{"id":1457185,"date":"2019-10-14T18:49:54","date_gmt":"2019-10-15T01:49:54","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=1457185"},"modified":"2019-10-14T18:51:52","modified_gmt":"2019-10-15T01:51:52","slug":"%e8%8d%af%e6%98%8e%e5%ba%b7%e5%be%b7%e9%80%9f%e9%80%92%ef%bc%9a%e7%b3%bb%e5%88%97%e6%96%b0%e7%aa%81%e7%a0%b4%e5%87%ba%e5%b8%88-%e6%94%bb%e5%85%8b%e5%9b%b0%e6%89%b0%e7%94%b7%e6%80%a7%e5%8d%83","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/%e8%8d%af%e6%98%8e%e5%ba%b7%e5%be%b7%e9%80%9f%e9%80%92%ef%bc%9a%e7%b3%bb%e5%88%97%e6%96%b0%e7%aa%81%e7%a0%b4%e5%87%ba%e5%b8%88-%e6%94%bb%e5%85%8b%e5%9b%b0%e6%89%b0%e7%94%b7%e6%80%a7%e5%8d%83\/.html","title":{"rendered":"\u836f\u660e\u5eb7\u5fb7\u901f\u9012\uff1a\u7cfb\u5217\u65b0\u7a81\u7834\u51fa\u5e08 \u653b\u514b\u56f0\u6270\u7537\u6027\u7684\u201c\u5343\u5e74\u6740\u624b\u201d\uff08\u56fe\uff09"},"content":{"rendered":"

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\u4ece\u9996\u4f8b\u524d\u5217\u817a\u764c\u5230\u4e24\u4e2a\u8bfa\u5956<\/b><\/p>\n

\u73b0\u5728\u7684\u4eba\u4eec\u5f88\u96be\u60f3\u8c61\uff0c\u524d\u5217\u817a\u764c\u57281853\u5e74\u88ab\u9996\u6b21\u786e\u8bca\u65f6\uff0c\u7adf\u88ab\u8ba4\u4e3a\u662f\u201c\u4e00\u79cd\u975e\u5e38\u7f55\u89c1\u7684\u75be\u75c5\u201d\u3002\u5728\u63a5\u4e0b\u6765\u7684\u8fd1\u4e00\u4e2a\u4e16\u7eaa\u91cc\uff0c\u79d1\u5b66\u5bb6\u548c\u533b\u751f\u4eec\u53d6\u5f97\u7684\u8fdb\u5c55\u4e5f\u6781\u4e3a\u6709\u9650\u3002\u4e0a\u4e16\u7eaa40\u5e74\u4ee3\uff0c\u524d\u5217\u817a\u764c\u662f\u6b7b\u4ea1\u7684\u4ee3\u540d\u8bcd\uff0c\u786e\u8bca\u540e\uff0c\u60a3\u8005\u7684\u751f\u5b58\u671f\u4ec5\u67091-2\u5e74\u3002<\/p>\n

\u8f6c\u673a\u51fa\u73b0\u57281941\u5e74\u3002\u8fd9\u4e00\u5e74\uff0c\u7f8e\u56fd\u829d\u52a0\u54e5\u5927\u5b66\u7684\u67e5\u5c14\u65af\u00b7\u54c8\u91d1\u65af\uff08Charles Huggins\uff09\u6559\u6388\u4e0e\u5408\u4f5c\u4f19\u4f34\u4eec\u53d1\u8868\u4e86\u591a\u7bc7\u8bba\u6587\uff0c\u63ed\u793a\u4e86\u6fc0\u7d20\u4e0e\u524d\u5217\u817a\u4e4b\u95f4\u7684\u5173\u7cfb\u3002\u7406\u8bba\u4e0a\u8bb2\uff0c\u524d\u5217\u817a\u7684\u751f\u957f\u4e0e\u53d1\u80b2\u4f9d\u8d56\u4e8e\u96c4\u6fc0\u7d20\u7684\u4f5c\u7528\u3002\u56e0\u6b64\u524d\u5217\u817a\u764c\u53ef\u80fd\u4e5f\u548c\u96c4\u6fc0\u7d20\u6709\u6240\u5173\u8054\u3002\u6362\u800c\u8a00\u4e4b\uff0c\u5982\u679c\u80fd\u6291\u5236\u96c4\u6fc0\u7d20\u7684\u529f\u80fd\uff0c\u6216\u8bb8\u5c31\u80fd\u6291\u5236\u524d\u5217\u817a\u764c\u7684\u751f\u957f\u3002<\/p>\n

