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\u836f\u660e\u5eb7\u5fb7\u62a5\u9053<\/b>\uff1a\u8fd1\u65e5\u300aNature\u300b\u6df1\u5ea6\u7efc\u8ff0\uff0c\u89e3\u5bc6\u764c\u7ec6\u80de\u7684\u201c\u9003\u8131\u7edd\u6280\u201d\uff0c\u9664\u57fa\u56e0\u7a81\u53d8\u4e4b\u5916\u53e6\u6709\u65b9\u6cd5\uff01<\/p>\n

\u8bf7\u770b\u836f\u660e\u5eb7\u5fb7\u56e2\u961f\u5bf9\u300aNature\u300b\u8be5\u7efc\u8ff0\u7684\u7f16\u8bd1\u6574\u7406\uff1a<\/p>\n

\u5386\u53f2\u4e0a\u8457\u540d\u7684\u9b54\u672f\u5927\u5e08\u54c8\u91cc\u00b7\u80e1\u8fea\u5c3c\uff08Harry Houdini\uff09\u6700\u62ff\u624b\u7684\u7edd\u6280\u5c31\u662f\u201c\u9003\u8131\u620f\u6cd5\u201d\uff0c\u4ed6\u80fd\u591f\u4ece\u4efb\u4f55\u624b\u94d0\u3001\u7ef3\u7d22\u3001\u4fdd\u9669\u67dc\u7b49\u675f\u7f1a\u4e2d\u6210\u529f\u9003\u8131\u3002\u800c\u764c\u7ec6\u80de\u4f3c\u4e4e\u4e5f\u662f\u7ec6\u80de\u4e2d\u7684\u201c\u80e1\u8fea\u5c3c\u201d\uff0c\u65e0\u8bba\u91c7\u7528\u4ec0\u4e48\u7c7b\u578b\u7684\u7597\u6cd5\uff0c\u603b\u6709\u4e00\u4e9b\u764c\u7ec6\u80de\u80fd\u591f\u9003\u8131\u7597\u6cd5\u7684\u6740\u4f24\u800c\u5377\u571f\u91cd\u6765<\/strong>\u3002\u5b83\u4eec\u53c8\u6709\u4ec0\u4e48\u201c\u7edd\u6280\u201d\u80fd\u591f\u5c61\u5c61\u9003\u8131\u6297\u764c\u7597\u6cd5\u7684\u8ffd\u6740\uff1f\u8fd1\u65e5\uff0cNature Reviews Drug Discovery<\/em>\u4e0a\u53d1\u8868\u7684\u4e00\u7bc7\u7efc\u8ff0\u5bf9\u764c\u7ec6\u80de\u7684\u201c\u9003\u8131\u620f\u6cd5\u201d\u8fdb\u884c\u4e86\u76d8\u70b9\u3002\u4eca\u5929\u836f\u660e\u5eb7\u5fb7\u5185\u5bb9\u56e2\u961f\u5c06\u7ed3\u5408\u8fd9\u7bc7\u7efc\u8ff0\u4e0e\u5176\u5b83\u516c\u5f00\u6750\u6599\u7684\u5185\u5bb9\uff0c\u4e3a\u8bfb\u8005\u4ecb\u7ecd\u4e00\u4e0b\u764c\u7ec6\u80de\u7684\u201c\u9003\u8131\u7edd\u6280\u201d\u548c\u6211\u4eec\u80fd\u591f\u91c7\u53d6\u7684\u5e94\u5bf9\u7b56\u7565<\/strong>\u3002<\/section>\n
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\"\"<\/a>\u25b2\u57fa\u56e0\u7a81\u53d8\u4ecb\u5bfc\u548c\u8868\u89c2\u9057\u4f20\u5b66\u4ecb\u5bfc\u7684\u8010\u836f\u6027\uff08\u56fe\u7247\u6765\u6e90\uff1a<\/strong>\u53c2\u8003\u8d44\u6599[2]\uff09<\/strong><\/h1>\n
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\u836f\u7269\u8bf1\u5bfc\u53ef\u5851\u6027\uff08drug-induced plasticity\uff09\u7684\u673a\u5236<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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<\/section>\n
\u8c03\u63a7\u7ec6\u80de\u53ef\u5851\u6027\u7684\u91cd\u8981\u8f6c\u5f55\u56e0\u5b50\u548c\u4fe1\u53f7\u901a\u8def<\/strong><\/section>\n
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\u79d1\u5b66\u5bb6\u4eec\u5bf9\u764c\u7ec6\u80de\u8f6c\u5f55\u7ec4\u7684\u5206\u6790\u53d1\u73b0\u4e86\u4e0e\u7ec6\u80de\u53ef\u5851\u6027\u76f8\u5173\u7684\u91cd\u8981\u8f6c\u5f55\u56e0\u5b50\uff0c\u5176\u4e2dSOX<\/em>\u57fa\u56e0\u5bb6\u65cf\u4e2d\u7684\u591a\u4e2a\u6210\u5458\u5728\u4ecb\u5bfc\u836f\u7269\u5f15\u53d1\u7684\u7ec6\u80de\u53ef\u5851\u6027\u65b9\u9762\u8d77\u5230\u91cd\u8981\u4f5c\u7528\u3002\u5176\u4e2d\uff0c\u5728\u52a8\u7269\u8bd5\u9a8c\u4e2d\uff0cSOX2<\/em>\u53ef\u4ee5\u8bf1\u5bfc\u524d\u5217\u817a\u764c\u548c\u80ba\u764c\u7ec6\u80de\u5206\u5316\u4e3a\u795e\u7ecf\u5185\u5206\u6ccc\u8868\u578b\u3002<\/strong>\u800cSOX10<\/em>\u80fd\u591f\u8bf1\u5bfc\u9ed1\u8272\u7d20\u7624\u548c\u4e73\u817a\u764c\u7ec6\u80de\u5206\u5316\u4e3a\u4e0e\u795e\u7ecf\u810a\uff08neural crest\uff09\u7ec6\u80de\u7c7b\u4f3c\u7684\u72b6\u6001\uff0c\u5e76\u4e14\u5bf9\u836f\u7269\u4ea7\u751f\u6297\u6027<\/strong>\u3002<\/section>\n
<\/section>\n
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<\/section>\n

