{"id":1457552,"date":"2019-10-30T16:34:45","date_gmt":"2019-10-30T23:34:45","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=1457552"},"modified":"2019-10-30T16:45:06","modified_gmt":"2019-10-30T23:45:06","slug":"%e7%b4%a2%e5%85%83%e7%94%9f%e7%89%a9%e5%9b%9b%e6%96%b0%e8%8d%af%e7%a6%8f%e9%9f%b3%e4%b9%8b%e5%bc%ba-pre-ipo%e8%9e%8d%e8%b5%84%e5%bf%ab%e9%80%9f%e8%be%be%e6%a0%87%ef%bc%88%e5%9b%be%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/%e7%b4%a2%e5%85%83%e7%94%9f%e7%89%a9%e5%9b%9b%e6%96%b0%e8%8d%af%e7%a6%8f%e9%9f%b3%e4%b9%8b%e5%bc%ba-pre-ipo%e8%9e%8d%e8%b5%84%e5%bf%ab%e9%80%9f%e8%be%be%e6%a0%87%ef%bc%88%e5%9b%be%ef%bc%89\/.html","title":{"rendered":"\u7d22\u5143\u751f\u7269\u56db\u65b0\u836f\u798f\u97f3\u4e4b\u5f3a Pre-IPO\u878d\u8d44\u5feb\u901f\u8fdb\u5c55\uff08\u56fe\uff09"},"content":{"rendered":"<p style=\"text-align: center;\"><span style=\"color: #000080;\"><strong>\u7d22\u5143\u751f\u7269\u542f\u52a8Pre-IPO\u878d\u8d44\uff0c4\u5927\u9996\u521b\u65b0\u836f\u6709\u671b\u52a9\u529b\u8d44\u672c\u4e4b\u8def\uff01<\/strong><\/span><\/p>\n<p><strong>\u836f\u660e\u5eb7\u5fb7<\/strong>\u5feb\u8baf\uff1a\u4e2d\u56fd\u7cbe\u51c6\u533b\u7597\u4f01\u4e1a- \u7d22\u5143\u751f\u7269\u8fd1\u65e5\u5ba3\u5e03<strong>\u542f\u52a8<\/strong><strong>Pre-IPO<\/strong><strong>\u878d\u8d44\uff0c\u4ee5\u652f\u6301\u5176<\/strong><strong>\u8ba1\u5212<\/strong><strong>\u5373\u5c06\u5f00\u5c55\u7684enzastaurin<\/strong><strong>\u7528\u4e8e\u6cbb\u7597\u521d\u53d1\u8111\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\uff08GBM<\/strong><strong>\uff09\u7684\u56fd\u9645\u591a\u4e2d\u5fc3 2b<\/strong><strong>\u671f\u7684\u4e34\u5e8a\u7814\u7a76<\/strong>\u3002<\/p>\n<p>\u7d22\u5143\u751f\u7269\u79f0\uff0c\u542f\u52a8<strong>Pre-IPO<\/strong>\u878d\u8d44\u4ee5\u6765\uff0c\u53cd\u54cd\u706b\u70ed<strong>\uff0c\u9884\u8ba1\u4e0d\u4e45\u5c06\u8fbe\u5230\u52df\u8d44\u76ee\u6807\uff0c\u516c\u53f8\u8ba1\u5212\u4e8e\u5e74\u5e95\u5b8c\u6210\u80a1\u6539<\/strong>\u5e76<strong>\u4f5c\u4e3a\u521b\u65b0\u578b\u516c\u53f8\u542f\u52a8<\/strong><strong>A<\/strong><strong>\u80a1\u4e0a\u5e02\u51c6\u5907\u5de5\u4f5c<\/strong>\u3002<\/p>\n<p>\u7d22\u5143\u751f\u7269\u4e0a\u8f6e\u878d\u8d44\u4e3a\u4e24\u5e74\u524d\u7684B\u8f6e\u878d\u8d44\uff0c\u7531\u4e45\u53cb\u8d44\u672c\u3001\u4ed9\u77b3\u8d44\u672c\u3001\u5206\u4eab\u8d44\u672c\u3001\u6d59\u5546\u4ea7\u878d\u3001\u8d8a\u79c0\u8d44\u672c\u3001\u4e7e\u77bb\u8d44\u672c\u548c\u95fb\u65b9\u79d1\u6280\u5171\u540c\u53c2\u4e0e<strong>\u5b8c\u6210\u4e86<\/strong><strong>3<\/strong><strong>\u4ebf\u5143\u878d\u8d44<\/strong>\u3002\u81ea\u8be5\u8f6e\u878d\u8d44\u5b8c\u6210\u81f3\u4eca\uff0c\u7d22\u5143\u751f\u7269\u5df2\u53d6\u5f97\u4e00\u7cfb\u5217\u91cd\u5927\u8fdb\u5c55\u3002<\/p>\n<p>\u672c\u6b21\u88ab\u6295\u8d44\u4eba\u975e\u5e38\u770b\u597d\u7684\u662f\u7d22\u5143\u751f\u7269\u5df2\u5f00\u53d1\u81f3\u4e34\u5e8a\u540e\u671f\u7684\u56db\u6b3e\u521b\u65b0\u836fDB102\u3001DB103\u3001DB104 \u548c DB105\uff0c\u5b83\u4eec<strong>\u5747\u4e3a\u4e00\u7c7b\u5168\u7403\u9996\u521b\uff08<\/strong><strong>first-in-class<\/strong><strong>\uff09\u836f\u7269\u3002\u56db\u6b3e\u521b\u65b0\u836f\u5982\u56db\u628a\u731b\u706b\uff0c\u5c06\u5728\u5168\u7403\u4ea7\u751f\u5de8\u5927\u7684\u793e\u4f1a\u6548\u76ca\uff0c\u540c\u65f6\u662f\u8be5\u516c\u53f8\u5728\u878d\u8d44\u884c\u7a0b\u4e2d\u7684\u5f3a\u5927\u63a8\u529b\u3002<\/strong><\/p>\n<p><strong>DB102<\/strong><strong>\uff08enzastaurin<\/strong><strong>\uff09\uff0c<\/strong>\u662f\u4e00\u6b3e\u5c0f\u5206\u5b50\u4e1d\u6c28\u9178\/\u82cf\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242\uff0c\u539f\u4e3a\u793c\u6765\uff08Eli Lilly and Company\uff09\u5f00\u53d1\uff0c\u5176\u4f5c\u7528\u673a\u7406\u5728\u4e8e<strong>\u4f5c\u7528\u4e8e<\/strong><strong>PKC\u03b2<\/strong><strong>\u3001PI3K<\/strong><strong>\u548cAKT<\/strong><strong>\u7b49\u80bf\u7624\u9886\u57df\u7684\u5173\u952e\u9776\u70b9\u4e0a<\/strong>\uff0c\u5177\u6709\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u6b7b\u4ea1\u548c\u963b\u788d\u80bf\u7624\u7ec6\u80de\u589e\u751f\u7684\u76f4\u63a5\u4f5c\u7528\uff0c\u4ee5\u53ca\u6291\u5236\u80bf\u7624\u8bf1\u5bfc\u7684\u8840\u7ba1\u751f\u6210\u7684\u95f4\u63a5\u4f5c\u7528\u3002\u8be5\u836f\u7528\u4e8e\u4e00\u7ebf<strong>\u6cbb\u7597\u521d\u6cbb\u9ad8\u5371\u5f25\u6f2b\u6027\u5927<\/strong><strong> B <\/strong><strong>\u7ec6\u80de\u6dcb\u5df4\u7624\uff08DLBCL<\/strong><strong>\uff09\u7684\u56fd\u9645\u4e34\u5e8a3<\/strong><strong>\u671f\u8bd5\u9a8c\u6b63\u5728\u4e2d\u56fd\u548c\u7f8e\u56fd\u5f00\u5c55\uff0c\u76ee\u524d\u5df2\u8d85\u5b8c\u621070%<\/strong><strong>\u7684\u75c5\u4f8b\u5165\u7ec4<\/strong>\u3002\u8be5\u836f\u7269\u7684\u7b2c2\u4e2a\u9002\u5e94\u75c7\u2014\u2014<strong>\u6cbb\u7597\u521d\u53d1\u8111\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\uff08GBM<\/strong><strong>\uff09<\/strong>\u7684\u56fd\u9645\u591a\u4e2d\u5fc32b\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684IND\u4e0d\u4e45\u524d\u83b7\u5f97\u7f8e\u56fdFDA\u6279\u51c6\uff0c \u6b63\u542f\u52a8\u8bd5\u9a8c\u7684\u51c6\u5907\u9636\u6bb5\u3002<\/p>\n<p><strong>DB103<\/strong><strong>\uff08pomaglumetad