\u836f\u660e\u5eb7\u5fb7\u62a5\u9053<\/b>\uff1a\u4e1a\u754c\u77e5\u540d\u7684\u5e74\u5ea6\u201c\u751f\u7269\u6280\u672f\u731b\u516c\u53f8\u201d\uff08FierceBiotech\u2019s 2019 Fierce 15\uff09\u699c\u5355\u8fd1\u65e5\u706b\u70ed\u51fa\u7089\u3002\u4eca\u5e74\u4e0a\u699c\u7684\u65b0\u5174\u751f\u7269\u6280\u672f\u516c\u53f8\u8986\u76d6\u9762\u66f4\u4e3a\u5e7f\u6cdb\uff0c\u9664\u4e86\u6cbb\u7597\u764c\u75c7\u548c\u7f55\u89c1\u75c5\u7684\u516c\u53f8\u4ee5\u5916\uff0c\u5f00\u53d1\u6cbb\u7597\u4f20\u67d3\u75c5\u3001\u75bc\u75db\u3001\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u516c\u53f8\u4e5f\u699c\u4e0a\u6709\u540d\u3002FierceBiotech\u8868\u793a\uff0c\u8fd9\u4e9b\u516c\u53f8\u6709\u53ef\u80fd\u5728\u4eca\u540e10-20\u5e74\u91cc\uff0c\u6210\u4e3a\u751f\u7269\u533b\u836f\u9886\u57df\u91cc\u7684\u91cd\u8981\u65b0\u751f\u529b\u91cf\u3002\u4ee5\u524d\u4e0a\u699c\u7684\u65b0\u5174\u516c\u53f8\u5305\u62ec\u8457\u540dmRNA\u7597\u6cd5\u516c\u53f8Moderna Therapeutics\uff0c\u4e13\u6ce8\u4e8e\u5f00\u53d1CAR-T\u7597\u6cd5\u7684Juno Therapeutics\uff08\u540e\u88ab\u65b0\u57fa\u516c\u53f8\u6536\u8d2d\uff09\uff0c\u5f00\u53d1\u6297\u764c\u7597\u6cd5\u7684TESARO\uff08\u540e\u88ab\u845b\u5170\u7d20\u53f2\u514b\u516c\u53f8\u6536\u8d2d\uff09\u3002\u8ba9\u6211\u4eec\u6765\u4e86\u89e3\u4e00\u4e0b\u4eca\u5e74\u4e0a\u699c\u7684\u751f\u7269\u533b\u836f\u65b0\u9510\u3002<\/p>\n
\u56fe\u7247\u6765\u6e90\uff1aFierceBiotech\u5b98\u7f51<\/p>\n
\u65b0\u9510\u540d\u79f0\uff1aAnthos Therapeutics
\n\u6210\u7acb\u5e74\u4efd\uff1a2019
\n\u4e34\u5e8a\u4e13\u653b\uff1a\u6cbb\u7597\u591a\u79cd\u5fc3\u8840\u7ba1\u75be\u75c5\u7684\u521b\u65b0\u7597\u6cd5<\/p>\n
Anthos Therapeutics\u5728\u4eca\u5e742\u6708\u83b7\u5f97\u9ed1\u77f3\u751f\u547d\u79d1\u5b662.5\u4ebf\u7f8e\u5143\u6295\u8d44\u3002\u8be5\u516c\u53f8\u7684\u4e3b\u6253\u4ea7\u54c1\u662f\u4ece\u8bfa\u534e\uff08Novartis\uff09\u516c\u53f8\u83b7\u5f97\u7684MAA868\u3002\u8fd9\u662f\u4e00\u6b3e\u6297\u51dd\u8840\u56e0\u5b50XI\/XIa\u7684\u5355\u514b\u9686\u6297\u4f53\u3002\u5b83\u5df2\u7ecf\u5b8c\u6210\u4e34\u5e8a\u524d\u548c1\u671f\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n
\u8840\u6813\u5f62\u6210\uff08thrombosis\uff09\u662f\u5bfc\u81f4\u53d1\u75c5\u548c\u6b7b\u4ea1\u7684\u91cd\u8981\u539f\u56e0\u3002\u8840\u6813\u53ef\u4ee5\u963b\u585e\u52a8\u8109\u6216\u8005\u9759\u8109\uff0c\u5728\u80ba\u90e8\u51fa\u73b0\u7684\u8840\u6813\u53ef\u9020\u6210\u80ba\u6813\u585e\uff0c\u800c\u5728\u5927\u8111\u51fa\u73b0\u7684\u8840\u6813\u53ef\u9020\u6210\u4e2d\u98ce\u3002\u76ee\u524d\u7684\u8840\u6db2\u7a00\u91ca\u5242\u901a\u5e38\u4f34\u968f\u7740\u51fa\u8840\u98ce\u9669\uff0c\u800c\u4e14\u9700\u8981\u6bcf\u65e5\u670d\u7528\u3002MAA868\u7684\u5b9e\u9a8c\u7ed3\u679c\u8868\u660e\u5b83\u4e0d\u4f46\u5177\u6709\u6297\u8840\u6813\u5f62\u6210\u7684\u6d3b\u6027\uff0c\u800c\u4e14\u51fa\u8840\u98ce\u9669\u5f88\u5c0f\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\u60a3\u8005\u53ea\u9700\u6bcf\u6708\u63a5\u53d7\u4e00\u6b21\u6cbb\u7597\u5c31\u53ef\u4ee5\u964d\u4f4e\u8840\u6813\u751f\u6210\u98ce\u9669\uff0c\u6709\u671b\u63d0\u9ad8\u60a3\u8005\u7528\u836f\u7684\u4f9d\u4ece\u6027\u3002<\/p>\n
\u65b0\u9510\u540d\u79f0\uff1aBlack Diamond Therapeutics
\n\u6210\u7acb\u5e74\u4efd\uff1a2015
\n\u4e34\u5e8a\u4e13\u653b\uff1a\u9776\u5411\u522b\u6784\u81f4\u764c\u57fa\u56e0\u7a81\u53d8\uff0c\u5f00\u53d1\u65b0\u4e00\u4ee3\u201c\u4e0d\u9650\u764c\u79cd\u201d\u7684\u7cbe\u51c6\u7597\u6cd5<\/p>\n
Black Diamond\u57282017\u5e74\u8d70\u51fa\u9690\u533f\u6a21\u5f0f\uff0c\u5e76\u4e14\u5728\u4eca\u5e74\u521d\u5b8c\u62108500\u4e07\u7f8e\u5143\u7684B\u8f6e\u878d\u8d44\u3002\u8be5\u516c\u53f8\u7684\u6280\u672f\u5e73\u53f0\u65e8\u5728\u53d1\u73b0\u80fd\u591f\u5bfc\u81f4\u764c\u75c7\u7684\u522b\u6784\u57fa\u56e0\u7a81\u53d8\uff08allosteric mutations\uff09\u3002\u8fd9\u4e9b\u522b\u6784\u7a81\u53d8\u4e0d\u53d1\u751f\u5728\u53d7\u4f53\u86cb\u767d\u6fc0\u9176\u7684\u6d3b\u6027\u4f4d\u70b9\uff0c\u800c\u662f\u901a\u8fc7\u5f71\u54cd\u86cb\u767d\u7684\u6574\u4f53\u6784\u8c61\uff0c\u8ba9\u53d7\u4f53\u86cb\u767d\u6fc0\u9176\u7684\u6d3b\u6027\u4e0d\u518d\u4f9d\u9760\u914d\u4f53\u7ed3\u5408\uff0c\u4ece\u800c\u5bfc\u81f4\u4fe1\u53f7\u901a\u8def\u7684\u8fc7\u5206\u6fc0\u6d3b\u548c\u764c\u75c7\u7684\u53d1\u751f\u3002<\/p>\n