\"\"<\/a>\u25b2\u67e5\u5c14\u65af\u00b7\u54c8\u91d1\u65af\u6559\u6388\uff08\u56fe\u7247\u6765\u6e90\uff1aNobel Foundation archive\uff09<\/p>\n

\u800c\u5728\u54c8\u91d1\u65af\u6559\u6388\u7684\u8fd9\u4e00\u7cfb\u5217\u7814\u7a76\u4e2d\uff0c\u79d1\u5b66\u5bb6\u4eec\u786e\u8ba4\u4e86\u96c4\u6fc0\u7d20\u4e0e\u96cc\u6fc0\u7d20\u4f1a\u5c55\u5f00\u7ade\u4e89\uff0c\u76f8\u4e92\u6291\u5236\u3002\u4e0e\u4ed6\u4eec\u5148\u524d\u6240\u8bbe\u60f3\u7684\u4e00\u6837\uff0c\u901a\u8fc7\u7ed9\u60a3\u8005\u6ce8\u5c04\u96cc\u6fc0\u7d20\uff0c\u80fd\u591f\u6709\u6548\u5730\u5ef6\u7f13\u524d\u5217\u817a\u764c\u7684\u75c5\u60c5\u8fdb\u5c55\u3002\u6b64\u5916\uff0c\u4ed6\u4eec\u8fd8\u53d1\u73b0\u901a\u8fc7\u624b\u672f\u5207\u9664\u777e\u4e38\uff0c\u4e5f\u80fd\u53d6\u5f97\u7c7b\u4f3c\u7684\u6548\u679c\u3002\u56e0\u6b64\uff0c\u8fd9\u79cd\u901a\u8fc7\u964d\u4f4e\u96c4\u6fc0\u7d20\u6c34\u5e73\u6765\u6cbb\u7597\u80bf\u7624\u7684\u505a\u6cd5\uff0c\u4e5f\u88ab\u79f0\u4f5c\u662f\u201c\u53bb\u52bf\u6cbb\u7597\u201d\u3002<\/p>\n

\u4e0d\u5c11\u79d1\u5b66\u5bb6\u8ba4\u4e3a\uff0c\u8fd9\u662f\u4eba\u7c7b\u9996\u6b21\u901a\u8fc7\u4f7f\u7528\u67d0\u79cd\u5316\u5b66\u7269\u8d28\u6765\u6210\u529f\u63a7\u5236\u524d\u5217\u817a\u764c\u7684\u75c5\u60c5\u3002\u7531\u4e8e\u53d1\u73b0\u4e86\u8fd9\u79cd\u6fc0\u7d20\u7597\u6cd5\uff0c\u54c8\u91d1\u65af\u6559\u6388\u4e5f\u65a9\u83b7\u4e861966\u5e74\u7684\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u3002<\/p>\n

