{"id":1458660,"date":"2019-12-17T17:55:15","date_gmt":"2019-12-18T01:55:15","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=1458660"},"modified":"2019-12-17T18:17:32","modified_gmt":"2019-12-18T02:17:32","slug":"%e3%80%90%e7%a7%91%e5%ad%a6%e3%80%91%e5%ad%90%e5%88%8a%ef%bc%9a%e9%99%88%e5%88%97%e5%b9%b3%e5%9b%a2%e9%98%9f%e5%88%a9%e7%94%a8%e6%8a%97%e7%99%8c%e6%96%b0%e6%80%9d%e8%b7%af%e8%a7%a3%e5%bc%80%e7%ba%a2","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/%e3%80%90%e7%a7%91%e5%ad%a6%e3%80%91%e5%ad%90%e5%88%8a%ef%bc%9a%e9%99%88%e5%88%97%e5%b9%b3%e5%9b%a2%e9%98%9f%e5%88%a9%e7%94%a8%e6%8a%97%e7%99%8c%e6%96%b0%e6%80%9d%e8%b7%af%e8%a7%a3%e5%bc%80%e7%ba%a2\/.html","title":{"rendered":"\u3010\u79d1\u5b66\u3011\u5b50\u520a\uff1a\u9648\u5217\u5e73\u56e2\u961f\u5229\u7528\u6297\u764c\u65b0\u601d\u8def\u89e3\u5f00\u7ea2\u6591\u72fc\u75ae\u4e4b\u8c1c\uff08\u56fe\uff09"},"content":{"rendered":"

\u836f\u660e\u5eb7\u5fb7\u62a5\u9053\uff1a\u8fc7\u53bb\u7684\u5341\u5e74\u91cc\uff0c\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u95ee\u4e16\uff0c\u5f7b\u5e95\u6539\u53d8\u4e86\u764c\u75c7\u7684\u6cbb\u7597\u683c\u5c40\u3002\u79d1\u5b66\u5bb6\u4eec\u627e\u5230\u4e86\u51e0\u4e2a\u5173\u952e\u7684\u201c\u5239\u8f66\u5206\u5b50\u201d\uff0c\u6bd4\u5982\u5927\u540d\u9f0e\u9f0e\u7684\u514d\u75ab\u68c0\u67e5\u70b9PD-1\uff0c\u5b83\u4eec\u4f1a\u9650\u5236\u514d\u75ab\u7cfb\u7edf\u626b\u9664\u4f5c\u6076\u7684\u764c\u7ec6\u80de\u3002\u56e0\u6b64\uff0c\u9488\u5bf9\u8fd9\u4e9b\u514d\u75ab\u6291\u5236\u56e0\u5b50\u5f00\u53d1\u7684\u7597\u6cd5\uff0c\u53ef\u4ee5\u91ca\u653e\u4eba\u4f53\u7684\u5929\u7136\u9632\u5fa1\u80fd\u529b\uff0c\u6709\u6548\u653b\u51fb\u80bf\u7624\u3002<\/p>\n

\u8036\u9c81\u5927\u5b66\u7684\u9648\u5217\u5e73\u6559\u6388\u662f\u4e3a\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u505a\u51fa\u91cd\u8981\u8d21\u732e\u7684\u5148\u9a71\u8005\u3002\u4ed6\u7387\u5148\u53d1\u73b0\u4e86PD-L1\u7684\u5b58\u5728\uff0c\u5e76\u8bc1\u660ePD-L1\u5bf9\u80bf\u7624\u7684\u751f\u5b58\u6709\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u73b0\u5728\uff0c\u9488\u5bf9PD-1\/PD-L1\u8fd9\u6761\u5206\u5b50\u901a\u8def\u7684\u6291\u5236\u5242\uff0c\u5df2\u6210\u529f\u5e94\u7528\u4e8e\u51e0\u79cd\u764c\u75c7\u7684\u6cbb\u7597\u3002<\/p>\n

\u9648\u5217\u5e73\u6559\u6388(\u9898\u56fe)\u662f\u80bf\u7624\u514d\u75ab\u9886\u57df\u7684\u5148\u9a71\uff08\u56fe\u7247\u6765\u6e90\uff1a\u8036\u9c81\u5927\u5b66\u5b98\u7f51\uff09<\/p>\n