Black Diamond\u7684\u6280\u672f\u5e73\u53f0\u80fd\u591f\u4ece\u6d77\u91cf\u7684\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u6570\u636e\u4e2d\u6839\u636e\u7279\u5b9a\u7b97\u6cd5\uff0c\u53d1\u73b0\u5177\u6709\u81f4\u764c\u80fd\u529b\u7684\u57fa\u56e0\u7a81\u53d8\u3002\u7136\u540e\u901a\u8fc7\u5bf9\u8fd9\u4e9b\u57fa\u56e0\u7a81\u53d8\u8fdb\u884c\u5206\u6790\uff0c\u4ed6\u4eec\u53ef\u4ee5\u5c06\u5177\u6709\u76f8\u540c\u4f5c\u7528\u673a\u5236\u6216\u8005\u7ed3\u679c\u7684\u522b\u6784\u57fa\u56e0\u7a81\u53d8\u5f52\u7eb3\u4e3a\u4e00\u7ec4\uff0c\u7136\u540e\u6709\u9488\u5bf9\u6027\u5730\u5f00\u53d1\u6291\u5236\u5242\u3002\u8fd9\u79cd\u6291\u5236\u5242\u5177\u6709\u540c\u65f6\u6291\u5236\u591a\u79cd\u522b\u6784\u57fa\u56e0\u7a81\u53d8\u5bfc\u81f4\u7684\u764c\u75c7\u7684\u6f5c\u529b\u3002<\/p>\n
\u76ee\u524d\uff0c\u8be5\u516c\u53f8\u7684\u7814\u53d1\u7ba1\u7ebf\u4e2d\u67095\u6b3e\u5728\u7814\u7597\u6cd5\u3002\u5176\u4e2d\u4e24\u6b3e\u6291\u5236\u5242\u5206\u522b\u9776\u5411EGFR\u548cHER2\u53d7\u4f53\u4e0a\u51fa\u73b0\u7684\u522b\u6784\u57fa\u56e0\u7a81\u53d8\u3002<\/p>\n
\u65b0\u9510\u540d\u79f0\uff1aCasma Therapeutics
\n\u6210\u7acb\u5e74\u4efd\uff1a2018
\n\u4e34\u5e8a\u4e13\u653b\uff1a\u5229\u7528\u7ec6\u80de\u7684\u81ea\u566c\u80fd\u529b\u6e05\u9664\u79ef\u7d2f\u7684\u7ec6\u80de\u201c\u5783\u573e\u201d\uff0c\u6062\u590d\u7ec6\u80de\u5065\u5eb7\u548c\u52a8\u6001\u5e73\u8861<\/p>\n
Casma Therapeutics\u57282018\u5e745\u6708\u6210\u7acb\uff0c\u5e76\u4e14\u83b7\u5f975800\u4e07\u7f8e\u5143\u7684A\u8f6e\u878d\u8d44\u3002\u8be5\u516c\u53f8\u7684\u6280\u672f\u5e73\u53f0\u5229\u7528\u5bf9\u7ec6\u80de\u672c\u8eab\u81ea\u566c\u529f\u80fd\u7684\u8c03\u8282\u6765\u6cbb\u7597\u808c\u8089\u3001\u809d\u810f\u3001\u708e\u75c7\u6027\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u3002<\/p>\n
\u7ec6\u80de\u7684\u81ea\u566c\u529f\u80fd\u662f\u7ec6\u80de\u4f53\u5185\u6e05\u9664\u53d7\u635f\u6216\u4e0d\u9700\u8981\u86cb\u767d\u548c\u7ec6\u80de\u5668\u7684\u5929\u7136\u673a\u5236\u3002Casma\u516c\u53f8\u5bf9\u81ea\u566c\u8fc7\u7a0b\u4e2d\u7684\u591a\u4e2a\u9a71\u52a8\u56e0\u5b50\u8fdb\u884c\u4e86\u6df1\u5165\u7684\u7814\u7a76\uff0c\u5e76\u4e14\u53d1\u73b0\u4e86\u53ef\u4ee5\u5f71\u54cd\u8fd9\u4e9b\u9a71\u52a8\u56e0\u5b50\u7684\u9776\u70b9\u3002\u901a\u8fc7\u9776\u5411\u8fd9\u4e9b\u9776\u70b9\uff0c\u8be5\u516c\u53f8\u53ef\u4ee5\u9009\u62e9\u6027\u5730\u5f71\u54cd\u81ea\u566c\u529f\u80fd\u7684\u53d1\u751f\uff0c\u5e2e\u52a9\u6e05\u9664\u7279\u5b9a\u81f4\u75c5\u86cb\u767d\u6216\u8005\u7ec6\u80de\u201c\u5e9f\u7269\u201d\u3002<\/p>\n
\u56fe\u7247\u6765\u6e90\uff1aCasma\u516c\u53f8\u5b98\u7f51<\/p>\n
\u8fd9\u4e00\u6280\u672f\u9996\u5148\u53ef\u4ee5\u7528\u4e8e\u6cbb\u7597\u79f0\u4e3a\u6eb6\u9176\u4f53\u8d2e\u79ef\u75c5\u7684\u7f55\u89c1\u75be\u75c5\uff0c\u5728\u8fd9\u7c7b\u75be\u75c5\u4e2d\uff0c\u7531\u4e8e\u6eb6\u9176\u4f53\u4e2d\u964d\u89e3\u7279\u5b9a\u5927\u5206\u5b50\u7684\u86cb\u767d\u9176\u529f\u80fd\u5f02\u5e38\uff0c\u5bfc\u81f4\u6709\u6bd2\u4ee3\u8c22\u5e95\u7269\u5728\u7ec6\u80de\u4e2d\u7684\u79ef\u7d2f\u3002<\/p>\n
\u6b64\u5916\uff0c\u5728\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e2d\uff0c\u5927\u8111\u7ec4\u7ec7\u4e2d\u7ecf\u5e38\u6709\u5f88\u591a\u6709\u6bd2\u86cb\u767d\u7684\u6c89\u79ef\uff0c\u8fd9\u4e00\u7b56\u7565\u4e5f\u53ef\u4ee5\u7528\u4e8e\u5e2e\u52a9\u6e05\u9664\u5927\u8111\u4e2d\u7684\u6bd2\u6027\u86cb\u767d\u3002\u8be5\u516c\u53f8\u5df2\u7ecf\u83b7\u5f97Michael J. Fox\u57fa\u91d1\u4f1a\u7684\u7814\u7a76\u57fa\u91d1\uff0c\u5f00\u53d1\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u6f5c\u5728\u7597\u6cd5\u3002\u53ef\u4ee5\u9884\u89c1\uff0c\u8fd9\u7c7b\u7597\u6cd5\u8fd8\u53ef\u4ee5\u5728\u66f4\u591a\u75be\u75c5\u7c7b\u578b\u4e2d\u5f97\u5230\u5e94\u7528\u3002<\/p>\n
\u65b0\u9510\u540d\u79f0\uff1aCelsius Therapeutics
\n\u6210\u7acb\u5e74\u4efd\uff1a2017
\n\u4e34\u5e8a\u4e13\u653b\uff1a\u7ed3\u5408\u5355\u7ec6\u80de\u6d4b\u5e8f\u4e0e\u673a\u5668\u5b66\u4e60\uff0c\u53d1\u6398\u75be\u75c5\u7684\u57fa\u56e0\u9a71\u52a8\u5b50<\/p>\n