\u54c8\u91d1\u65af\u6559\u6388\u7684\u91cd\u5927\u53d1\u73b0\u63ed\u5f00\u4e86\u524d\u5217\u817a\u764c\u5185\u5206\u6ccc\u7597\u6cd5\u7684\u5e37\u5e55\u3002\u5728\u6b64\u540e\u51e0\u5341\u5e74\u91cc\uff0c\u79d1\u5b66\u7a81\u7834\u5c42\u51fa\u4e0d\u7a77\uff0c\u591a\u79cd\u6291\u5236\u96c4\u6fc0\u7d20\u7684\u836f\u7269\u4e5f\u76f8\u7ee7\u51fa\u73b0\u3002\u5176\u4e2d\u4e00\u4e2a\u91cd\u8981\u7684\u63a8\u52a8\u6765\u81ea\u4e8e\u5b89\u5fb7\u9c81\u00b7\u8428\u5229\uff08Andrew Schally\uff09\u6559\u6388\u56e2\u961f\u3002\u4ed6\u4eec\u7684\u7814\u7a76\u8868\u660e\uff0c\u4e00\u79cd\u53eb\u9ec4\u4f53\u751f\u6210\u7d20\u91ca\u653e\u6fc0\u7d20\uff08LHRH\uff09\u7684\u4e0b\u4e18\u8111\u6fc0\u7d20\uff0c\u53ef\u4ee5\u901a\u8fc7\u4e00\u7cfb\u5217\u751f\u5316\u901a\u8def\uff0c\u6700\u7ec8\u4fc3\u8fdb\u777e\u916e\u7684\u751f\u6210\uff0c\u800c\u777e\u916e\u6b63\u662f\u4e00\u79cd\u4e3b\u8981\u7684\u96c4\u6fc0\u7d20\u3002\u57fa\u4e8e\u8fd9\u4e2a\u53d1\u73b0\uff0c\u79d1\u5b66\u5bb6\u4eec\u5f00\u53d1\u51fa\u4e86\u4e00\u79cd\u53eb\u505aLHRH\u7c7b\u4f3c\u7269\u7684\u836f\u7269\u3002\u5728\u60a3\u8005\u4f53\u5185\uff0c\u9ad8\u6c34\u5e73\u7684LHRH\u7c7b\u4f3c\u7269\u80fd\u591f\u6291\u5236\u777e\u916e\u7684\u751f\u6210\uff0c\u540c\u6837\u8d77\u5230\u6cbb\u7597\u6548\u679c\u3002\u7531\u4e8e\u53d1\u73b0LHRH\uff0c\u8428\u5229\u6559\u6388\u4e5f\u4e0e\u53e6\u5916\u4e24\u540d\u79d1\u5b66\u5bb6\u4e00\u9053\uff0c\u5206\u4eab\u4e861977\u5e74\u7684\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u3002<\/p>\n

\"\"<\/a>\u25b2\u5b89\u5fb7\u9c81\u00b7\u8428\u5229\u6559\u6388\uff08\u56fe\u7247\u6765\u6e90\uff1aNobelprize.org\uff09<\/p>\n

\u6fc0\u7d20\u7597\u6cd5\u4e0d\u65ad\u7a81\u7834\u74f6\u9888<\/b><\/p>\n

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\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u7684\u5b58\u5728\u4e00\u5ea6\u8ba9\u6291\u5236\u96c4\u6fc0\u7d20\u7684\u5185\u5206\u6ccc\u7597\u6cd5\u9677\u5165\u74f6\u9888\uff0c\u6cbb\u7597\u4ec5\u4f9d\u8d56\u4e8e\u5316\u7597\u548c\u653e\u7597\u7b49\u6781\u5176\u6709\u9650\u7684\u624b\u6bb5\u3002\u76f4\u5230\u65b0\u4e16\u7eaa\uff0c\u76f8\u5173\u6cbb\u7597\u9886\u57df\u624d\u7ec8\u4e8e\u53c8\u8fce\u6765\u4e86\u65b0\u7684\u7a81\u7834\u3002<\/p>\n

\u5176\u4e2d\u7684\u7a81\u7834\u4e4b\u4e00\u662f\u201c\u6297\u96c4\u6fc0\u7d20\u7597\u6cd5\u201d\u3002\u4e0e\u5148\u524d\u7684\u7597\u6cd5\u4e0d\u540c\uff0c\u8fd9\u7c7b\u7597\u6cd5\u76f4\u63a5\u4f5c\u7528\u4e8e\u96c4\u6fc0\u7d20\u53d7\u4f53\uff0c\u6291\u5236\u96c4\u6fc0\u7d20\u4e0e\u5176\u7ed3\u5408\uff0c\u505a\u5f97\u66f4\u4e3a\u5f7b\u5e95\u3002\u4e8b\u5b9e\u4e0a\uff0c\u65e9\u57281989\u5e74\uff0c\u7b2c\u4e00\u4ee3\u6297\u96c4\u6fc0\u7d20\u7597\u6cd5flutamide\u5c31\u5df2\u83b7\u7f8e\u56fdFDA\u6279\u51c6\u4e0a\u5e02\u3002\u7136\u800c\u65e9\u671f\u6297\u96c4\u6fc0\u7d20\u4e0e\u96c4\u6fc0\u7d20\u53d7\u4f53\u7684\u4eb2\u548c\u529b\u5e76\u4e0d\u9ad8\uff0c\u56e0\u6b64\u9650\u5236\u4e86\u8fd9\u7c7b\u7597\u6cd5\u7684\u5e94\u7528\u3002<\/p>\n