 <\/p>\n

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\u764c\u75c7\u76f8\u5173\u6210\u7ea4\u7ef4\u7ec6\u80de\uff08CAFs\uff09\u5728\u9ed1\u8272\u7d20\u7624\u4e2d\u901a\u8fc7\u5206\u6ccc\u809d\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff08HGF\uff09\u7b49\u53ef\u6eb6\u6027\u56e0\u5b50\uff0c\u4ee5\u53ca\u4e0e\u764c\u7ec6\u80de\u7684\u63a5\u89e6\uff0c\u4fc3\u8fdb\u7597\u6cd5\u6297\u6027\u4ea7\u751f\u3002\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u8868\u660e\uff0c\u8840\u6d46\u4e2dHGF\u56e0\u5b50\u6c34\u5e73\u8d8a\u9ad8\uff0c\u60a3\u8005\u5bf9BRAF\u6291\u5236\u5242vemurafenib\u7684\u54cd\u5e94\u8d8a\u5dee\u3002<\/section>\n
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\u9664\u4e86CAFs\u4ee5\u5916\uff0c\u5de8\u566c\u7ec6\u80de\u3001\u708e\u75c7\u3001\u548c\u8840\u7ba1\u5bc6\u5ea6\/\u5206\u5e03\u90fd\u4e0e\u836f\u7269\u6297\u6027\u7684\u4ea7\u751f\u76f8\u5173\u3002<\/section>\n
<\/section>\n
\n
\n
\n
\n
\n
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\u9776\u5411\u764c\u7ec6\u80de\u53ef\u5851\u6027\u7684\u7b56\u7565<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
\n
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\u7531\u4e8e\u7ec6\u80de\u53ef\u5851\u6027\u5728\u836f\u7269\u8010\u53d7\u548c\u6297\u6027\u7684\u4ea7\u751f\u65b9\u9762\u5177\u6709\u7684\u91cd\u8981\u4f5c\u7528\uff0c\u9776\u5411\u4fc3\u8fdb\u7ec6\u80de\u53ef\u5851\u6027\u7684\u673a\u5236\u6709\u671b\u5e26\u6765\u66f4\u6df1\u5165\u548c\u6301\u4e45\u7684\u7597\u6548\u3002\u9488\u5bf9\u7ec6\u80de\u53ef\u5851\u6027\u7684\u6cbb\u7597\u7b56\u7565\u53ef\u4ee5\u5206\u4e3a\u4e09\u5927\u7c7b\uff1a\u901a\u8fc7\u6291\u5236\u8c03\u63a7\u7ec6\u80de\u53ef\u5851\u6027\u7684\u5206\u5b50\u673a\u5236\uff0c\u9632\u6b62\u53ef\u5851\u6027\u7684\u4ea7\u751f\uff1b<\/strong>\u7279\u5f02\u6027\u9776\u5411\u7ec6\u80de\u8f6c\u5316\u4e4b\u540e\u7684\u5f62\u6001\uff1b<\/strong>\u9006\u8f6c\u7ec6\u80de\u8f6c\u5316\u7684\u8fc7\u7a0b<\/strong>\u3002\u4e0b\u9762\u6211\u4eec\u6765\u770b\u770b\u79d1\u5b66\u5bb6\u4eec\u5728\u8fd9\u4e09\u4e2a\u65b9\u9762\u53d6\u5f97\u4e86\u54ea\u4e9b\u8fdb\u5c55\u3002<\/section>\n
<\/section>\n

