{"id":1458076,"date":"2019-11-20T16:38:58","date_gmt":"2019-11-21T00:38:58","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=1458076"},"modified":"2019-12-07T10:40:32","modified_gmt":"2019-12-07T18:40:32","slug":"%e8%8d%af%e6%98%8e%e5%ba%b7%e5%be%b7%ef%bc%9aucsd%e7%a7%91%e7%a0%94%e4%ba%ba%e5%91%98%e5%8f%91%e7%8e%b0%e4%b8%8e%e7%99%8c%e7%97%87%e6%9e%81%e4%ba%a4%e5%85%b3%e7%9a%84%e5%9f%ba%e5%9b%a0%ef%bc%88","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/%e8%8d%af%e6%98%8e%e5%ba%b7%e5%be%b7%ef%bc%9aucsd%e7%a7%91%e7%a0%94%e4%ba%ba%e5%91%98%e5%8f%91%e7%8e%b0%e4%b8%8e%e7%99%8c%e7%97%87%e6%9e%81%e4%ba%a4%e5%85%b3%e7%9a%84%e5%9f%ba%e5%9b%a0%ef%bc%88\/.html","title":{"rendered":"\u52a0\u5927\u5723\u5730\u4e9a\u54e5\u5206\u6821\u3001\u65af\u5766\u798f\u8054\u5408\u56e2\u961f\u53d1\u73b0\u4e0e\u764c\u75c7\u201c\u6027\u547d\u4ea4\u5173\u201d\u7684\u57fa\u56e0\uff08\u56fe\uff09"},"content":{"rendered":"
\"\u836f\u660e\u5eb7\u5fb7\u4f9b\u56fe\"<\/div>\n
\u836f\u660e\u5eb7\u5fb7\u56fe<\/div>\n
<\/div>\n

\u636e\u3010\u836f\u660e\u5eb7\u5fb7\u3011\u62a5\u9053\uff1a\u9876\u5c16\u5b66\u672f\u671f\u520a\u300a\u81ea\u7136\u300b\u6700\u8fd1\u4e00\u671f\u53d1\u8868\u4e86\u4e00\u7bc7\u5173\u4e8e\u764c\u75c7\u7684\u91cd\u8981\u53d1\u73b0\u7684\u8bba\u6587 \u2014 \u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821(UCSD)\u4e0e\u65af\u5766\u798f\u5927\u5b66(Stanford University)\u7684\u4e00\u4e2a\u8054\u5408\u7814\u53d1\u56e2\u961f\u6307\u51fa\uff0c\u4ed6\u4eec\u53d1\u73b0\u4e00\u7c7bDNA\u53ef\u80fd\u662f\u764c\u75c7\u96be\u6cbb\u7684\u5173\u952e\u3002<\/p>\n