2012\u5e74\uff0c\u7531Medivation\uff08\u540e\u88ab\u8f89\u745e\u6536\u8d2d\uff09\u4e0e\u5b89\u65af\u6cf0\u6765\uff08Astellas\uff09\u5171\u540c\u5f00\u53d1\u7684Xtandi\uff08enzalutamide\uff09\u83b7\u6279\u4e0a\u5e02\u3002\u4f5c\u4e3a\u65b0\u4e00\u4ee3\u6297\u96c4\u6fc0\u7d20\u7597\u6cd5\uff0c\u5b83\u65e2\u80fd\u6291\u5236\u96c4\u6fc0\u7d20\u4e0e\u5176\u53d7\u4f53\u7ed3\u5408\uff0c\u8fd8\u80fd\u6291\u5236\u96c4\u6fc0\u7d20\u53d7\u4f53\u8fdb\u5165\u7ec6\u80de\u6838\uff0c\u963b\u6b62\u5b83\u542f\u52a8\u4e0b\u6e38\u7684\u751f\u5316\u901a\u8def\u3002\u5728\u7f79\u60a3\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\uff0c\u4e14\u75c5\u60c5\u5df2\u53d1\u751f\u8f6c\u79fb\uff0c\u5316\u7597\u90fd\u65e0\u80fd\u4e3a\u529b\u7684\u60a3\u8005\u4e2d\uff0c\u5018\u82e5\u63a5\u53d7\u4e86Xtandi\u7684\u6cbb\u7597\uff0c\u6709\u4e00\u534a\u7684\u60a3\u8005\u80fd\u6d3b\u8fc718.4\u4e2a\u6708\u3002\u8fd9\u4e00\u6570\u5b57\u6bd4\u5b89\u6170\u5242\u5bf9\u7167\u7ec4\u591a\u51fa\u4e86\u8fd15\u4e2a\u6708\u3002<\/p>\n

\"\"<\/a>\u25b2Xtandi\u4f5c\u7528\u673a\u7406\uff08\u56fe\u7247\u6765\u6e90\uff1a\u53c2\u8003\u8d44\u6599[9]\uff09<\/p>\n

2018\u5e74\u548c2019\u5e74\uff0c\u6768\u68ee\uff08Janssen\uff09\u7684Erleada\uff08apalutamide\uff09\u4e0e\u62dc\u8033\uff08Bayer\uff09\u7684Nubeqa\uff08darolutamide\uff09\u4e5f\u5148\u540e\u83b7FDA\u6279\u51c6\u4e0a\u5e02\uff0c\u52a0\u5165\u5230\u4e86\u6cbb\u7597\u53bb\u52bf\u62b5\u6297\u6027\u524d\u5217\u817a\u764c\u7684\u5927\u519b\u4e2d\u3002<\/p>\n

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\u53c2\u8003\u8d44\u6599:
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\n[5] \u97e9\u82cf\u519b\uff0c\u5f20\u601d\u7ef4\uff0c\u9648\u4e07\u9752\u7b49\uff0e\u4e2d\u56fd\u524d\u5217\u817a\u764c\u53d1\u75c5\u73b0\u72b6\u548c\u6d41\u884c\u8d8b\u52bf\u5206\u6790, \u4e34\u5e8a\u80bf\u7624\u6742\u5fd7, 2013 Apr; 18(4): 330-334
\n[6]\u514d\u75ab\u7597\u6cd5\uff0c\u53ea\u77e5PD-1\uff1f\u5168\u7403\u6700\u65b0\u514d\u75ab\u7597\u6cd5\u6c47\u603b\u2014\u2014\u524d\u5217\u817a\u764c\u7bc7,Jul 18, 2019, from http:\/\/www.sohu.com\/a\/327681515_452785
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\n[8] PARP\u6291\u5236\u5242\u5965\u62c9\u5e15\u5229\u6cbb\u7597\u524d\u5217\u817a\u764c\u8fbe\u52303\u671f\u4e34\u5e8a\u4e3b\u8981\u7ec8\u70b9 Aug 8,2019, from https:\/\/med.sina.com\/article_detail_103_2_69707.html
\n[9] Hoffman-Censits and Kelly, (2013). Enzalutamide: A Novel Antiandrogen for Patients with Castrate-Resistant Prostate Cancer. Clinical Cancer Research, DOI: 10.1158\/1078-0432.CCR-12-2910
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