 <\/p>\n

<\/section>\n


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\u56e0\u4e3a\u5bf9\u4ea7\u751f\u8010\u53d7\u7684\u6b8b\u4f59\u764c\u7ec6\u80de\u8fdb\u884c\u6301\u7eed\u6cbb\u7597\u53ef\u80fd\u5bfc\u81f4\u5b83\u4eec\u8f6c\u53d8\u4e3a\u6c38\u4e45\u8010\u836f\u7684\u5f62\u6001\uff0c\u7406\u8bba\u4e0a\u4f7f\u7528\u95f4\u6b47\u6027\u6cbb\u7597\u53ef\u80fd\u5e2e\u52a9\u6291\u5236\u6297\u6027\u7684\u4ea7\u751f<\/strong>\u3002\u6709\u8da3\u7684\u662f\uff0c\u5728\u4f7f\u7528vemurafenib\u6cbb\u7597\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u65f6\uff0c\u95f4\u6b47\u6027\u7ed9\u836f\u65b9\u5f0f\u5c06\u7ec6\u80de\u5bf9\u836f\u7269\u654f\u611f\u7684\u65f6\u95f4\u5ef6\u957f\u4e86\u4e00\u500d\u3002\u95f4\u6b47\u6027\u6cbb\u7597\u65b9\u5f0f\u5728\u63a7\u5236\u524d\u5217\u817a\u764c\u60a3\u8005\u7684\u80bf\u7624\u8fdb\u5c55\u65b9\u9762\u4e5f\u8868\u73b0\u51fa\u53ef\u559c\u7684\u6548\u679c\u3002<\/section>\n
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\u800c\u5e94\u4ed8\u7ec6\u80de\u53ef\u5851\u6027\u4ea7\u751f\u7684\u53e6\u4e00\u4e2a\u65b9\u6cd5\u662f\u9776\u5411\u5bfc\u81f4\u7ec6\u80de\u8868\u578b\u53d8\u5316\u7684\u5173\u952e\u4fe1\u53f7\u8282\u70b9<\/strong>\u3002\u76ee\u524d\u6709\u591a\u6b3e\u5728\u7814\u7597\u6cd5\u5728\u4e34\u5e8a\u524d\u548c\u65e9\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u9776\u5411\u5728\u7ec6\u80de\u5f62\u6001\u8f6c\u5316\u4e2d\u8d77\u5230\u91cd\u8981\u4f5c\u7528\u7684\u8868\u89c2\u9057\u4f20\u5b66\u56e0\u5b50\u3001\u8f6c\u5f55\u56e0\u5b50\u4ee5\u53ca\u5173\u952e\u6027\u4fe1\u53f7\u901a\u8def\uff0c\u8be6\u7ec6\u4fe1\u606f\u8bf7\u770b\u4e0b\u9762\u7684\u8868\u683c\u3002<\/section>\n
<\/section>\n

