{"id":1478043,"date":"2020-06-24T17:10:11","date_gmt":"2020-06-25T00:10:11","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=1478043"},"modified":"2020-06-24T17:10:11","modified_gmt":"2020-06-25T00:10:11","slug":"ucsd%e4%bb%98%e5%90%91%e4%b8%9c%e6%95%99%e6%8e%88%e7%a7%91%e7%a0%94%e7%bb%84%e5%8f%91%e7%8e%b0%e6%b2%bb%e7%96%97%e5%b8%95%e9%87%91%e6%a3%ae%e6%96%b0%e7%ad%96%e7%95%a5%e5%9b%be%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/ucsd%e4%bb%98%e5%90%91%e4%b8%9c%e6%95%99%e6%8e%88%e7%a7%91%e7%a0%94%e7%bb%84%e5%8f%91%e7%8e%b0%e6%b2%bb%e7%96%97%e5%b8%95%e9%87%91%e6%a3%ae%e6%96%b0%e7%ad%96%e7%95%a5%e5%9b%be%ef%bc%89\/.html","title":{"rendered":"UCSD\u4ed8\u5411\u4e1c\u6559\u6388\u79d1\u7814\u7ec4\u53d1\u73b0\u6cbb\u7597\u5e15\u91d1\u68ee\u65b0\u7b56\u7565(\u56fe\uff09"},"content":{"rendered":"

\u836f\u660e\u5eb7\u5fb7\u5185\u5bb9\u56e2\u961f\u7f16\u53d1\u62a5\u9053\uff1a<\/strong>\u4eca\u5929\uff0c\u9876\u5c16\u5b66\u672f\u671f\u520a\u300a\u81ea\u7136\u300b\u6742\u5fd7\u53d1\u8868\u4e86\u6700\u65b0\u4e00\u6279\u7814\u7a76\u8bba\u6587\uff0c\u5176\u4e2d\u7531\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821\uff08UCSD\uff09\u7684\u4ed8\u5411\u4e1c\u6559\u6388\u8bfe\u9898\u7ec4\u5e26\u6765\u7684\u4e00\u9879\u7814\u7a76\u8363\u767b\u300a\u81ea\u7136\u300b\u5c01\u9762\u3002<\/strong>\u5728\u8fd9\u9879\u7814\u7a76\u91cc\uff0c\u79d1\u5b66\u5bb6\u4eec\u4f7f\u7528\u4e00\u79cd\u7b80\u6d01\u7684\u65b9\u6cd5\uff0c\u6210\u529f\u9006\u8f6c\u4e86\u5e15\u91d1\u68ee\u5c0f\u9f20\u7684\u75c5\u7406\u75c7\u72b6\uff01\u80fd\u767b\u4e0a\u300a\u81ea\u7136\u300b\u7684\u5c01\u9762\uff0c\u4e5f\u8bc1\u660e\u4e86\u8fd9\u9879\u7814\u7a76\u7684\u91cd\u78c5\u6027\u3002<\/p>\n

\"\"<\/a>Cover image: Lantao Gou<\/p>\n

\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821\u7684\u5b98\u65b9\u65b0\u95fb\u7a3f\u5411\u6211\u4eec\u8bb2\u8ff0\u4e86\u8fd9\u4e2a\u7814\u7a76\u80cc\u540e\u7684\u6709\u8da3\u6545\u4e8b<\/strong>\u3002\u5341\u591a\u5e74\u6765\uff0c\u4ed8\u5411\u4e1c\u6559\u6388\u7684\u8bfe\u9898\u7ec4\u90fd\u5728\u7814\u7a76\u4e00\u79cd\u53eb\u505aPTB\u7684\u86cb\u767d\u8d28\u3002\u5b83\u80fd\u591f\u7ed3\u5408RNA\uff0c\u51b3\u5b9a\u57fa\u56e0\u7684\u201c\u5f00\u201d\u548c\u201c\u5173\u201d\u3002<\/section>\n
<\/section>\n
\u51e0\u5e74\u524d\uff0c\u4ed8\u5411\u4e1c\u6559\u6388\u8bfe\u9898\u7684\u4e00\u540d\u535a\u58eb\u540e\u7814\u7a76\u5458\u4f7f\u7528siRNA\u6280\u672f\uff0c\u5e72\u6270\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2dPTB\u86cb\u767d\u7684\u4ea7\u751f\uff0c\u60f3\u8981\u89c2\u5bdf\u8fd9\u4e9b\u7ec6\u80de\u4f1a\u53d1\u751f\u4ec0\u4e48\u53d8\u5316\u3002\u4f46\u6bcf\u6b21\u90fd\u4f7f\u7528siRNA\u8fdb\u884c\u5e72\u6270\uff0c\u662f\u4e00\u6869\u67af\u71e5\u7684\u91cd\u590d\u52b3\u52a8\u3002\u56e0\u6b64\u8fd9\u540d\u535a\u58eb\u540e\u7814\u7a76\u5458\u6784\u5efa\u4e86\u4e00\u79cd\u5168\u65b0\u7684\u7ec6\u80de\u7cfb\uff0c\u4f7f\u5176PTB\u86cb\u767d\u6c38\u4e45\u7f3a\u5931\u3002<\/strong><\/section>\n
\u00a0<\/strong><\/section>\n