methionil<\/strong><strong>\uff09<\/strong>\uff0c\u662f\u4e00\u6b3e\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u7cbe\u795e\u5206\u88c2\u75c7\u7684\u836f\u7269\uff0c\u662f\u7d22\u5143\u751f\u7269\u4ece\u793c\u6765\u516c\u53f8\u5f15\u8fdb\uff0c\u9776\u70b9\u662f\u8c37\u6c28\u9178\u53d7\u4f53\u3002\u8be5\u836f\u7269\u7684\u56fd\u9645\u591a\u4e2d\u5fc3\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u4e8e2018\u5e74\u5e95\u83b7\u5f97\u4e2d\u56fd\u56fd\u5bb6\u836f\u76d1\u5c40\u7684\u6279\u51c6\uff0c\u76ee\u524d\u5df2\u987a\u5229<strong>\u542f\u52a8<\/strong><strong>1b<\/strong><strong>\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6709\u671b\u6210\u4e3a\u8be5\u9886\u57df\u7684\u91cd\u78c5\u54c1\u79cd<\/strong>\u3002<strong>\u00a0<\/strong><\/p>\n<p><strong>DB104<\/strong><strong>\uff08liafensine<\/strong><strong>\uff09<\/strong>\uff0c\u662f\u4ece ARMI\/\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\uff08BMS\uff09 \u83b7\u5f97\u7684<strong>\u6297\u6291\u90c1\u75c7\u836f\u7269<\/strong>\u3002<\/p>\n<p><strong>DB105<\/strong>\uff0c\u662f\u4e00\u6b3e\u5177\u6709\u9009\u62e9\u6027\u3001\u5f3a\u6548\u3001\u5168\u65b0\u7684\u62ee\u6297\u5242\uff0c<strong>\u9776\u6807\u4e3a<\/strong><strong>\u03b1-2C<\/strong><strong>\u80be\u4e0a\u817a\u7d20\u53d7\u4f53(AR)<\/strong><strong>\uff0c\u5f00\u53d1\u7528\u4e8e\u6cbb\u7597\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u3002<\/strong>\u8be5\u836f\u7269\u539f\u7531\u82ac\u5170\u5965\u7acb\u5b89\u96c6\u56e2\u5f00\u53d1\uff0c\u76ee\u524d\u7d22\u5143\u751f\u7269\u62e5\u6709\u8be5\u836f\u7684\u5168\u7403\u6743\u76ca\u3002<\/p>\n<p>\u7d22\u5143\u751f\u7269\u521b\u7acb\u4e8e2012\u5e74\uff0c\u662f\u4e00\u5bb6\u65b0\u578b\u7684\u3001\u4ee5\u5feb\u901f\u6709\u6548\u7684\u6a21\u5f0f\u5f00\u53d1\u4e00\u7c7b\u65b0\u836f\u7684\u7cbe\u51c6\u533b\u7597\u4f01\u4e1a\u3002\u8be5\u516c\u53f8\u72ec\u7279\u7684\u6a21\u5f0f\u5728\u4e8e\uff0c\u4ece\u56fd\u9645\u5927\u836f\u5382\u5f15\u8fdb\u7ecf\u8fc7\u4e34\u5e8a\u540e\u671f\u8bd5\u9a8c\u8bc1\u660e\u5176\u5b89\u5168\u6027\u4e14\u663e\u793a\u5bf9\u90e8\u5206\u60a3\u8005\u6709\u6548\u7684\u65b0\u836f\uff0c\u5e76\u5229\u7528\u5176\u72ec\u521b\u7684\u751f\u7269\u6807\u8bb0\u7269\u5e73\u53f0\u6280\u672f<strong>\u5728\u6b8b\u4f59\u7684\u4e34\u5e8a\u6837\u672c\u4e2d\u627e\u5230\u53ef\u9884\u6d4b\u836f\u7269\u7597\u6548\u7684\u751f\u7269\u6807\u8bb0\u7269<\/strong>\u3002\u901a\u8fc7\u8fd9\u4e9b\u65b0\u53d1\u73b0\u7684\u751f\u7269\u6807\u8bb0\u7269\u4f5c\u4e3a\u4f34\u968f\u8bca\u65ad\u6765\u7b5b\u9009\u60a3\u8005\uff0c\u7d22\u5143\u751f\u7269\u80fd\u591f<strong>\u5728\u654f\u611f\u60a3\u8005\u4e2d\u91cd\u65b0\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4ece\u800c\u4f18\u5316\u7597\u6548\u3001\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u63d0\u9ad8\u65b0\u836f\u5f00\u53d1\u7684\u6210\u529f\u7387\uff0c<\/strong>\u4ece\u800c\u8fbe\u5230\u4ee5\u8f83\u4f4e\u7684\u6210\u672c\u3001\u8f83\u77ed\u7684\u65f6\u95f4\u5f00\u53d1\u521b\u65b0\u836f\u7684\u76ee\u7684\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-1457557\" src=\"https:\/\/www.sandiegochinesepress.com\/press\/wp-content\/uploads\/2019\/10\/luo.jpg\" alt=\"\" width=\"840\" height=\"450\" srcset=\"https:\/\/www.sandiegochinesepress.com\/press\/wp-content\/uploads\/2019\/10\/luo.jpg 