Celsius Therapeutics\u516c\u53f8\u7684\u7814\u53d1\u6a21\u5f0f\u662f\u5bf9\u60a3\u8005\u7684\u7ec4\u7ec7\u8fdb\u884c\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff0c\u7136\u540e\u4f7f\u7528\u673a\u5668\u5b66\u4e60\u548c\u4eba\u5de5\u667a\u80fd\u5bf9\u4ea7\u751f\u7684\u6d77\u91cf\u6570\u636e\u8fdb\u884c\u5206\u6790\uff0c\u53d1\u73b0\u9a71\u52a8\u75be\u75c5\u7684\u56e0\u7d20\u3002\u8bb8\u591a\u75be\u75c5\u7684\u53d1\u751f\u53ef\u80fd\u662f\u7531\u4e8e\u4e0d\u540c\u79cd\u7c7b\u7ec6\u80de\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u6216\u8005\u8054\u5408\u529f\u80fd\u969c\u788d\u5bfc\u81f4\u7684\uff0c\u800c\u4f20\u7edf\u7684\u57fa\u56e0\u6d4b\u5e8f\u56e0\u4e3a\u68c0\u6d4b\u7684\u662f\u591a\u4e2a\u7ec6\u80de\u7684\u5e73\u5747\u503c\uff0c\u53ef\u80fd\u65e0\u6cd5\u68c0\u6d4b\u5230\u8fd9\u4e9b\u5bfc\u81f4\u75be\u75c5\u7684\u53d8\u5316\u3002<\/p>\n
\u4f7f\u7528\u5355\u7ec6\u80deRNA\u6d4b\u5e8f\uff0cCelsius\u516c\u53f8\u80fd\u591f\u4ee5\u975e\u5e38\u9ad8\u7684\u6e05\u6670\u5ea6\uff0c\u83b7\u53d6\u7ec6\u80de\u7684\u57fa\u56e0\u8868\u8fbe\u548c\u884c\u4e3a\u53d8\u5316\u4fe1\u606f\u3002\u8fd9\u4e9b\u4fe1\u606f\u4e0e\u673a\u5668\u5b66\u4e60\u76f8\u7ed3\u5408\uff0c\u53ef\u80fd\u63d0\u4f9b\u5173\u4e8e\u5168\u65b0\u9776\u70b9\u7684\u6d1e\u89c1\u3002\u8be5\u516c\u53f8\u76ee\u524d\u7684\u4e3b\u8981\u7814\u53d1\u9879\u76ee\u5305\u62ec\u5bf9\u514d\u75ab\u6027\u80a0\u9053\u75be\u75c5\uff08IBD\uff09\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u3001\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u7ec4\u7ec7\u7684\u6d4b\u5e8f\u548c\u7b5b\u9009\uff0c\u65e8\u5728\u53d1\u73b0\u6cbb\u7597\u708e\u75c7\u6027\u75be\u75c5\u548c\u764c\u75c7\u7684\u65b0\u9776\u70b9\u3002<\/p>\n
\u8be5\u516c\u53f8\u53bb\u5e74\u83b7\u5f976500\u4e07\u7f8e\u5143\u7684A\u8f6e\u878d\u8d44\uff0c\u4eca\u5e74\u53c8\u4e0e\u6768\u68ee\u8fbe\u6210\u5408\u4f5c\u534f\u8bae\uff0c\u5e2e\u52a9\u5f00\u53d1\u9884\u6d4b\u836f\u7269\u53cd\u5e94\u7684\u751f\u7269\u6807\u5fd7\u7269\u3002<\/p>\n
\u65b0\u9510\u540d\u79f0\uff1aConfo Therapeutics
\n\u6210\u7acb\u5e74\u4efd\uff1a2015
\n\u4e34\u5e8a\u4e13\u653b\uff1a\u9776\u5411G\u86cb\u767d\u5076\u8054\u53d7\u4f53\uff0c\u6cbb\u7597\u7ea4\u7ef4\u5316\u3001\u4ee3\u8c22\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5<\/p>\n
G\u86cb\u767d\u5076\u8054\u53d7\u4f53\uff08GPCR\uff09\u662f\u4eba\u4f53\u4e2d\u6700\u5927\u7684\u819c\u86cb\u767d\u5bb6\u65cf\uff0c\u5b83\u4eec\u4e5f\u662f\u6cbb\u7597\u4e0d\u540c\u75be\u75c5\u7684\u70ed\u95e8\u836f\u7269\u9776\u70b9\u3002\u5bf9GPCR\u7684\u4f20\u7edf\u7406\u89e3\u662f\u5b83\u50cf\u5f00\u5173\u4e00\u6837\u53ef\u4ee5\u88ab\u6fc0\u6d3b\u6216\u8005\u6291\u5236\u3002\u7136\u800c\uff0c\u65b0\u8fd1\u7814\u7a76\u8868\u660e\uff0cGPCR\u7684\u4e0d\u540c\u914d\u4f53\uff0c\u53ef\u4ee5\u5bfc\u81f4GPCR\u88ab\u56fa\u5b9a\u5728\u7279\u5b9a\u6784\u8c61\uff0c\u4ece\u800c\u6fc0\u53d1\u4e0d\u4e00\u6837\u7684\u4e0b\u6e38\u4fe1\u53f7\u901a\u8def\u3002<\/p>\n
Confo\u516c\u53f8\u5229\u7528\u79f0\u4e3aConfobodies\u7684\u6297\u4f53\u7247\u6bb5\uff0c\u5c06GPCR\u7684\u7ed3\u6784\u7a33\u5b9a\u5728\u7279\u5b9a\u6784\u8c61\u3002\u8fd9\u79cd\u65b9\u6cd5\u80fd\u591f\u66b4\u9732\u51faGPCR\u5728\u7279\u5b9a\u6784\u8c61\u4e0b\u53ef\u4ee5\u88ab\u5c0f\u5206\u5b50\u836f\u7269\u9776\u5411\u7684\u533a\u57df\uff0c\u4ece\u800c\u63d0\u9ad8\u9ad8\u901a\u91cf\u7b5b\u9009\u7684\u6548\u7387\u3002<\/p>\n
\u56fe\u7247\u6765\u6e90\uff1aConfo\u516c\u53f8\u5b98\u7f51<\/p>\n
\u8be5\u516c\u53f8\u5728\u4eca\u5e745\u6708\u5b8c\u6210\u6570\u989d\u4e3a3340\u4e07\u7f8e\u5143\u7684A\u8f6e\u878d\u8d44\u3002<\/p>\n
\u65b0\u9510\u540d\u79f0\uff1aDewpoint Therapeutics
\n\u6210\u7acb\u5e74\u4efd\uff1a2018
\n\u4e34\u5e8a\u4e13\u653b\uff1a\u5f00\u53d1\u9488\u5bf9\u751f\u7269\u5206\u5b50\u7f29\u5408\u7269\uff08biomolecular condensates\uff09\u7684\u836f\u7269\u5f00\u53d1\u5e73\u53f0<\/p>\n