\"\"<\/a>\u25b2\u4ed8\u5411\u4e1c\u6559\u6388\u8bfe\u9898\u7ec4\uff08\u56fe\u7247\u6765\u6e90\uff1a<\/strong>\u4ed8\u5411\u4e1c\u6559\u6388\u5b9e\u9a8c\u5ba4\u5b98\u7f51\uff09<\/strong><\/p>\n

<\/section>\n
\u7136\u800c\u5c31\u662f\u8fd9\u79cd\u4e3a\u4e86\u201c\u5077\u61d2\u201d\u624d\u8bde\u751f\u7684\u7ec6\u80de\u7cfb\uff0c\u5e26\u6765\u4e86\u610f\u60f3\u4e0d\u5230\u7684\u540e\u679c\u3002<\/strong>\u65b0\u95fb\u7a3f\u900f\u9732\uff0c\u5728\u51e0\u5468\u7684\u57f9\u517b\u540e\uff0c\u57f9\u517b\u76bf\u4e2d\u51e0\u4e4e\u5df2\u7ecf\u4e0d\u89c1\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u8e2a\u5f71\u3002\u76f8\u53cd\uff0c\u6574\u4e2a\u57f9\u517b\u76bf\u91cc\u957f\u6ee1\u4e86\u795e\u7ecf\u5143\u7ec6\u80de\uff01<\/strong><\/section>\n
<\/section>\n
\u4e5f\u5c31\u662f\u8bf4\uff0c\u53ea\u8981\u6572\u9664PTB<\/em>\u4e00\u4e2a\u57fa\u56e0\uff0c\u5c31\u53ef\u4ee5\u8ba9\u591a\u79cd\u7ec6\u80de\u8f6c\u5316\u4e3a\u795e\u7ecf\u5143\u3002<\/strong><\/section>\n
\u00a0<\/strong><\/section>\n

\"\"<\/a>\u25b2\u672c\u7814\u7a76\u7684\u7b2c\u4e00\u4f5c\u8005\u94b1\u6d69\u535a\u58eb\uff08\u56fe\u7247\u6765\u6e90\uff1a<\/strong>\u4ed8\u5411\u4e1c\u6559\u6388\u5b9e\u9a8c\u5ba4\u5b98\u7f51\uff09<\/strong><\/p>\n