840w, https:\/\/www.sandiegochinesepress.com\/press\/wp-content\/uploads\/2019\/10\/luo-768x411.jpg 768w\" sizes=\"auto, (max-width: 840px) 100vw, 840px\" \/><\/p>\n<p>\u5728\u63a5\u53d7\u836f\u660e\u5eb7\u5fb7\u7b49\u5a92\u4f53\u4e13\u8bbf\u4e2d\uff0c\u7d22\u5143\u751f\u7269\u521b\u59cb\u4eba\u3001\u8463\u4e8b\u957f\u7f57\u6587\u535a\u58eb\uff08\u4e0a\u56fe\uff09\u8868\u793a\uff1a\u201c\u6211\u4eec\u671f\u5f85\u5176\u4e2d\u7684 enzastaurin\uff08DB102\uff09\u80fd\u6210\u4e3a\u4e2d\u56fd\u4e1a\u754c\u91cd\u78c5\u7684 &#8216;first-in-class&#8217; \u6cbb\u7597\u836f\u8fdb\u5165\u5e02\u573a\uff0c\u516c\u53f8\u4e89\u53d6\u5728\u672a\u6765\u4e24\u5e74\u5185\u5b8c\u62103\u671f\u4e34\u5e8a\u7814\u7a76\u3002<\/p>\n<p>\u8877\u5fc3\u671f\u5f85\u7d22\u5143\u751f\u7269\u7684\u878d\u8d44\u4e4b\u65c5\u4e00\u5207\u987a\u5229\uff0c\u5e76\u5728\u8d44\u672c\u5e02\u573a\u7684\u52a9\u529b\u4e0b\uff0c\u65e9\u65e5\u5c06\u539f\u521b\u65b0\u836f\u5e26\u7ed9\u4e2d\u56fd\u3001\u4e43\u81f3\u5168\u7403\u7684\u60a3\u8005\u3002<\/p>\n<p>\u53e6\u636e\u533b\u836f\u89c2\u6f9c\u6d88\u606f\uff1a<\/p>\n<p>4\u6b3e\u6297\u764c\u65b0\u836f\u83b7\u6279\u4e34\u5e8a\uff0c\u6765\u81ea\u7f57\u6c0f\u3001\u8bfa\u534e\u3001\u6b63\u5927\u5929\u6674\u548c\u6cfd\u749f\u751f\u7269\u3002<\/p>\n<p>\u6839\u636e\u4e2d\u56fd\u56fd\u5bb6\u836f\u76d1\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u6700\u65b0\u516c\u793a\uff0c\u53c8\u6709\u591a\u6b3e\u836f\u7269\u83b7\u5f97\u4e34\u5e8a\u8bd5\u9a8c\u9ed8\u793a\u8bb8\u53ef\uff0c\u5176\u4e2d\u5305\u62ec\uff1a<\/p>\n<ul>\n<li>\u7f57\u6c0f\uff08Roche\uff09\u7684\u91cd\u78c5<strong>\u201c<\/strong><strong>\u4e0d\u9650\u764c\u79cd\u201d<\/strong><strong>\u7597\u6cd5entrectinib<\/strong><strong>\u80f6\u56ca<\/strong>\uff0c\u62df\u5f00\u53d1\u7528\u4e8e\u643a\u5e26ROS1\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u6216<em>NTRK1\/2\/3<\/em>\u57fa\u56e0\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u7684\u6cbb\u7597\u3002<\/li>\n<li>\u8bfa\u534e\uff08Novartis\uff09\u7684<strong>BRAF<\/strong><strong>\u6291\u5236\u5242\u8fbe\u62c9\u975e\u5c3c\u80f6\u56ca<\/strong>\uff0c\u8054\u5408\u66f2\u7f8e\u66ff\u5c3c\u7528\u4e8e\u6cbb\u7597<em>BRAF