\u62a5\u9053\u79f0\uff0c\u4f5c\u4e3a\u9057\u4f20\u4fe1\u606f\u7684\u8f7d\u4f53\uff0cDNA\u4e0a\u7f16\u7801\u4e86\u751f\u547d\u7684\u84dd\u56fe\u3002\u5728\u4e00\u4e2a\u5178\u578b\u7684\u4eba\u7c7b\u7ec6\u80de\u91cc\uff0c\u90fd\u670923\u5bf9\u7531DNA\u548c\u86cb\u767d\u8d28\u7ec4\u6210\u7684\u67d3\u8272\u4f53\uff0c\u5b83\u4eec\u7684\u5e73\u5747\u5927\u5c0f\u867d\u7136\u53ea\u67096\u5fae\u7c73\uff0c\u53ea\u80fd\u5728\u663e\u5fae\u955c\u4e0b\u770b\u5230\u5b83\u4eec\u7684\u6a21\u6837\u3002\u4f46\u5982\u679c\u628a\u4e00\u4e2a\u7ec6\u80de\u91cc\u7684DNA\u62c9\u76f4\uff0c\u5934\u5c3e\u76f8\u8fde\uff0c\u90a3\u4e48\u603b\u957f\u5ea6\u5c31\u53ef\u4ee5\u63a5\u8fd12\u7c73\uff01\u800c\u5982\u679c\u628a\u4eba\u4f53\u5185\u6240\u6709\u7ec6\u80de\u91cc\u7684DNA\u62fc\u63a5\u5728\u4e00\u8d77\uff0c\u603b\u957f\u5ea6\u66f4\u662f\u592a\u9633\u7cfb\u76f4\u5f84\u7684\u4e24\u500d\uff01\u800c\u751f\u547d\u7684\u7cbe\u5999\u4e4b\u5904\u5219\u5728\u4e8e\uff0c\u867d\u7136DNA\u91cc\u6709\u7740\u5982\u6b64\u6d69\u701a\u7684\u9057\u4f20\u4fe1\u606f\uff0c\u6bcf\u4e00\u6761\u57fa\u56e0\u7684\u8868\u8fbe\uff0c\u5374\u90fd\u53d7\u5230\u4e86\u7cbe\u786e\u7684\u8c03\u63a7\u3002\u5728\u4eba\u7c7b\u548c\u5176\u4ed6\u771f\u6838\u751f\u7269\u91cc\uff0c\u901a\u5e38\u60c5\u51b5\u4e0b\uff0cDNA\u90fd\u4f1a\u7d27\u7d27\u7f20\u7ed5\u5728\u4e00\u79cd\u53eb\u505a\u201c\u7ec4\u86cb\u767d\u516b\u805a\u4f53\u201d\u7684\u7ed3\u6784\u4e0a\u3002\u7b49\u5230\u9700\u8981\u4f7f\u7528\u67d0\u6bb5DNA\u7684\u9057\u4f20\u4fe1\u606f\u65f6\uff0c\u8fd9\u4e9b\u7d27\u7d27\u7f20\u7ed5\u7684DNA\u624d\u4f1a\u677e\u5f00\u3002\u4ece\u67d0\u79cd\u7a0b\u5ea6\u4e0a\u8bb2\uff0c\u8fd9\u6709\u70b9\u7c7b\u4f3c\u6211\u4eec\u53e4\u4ee3\u7684\u201c\u7af9\u7b80\u201d\u3002\u5e73\u65f6\u5b83\u90fd\u88ab\u6298\u53e0\u8d77\u6765\uff0c\u53ea\u6709\u5728\u88ab\u9605\u8bfb\u65f6\u624d\u4f1a\u88ab\u5c55\u5f00\u3002<\/p>\n

\"\u836f\u660e\u5eb7\u5fb7\u56fe\"<\/div>\n
\u56fe\u7247\u6765\u6e90\uff1avlasta2, bluefootedbooby on flickr.com [CC BY 2.0 (https:\/\/creativecommons.org\/licenses\/by\/2.0)]<\/div>\n
<\/div>\n

\u4f46\u79d1\u5b66\u5bb6\u4eec\u53d1\u73b0\uff0c\u764c\u7ec6\u80de\u91cc\u7684DNA\uff0c\u770b\u8d77\u6765\u6709\u4e9b\u4e0d\u4e00\u6837\u30022014\u5e74\uff0c\u53d1\u8868\u5728\u300a\u79d1\u5b66\u300b\u6742\u5fd7\u4e0a\u7684\u4e00\u7bc7\u8bba\u6587\u53d1\u73b0\uff0c\u764c\u7ec6\u80de\u91cc\u5b58\u5728\u4e00\u79cd\u53eb\u505a\u201c\u67d3\u8272\u4f53\u5916DNA\u201d(extrachromosomal DNA\uff0c\u7f29\u5199\u662fecDNA)\u7684\u7279\u6b8aDNA\u3002\u987e\u540d\u601d\u4e49\uff0c\u5b83\u5e76\u4e0d\u50cf\u4f20\u7edf\u7684DNA\u90a3\u6837\u88ab\u538b\u7f29\u5728\u67d3\u8272\u4f53\u4e2d\u3002\u800c\u4e14\uff0c\u8fd9\u79cdDNA\u80fd\u8ba9\u764c\u7ec6\u80de\u53d1\u751f\u5feb\u901f\u53d8\u5f02\uff0c\u4e0e\u764c\u75c7\u6cbb\u7597\u7684\u8010\u836f\u6027\u6709\u5173\u30022017\u5e74\uff0c\u5728\u300a\u81ea\u7136\u300b\u6742\u5fd7\u4e0a\uff0c\u7814\u7a76\u4eba\u5458\u4eec\u53c8\u53d1\u73b0\uff0c\u5e26\u6709\u81f4\u764c\u57fa\u56e0\u7684ecDNA\uff0c\u5176\u51fa\u73b0\u7684\u9891\u7387\u8981\u6bd4\u9884\u671f\u9ad8\u51fa\u975e\u5e38\u591a\uff01\u5728\u5065\u5eb7\u7684\u4eba\u7c7b\u7ec6\u80de\u91cc\uff0c\u51e0\u4e4e\u770b\u4e0d\u5230\u5b83\u4eec\u7684\u75d5\u8ff9\u3002\u800c\u5728\u5c06\u8fd1\u4e00\u534a\u7684\u4eba\u7c7b\u764c\u75c7\u91cc\uff0c\u90fd\u53ef\u4ee5<\/p>\n