 <\/p>\n

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\u7ec6\u80de\u8f6c\u5316\u4e3a\u5bf9\u836f\u7269\u4ea7\u751f\u6297\u6027\u7684\u5f62\u6001\u4e4b\u540e\uff0c\u867d\u7136\u5bf9\u5df2\u6709\u7597\u6cd5\u4ea7\u751f\u4e86\u6297\u6027\uff0c\u4f46\u662f\u53ef\u80fd\u66b4\u9732\u51fa\u65b0\u7684\u5f31\u70b9\uff0c\u9776\u5411\u65b0\u7684\u5f31\u70b9\u53ef\u80fd\u5e26\u6765\u65b0\u7597\u6cd5\u3002<\/section>\n
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\u4f8b\u5982\uff0c\u5728NSCLC\u4e2d\uff0c\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176AXL\u7684\u8868\u8fbe\u4e0e\u764c\u7ec6\u80de\u7684\u4e0a\u76ae\u95f4\u8d28\u8f6c\u5316\uff08EMT\uff09\u7279\u5f81\u76f8\u5173\uff0c\u8fd9\u610f\u5473\u7740AXL\u53ef\u80fd\u6210\u4e3a\u6cbb\u7597NSCLC\u7684\u65b0\u9776\u70b9\u3002AXL\u6291\u5236\u5242SGI-7079\u4e0eEGFR\u6291\u5236\u5242erlotinib\u8054\u7528\uff0c\u80fd\u591f\u5728\u5c0f\u9f20\u6a21\u578b\u4e2d\u63d0\u9ad8\u95f4\u8d28\u6837NSCLC\u7ec6\u80de\u5bf9erlotinib\u7684\u654f\u611f\u6027\u3002\u9ed1\u8272\u7d20\u7624\u7ec6\u80de\u5728\u63a5\u53d7\u836f\u7269\u6cbb\u7597\u540e\u4e5f\u4f1a\u63d0\u9ad8AXL\u7684\u8868\u8fbe\uff0c\u5728\u80bf\u7624\u79fb\u690d\u6a21\u578b\u4e2d\uff0c\u4f7f\u7528\u9776\u5411AXL\u7684\u6297\u4f53\u5076\u8054\u836f\u7269\u548cMAPK\u6291\u5236\u5242\u80fd\u591f\u534f\u540c\u4f5c\u7528\uff0c\u6291\u5236\u80bf\u7624\u7684\u751f\u957f\u3002<\/section>\n
<\/section>\n
\u9488\u5bf9\u7ec6\u80de\u8f6c\u5316\u540e\u5f62\u6001\u4e2d\u65b0\u9776\u70b9\u7684\u7814\u7a76\u4fe1\u606f\u8bf7\u53c2\u89c1\u4e0b\u9762\u7684\u8868\u683c\u3002<\/section>\n
<\/section>\n

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[1] Boumahdi & Sauvage, (2019). The great escape: tumour cell plasticity in resistance to targeted therapy. Nature Reviews Drug Discovery, https:\/\/doi.org\/10.1038\/s41573-019-0044-1<\/p>\n

[2] Easwaran et al., (2014). Cancer Epigenetics: Tumor Heterogeneity, Plasticity of Stem-like States, and Drug Resistance. Molecular Cell, https:\/\/doi.org\/10.1016\/j.molcel.2014.05.015.<\/p>\n

[3] Pisco & Huang, (2015). Non-genetic cancer cell plasticity and therapy-induced stemness in tumour relapse: \u2018What does not kill me strengthens me\u2019. BJC, https:\/\/doi.org\/10.1038\/bjc.2015.146<\/p>\n","protected":false},"excerpt":{"rendered":"

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