\u9664\u4e86PD-1\/PD-L1\u901a\u8def\uff0c\u9648\u5217\u5e73\u6559\u6388\u5728\u80bf\u7624\u514d\u75ab\u9886\u57df\u8fd8\u9274\u5b9a\u51fa\u4e86\u5f88\u591a\u65b0\u7684\u5206\u5b50\u548c\u901a\u8def\uff0cPD-1H\uff08\u53c8\u540dVISTA\uff09\u662f\u5176\u4e2d\u4e4b\u4e00\u3002\u4ed6\u4eec\u53d1\u73b0\uff0cPD-1H\uff08\u5373PD-1\u540c\u6e90\u7269\uff09\u662f\u8868\u8fbe\u5728T\u6dcb\u5df4\u7ec6\u80de\u548c\u9ad3\u7ec6\u80de\u8868\u9762\u7684\u4e00\u79cd\u6291\u5236\u5206\u5b50\u3002<\/p>\n

\u5728\u6700\u65b0\u53d1\u8868\u4e8e\u300a\u79d1\u5b66\u300b\u5b50\u520aScience Translational Medicine\u7684\u4e00\u7bc7\u8bba\u6587\u4e2d\uff0c\u8fd9\u652f\u7814\u7a76\u56e2\u961f\u62a5\u544a\u4e86PD-1H\u7684\u65b0\u529f\u80fd\uff0c\u518d\u5ea6\u62d3\u5bbd\u6211\u4eec\u5bf9\u514d\u75ab\u6291\u5236\u56e0\u5b50\u7684\u8ba4\u8bc6\uff0c\u5e2e\u52a9\u6211\u4eec\u7406\u89e3\u4e00\u79cd\u4e9f\u9700\u65b0\u7597\u6cd5\u7684\u75be\u75c5\u2014\u2014\u7ea2\u6591\u72fc\u75ae\uff08Lupus Erythematosus\uff09\u3002\u8fd9\u4e00\u6b21\uff0c\u548c\u6cbb\u7597\u764c\u75c7\u76f8\u53cd\uff0c\u4ed6\u4eec\u901a\u8fc7\u201c\u675f\u7f1a\u201d\u514d\u75ab\u7cfb\u7edf\u6765\u653b\u514b\u4eba\u7c7b\u75be\u75c5\u3002<\/p>\n

\u719f\u6089\u7f8e\u5267\u7684\u8bfb\u8005\u53ef\u80fd\u901a\u8fc7\u300a\u8c6a\u65af\u533b\u751f\u300b\u542c\u8fc7\u72fc\u75ae\uff08Lupus\uff09\u7684\u540d\u79f0\u3002\u7ea2\u6591\u72fc\u75ae\u662f\u4e00\u79cd\u81ea\u8eab\u514d\u75ab\u75be\u75c5\uff0c\u4e5f\u5c31\u662f\u8bf4\uff0c\u514d\u75ab\u7cfb\u7edf\u201c\u5012\u6208\u201d\u653b\u51fb\u673a\u4f53\u81ea\u8eab\u7684\u5668\u5b98\u7ec4\u7ec7\u3002<\/p>\n

\u5e38\u89c1\u7684\u4e24\u79cd\u7ea2\u6591\u72fc\u75ae\uff0c\u4e00\u662f\u76d8\u72b6\u7ea2\u6591\u72fc\u75ae\uff08DLE\uff09\uff0c\u4e3b\u8981\u5f71\u54cd\u76ae\u80a4\uff0c\u9762\u90e8\u7684\u8774\u8776\u5f62\u7ea2\u6591\u662f\u60a3\u8005\u7684\u7ecf\u5178\u8868\u73b0\uff1b\u4e00\u662f\u7cfb\u7edf\u6027\uff08\u6216\u79f0\u5168\u8eab\u6027\uff09\u7ea2\u6591\u72fc\u75ae\uff08SLE\uff09\uff0c\u5f71\u54cd\u7684\u4e0d\uff08\u6b62\uff09\u662f\u76ae\u80a4\uff0c\u8fd8\u5305\u62ec\u5185\u810f\u5668\u5b98\uff0c\u4e25\u91cd\u65f6\u4f1a\u51fa\u73b0\u5fc3\u3001\u80ba\u3001\u80be\u7b49\u810f\u5668\u635f\u4f24\u5e76\u5371\u53ca\u751f\u547d\u3002<\/p>\n