V600<\/em>\u7a81\u53d8\u7684\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u6210\u5e74\u60a3\u8005\u3002<\/li>\n<li>\u6b63\u5927\u5929\u6674\u7684<strong>1.1<\/strong><strong>\u7c7b\u5728\u7814\u65b0\u836fTQ-B3101<\/strong><strong>\u80f6\u56ca<\/strong>\uff0c\u62df\u7528\u4e8e\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08ALK\uff09\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u548c\u8f6c\u79fb\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u3001\u80c3\u764c\u3001\u6dcb\u5df4\u7624\u7b49\u3002<\/li>\n<li>\u6cfd\u749f\u751f\u7269\u7684<strong>\u591a\u6fc0\u9176\u6291\u5236\u5242\u7532\u82ef\u78fa\u9178\u591a\u7eb3\u975e\u5c3c\u7247<\/strong>\uff0c\u4e0e\u7279\u745e\u666e\u5229\u5355\u6297\u6ce8\u5c04\u6db2\u8054\u5408\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c\u3002<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-1457558\" src=\"https:\/\/www.sandiegochinesepress.com\/press\/wp-content\/uploads\/2019\/10\/9.png\" alt=\"\" width=\"707\" height=\"401\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-1457558\" src=\"https:\/\/www.sandiegochinesepress.com\/press\/wp-content\/uploads\/2019\/10\/9.png\" alt=\"\" width=\"707\" height=\"401\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u25b2<\/strong><strong>\u56fe\u7247\u6765\u6e90\uff1aCDE<\/strong><strong>\u5b98\u7f51<\/strong><\/p>\n<p><strong>\u00a0<\/strong><span style=\"color: #000080;\"><strong>1.<\/strong><strong>\u7f57\u6c0f\u91cd\u78c5\u65b0\u836f\uff1aEntrectinib<\/strong><strong>\u80f6\u56ca<\/strong><\/span><\/p>\n<p>Entrectinib<strong>\u662f\u4e00\u6b3e\u9488\u5bf9<\/strong><em><strong>NTRK<\/strong><\/em><strong>\u548c<\/strong><em><strong>ROS1<\/strong><\/em><strong>\u57fa\u56e0\u878d\u5408\u800c\u8bbe\u8ba1\u7684\u7279\u5f02\u6027\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5242<\/strong>\uff0c\u5b83\u80fd\u591f\u6291\u5236TRK A\/B\/C\u548cROS1\u6fc0\u9176\u6d3b\u6027\u3002\u4eca\u5e746\u6708\uff0c\u7f57\u6c0f\u516c\u53f8\u5ba3\u5e03\u5176<strong>\u201c<\/strong><strong>\u4e0d\u9650\u764c\u79cd\u201d<\/strong><strong>\u4e2a\u4f53\u5316\u836f\u7269entrectinib<\/strong><strong>\u83b7\u5f97\u65e5\u672c\u539a\u751f\u52b3\u52a8\u7701\uff08MHLW<\/strong><strong>\uff09\u6279\u51c6\uff0c\u6cbb\u7597\u643a\u5e26<\/strong><em><strong>NTRK<\/strong><\/em><strong>\u57fa\u56e0\u878d\u5408\u7684\u665a\u671f\u590d\u53d1\u5b9e\u4f53\u7624\u60a3\u8005<\/strong>\u3002\u8fd9\u662fentrectinib\u5728\u5168\u7403\u8303\u56f4\u5185\u9996\u6b21\u83b7\u6279\u3002\u7ee7\u53bb\u5e74Loxo