\u5728\u7ec6\u80de\u4e2d\uff0c\u9664\u4e86\u6211\u4eec\u719f\u77e5\u7684\u7ebf\u7c92\u4f53\u3001\u5185\u8d28\u7f51\u7b49\u5177\u6709\u7ec6\u80de\u819c\u7684\u7ec6\u80de\u5668\u4ee5\u5916\uff0c\u8fd8\u5b58\u5728\u7740\u591a\u79cd\u6ca1\u6709\u7ec6\u80de\u819c\u7684\u7ec6\u80de\u5668\uff0c\u8fd9\u4e9b\u901a\u8fc7\u6db2\u76f8\u5206\u79bb\uff08liquid-liquid phase separation\uff09\u5f62\u6210\u7684\u65e0\u819c\u7ec6\u80de\u5668\u80fd\u591f\u4fc3\u8fdb\u6216\u8005\u6291\u5236\u7ec6\u80de\u5185\u7684\u591a\u79cd\u86cb\u767d\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u800c\u5f71\u54cd\u8fd9\u4e9b\u7ed3\u6784\u7ec4\u88c5\u6216\u8005\u62c6\u9664\u7684\u57fa\u56e0\u7a81\u53d8\u80fd\u591f\u5f71\u54cd\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u3001\u764c\u75c7\u7b49\u75be\u75c5\u7684\u8fdb\u5c55\u3002\u4f8b\u5982\uff0c\u5728\u808c\u840e\u7f29\u6027\u4fa7\u7d22\u786c\u5316\uff08ALS\uff09\u7b49\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e2d\uff0c\u5b58\u5728\u79f0\u4e3a\u5e94\u6fc0\u9897\u7c92\uff08stress granule\uff09\u7684\u7f29\u5408\u7269\u3002\u5728ALS\u60a3\u8005\u4e2d\uff0c\u57fa\u56e0\u7a81\u53d8\u4f1a\u5bfc\u81f4\u5e94\u6fc0\u9897\u7c92\u7684\u884c\u4e3a\u5f02\u5e38\u3002<\/p>\n
Dewpoint\u516c\u53f8\u5f00\u53d1\u7684\u6280\u672f\u5e73\u53f0\uff0c\u80fd\u591f\u7b5b\u9009\u5c06\u751f\u7269\u5206\u5b50\u7f29\u5408\u7269\u884c\u4e3a\u6062\u590d\u6b63\u5e38\u7684\u5c0f\u5206\u5b50\uff0c\u4ece\u800c\u4e3a\u6cbb\u7597\u795e\u7ecf\u9000\u884c\u75be\u75c5\u7b49\u7591\u96be\u75c5\u75c7\u63d0\u4f9b\u521b\u65b0\u6cbb\u7597\u624b\u6bb5\u3002<\/p>\n
\u8be5\u516c\u53f8\u5728\u4eca\u5e74\u521d\u5b8c\u6210\u4e866000\u4e07\u7f8e\u5143\u7684A\u8f6e\u878d\u8d44\u3002<\/p>\n
\u65b0\u9510\u540d\u79f0\uff1aFrontier Medicines
\n\u6210\u7acb\u5e74\u4efd\uff1a2018
\n\u4e34\u5e8a\u4e13\u653b\uff1a\u4f7f\u7528\u5316\u5b66\u86cb\u767d\u7ec4\u5b66\uff08chemoproteomics\uff09\u53d1\u73b0\u86cb\u767d\u4e2d\u6682\u65f6\u5b58\u5728\u7684\u7ed3\u5408\u4f4d\u70b9\uff0c\u4e3a\u9776\u5411\u201c\u4e0d\u53ef\u6210\u836f\u201d\u86cb\u767d\u63d0\u4f9b\u65b0\u624b\u6bb5\u3002<\/p>\n
\u5728\u836f\u7269\u5f00\u53d1\u9886\u57df\uff0c\u201c\u4e0d\u53ef\u6210\u836f\u201d\u610f\u5473\u7740\u86cb\u767d\u8868\u9762\u6ca1\u6709\u53ef\u4f9b\u5c0f\u5206\u5b50\u5316\u5408\u7269\u7ed3\u5408\u7684\u4f4d\u70b9\uff0c\u56e0\u6b64\u65e0\u6cd5\u4f7f\u7528\u5c0f\u5206\u5b50\u836f\u7269\u9776\u5411\u3002\u76ee\u524d\uff0c\u4eba\u4f53\u4e2d20000\u4e2a\u5de6\u53f3\u86cb\u767d\u4e2d\uff0c\u9ad8\u8fbe90%\u7684\u86cb\u767d\u5c5e\u4e8e\u8fd9\u4e2a\u7c7b\u578b\u3002<\/p>\n
Frontier Medicines\u516c\u53f8\u8ba4\u4e3a\uff0c\u5728\u5929\u7136\u751f\u7406\u72b6\u6001\u4e0b\u7684\u86cb\u767d\u5177\u6709\u53ef\u5851\u6027\uff0c\u5728\u5b83\u4eec\u6784\u8c61\u53d8\u5316\u6216\u8005\u79fb\u52a8\u7684\u65f6\u5019\uff0c\u5c06\u66b4\u9732\u51fa\u53ef\u4ee5\u88ab\u9776\u5411\u7684\u4f4d\u70b9\u3002\u867d\u7136\u8fd9\u4e9b\u4f4d\u70b9\u53ef\u80fd\u662f\u6682\u65f6\uff0c\u7136\u800c\u5728\u6070\u5f53\u7684\u65f6\u5019\u4f7f\u7528\u5408\u9002\u7684\u5c0f\u5206\u5b50\uff0c\u53ef\u4ee5\u901a\u8fc7\u4e0e\u8fd9\u4e9b\u4f4d\u70b9\u76f8\u7ed3\u5408\uff0c\u5c06\u86cb\u767d\u9501\u5728\u56fa\u5b9a\u7684\u6784\u8c61\u3002<\/p>\n
\u8be5\u516c\u53f8\u7684\u5316\u5b66\u86cb\u767d\u7ec4\u5b66\u5e73\u53f0\u80fd\u591f\u5728\u5929\u7136\u7684\u7ec6\u80de\u73af\u5883\u4e0b\u5bf9\u5927\u91cf\u86cb\u767d\u8fdb\u884c\u7b5b\u9009\uff0c\u53d1\u73b0\u4e0e\u5c0f\u5206\u5b50\u5316\u5408\u7269\u7ed3\u5408\u7684\u4f4d\u70b9\u3002\u540c\u65f6\u8be5\u516c\u53f8\u8fd8\u5728\u5f00\u53d1\u86cb\u767d\u964d\u89e3\u6280\u672f\uff0c\u8ba9\u4e0e\u86cb\u767d\u7ed3\u5408\u7684\u5c0f\u5206\u5b50\u5316\u5408\u7269\u80fd\u591f\u4ecb\u5bfc\u5bf9\u9776\u70b9\u7684\u5b9a\u5411\u86cb\u767d\u964d\u89e3\uff0c\u4ece\u800c\u4e3a\u9776\u5411\u201c\u4e0d\u53ef\u6210\u836f\u201d\u9776\u70b9\u6dfb\u52a0\u4e86\u4e00\u9879\u65b0\u6b66\u5668\u3002<\/p>\n
\u8be5\u516c\u53f8\u5728\u4eca\u5e746\u6708\u5b8c\u6210\u6570\u989d\u4e3a6700\u4e07\u7f8e\u5143\u7684A\u8f6e\u878d\u8d44\u3002<\/p>\n
\u65b0\u9510\u540d\u79f0\uff1aKymera Therapeutics
\n\u6210\u7acb\u5e74\u4efd\uff1a2016
\n\u4e34\u5e8a\u4e13\u653b\uff1a\u5229\u7528\u7ec6\u80de\u7684\u6cdb\u7d20-\u86cb\u767d\u9176\u4f53\u7cfb\u7edf\uff0c\u9776\u5411\u964d\u89e3\u81f4\u75c5\u86cb\u767d\u3002<\/p>\n
