e2\u961f\u51b3\u5b9a\u4f7f\u7528\u8868\u578b\u7b5b\u9009\uff08phenotypic screen\uff09\u6765\u627e\u51fa\u53ef\u4ee5\u5f71\u54cd\u764c\u7ec6\u80de\u4fb5\u88ad\u6027\u7684\u836f\u7269\u3002\u4ed6\u4eec\u53d1\u73b0\uff0c\u9ad8\u5ea6\u8fdb\u5316\u7684\u764c\u7ec6\u80de\u4e2d\u5b58\u5728\u4e00\u79cd\u53eb\u505a\u6838\u4ec1\u5468\u533a\u5ba4\uff08perinucleolar compartment, PNC\uff09\u7684\u7ed3\u6784\u3002PNC\u662f\u4e00\u4e2a\u548c\u7ec6\u80de\u6838\u4ec1\u8fde\u5728\u4e00\u8d77\u7684\u4e9a\u6838\u5c0f\u4f53\u3002\u4efb\u4f55\u65e9\u671f\u7684\u764c\u75c7\u7ec6\u80de\u90fd\u6ca1\u6709PNC\uff0c\u4f46\u662f\u5904\u4e8e\u8f6c\u79fb\u671f\u7684\u764c\u7ec6\u80de\u4e2d\uff0c\u5f88\u5927\u4e00\u90e8\u5206\u90fd\u5177\u6709PNC\uff0c\u800c\u5728\u8f6c\u79fb\u75c5\u7076\u7684\u764c\u7ec6\u80de\u4e2d\uff0c100%\u7684\u7ec6\u80de\u90fd\u6709PNC\u3002<\/p>\n

\"\"<\/a>\u25b2\u7535\u5b50\u663e\u5fae\u955c\u4e0b\u7684PNC\uff08\u56fe\u7247\u6765\u6e90\uff1a\u53c2\u8003\u8d44\u6599[1]\uff09<\/p>\n

\u4e8e\u662f\uff0cMarugan\u535a\u58eb\u7684\u56e2\u961f\u8fdb\u884c\u4e86\u4e00\u4e2a\u9ad8\u901a\u91cf\u8868\u578b\u7b5b\u9009\uff0c\u5bfb\u627e\u90a3\u4e9b\u80fd\u591f\u62c6\u6563PNC\u4f46\u662f\u4e0d\u4f1a\u6740\u6b7b\u7ec6\u80de\u7684\u5c0f\u5206\u5b50\u3002\u4ed6\u4eec\u53d1\u73b0\u4e86\u4e00\u79cd\u540e\u6765\u540d\u4e3ametarrestin\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\uff0c\u5b83\u80fd\u591f\u975e\u5e38\u6709\u6548\u5730\u5728\u5b9e\u4f53\u7624\u4e2d\u62c6\u6563PNC\uff0c\u90a3\u4e48\u5b83\u5bf9\u764c\u75c7\u8f6c\u79fb\u6709\u4ec0\u4e48\u5f71\u54cd\u5462\uff1f<\/p>\n

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\"\"<\/a>\u25b2Metarrestin\u5728\u672a\u51fa\u73b0\u764c\u75c7\u8f6c\u79fb\u7684\u5c0f\u9f20\u6a21\u578b\u4e2d\u6291\u5236\u8f6c\u79fb\u7684\u53d1\u751f\uff08\u56feA\uff09\uff0c\u5728\u51fa\u73b0\u764c\u75c7\u8f6c\u79fb\u7684\u5c0f\u9f20\u6a21\u578b\u4e2d\u964d\u4f4e\u8f6c\u79fb\u7684\u6570\u76ee\u5e76\u5ef6\u957f\u52a8\u7269\u5bff\u547d\uff08\u56feB\uff09\uff08\u56fe\u7247\u6765\u6e90\uff1a\u53c2\u8003\u8d44\u6599[3]\uff09<\/p>\n