\u89c2\u5bdf\u5230ecDNA\u3002\u800c\u5728\u8fd9\u9879\u7814\u7a76\u91cc\uff0c\u5229\u7528\u8d85\u7ed3\u6784\u6210\u50cf\u6280\u672f\u3001\u5149\u5b66\u6d4b\u7ed8\u3001\u4ee5\u53ca\u5168\u57fa\u56e0\u7ec4\u6d4b\u5e8f\u5206\u6790\uff0c\u79d1\u5b66\u5bb6\u4eec\u5bf9ecDNA\u6709\u4e86\u8fdb\u4e00\u6b65\u7684\u8ba4\u8bc6\u3002<\/p>\n

\n
\"\u4f7f\u7528\u626b\u63cf\u7535\u5b50\u663e\u5fae\u955c\uff0c\u6211\u4eec\u5728\u764c\u7ec6\u80de\u91cc\u770b\u5230\u4e86\u67d3\u8272\u4f53DNA(\u84dd\u8272\u7bad\u5934)\u548cecDNA(\u6a59\u8272\u7bad\u5934)(\u56fe\u7247\u6765\u6e90\uff1aImage<\/div>\n
\u4f7f\u7528\u626b\u63cf\u7535\u5b50\u663e\u5fae\u955c\uff0c\u6211\u4eec\u5728\u764c\u7ec6\u80de\u91cc\u770b\u5230\u4e86\u67d3\u8272\u4f53DNA(\u84dd\u8272\u7bad\u5934)\u548cecDNA(\u6a59\u8272\u7bad\u5934)(\u56fe\u7247\u6765\u6e90\uff1aImage courtesy of Paul Mischel, UC San Diego)<\/div>\n
<\/div>\n<\/div>\n