\u5229\u7528\u7ec6\u80de\u7684\u6cdb\u7d20-\u86cb\u767d\u9176\u4f53\u7cfb\u7edf\u9776\u5411\u964d\u89e3\u81f4\u75c5\u86cb\u767d\u6b63\u5728\u6210\u4e3a\u9776\u5411\u201c\u4e0d\u53ef\u6210\u836f\u201d\u86cb\u767d\u7684\u4e00\u4e2a\u91cd\u8981\u624b\u6bb5\u3002Kymera\u516c\u53f8\u5df2\u7ecf\u5f00\u53d1\u51fa\u4e00\u7cfb\u5217\u80fd\u591f\u5c06E3\u8fde\u63a5\u9176\u4e0e\u9776\u70b9\u86cb\u767d\u62c9\u5230\u4e00\u8d77\u7684\u5c0f\u5206\u5b50\u5de5\u5177\u3002\u8be5\u516c\u53f8\u7684\u6280\u672f\u5e73\u53f0\u76ee\u524d\u5df2\u7ecf\u5f00\u53d1\u51fa\u9776\u5411\u86cb\u767d\u6fc0\u9176IRAK4\u548c\u8f6c\u5f55\u56e0\u5b50STAT3\u7684\u86cb\u767d\u964d\u89e3\u5242\u3002\u8be5\u516c\u53f8\u7684\u4e3b\u6253\u4ea7\u54c1KYM-001\u9776\u5411\u643a\u5e26\u7a81\u53d8\u7684IRAK4\uff0c\u53ef\u4ee5\u7528\u4e8e\u6cbb\u7597\u4fb5\u88ad\u6027B\u7ec6\u80de\u6dcb\u5df4\u7624\u3002\u8fd9\u6b3e\u5728\u7814\u7597\u6cd5\u5373\u5c06\u5728\u4eca\u5e74\u4e0b\u534a\u5e74\u8fdb\u5165\u4e34\u5e8a\u671f\u5f00\u53d1\u9636\u6bb5\u3002<\/p>\n
\u56fe\u7247\u6765\u6e90\uff1aKymera\u516c\u53f8\u5b98\u7f51<\/p>\n
\u8be5\u516c\u53f8\u53bb\u5e74\u5b8c\u62106500\u4e07\u7f8e\u5143\u7684B\u8f6e\u878d\u8d44\uff0c\u5e76\u4e14\u4e0e\u845b\u5170\u7d20\u53f2\u514b\uff08GSK\uff09\u548cVertex Pharmaceuticals\u516c\u53f8\u5206\u522b\u8fbe\u6210\u7814\u53d1\u5408\u4f5c\u3002<\/p>\n
\u65b0\u9510\u540d\u79f0\uff1aLocus Biosciences
\n\u6210\u7acb\u5e74\u4efd\uff1a2015
\n\u4e34\u5e8a\u4e13\u653b\uff1a\u4f7f\u7528CRISPR\u6280\u672f\u6b66\u88c5\u7684\u566c\u83cc\u4f53\u6cbb\u7597\u7ec6\u83cc\u611f\u67d3\u548c\u5fae\u751f\u7269\u7ec4\u76f8\u5173\u75be\u75c5<\/p>\n
\u566c\u83cc\u4f53\u662f\u81ea\u7136\u754c\u4e2d\u5b58\u5728\u7684\u4ee5\u6740\u6b7b\u7ec6\u83cc\u4e3a\u751f\u7684\u75c5\u6bd2\u3002\u968f\u7740\u7ec6\u83cc\u8010\u836f\u6027\u95ee\u9898\u7684\u65e5\u76ca\u52a0\u91cd\uff0c\u591a\u5bb6\u516c\u53f8\u5728\u5f00\u53d1\u4f7f\u7528\u566c\u83cc\u4f53\u6cbb\u7597\u7ec6\u83cc\u6027\u611f\u67d3\u7684\u521b\u65b0\u7597\u6cd5\u3002<\/p>\n
\u5728\u81ea\u7136\u754c\u4e2d\u53d1\u73b0\u7684\u5929\u7136\u566c\u83cc\u4f53\u867d\u7136\u5177\u6709\u6740\u6b7b\u7279\u5b9a\u83cc\u682a\u7684\u6548\u679c\uff0c\u4f46\u662f\u5728\u6740\u83cc\u6548\u529b\u65b9\u9762\u901a\u5e38\u4e0d\u5f3a\u3002Locus Biosciences\u7684\u7814\u53d1\u7b56\u7565\u662f\u4e3a\u5929\u7136\u7684\u566c\u83cc\u4f53\u6b66\u88c5\u4e0a\u65b0\u7684\u6b66\u5668\u3002\u8be5\u516c\u53f8\u5728\u566c\u83cc\u4f53\u4e2d\u52a0\u4e0a\u4e86\u8868\u8fbeCRISPR-Cas3\u9176\u7684\u8f6c\u57fa\u56e0\u3002\u4e0e\u6211\u4eec\u719f\u77e5\u7684CRISPR-Cas9\u4e0d\u540c\uff0cCRISPR-Cas3\u7684\u4f5c\u7528\u662f\u5207\u788e\u5b83\u7684DNA\u9776\u70b9\uff0c\u4ece\u800c\u5bfc\u81f4\u7ec6\u83cc\u7684\u6b7b\u4ea1\u3002<\/p>\n
\u7531\u4e8e\u566c\u83cc\u4f53\u5bf9\u4e8e\u9776\u5411\u7684\u83cc\u682a\u5177\u6709\u9ad8\u5ea6\u7684\u9009\u62e9\u6027\uff0c\u56e0\u6b64\u8fd9\u79cd\u7597\u6cd5\u53ea\u4f1a\u5728\u7279\u5b9a\u7ec6\u83cc\u5185\u90e8\u5207\u788eDNA\uff0c\u5177\u6709\u5f88\u9ad8\u7684\u5b89\u5168\u6027\u3002<\/p>\n
Locus\u516c\u53f8\u5728\u4eca\u5e741\u6708\u4e0e\u6768\u68ee\u8fbe\u6210\u6570\u989d\u53ef\u9ad8\u8fbe7.92\u4ebf\u7f8e\u5143\u7684\u7814\u53d1\u534f\u8bae\u3002<\/p>\n
\u65b0\u9510\u540d\u79f0\uff1aMaze Therapeutics
\n\u6210\u7acb\u5e74\u4efd\uff1a2018
\n\u4e34\u5e8a\u4e13\u653b\uff1a\u5229\u7528\u5929\u7136\u5b58\u5728\u7684\u57fa\u56e0\u53d8\u5f02\u548c\u5927\u89c4\u6a21\u57fa\u56e0\u7b5b\u9009\uff0c\u53d1\u73b0\u9884\u9632\u75be\u75c5\u7684\u57fa\u56e0\u53d8\u5f02\u5e76\u4e14\u5f00\u53d1\u57fa\u4e8e\u8fd9\u4e9b\u57fa\u56e0\u529f\u80fd\u7684\u7597\u6cd5\u3002<\/p>\n