Oncology\u516c\u53f8\u548c\u62dc\u8033\uff08Bayer\uff09\u8054\u5408\u5f00\u53d1\u7684Vitrakvi\uff08larotrectinib\uff09\u83b7\u5f97FDA\u6279\u51c6\u4e0a\u5e02\u4e4b\u540e\uff0c\u8fd9\u662f\u7b2c\u4e8c\u6b3e\u9776\u5411<em>NTRK<\/em>\u57fa\u56e0\u878d\u5408\u7684\u7cbe\u51c6\u7597\u6cd5\u83b7\u5f97\u6279\u51c6\u4e0a\u5e02\u3002\u00a0\u636e\u6089\uff0c\u8be5\u83b7\u6279\u57fa\u4e8e\u591a\u9879\u56fd\u9645\u5f00\u653e\u6027\u8bd5\u9a8c\u6570\u636e\u3002\u6570\u636e\u663e\u793a\uff1aentrectinib\u5bf910\u591a\u79cd\u4e0d\u540c\u7c7b\u578b\u7684NTRK\u878d\u5408\u9633\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u5747\u6709\u6cbb\u7597\u6548\u679c\uff0c\u8d85\u8fc7\u4e00\u534a\u7684\u60a3\u8005\u80bf\u7624\u7f29\u5c0f\uff0c\u603b\u7f13\u89e3\u7387\u8fbe\u523056.9%\uff0c\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\u4e3a10.4\u4e2a\u6708\u3002<\/p>\n<p>\u76ee\u524d\uff0c\u8be5\u836f\u7684\u65b0\u836f\u7533\u8bf7\u88abFDA\u6388\u4e88\u4f18\u5148\u5ba1\u8bc4\u8d44\u683c\uff0c\u7528\u4e8e\u6cbb\u7597NTRK\u878d\u5408\u9633\u6027\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\uff0c\u4ee5\u53caROS1\u878d\u5408\u9633\u6027NSCLC\u60a3\u8005\u3002\u6b64\u6b21\u8be5\u836f\u5728\u4e2d\u56fd\u83b7\u6279\u4e34\u5e8a\uff0c\u62df\u5f00\u53d1\u7528\u4e8e<strong>\u643a\u5e26<\/strong><strong>ROS1<\/strong><strong>\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u6216<\/strong><em><strong>NTRK1\/2\/3<\/strong><\/em><strong>\u57fa\u56e0\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005<\/strong>\u7684\u6cbb\u7597\u3002<\/p>\n<p><span style=\"color: #000080;\"><strong>2.<\/strong><strong>\u8bfa\u534e\u7684BRAF<\/strong><strong>\u6291\u5236\u5242\u8fbe\u62c9\u975e\u5c3c\u80f6\u56ca<\/strong><\/span><\/p>\n<p>\u8fbe\u62c9\u975e\u5c3c\uff08dabrafenib\uff09\u662f\u4e00\u6b3eBRAF\u6291\u5236\u5242\u836f\u7269\u3002\u8be5\u836f\u4e0d\u80fd\u7528\u4e8e\u91ce\u751f\u578b\u9ed1\u8272\u7d20\u7624\uff0c\u4f7f\u7528\u524d\u9700\u68c0\u6d4b<em>BRAF V600E<\/em>\u7a81\u53d8\u3002BRAF\u662f\u4e00\u79cd\u539f\u764c\u57fa\u56e0\uff0c\u5927\u7ea68%\u7684\u4eba\u7c7b\u80bf\u7624\u53d1\u751f<em>BRAF<\/em>\u7a81\u53d8\uff0c\u4e14\u7edd\u5927\u90e8\u5206\u7a81\u53d8\u5f62\u5f0f\u4e3a<em>BRAF V600E<\/em>\u7a81\u53d8\uff0c\u4e3b\u8981\u53d1\u751f\u4e8e\u9ed1\u8272\u7d20\u7624\u3001\u7532\u72b6\u817a\u764c\u548c\u7ed3\u80a0\u764c\u7b49\u80bf\u7624\u4e2d\u3002\u8be5\u7a81\u53d8\u5bfc\u81f4\u4e0b\u6e38MEK\/ERK\u4fe1\u53f7\u901a\u8def\u6301\u7eed\u6fc0\u6d3b\uff0c\u5bf9\u80bf\u7624\u7684\u751f\u957f\u589e\u6b96\u548c\u4fb5\u88ad\u8f6c\u79fb\u81f3\u5173\u91cd\u8981\u3002\u8fbe\u62c9\u975e\u5c3c\u7531\u845b\u5170\u7d20\u53f2\u514b\uff08GSK\uff09\u7814\u53d1\uff0c2013\u5e74\uff0cFDA\u6279\u51c6\u4e86\u5176<strong>\u7528\u4e8e\u6cbb\u7597\u8f6c\u79fb\u6027\u9ed1\u8272\u7d20\u7624\u548c\u4e0d\u80fd\u884c\u624b\u672f\u6cbb\u7597\u7684\u9ed1\u8272\u7d20\u7624\u75c5\u4eba<\/strong>\u30022014\u5e74\u4e4b\u540e\uff0c\u5728GSK\u4e0e\u8bfa\u534e\u7684\u4