2018\u5e74\uff0cMarugan\u535a\u58eb\u7684\u56e2\u961f\u5728Science Translational Medicine\u4e0a\u53d1\u8868\u4e86\u5173\u4e8emetarrestin\u7684\u7814\u7a76\u3002\u8fdb\u4e00\u6b65\u7814\u7a76\u53d1\u73b0\u4e86metarrestin\u7684\u9776\u70b9\uff0c\u539f\u6765\u5b83\u4e0e\u4e00\u79cd\u540d\u53ebeEF1A2\u7684\u86cb\u767d\u76f8\u7ed3\u5408\uff0ceEF1A2\u63a7\u5236RNA\u805a\u5408\u91761\uff08Pol 1\uff09\u7684\u529f\u80fd\u3002\u800cPol 1\u5219\u5bf9\u5408\u6210\u6838\u7cd6\u4f53RNA\u81f3\u5173\u91cd\u8981\u3002\u6240\u4ee5\u5728\u764c\u75c7\u7ec6\u80de\u4e2d\uff0ceEF1A2\u80fd\u591f\u5e2e\u52a9\u63d0\u9ad8\u6838\u7cd6\u4f53\u7684\u751f\u7269\u5408\u6210\uff0c\u5bf9\u4e8e\u7ec6\u80de\u7684\u5feb\u901f\u589e\u6b96\u3001\u5206\u88c2\u548c\u8fdb\u5316\u90fd\u5f88\u91cd\u8981\u3002Metarrestin\u901a\u8fc7\u963b\u65adeEF1A2\uff0c\u5728\u9ad8\u5ea6\u8fdb\u5316\u7684\u764c\u7ec6\u80de\u4e2d\u963b\u65ad\u4e86\u65b0\u6838\u7cd6\u4f53\u7684\u751f\u6210\u3002<\/p>\n

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Marugan\u535a\u58eb\u8868\u793a\uff0c\u76ee\u524d\u5173\u4e8emetarrestin\u7684\u4e34\u5e8a\u524d\u8bd5\u9a8c\u5df2\u7ecf\u5168\u90e8\u5b8c\u6210\uff0cIND\u7533\u8bf7\u5373\u5c06\u9012\u4ea4\u7ed9FDA\u3002\u8fd9\u6b3e\u5019\u9009\u836f\u7269\u7684\u51fa\u73b0\u662f\u591a\u4e2a\u7814\u7a76\u673a\u6784\u534f\u4f5c\u7684\u7ed3\u6676\u3002\u6700\u521d\u4f7f\u7528PNC\u8fdb\u884c\u8868\u578b\u7b5b\u9009\u7684\u60f3\u6cd5\u6765\u81ea\u897f\u5317\u5927\u5b66\uff08Northwestern University\uff09\u7684Sui Huang\u6559\u6388\u3002\u582a\u8428\u65af\u5927\u5b66\uff08Kansas University\uff09\u7684\u4e13\u4e1a\u5316\u5b66\u4e2d\u5fc3\uff08Specialized Chemistry Center\uff09\u5e2e\u52a9\u8fdb\u884c\u4e86\u533b\u836f\u5316\u5b66\u7814\u7a76\u3002\u56fd\u5bb6\u8f6c\u5316\u79d1\u5b66\u4fc3\u8fdb\u4e2d\u5fc3\u5219\u8fdb\u884c\u4e86\u4e34\u5e8a\u524d\u5f00\u53d1\u5de5\u4f5c\uff0c\u5305\u62ecGMP\u6269\u5927\u751f\u4ea7\uff0c\u6bd2\u7406\u7814\u7a76\u548c\u914d\u65b9\u3002\u4ed6\u4eec\u8fd8\u5c06\u4e0e\u7f8e\u56fd\u56fd\u5bb6\u764c\u75c7\u7814\u7a76\u6240\uff08NCI\uff09\u5408\u4f5c\uff0c\u8fdb\u884c1\u671f\u548c2\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n

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\u53c2\u8003\u8d44\u6599\uff1a
\n[1] Anderson et al., (2018). A framework for the development of effective anti-metastatic agents. Nature Reviews Clinical Oncology, https:\/\/doi.org\/10.1038\/s41571-018-0134-8
\n[1] Slusarczyk et al., (2011). Structure and Function of the Perinucleolar Compartment in Cancer Cells. Cold Spring Harbor Symposia on Quantitative Biology, DOI: 10.1101\/sqb.2010.75.026
\n[2] Frankowski et al., (2018). Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis. Science Translational Medicine, DOI: 10.1126\/scitranslmed.aap8307.
\n[3] The Peculiarity of Cancer Metastasis may be the Key to Controlling the Disease. Retrieved September 22, 2019, from https:\/\/wxpress.wuxiapptec.com\/the-peculiarity-of-cancer-metastasis-may-be-the-key-to-controlling-the-disease\/<\/p>\n

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