\u4eba\u7c7b\u57fa\u56e0\u4e2d\u5929\u7136\u5b58\u5728\u7684\u591a\u6837\u6027\u53ef\u80fd\u63d0\u9ad8\uff0c\u4e5f\u53ef\u4ee5\u964d\u4f4e\u7279\u5b9a\u75be\u75c5\u7684\u98ce\u9669\u3002\u4f8b\u5982\uff0c\u643a\u5e26APOE4\u7b49\u4f4d\u57fa\u56e0\u7684\u4eba\u7fa4\u60a3\u4e0a\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08AD\uff09\u7684\u98ce\u9669\u63d0\u9ad8\uff0c\u800c\u643a\u5e26APOE2\u7b49\u4f4d\u57fa\u56e0\u7684\u4eba\u7fa4\u60a3\u4e0aAD\u7684\u98ce\u9669\u5219\u4f1a\u964d\u4f4e\u3002\u643a\u5e26\u540c\u6837\u81f4\u547d\u57fa\u56e0\u7a81\u53d8\u7684\u60a3\u8005\u53ef\u80fd\u56e0\u4e3a\u8eab\u4f53\u4e2d\u5176\u5b83\u57fa\u56e0\u7684\u591a\u6837\u6027\u800c\u4ea7\u751f\u4e25\u91cd\u7a0b\u5ea6\u4e0d\u540c\u7684\u75c7\u72b6\u3002Maze\u516c\u53f8\u7684\u7814\u53d1\u7b56\u7565\u662f\u63a2\u7d22\u4eba\u7c7b\u4e2d\u5df2\u7ecf\u5b58\u5728\u7684\u57fa\u56e0\u591a\u6837\u6027\uff0c\u4ece\u4e2d\u53d1\u73b0\u80fd\u591f\u964d\u4f4e\u7279\u5b9a\u75be\u75c5\u98ce\u9669\u7684\u57fa\u56e0\u53d8\u5f02\uff0c\u7136\u540e\u5f00\u53d1\u521b\u65b0\u7597\u6cd5\u6765\u6a21\u62df\u8fd9\u4e9b\u57fa\u56e0\u53d8\u5f02\u7684\u6548\u679c\u3002<\/p>\n
\u56fe\u7247\u6765\u6e90\uff1aMaze\u516c\u53f8\u5b98\u7f51<\/p>\n
\u8be5\u516c\u53f8\u76ee\u524d\u7684\u4e3b\u6253\u7814\u53d1\u9879\u76ee\u7528\u4e8e\u6cbb\u7597\u808c\u840e\u7f29\u6027\u4fa7\u7d22\u786c\u5316\u75c7\uff0c\u5176\u5b83\u6cbb\u7597\u9886\u57df\u5305\u62ec\u4ee3\u8c22\u7c7b\u75be\u75c5\uff0c\u80be\u75c5\u548c\u9752\u5149\u773c\u3002<\/p>\n
\u65b0\u9510\u540d\u79f0\uff1aNkarta Therapeutics
\n\u6210\u7acb\u5e74\u4efd\uff1a2015
\n\u4e34\u5e8a\u4e13\u653b\uff1a\u57fa\u4e8e\u5929\u7136\u6740\u4f24\u7ec6\u80de\uff08NK cells\uff09\u7684\u5373\u7528\u578b\u6297\u764c\u7597\u6cd5\u3002<\/p>\n
CAR-T\u7597\u6cd5\u662f\u764c\u75c7\u6cbb\u7597\u9886\u57df\u7684\u91cd\u8981\u7a81\u7834\u3002\u7136\u800c\u5b83\u7684\u5e94\u7528\u53d7\u5230\u591a\u79cd\u56e0\u7d20\u7684\u9650\u5236\uff0c\u5305\u62ec\u9700\u8981\u4ece\u60a3\u8005\u81ea\u8eab\u83b7\u53d6T\u7ec6\u80de\uff0c\u590d\u6742\u8d39\u65f6\u7684\u5236\u9020\u8fc7\u7a0b\uff0c\u4ee5\u53ca\u53ef\u80fd\u4ea7\u751f\u7684\u526f\u4f5c\u7528\u3002Nkarta\u516c\u53f8\u8ba4\u4e3a\uff0c\u5bf9NK\u7ec6\u80de\u8fdb\u884c\u6539\u9020\u800c\u4ea7\u751f\u7684\u6297\u764c\u7597\u6cd5\uff0c\u53ef\u4ee5\u7a81\u7834\u8fd9\u4e9b\u5c40\u9650\u6027\u3002\u4e3a\u764c\u75c7\u60a3\u8005\u5e26\u6765\u66f4\u597d\u7684\u6cbb\u7597\u9009\u62e9\u3002<\/p>\n
NK\u7ec6\u80de\u662f\u4eba\u4f53\u5148\u5929\u514d\u75ab\u7cfb\u7edf\u7684\u91cd\u8981\u6210\u5458\u3002\u6539\u9020NK\u7ec6\u80de\u7684\u8fc7\u7a0b\u548cCAR-T\u7597\u6cd5\u7c7b\u4f3c\uff0c\u90fd\u9700\u8981\u5728\u7ec6\u80de\u8868\u9762\u8868\u8fbe\u8bc6\u522b\u764c\u75c7\u7279\u5f02\u6027\u6297\u539f\u7684\u53d7\u4f53\u3002\u57fa\u4e8eNK\u7ec6\u80de\u7684\u6297\u764c\u7597\u6cd5\u7684\u4f18\u52bf\u5728\u4e8e\uff0c\u60a3\u8005\u53ef\u4ee5\u63a5\u53d7\u4ece\u5065\u5eb7\u4f9b\u4f53\u4e2d\u83b7\u5f97\u7684NK\u7ec6\u80de\u800c\u4e0d\u4f1a\u4ea7\u751f\u514d\u75ab\u6392\u65a5\u53cd\u5e94\u3002\u800c\u4e14\u57fa\u4e8eNK\u7ec6\u80de\u7684\u7ec6\u80de\u7597\u6cd5\u4e0d\u4f1a\u4ea7\u751f\u7ec6\u80de\u56e0\u5b50\u91ca\u653e\u7efc\u5408\u5f81\u8fd9\u6837\u7684\u4e25\u91cd\u526f\u4f5c\u7528\u3002<\/p>\n
\u56fe\u7247\u6765\u6e90\uff1aNkarta\u516c\u53f8\u5b98\u7f51<\/p>\n
\u8be5\u516c\u53f8\u76ee\u524d\u7684\u4e3b\u6253\u7814\u53d1\u9879\u76ee\u5305\u62ec\u9776\u5411NKG2D\u7684NK\u7ec6\u80de\u7597\u6cd5NKX101\uff0c\u5b83\u5c06\u7528\u4e8e\u6cbb\u7597\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u548c\u809d\u810f\u76f8\u5173\u5b9e\u4f53\u7624\u3002\u53e6\u4e00\u6b3e\u9776\u5411CD19\u7684NK\u7ec6\u80de\u7597\u6cd5\u5c06\u7528\u4e8e\u6cbb\u7597B\u7ec6\u80de\u8840\u6db2\u764c\u75c7\u3002<\/p>\n
\u65b0\u9510\u540d\u79f0\uff1aNocion Therapeutics
\n\u6210\u7acb\u5e74\u4efd\uff1a2017
\n\u4e34\u5e8a\u4e13\u653b\uff1a\u5f00\u53d1\u9776\u5411\u4f24\u5bb3\u6027\u611f\u53d7\u5668\u7684\u54b3\u55fd\u3001\u7619\u75d2\u3001\u75bc\u75db\u4e0e\u708e\u75c7\u7597\u6cd5\u3002<\/p>\n
Nocion\u516c\u53f8\u6cbb\u7597\u7684\u75be\u75c5\u9886\u57df\u662f\u54b3\u55fd\u3001\u7619\u75d2\u548c\u75bc\u75db\u3002\u76ee\u524d\u6cbb\u7597\u8fd9\u4e9b\u75c7\u72b6\u7684\u5927\u90e8\u5206\u7597\u6cd5\u4e3a\u4eff\u5236\u836f\uff0c\u8be5\u516c\u53f8\u5e0c\u671b\u57fa\u4e8e\u4f24\u5bb3\u6027\u611f\u53d7\u5668\u7684\u65b0\u578b\u7597\u6cd5\u80fd\u591f\u4e3a\u8fd9\u4e9b\u75be\u75c5\u9886\u57df\u5e26\u6765\u521b\u65b0\u3002<\/p>\n