\u7531\u4e8e\u4eba\u4eec\u5bf9\u8fd9\u79cd\u75be\u75c5\u7684\u53d1\u75c5\u539f\u56e0\u3001\u8fdb\u5c55\u56e0\u7d20\u90fd\u8fd8\u4e0d\u6e05\u695a\uff0c\u7ea2\u6591\u72fc\u75ae\u7684\u7597\u6cd5\u975e\u5e38\u6709\u9650\u3002\u4e8b\u5b9e\u4e0a\uff0c\u8fc7\u53bb60\u5e74\u91cc\uff0c\u5168\u4e16\u754c\u53ea\u6709\u4e00\u79cd\u836f\u7269\u83b7\u6279\u6cbb\u7597SLE\uff0cDLE\u5219\u8fd8\u6ca1\u6709\u83b7\u6279\u7597\u6cd5\u3002\u5f04\u6e05\u695a\u7ea2\u6591\u72fc\u75ae\u53d1\u75c5\u7684\u5173\u952e\u56e0\u7d20\uff0c\u65e0\u7591\u4f1a\u4e3a\u5f00\u53d1\u65b0\u836f\u7269\u63d0\u4f9b\u6781\u5927\u5e2e\u52a9\u3002<\/p>\n

\"\u25b2\u7ea2\u6591\u72fc\u75ae\u591a\u53d1\u4e8e\u9752\u5e74\u5973\u6027\uff0c\u5982\u679c\u4f60\u77e5\u9053\u4e00\u4f4d\u540d\u53eb\u8f7b\u821e\u98de\u626c\u7684\u60a3\u8005\uff0c\u90a3\u4e48\u4f60\u66b4\u9732\u5e74\u9f84\u4e86\u2026\u2026\uff08\u56fe\u7247\u6765\u6e90\uff1a123RF\uff09\"
\n\u25b2\u7ea2\u6591\u72fc\u75ae\u591a\u53d1\u4e8e\u9752\u5e74\u5973\u6027\uff0c\u5982\u679c\u4f60\u77e5\u9053\u4e00\u4f4d\u540d\u53eb\u8f7b\u821e\u98de\u626c\u7684\u60a3\u8005\uff0c\u90a3\u4e48\u4f60\u66b4\u9732\u5e74\u9f84\u4e86\u2026\u2026\uff08\u56fe\u7247\u6765\u6e90\uff1a123RF\uff09<\/p>\n

\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\uff0c\u79d1\u5b66\u5bb6\u4eec\u53d1\u73b0\uff0c\u5f53\u5c0f\u9f20\u7f3a\u4e4f\u514d\u75ab\u6291\u5236\u56e0\u5b50PD-1H\u65f6\uff0c\u5e74\u8f7b\u7684\u96cc\u6027\u5c0f\u9f20\u4e2d\u6709\u8d85\u8fc71\/3\u51fa\u73b0\u8131\u6bdb\u3001\u7ea2\u6591\u7b49\u76ae\u80a4\u635f\u4f24\u7684\u75c7\u72b6\uff0c\u534a\u6570\u4f1a\u53d1\u5c55\u51fa\u5fc3\u810f\u7b49\u5668\u5b98\u7684\u95ee\u9898\uff0c\u7ec4\u7ec7\u5b66\u7279\u5f81\u4e0a\u4e0e\u4eba\u7c7b\u7684\u4e24\u79cd\u7ea2\u6591\u72fc\u75ae\u5341\u5206\u76f8\u4f3c\u3002<\/p>\n

\u6b64\u5916\uff0c\u7ea2\u6591\u72fc\u75ae\u7279\u5f81\u6027\u7684\u6297\u6838\u6297\u4f53\u5728\u8fd9\u4e9b\u7f3a\u5c11PD-1H\u7684\u96cc\u6027\u5c0f\u9f20\u4e2d\u4e5f\u968f\u5e74\u9f84\u9010\u6e10\u589e\u591a\u3002\u201c\u8fd9\u4e9b\u53d1\u73b0\u4e5f\u8868\u660e\uff0c\u7f3a\u5931PH-1H\u7684\u5c0f\u9f20\u6216\u8bb8\u53ef\u4ee5\u4f5c\u4e3a\u7814\u7a76\u7ea2\u6591\u72fc\u75ae\u590d\u6742\u75c5\u7406\u56e0\u7d20\u7684\u4e00\u79cd\u65b0\u7684\u52a8\u7269\u6a21\u578b\u3002\u201d\u7814\u7a76\u4f5c\u8005\u5728\u8bba\u6587\u4e2d\u8bf4\u3002<\/p>\n