\u5177\u4f53\u6765\u770b\uff0c\u79d1\u5b66\u5bb6\u4eec\u6307\u51fa\uff0cecDNA\u662f\u4e00\u79cd\u7279\u6b8a\u7684\u73af\u72b6\u7ed3\u6784\uff0c\u770b\u8d77\u6765\u6709\u70b9\u50cf\u7ec6\u83cc\u91cc\u7684\u8d28\u7c92DNA\u3002\u800c\u7ed3\u6784\u4e0a\u7684\u5206\u6790\u5219\u8868\u660e\uff0c\u8fd9\u7c7b\u72ec\u7acb\u4e8e\u67d3\u8272\u4f53\u5b58\u5728\u7684\u73af\u72b6DNA\uff0c\u5728\u8868\u8fbe\u4e0a\u5e76\u4e0d\u600e\u4e48\u53d7\u9650\uff0c\u800c\u662f\u5f88\u5bb9\u6613\u5c31\u542f\u52a8\u8f6c\u5f55\u548c\u8868\u8fbe\u7684\u7a0b\u5e8f\u3002\u4e0d\u5e78\u7684\u662f\uff0c\u5728\u8fd9\u4e9bDNA\u4e0a\uff0c\u5f80\u5f80\u90fd\u662f\u4e00\u4e9b\u81f4\u764c\u57fa\u56e0\u3002\u56e0\u6b64\uff0c\u764c\u7ec6\u80de\u80fd\u591f\u719f\u7ec3\u5730\u4f7f\u7528ecDNA\uff0c\u542f\u52a8\u5927\u91cf\u81f4\u764c\u57fa\u56e0\uff0c\u5e2e\u52a9\u5b83\u4eec\u5feb\u901f\u751f\u957f\uff0c\u5e76\u5bf9\u73af\u5883\u5feb\u901f\u505a\u51fa\u53cd\u5e94\uff0c\u4ea7\u751f\u8010\u836f\u6027\u3002\u66f4\u53ef\u6015\u7684\u662f\uff0c\u5f53\u764c\u7ec6\u80de\u53d1\u751f\u5206\u88c2\u65f6\uff0c\u8fd9\u4e9becDNA\u5e76\u4e0d\u50cf\u67d3\u8272\u4f53\u90a3\u6837\uff0c\u4f1a\u88ab\u5e73\u5747\u5206\u914d\u3002\u76f8\u53cd\uff0c\u4e00\u4e2a\u5b50\u7ec6\u80de\u91cc\uff0c\u53ef\u80fd\u83b7\u5f97\u5927\u91cf\u7684ecDNA\uff0c\u800c\u5b83\u4e0a\u5934\u53ef\u80fd\u5168\u662f\u81f4\u764c\u7684\u57fa\u56e0\u3002\u8fd9\u6837\u7684\u7ec6\u80de\u4e5f\u4f1a\u66f4\u5177\u5371\u5bb3\u30022017\u5e74\uff0c\u9876\u7ea7\u533b\u5b66\u671f\u520a\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\u4e0a\u7684\u4e00\u9879\u7814\u7a76\u4e5f\u8bc1\u5b9e\uff0c\u5728\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\uff0c\u764c\u7ec6\u80de\u7684\u7a81\u53d8\u6570\u91cf\u662f\u591a\u662f\u5c11\uff0c\u5e76\u4e0d\u4f1a\u5f71\u54cd\u60a3\u8005\u7684\u9884\u540e\u3002\u76f8\u53cd\uff0c\u57fa\u56e0\u62f7\u8d1d\u6570\u53d8\u5316\u8d8a\u591a\u7684\u60a3\u8005\uff0c\u764c\u75c7\u5c31\u8d8a\u96be\u6cbb\uff0c\u4ed6\u4eec\u7684\u9884\u540e\u4e5f\u5c31\u8d8a\u5dee\u3002<\/p>\n