\u8be5\u516c\u53f8\u5f00\u53d1\u7684\u540d\u4e3anocion\u7684\u521b\u65b0\u836f\u7269\u80fd\u591f\u901a\u8fc7\u611f\u89c9\u795e\u7ecf\u5143\u8868\u9762\u7684\u5927\u5b54\u4f24\u5bb3\u6027\u611f\u53d7\u5668\uff08large-pore nociceptor\uff09\u8fdb\u5165\u5230\u611f\u89c9\u795e\u7ecf\u5143\u5185\u90e8\uff0c\u7136\u540e\u963b\u65ad\u795e\u7ecf\u5143\u8868\u9762\u7684\u94a0\u79bb\u5b50\u901a\u9053\uff0c\u4ece\u800c\u6291\u5236\u795e\u7ecf\u51b2\u52a8\u7684\u53d1\u653e\u3002\u8fd9\u7c7b\u836f\u7269\u7684\u72ec\u7279\u4e4b\u5904\u5728\u4e8e\uff0c\u53ea\u4f1a\u8fdb\u5165\u5927\u5b54\u4f24\u5bb3\u6027\u611f\u53d7\u5668\u5df2\u7ecf\u88ab\u6fc0\u6d3b\u7684\u611f\u89c9\u795e\u7ecf\u5143\uff0c\u800c\u4e0d\u4f1a\u8fdb\u5165\u5176\u5b83\u7ec6\u80de\u3002\u56e0\u6b64\u5b83\u7684\u4f5c\u7528\u6709\u5f88\u5f3a\u7684\u7279\u5f02\u6027\u3002\u80fd\u591f\u5728\u6291\u5236\u75bc\u75db\u6216\u8005\u7619\u75d2\u7684\u540c\u65f6\uff0c\u4e0d\u4f1a\u5f71\u54cd\u5230\u89e6\u89c9\u795e\u7ecf\u5143\u6216\u8005\u5176\u5b83\u795e\u7ecf\u5143\u7684\u6d3b\u6027\u3002<\/p>\n
\u56fe\u7247\u6765\u6e90\uff1aNocion\u516c\u53f8\u5b98\u7f51<\/p>\n
\u8fd9\u5bb6\u516c\u53f8\u5728\u4eca\u5e744\u6708\u5b8c\u6210\u6570\u989d\u4e3a2700\u4e07\u7f8e\u5143\u7684A\u8f6e\u878d\u8d44\u3002<\/p>\n
\u65b0\u9510\u540d\u79f0\uff1aPrelude Therapeutics
\n\u6210\u7acb\u5e74\u4efd\uff1a2016
\n\u4e34\u5e8a\u4e13\u653b\uff1a\u901a\u8fc7\u9776\u5411\u86cb\u767d\u8d28\u7cbe\u6c28\u9178\u7532\u57fa\u8f6c\u79fb\u91765\uff08PRMT5\uff09\uff0c\u6cbb\u7597\u8010\u836f\u6027\u5b9e\u4f53\u7624\u548c\u8840\u6db2\u764c\u75c7<\/p>\n
\u6cbb\u7597\u83b7\u5f97\u6027\u8010\u836f\u6027\u662f\u591a\u79cd\u764c\u75c7\u60a3\u8005\u5728\u83b7\u5f97\u7f13\u89e3\u4e4b\u540e\u75be\u75c5\u590d\u53d1\u7684\u4e3b\u8981\u539f\u56e0\u3002Prelude\u516c\u53f8\u7684\u7814\u53d1\u7b56\u7565\u662f\u5f00\u53d1\u9776\u5411\u4ecb\u5bfc\u83b7\u5f97\u6027\u8010\u836f\u6027\u7684\u4fe1\u53f7\u901a\u8def\u3002\u8be5\u516c\u53f8\u7684\u4e3b\u6253\u4ea7\u54c1\u9776\u5411PRMT5\u3002PRMT5\u662f\u4e00\u79cd\u5728\u7ec4\u86cb\u767d\u548c\u5176\u5b83\u86cb\u767d\u7684\u7cbe\u6c28\u9178\u4e0a\u6dfb\u52a0\u7532\u57fa\u5316\u4fee\u9970\u7684\u86cb\u767d\u9176\u3002\u7cbe\u6c28\u9178\u7532\u57fa\u5316\u80fd\u591f\u5f71\u54cdmRNA\u526a\u63a5\uff0c\u7ec6\u80de\u5468\u671f\u7b49\u751f\u7406\u8fc7\u7a0b\uff0c\u88ab\u8ba4\u4e3a\u662f\u81f4\u764c\u548c\u8010\u836f\u6027\u4ea7\u751f\u7684\u91cd\u8981\u673a\u5236\u3002\u5b83\u5728\u591a\u79cd\u764c\u75c7\u4e2d\u8fc7\u5ea6\u8868\u8fbe\uff0c\u5305\u62ec\u8180\u80f1\u764c\uff0c\u4e09\u9634\u6027\u4e73\u817a\u764c\uff0c\u4ee5\u53ca\u6dcb\u5df4\u7624\u548c\u9ad3\u7cfb\u8840\u6db2\u764c\u75c7\u3002<\/p>\n
\u56fe\u7247\u6765\u6e90\uff1aPrelude\u516c\u53f8\u5b98\u7f51<\/p>\n
\u8be5\u516c\u53f8\u7684\u4e3b\u6253PRMT5\u6291\u5236\u5242PRT543\u76ee\u524d\u57281\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u63a5\u53d7\u68c0\u9a8c\u3002PRMT5\u540c\u65f6\u5728MYC\u4ecb\u5bfc\u7684\u81f4\u764c\u4f5c\u7528\u548cJAK3\u4fe1\u53f7\u901a\u8def\u4e2d\u4e5f\u8d77\u5230\u91cd\u8981\u4f5c\u7528\uff0c\u662f\u4e00\u4e2a\u5bcc\u6709\u6f5c\u529b\u7684\u9776\u70b9\u3002<\/p>\n
\u65b0\u9510\u540d\u79f0\uff1aQuell Therapeutics
\n\u6210\u7acb\u5e74\u4efd\uff1a2019
\n\u4e34\u5e8a\u4e13\u653b\uff1a\u901a\u8fc7\u6539\u9020\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg\uff09\uff0c\u6cbb\u7597\u5668\u5b98\u79fb\u690d\u6392\u65a5\u3001\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u548c\u708e\u75c7\u6027\u75be\u75c5\u3002<\/p>\n
Treg\u7ec6\u80de\u662f\u4eba\u4f53\u4e2d\u63a7\u5236\u514d\u75ab\u53cd\u5e94\u7684T\u7ec6\u80de\u4e9a\u7fa4\u3002\u5b83\u53c2\u4e0e\u591a\u79cd\u514d\u75ab\u8c03\u8282\u8fc7\u7a0b\uff0c\u5728\u7ef4\u6301\u673a\u4f53\u514d\u75ab\u5e73\u8861\u548c\u9884\u9632\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u4ee5\u53ca\u79fb\u690d\u6392\u65a5\u65b9\u9762\u53d1\u6325\u91cd\u8981\u7684\u4f5c\u7528\u3002Quell\u516c\u53f8\u7684\u7b56\u7565\u662f\u5229\u7528CAR-T\u7ec6\u80de\u7684\u539f\u7406\uff0c\u5728Treg\u7ec6\u80de\u8868\u9762\u8868\u8fbe\u7279\u5b9a\u5d4c\u5408\u6297\u539f\u53d7\u4f53\uff08CAR\uff09\uff0c\u4ece\u800c\u5c06Treg\u7ec6\u80de\u52df\u96c6\u5230\u8eab\u4f53\u7684\u7279\u5b9a\u533a\u57df\uff0c\u5728\u5c40\u90e8\u6784\u5efa\u514d\u75ab\u6291\u5236\u73af\u5883\u3002\u8fd9\u53ef\u4ee5\u7528\u4e8e\u4fdd\u62a4\u79fb\u690d\u7684\u5668\u5b98\u4e0d\u53d7\u5bbf\u4e3b\u514d\u75ab\u7cfb\u7edf\u7684\u653b\u51fb\uff0c\u6216\u8005\u6291\u5236\u81ea\u8eab\u514d\u75ab\u53cd\u5e94\u548c\u708e\u75c7\u3002<\/p>\n