\"\u25b2\u6572\u9664PD-1H\u7684\u96cc\u6027\u5c0f\u9f20\u53d1\u5c55\u51fa\u4e0e\u7ea2\u6591\u72fc\u75ae\u7c7b\u4f3c\u7684\u76ae\u80a4\u635f\u4f24\u75c7\u72b6\uff08\u56fe\u7247\u6765\u6e90\uff1a\u53c2\u8003\u8d44\u6599[1]\uff09\"
\n\u25b2\u6572\u9664PD-1H\u7684\u96cc\u6027\u5c0f\u9f20\u53d1\u5c55\u51fa\u4e0e\u7ea2\u6591\u72fc\u75ae\u7c7b\u4f3c\u7684\u76ae\u80a4\u635f\u4f24\u75c7\u72b6\uff08\u56fe\u7247\u6765\u6e90\uff1a\u53c2\u8003\u8d44\u6599[1]\uff09<\/p>\n

\u4e3a\u4e86\u8fdb\u4e00\u6b65\u786e\u8ba4PD-1H\u4e0e\u7ea2\u6591\u72fc\u75ae\u7684\u5173\u7cfb\uff0c\u7814\u7a76\u4eba\u5458\u68c0\u67e5\u4e86DLE\u60a3\u8005\u7684\u76ae\u80a4\u7ec4\u7ec7\u548cSLE\u60a3\u8005\u7684\u8840\u6db2\u6837\u54c1\u3002\u4e0e\u5065\u5eb7\u7684\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u7ea2\u6591\u72fc\u75ae\u60a3\u8005\u7684\u591a\u79cd\u514d\u75ab\u7ec6\u80de\u4e2d\u5927\u91cf\u8868\u8fbePD-1H\u3002<\/p>\n

\u201c\u8fd9\u79cd\u5206\u5b50\u663e\u7136\u4e0e\u6291\u5236\u7ea2\u6591\u72fc\u75ae\u6709\u5173\u3002\u5b83\u4f3c\u4e4e\u8fd8\u6709\u9009\u62e9\u6027\uff0c\u56e0\u4e3a\u5728\u5176\u4ed6\u51e0\u79cd\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u4e2d\u6ca1\u6709\u540c\u6837\u7684\u4f5c\u7528\u3002\u201d\u9648\u5217\u5e73\u6559\u6388\u8bf4\u3002<\/p>\n

\"<\/p>\n

\u25b2\u7ea2\u6591\u72fc\u75ae\u60a3\u8005\u7684\u76ae\u80a4\u6837\u672c\u663e\u793a\uff0c\u514d\u75ab\u7cfb\u7edf\u7684\u57fa\u56e0\u6d3b\u6027\u66f4\u9ad8\uff08\u56fe\u7247\u6765\u6e90\uff1a\u53c2\u8003\u8d44\u6599[2]\uff09<\/p>\n

\u65e2\u7136\u5982\u6b64\uff0cPD-1H\u80fd\u5426\u4f5c\u4e3a\u6cbb\u7597\u7ea2\u6591\u72fc\u75ae\u7684\u9776\u70b9\u5462\uff1f\u4e3a\u4e86\u68c0\u9a8c\u8fd9\u4e2a\u731c\u60f3\uff0c\u79d1\u5b66\u5bb6\u4eec\u7ed9\u7ea2\u6591\u72fc\u75ae\u6a21\u578b\u7684\u5c0f\u9f20\u4f7f\u7528\u4e86\u4e00\u79cd\u80fd\u6fc0\u6d3bPD-1H\u7684\u5355\u514b\u9686\u6297\u4f53\u3002<\/p>\n

\u6548\u679c\u5f88\u660e\u663e\uff01\u4f7f\u7528PD-1H\u5355\u6297\u6fc0\u52a8\u5242\u540e\uff0c\u5c0f\u9f20\u4eec\u4e0d\u4ec5\u56e0\u6b64\u53d1\u75c5\u65f6\u95f4\u63a8\u8fdf\uff0c\u76ae\u80a4\u95ee\u9898\u4e5f\u5f97\u5230\u660e\u663e\u6539\u5584\u3002\u6b64\u5916\uff0c\u708e\u6027\u7ec6\u80de\u56e0\u5b50\u3001\u8d8b\u5316\u56e0\u5b50\u548c\u514d\u75ab\u7ec6\u80de\u7684\u6269\u589e\u90fd\u663e\u8457\u51cf\u5c11\uff0c\u663e\u793a\u51fa\u514d\u75ab\u7cfb\u7edf\u5bf9\u81ea\u8eab\u7ec4\u7ec7\u7684\u653b\u51fb\u6027\u964d\u4f4e\u3002<\/p>\n