e1a\u52a1\u4e92\u6362\u4e2d\uff0c\u8bfa\u534e\u4ee5145\u4ebf\u7f8e\u5143\u6536\u8d2d\u4e86GSK\u7684\u6297\u80bf\u7624\u4ea7\u54c1\uff0c\u8fbe\u62c9\u975e\u5c3c\u5c31\u662f\u5176\u4e2d\u4e4b\u4e00\u3002\u4e4b\u540e\u51e0\u5e74\uff0c\u8be5\u836f\u53c8\u6536\u83b7\u4e86\u591a\u9879\u9002\u5e94\u75c7\u7684\u83b7\u6279\uff1a2017\u5e746\u6708\uff0cFDA\u6279\u51c6\u8fbe\u62c9\u975e\u5c3c\u4e0e\u66f2\u7f8e\u66ff\u5c3c\u8054\u5408\u6cbb\u7597<em>BRAF\u00a0V600E<\/em>\u7a81\u53d8\u7684\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u30022018\u5e74\u8be5\u836f\u7269\u518d\u6b21\u83b7\u6279\u4e24\u4e2a\u9002\u5e94\u75c7\uff0c\u5206\u522b\u4e3a<em>BRAF\u00a0V600E<\/em>\u7a81\u53d8\u9633\u6027\u7684\u665a\u671f\u7532\u72b6\u817a\u672a\u5206\u5316\u764c\u60a3\u8005\uff0c\u4ee5\u53ca<em>BRAF\u00a0V600E<\/em>\u7a81\u53d8\u76843\u671f\u9ed1\u8272\u7d20\u7624\u60a3\u8005\u624b\u672f\u5207\u9664\u540e\u7684\u8f85\u52a9\u6cbb\u7597\u3002<\/p>\n<p>\u4eca\u5e741\u6708\uff0c\u4e2d\u56fd\u56fd\u5bb6\u836f\u76d1\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u53d7\u7406\u4e86\u8fbe\u62c9\u975e\u5c3c\u7684\u4e0a\u5e02\u7533\u8bf7\uff0c\u968f\u540e\u8be5\u836f\u88ab\u7eb3\u5165\u4f18\u5148\u5ba1\u8bc4\u7a0b\u5e8f\u3002<strong>\u76ee\u524d\uff0c\u8be5\u4ea7\u54c1\u7684\u529e\u7406\u72b6\u6001\u4e3a<\/strong><strong>&#8220;<\/strong><strong>\u5728\u5ba1\u8bc4\u5ba1\u6279\u4e2d&#8221;<\/strong>\u3002\u6b64\u6b21\uff0c\u8be5\u836f\u83b7\u5f97\u4e34\u5e8a\u9ed8\u793a\u8bb8\u53ef\uff0c\u62df\u5f00\u53d1\u9002\u5e94\u75c7\u4e3a<strong>\u8054\u5408\u66f2\u7f8e\u66ff\u5c3c\u7528\u4e8e\u6cbb\u7597<\/strong><em><strong>BRAF V600<\/strong><\/em><strong>\u7a81\u53d8\u7684\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u6210\u5e74\u60a3\u8005<\/strong>\u3002<\/p>\n<p><span style=\"color: #000080;\"><strong>3.<\/strong><strong>\u6b63\u5927\u5929\u6674\u7684TQ-B3101<\/strong><strong>\u80f6\u56ca<\/strong><\/span><\/p>\n<p>TQ-B3101\u80f6\u56ca\u662f\u7531\u6b63\u5927\u5929\u6674\u7814\u5236\u7533\u62a5\u7684\u4e00\u6b3e\u5c0f\u5206\u5b50\u9776\u5411\u6291\u5236\u5242\uff0c\u6ce8\u518c\u5206\u7c7b\u4e3a\u539f\u5316\u836f1.1\u7c7b\u3002\u67e5\u8be2\u6839\u636e\u4e2d\u56fd\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u767b\u8bb0\u4e0e\u4fe1\u606f\u516c\u793a\u5e73\u53f0\u53ef\u77e5\uff0c\u4e00\u9879\u8bc4\u4ef7TQ-B3101\u80f6\u56ca\u6cbb\u7597<strong>ROS1<\/strong><strong>\u9633\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u53d7\u8bd5\u8005<\/strong>\u7597\u6548\u548c\u5b89\u5168\u6027\u76842\u671f\u5355\u81c2\u3001\u591a\u4e2d\u5fc3\u4e34\u5e8a\u7814\u7a76\u6b63\u5728\u62db\u52df\u60a3\u8005\u3002<\/p>\n<p>\u6b64\u6b21\u8be5\u4ea7\u54c1\u83b7\u5f97\u4e34