\u65b0\u9510\u540d\u79f0\uff1aSanifit
\n\u6210\u7acb\u5e74\u4efd\uff1a2014
\n\u4e34\u5e8a\u4e13\u653b\uff1a\u5f00\u53d1\u6cbb\u7597\u9499\u5316\u9632\u5fa1\uff08calciphylaxis\uff09\u7684\u521b\u65b0\u7597\u6cd5\u3002<\/p>\n
\u9499\u5316\u9632\u5fa1\u662f\u4e00\u79cd\u76ae\u80a4\u548c\u8102\u80aa\u7ec4\u7ec7\u7684\u4e25\u91cd\u8840\u7ba1\u9499\u5316\u75be\u75c5\u3002\u5728\u5c0f\u8840\u7ba1\u4e2d\u7684\u9499\u6c89\u79ef\u4f1a\u5bfc\u81f4\u8840\u7ba1\u963b\u585e\uff0c\u5e26\u6765\u975e\u5e38\u75bc\u75db\u7684\u5931\u80fd\u6027\u6162\u6027\u76ae\u80a4\u75c5\u53d8\u3002\u9499\u5316\u9632\u5fa1\u57281-4%\u63a5\u53d7\u900f\u6790\u7684\u6162\u6027\u80be\u75c5\u60a3\u8005\u4e2d\u4ea7\u751f\uff0c\u60a3\u8005\u4e00\u5e74\u6b7b\u4ea1\u7387\u9ad8\u8fbe55%\u3002<\/p>\n
\u8be5\u516c\u53f8\u7684\u4e3b\u6253\u4ea7\u54c1SNF472\u662f\u4e00\u6b3e\u5177\u6709\u72ec\u7279\u673a\u5236\u7684\u9499\u5316\u6291\u5236\u5242\u3002\u5b83\u7684\u4f5c\u7528\u65b9\u5f0f\u662f\u4e0e\u9499\u5316\u90e8\u4f4d\u7684\u7f9f\u57fa\u78f7\u7070\u77f3\uff08HAP\uff09\u6676\u4f53\u76f8\u7ed3\u5408\uff0c\u4ece\u800c\u6291\u5236\u6676\u4f53\u7684\u7ee7\u7eed\u589e\u957f\uff0c\u9632\u6b62\u8840\u7ba1\u7684\u963b\u585e\u3002<\/p>\n
SNF472\u57282\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5df2\u7ecf\u8868\u73b0\u51fa\u4fc3\u8fdb\u4f24\u53e3\u6108\u5408\u548c\u63a7\u5236\u4e0e\u9499\u5316\u9632\u5fa1\u76f8\u5173\u75bc\u75db\u7684\u6548\u679c\u3002\u5b83\u5df2\u7ecf\u83b7\u5f97\u7f8e\u56fdFDA\u548c\u6b27\u76dfEMA\u6388\u4e88\u7684\u5b64\u513f\u836f\u8d44\u683c\u3002\u68c0\u9a8c\u5b83\u7684\u7597\u6548\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5c06\u5728\u4eca\u5e74\u665a\u4e9b\u65f6\u5019\u8fdb\u884c\u3002<\/p>\n
\u56fe\u7247\u6765\u6e90\uff1aSanifit\u516c\u53f8\u5b98\u7f51<\/p>\n
\u8be5\u516c\u53f8\u6700\u8fd1\u5b8c\u6210\u4e86\u6570\u989d\u4e3a6290\u4e07\u7f8e\u5143\u7684D\u8f6e\u878d\u8d44\u3002<\/p>\n
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\n[1] FierceBiotech’s 2019 Fierce 15. Retrieved September 23, 2019, from https:\/\/www.fiercebiotech.com\/special-report\/fiercebiotech-s-2019-fierce-15
\n[2] Anthos Therapeutics. Retrieved September 23, 2019, from https:\/\/www.anthostherapeutics.com\/#about-maa868
\n[3] Black Diamond Therapeutics. Retrieved September 23, 2019, from https:\/\/www.blackdiamondtherapeutics.com\/pipeline\/
\n[4] Casma Therapeutics. Retrieved September 23, 2019, from https:\/\/www.casmatx.com\/approach\/
\n[5] Celsius Therapeutics. Retrieved September 23, 2019, from https:\/\/celsiustx.com\/programs\/
\n[6] Confo Therapeutics. Retrieved September 23, 2019, from http:\/\/confotherapeutics.com\/research.html
\n[7] Dewpoint Therapeutics. Retrieved September 23, 2019, from https:\/\/dewpointx.com\/approach\/#new-approach
\n[8] Frontier Medicines. Retrieved September 23, 2019, from https:\/\/frontiermeds.com\/
\n[9] Kymera Therapeutics. Retrieved September 23, 2019, from https:\/\/www.kymeratx.com\/science\/
\n[10] Locus Biosciences. Retrieved September 23, 2019, from https:\/\/www.locus-bio.com\/technology\/
\n[11] Maze Therapeutics. Retrieved September 23, 2019, from https:\/\/mazetx.com\/science\/
\n[12] Nkarta Therapeutics. Retrieved September 23, 2019, from https:\/\/www.nkartatx.com\/technology\/
\n[13] Nocion Therapeutics. Retrieved September 23, 2019, from https:\/\/www.nociontx.com\/
\n[14] Prelude Therapeutics. Retrieved September 23, 2019, from https:\/\/preludetx.com\/prmt5\/
\n[15] Quell Therapeutics. Retrieved September 23, 2019, from https:\/\/www.quell-tx.com\/
\n[16] Sanifit. Retrieved September 23, 2019, from https:\/\/www.sanifit.com\/lead-compound-snf472\/#mechanism-of-action<\/p>\n","protected":false},"excerpt":{"rendered":"
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