\"\u25b2\u6fc0\u6d3bPD-1H\u7684\u5355\u6297\uff08MH5A\uff09\u63a8\u8fdf\u7ea2\u6591\u72fc\u75ae\u5c0f\u9f20\u53d1\u75c5\u5e76\u51cf\u8f7b\u75c7\u72b6\uff08\u56fe\u7247\u6765\u6e90\uff1a\u53c2\u8003\u8d44\u6599[1]\uff09\"
\n\u25b2\u6fc0\u6d3bPD-1H\u7684\u5355\u6297\uff08MH5A\uff09\u63a8\u8fdf\u7ea2\u6591\u72fc\u75ae\u5c0f\u9f20\u53d1\u75c5\u5e76\u51cf\u8f7b\u75c7\u72b6\uff08\u56fe\u7247\u6765\u6e90\uff1a\u53c2\u8003\u8d44\u6599[1]\uff09<\/p>\n

\u9664\u4e86\u63ed\u793aPD-1H\u5728\u7ea2\u6591\u72fc\u75ae\u8fd9\u4e00\u75be\u75c5\u4e2d\u7684\u5173\u952e\u4f5c\u7528\u5916\uff0c\u7814\u7a76\u8005\u4e5f\u5728\u8bba\u6587\u4e2d\u63d0\u5230\uff0c\u4f5c\u4e3a\u514d\u75ab\u68c0\u67e5\u70b9\uff0cPD-1H\u7684\u4f5c\u7528\u8fc7\u53bb\u66f4\u591a\u96c6\u4e2d\u4e8e\u80bf\u7624\u8fdb\u5c55\uff0c\u76ee\u524d\u5df2\u6709\u901a\u8fc7\u963b\u65adPD-1H\u8fdb\u884c\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002\u56e0\u6b64\uff0c\u201c\u672a\u6765\u5728\u901a\u8fc7\u963b\u65adPD-1H\u6cbb\u7597\u764c\u75c7\u65f6\uff0c\u4e86\u89e3\u54ea\u4e9b\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u9ad8\u8868\u8fbePD-1H\uff0c\u53ef\u80fd\u6709\u52a9\u4e8e\u9884\u6d4b\u53ef\u80fd\u7684\u5668\u5b98\u7279\u5f02\u6027\u514d\u75ab\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u3002\u201d\u8bba\u6587\u4f5c\u8005\u5728\u8ba8\u8bba\u90e8\u5206\u8bf4\u3002<\/p>\n

\u6211\u4eec\u795d\u8d3a\u9648\u5217\u5e73\u6559\u6388\u7684\u56e2\u961f\u53d1\u8868\u65b0\u7684\u7814\u7a76\u6210\u679c\uff0c\u4e5f\u671f\u5f85\u8fd9\u4e00\u53d1\u73b0\u80fd\u8ba9\u4eba\u4eec\u66f4\u597d\u5730\u7406\u89e3\u514d\u75ab\u6291\u5236\u56e0\u5b50\u548c\u81ea\u8eab\u514d\u75ab\u75be\u75c5\uff0c\u65e9\u65e5\u4e3a\u60a3\u8005\u5e26\u6765\u798f\u97f3\u3002<\/p>\n

\u6765\u6e90\uff1a\u836f\u660e\u5eb7\u5fb7<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u9664\u4e86\u63ed\u793aPD-1H\u5728\u7ea2\u6591\u72fc\u75ae\u8fd9\u4e00\u75be\u75c5\u4e2d\u7684\u5173\u952e\u4f5c\u7528\u5916\uff0c\u7814\u7a76\u8005\u4e5f\u5728\u8bba\u6587\u4e2d\u63d0\u5230\uff0c\u4f5c\u4e3a\u514d\u75ab\u68c0\u67e5\u70b9……<\/p>\n","protected":false},"author":3,"featured_media":1458661,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-1458660","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science_technology_education"],"_links":{"self":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1458660","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/comments?post=1458660"}],"version-history":[{"count":0,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1458660\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media\/1458661"}],"wp:attachment":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media?parent=1458660"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/categories?post=1458660"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/tags?post=1458660"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}