\u201c\u8fd9\u662f\u4e00\u4e2a\u98a0\u8986\u6027\u7684\u53d1\u73b0\u3002\u764c\u7ec6\u80deecDNA\u4e0e\u666e\u901aDNA\u7684\u5f62\u72b6\u4e0d\u4e00\u6837\uff0c\u8fd9\u4e2a\u53d1\u73b0\u6709\u975e\u5e38\u91cd\u8981\u7684\u6f5c\u5728\u4ef7\u503c\u3002\u5b83\u4e0d\u4f46\u80fd\u5e2e\u52a9\u6211\u4eec\u7406\u89e3\u764c\u75c7\u7684\u751f\u7269\u5b66\uff0c\u4e5f\u4f1a\u5bf9\u4e34\u5e8a\u5e26\u6765\u5f71\u54cd\uff0c\u201d\u672c\u7814\u7a76\u7684\u901a\u8baf\u4f5c\u8005\u4e4b\u4e00Paul S. Mischel\u6559\u6388\u8bf4\u9053\uff1a\u201c\u901a\u8fc7\u8868\u660eecDNA\u662f\u4e00\u79cd\u73af\u72b6\u7ed3\u6784\uff0c\u5e76\u4e14\u63ed\u9732\u5b83\u7684\u8868\u89c2\u9057\u4f20\u5b66\u7ed3\u6784\uff0c\u6211\u4eec\u53d1\u73b0\u4e86\u975e\u5e38\u91cd\u8981\u7684\u4fe1\u606f\u3002\u5b83\u8ba9\u6211\u4eec\u66f4\u597d\u5730\u4e86\u89e3\u764c\u7ec6\u80de\u91cc\u5df2\u906d\u7834\u574f\u7684\u57fa\u56e0\u7ec4\u548c\u8868\u89c2\u9057\u4f20\u5b66\u7ec4\uff0c\u4e3a\u51763D\u7ed3\u6784\u5e26\u6765\u4e86\u65b0\u7684\u6d1e\u89c1\u3002\u8fd9\u5728\u7ed3\u6784\u57fa\u7840\u4e0a\u8ba9\u6211\u4eec\u7406\u89e3\u4e3a\u4f55\u4e00\u4e9b\u7279\u5b9a\u7684\u764c\u7ec6\u80de\u5982\u6b64\u5177\u6709\u4fb5\u88ad\u6027\u3002\u201d\u603b\u7ed3\u6765\u770b\uff0c\u8fc7\u53bb\u7684\u79d1\u5b66\u5bb6\u4eec\u5f80\u5f80\u4e13\u6ce8\u4e8e\u54ea\u4e9b\u57fa\u56e0\u4e0e\u764c\u75c7\u76f8\u5173\u3002\u73b0\u5728\u6211\u4eec\u77e5\u9053\uff0c\u8fd9\u4e9b\u57fa\u56e0\u7684\u4f4d\u7f6e\u4e5f\u540c\u6837\u91cd\u8981\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u5c31\u57282\u4e2a\u6708\u524d\uff0c\u4e00\u5bb6\u540d\u4e3aBoundless Bio\u7684\u751f\u7269\u6280\u672f\u516c\u53f8\u83b7\u5f97\u4e864600\u4e07\u7f8e\u5143\u7684\u878d\u8d44\uff0c\u60f3\u8981\u6291\u5236\u764c\u7ec6\u80de\u5185ecDNA\u7684\u4ea7\u751f\u548c\u4ee3\u8c22\uff0c\u5176\u5171\u540c\u521b\u59cb\u4ebaHoward Y. Chang\u6559\u6388\u4e5f\u662f\u8fd9\u9879\u300a\u81ea\u7136\u300b\u7814\u7a76\u7684\u901a\u8baf\u4f5c\u8005\u4e4b\u4e00\u3002\u5728\u878d\u8d44\u7684\u65b0\u95fb\u7a3f\u4e2d\uff0c\u4ed6\u4eec\u4fe1\u5fc3\u6ee1\u6ee1\u5730\u6307\u51fa\uff0c\u9776\u5411ecDNA\u7684\u521b\u65b0\u7597\u6cd5\u5c06\u4f1a\u662f\u5316\u7597\u3001\u9776\u5411\u7597\u6cd5\u3001\u514d\u75ab\u7597\u6cd5\u540e\uff0c\u764c\u75c7\u6cbb\u7597\u7684\u7b2c\u56db\u6b21\u9769\u547d\u3002<\/p>\n

\u53c2\u8003\u8d44\u6599\uff1a<\/p>\n

[1] Wu, S., Turner, K.M., Nguyen, N. et al. Circular ecDNA promotes accessible chromatin and high oncogene expression. Nature (2019) doi:10.1038\/s41586-019-1763-5<\/p>\n

[2] Vicious circles: Ring-shaped DNA provides cancer cells with a malignant twist, Retrieved November 20, 2019, from https:\/\/www.eurekalert.org\/pub_releases\/2019-11\/uoc–vcr111819.php<\/p>\n

[3] \u764c\u75c7\u514d\u75ab\u7597\u6cd5\u4e4b\u540e\u5c31\u662f\u5b83\uff0c\u8fd9\u5bb6\u516c\u53f8\u54ea\u6765\u7684\u5e95\u6c14\uff1fRetrieved November 20, 2019, from https:\/\/mp.weixin.qq.com\/s?__biz=MzIzMTU0NTM5MA==&mid=2247492875&idx=1&sn=97ce76ee5da3856df8509d8073d5077d<\/p>\n

[4] Mariam Jamal-Hanjani et al., (2019)\uff0c Tracking the Evolution of Non\u2013Small-Cell Lung Cancer, NEJM, DOI: 10.1056\/NEJMoa1616288<\/p>\n","protected":false},"excerpt":{"rendered":"

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