\u5e8a\u8bd5\u9a8c\u8bb8\u53ef\uff0c\u62df\u7528\u4e8e<strong>\u95f4\u53d8\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08<\/strong><strong>ALK<\/strong><strong>\uff09\u9633\u6027\u7684\u5c40\u90e8\u665a\u671f\u548c\u8f6c\u79fb\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC<\/strong><strong>\uff09\u3001\u80c3\u764c\u3001\u6dcb\u5df4\u7624<\/strong>\u7b49\u3002\u8fd9\u610f\u5473\u7740\uff0cTQ-B3101\u80f6\u56ca\u5c06\u88ab\u5f00\u53d1\u7528\u4e8e\u66f4\u591a\u764c\u75c7\u79cd\u7c7b\u3002<\/p>\n<p><span style=\"color: #000080;\"><strong>4.<\/strong><strong>\u6cfd\u749f\u751f\u7269\u7684\u7532\u82ef\u78fa\u9178\u591a\u7eb3\u975e\u5c3c\u7247<\/strong><\/span><\/p>\n<p>\u591a\u7eb3\u975e\u5c3c\u662f\u6cfd\u749f\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u76841\u7c7b\u5316\u5b66\u65b0\u836f\uff0c\u662f\u4e00\u6b3e\u591a\u6fc0\u9176\u6291\u5236\u5242\u3002\u6839\u636e\u516c\u5f00\u4fe1\u606f\uff0c\u8be5\u6291\u5236\u5242\u65e2\u53ef<strong>\u6291\u5236<\/strong><strong>VEGFR<\/strong><strong>\u3001PDGFR<\/strong><strong>\u7b49\u591a\u79cd\u53d7\u4f53\u916a\u6c28\u9178\u6fc0\u9176\u7684\u6d3b\u6027<\/strong>\uff0c<strong>\u4e5f\u53ef\u76f4\u63a5\u6291\u5236\u5404\u79cd<\/strong><strong>Raf<\/strong><strong>\u6fc0\u9176\uff0c\u5e76\u6291\u5236\u4e0b\u6e38\u7684\u4e1d\u6c28\u9178-<\/strong><strong>\u82cf\u6c28\u9178\u6fc0\u9176\u4fe1\u53f7\u4f20\u5bfc\u901a\u8def<\/strong>\uff0c\u5177\u6709\u6291\u5236\u80bf\u7624\u7ec6\u80de\u589e\u6b96\u548c\u80bf\u7624\u8840\u7ba1\u7684\u5f62\u6210\uff0c\u53d1\u6325\u53cc\u91cd\u6291\u5236\u3001\u591a\u9776\u70b9\u963b\u65ad\u7684\u6297\u80bf\u7624\u4f5c\u7528\u3002<\/p>\n<p>\u76ee\u524d\u8be5\u5728\u7814\u836f\u7269\u6b63\u5f00\u5c553\u671f\u4e34\u5e8a\uff0c\u5176\u4e2d\u4e00\u9879\u665a\u671f\u809d\u764c2\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5171\u5165\u7ec4106\u4f8b\u665a\u671f\u4e0d\u53ef\u624b\u672f\u7684\u809d\u7ec6\u80de\u764c\u60a3\u8005\uff0c\u7ecf\u72ec\u7acb\u5f71\u50cf\u5b66\u8bc4\u4f3016\u5468\u75be\u75c5\u63a7\u5236\u7387\u4e3a42.5%\uff0c\u4e14\u603b\u4f53\u5b89\u5168\u6027\u826f\u597d\u3002\u6b64\u6b21\u8be5\u836f\u7269\u83b7\u5f97\u4e34\u5e8a\u9ed8\u793a\u8bb8\u53ef\u7684\u9002\u5e94\u75c7\u4e3a\uff1a<strong>\u4e0e\u7279\u745e\u666e\u5229\u5355\u6297\u6ce8\u5c04\u6db2\u8054\u5408\u6cbb\u7597\u665a\u671f\u809d\u7ec6\u80de\u764c<\/strong>\u3002\u5176\u4e2d\uff0c\u7279\u745e\u666e\u5229\u5355\u6297\u6ce8\u5c04\u6db2\u662f\u7531\u541b\u5b9e\u751f\u7269\u7814\u53d1\u7684PD-1\u5355\u6297\u65b0\u836f\uff0c\u5df2\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\u3002<\/p>\n<p>(\u7f8e\u56fd\u534e\u6587\u7f51 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