<\/section>\n
\u987a\u7740\u8fd9\u4e00\u65b9\u5411\uff0c\u4ed8\u5411\u4e1c\u6559\u6388\u4e0e\u5176\u8bfe\u9898\u7ec4\u7684\u53e6\u4e00\u540d\u535a\u58eb\u540e\u7814\u7a76\u5458\u94b1\u6d69\u535a\u58eb\uff08\u4e5f\u662f\u672c\u6587\u7684\u7b2c\u4e00\u4f5c\u8005\uff09\u5c06\u76ee\u5149\u653e\u5728\u4e86\u5e15\u91d1\u68ee\u75c5\u7b49\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e0a\u3002\u4ee5\u5e15\u91d1\u68ee\u75c5\u4e3a\u4f8b\uff0c\u8fd9\u79cd\u75be\u75c5\u7684\u4e3b\u8981\u75c5\u7406\u6539\u53d8\uff0c\u662f\u8111\u4e2d\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u51fa\u73b0\u53d8\u6027\u548c\u6b7b\u4ea1\uff0c\u4ece\u800c\u663e\u8457\u51cf\u5c11\u8111\u90e8\u7684\u591a\u5df4\u80fa\u6c34\u5e73\u3002\u76ee\u524d\u7684\u5e15\u91d1\u68ee\u75c5\u836f\u7269\u53ea\u80fd\u7f13\u89e3\u75c7\u72b6\uff0c\u5e76\u4e0d\u80fd\u4ece\u6839\u672c\u4e0a\u963b\u6b62\u6216\u9006\u8f6c\u8fd9\u4e9b\u795e\u7ecf\u5143\u7684\u53d8\u6027\u548c\u6b7b\u4ea1\u3002<\/section>\n
<\/section>\n
\u5982\u679c\u6211\u4eec\u5728PTB<\/em>\u57fa\u56e0\u4e0a\u505a\u6587\u7ae0\uff0c\u6709\u6ca1\u6709\u53ef\u80fd\u8ba9\u5927\u8111\u91cc\u7684\u666e\u901a\u7ec6\u80de\u534e\u4e3d\u53d8\u8eab\uff0c\u53d8\u6210\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\uff0c\u505a\u5230\u9006\u8f6c\u75c5\u60c5\uff1f<\/strong><\/section>\n
<\/section>\n
\u8fd9\u6b63\u662f\u7814\u7a76\u4eba\u5458\u4eec\u60f3\u8981\u56de\u7b54\u7684\u95ee\u9898\u3002\u4ed6\u4eec\u4f7f\u7528\u4e86\u4e00\u79cd\u5c0f\u9f20\u6a21\u578b\uff0c\u5e76\u7528\u836f\u7269\u8bf1\u5bfc\u5c0f\u9f20\u7684\u591a\u5df4\u80fa\u80fd\u795e\u7ecf\u5143\u6b7b\u4ea1\u3002\u8fd9\u4e9b\u5c0f\u9f20\u4e5f\u5982\u540c\u9884\u6599\uff0c\u51fa\u73b0\u4e86\u5e15\u91d1\u68ee\u75c5\u7684\u79cd\u79cd\u75c5\u60c5\u3002<\/section>\n
<\/section>\n
\u4e4b\u540e\uff0c\u7814\u7a76\u4eba\u5458\u4eec\u4f7f\u7528\u817a\u76f8\u5173\u75c5\u6bd2\uff08AAV\uff09\u8f7d\u4f53\uff0c\u5c06\u4e00\u6bb5\u7279\u6b8a\u7684DNA\u9001\u5165\u5230\u5c0f\u9f20\u7684\u4e2d\u8111\uff08\u5e15\u91d1\u68ee\u75c5\u7684\u4e3b\u8981\u75c5\u53d8\u90e8\u4f4d\uff09\u3002\u8fd9\u6bb5\u7279\u6b8a\u7684DNA\u80fd\u4e0e\u7f16\u7801PTB\u86cb\u767d\u7684RNA\u8fdb\u884c\u7ed3\u5408\uff0c\u5e76\u8bf1\u5bfc\u540e\u8005\u88ab\u964d\u89e3\u3002<\/strong>\u8fd9\u6837\u4e00\u6765\uff0c\u5c0f\u9f20\u5c31\u65e0\u6cd5\u987a\u5229\u5730\u5408\u6210PTB\u86cb\u767d\u3002\u901a\u8fc7\u8fd9\u79cd\u65b9\u6cd5\uff0c\u7814\u7a76\u4eba\u5458\u4eec\u5e0c\u671b\u80fd\u591f\u523a\u6fc0\u795e\u7ecf\u5143\u7684\u4ea7\u751f\u3002<\/section>\n
<\/section>\n

\"\"<\/a><\/p>\n

\u25b2\u5c0f\u9f20\u7684\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\uff08\u5de6\uff09\u5728\u91cd\u7f16\u7a0b\u540e\uff0c\u6210\u529f\u53d8\u6210\u4e86\u795e\u7ecf\u5143\u7ec6\u80de\uff08\u53f3\uff09\uff08\u56fe\u7247\u6765\u6e90\uff1a<\/strong>UC San Diego Health Sciences\uff09<\/strong><\/section>\n
<\/section>\n
\u7ecf\u8fc7\u8fd9\u79cd\u57fa\u56e0\u7597\u6cd5\u7684\u6cbb\u7597\u540e\uff0c\u5c0f\u9f20\u8111\u4e2d\u7684\u90e8\u5206\u8d77\u7ed3\u6784\u4f5c\u7528\u7684\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\uff0c\u679c\u7136\u53d8\u6210\u4e86\u795e\u7ecf\u5143\u3002\u7814\u7a76\u4eba\u5458\u4eec\u4f30\u8ba1\uff0c\u795e\u7ecf\u5143\u7684\u6570\u76ee\u5927\u6982\u589e\u52a0\u4e8630%\u3002<\/strong>\u800c\u8fd9\u4e9b\u5c0f\u9f20\u8111\u4e2d\u7684\u591a\u5df4\u80fa\u6c34\u5e73\uff0c\u4e5f\u548c\u6b63\u5e38\u503c\u8f83\u4e3a\u7c7b\u4f3c\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u63a5\u53d7\u4e86AAV\u7a7a\u8f7d\u4f53\u6216\u65e0\u5173\u57fa\u56e0\u7684\u5bf9\u7167\u7ec4\u5c0f\u9f20\u5219\u6ca1\u6709\u51fa\u73b0\u8fd9\u4e9b\u53d8\u5316\u3002<\/section>\n
\u00a0<\/section>\n
\u66f4\u4ee4\u4eba\u53ef\u559c\u7684\u662f\uff0c\u5728\u4e00\u6b21\u6cbb\u7597\u76843\u4e2a\u6708\u540e\uff0c\u8fd9\u4e9b\u5c0f\u9f20\u7684\u56db\u80a2\u8fd0\u52a8\u80fd\u529b\u5c31\u6062\u590d\u4e86\u6b63\u5e38\uff0c\u5e76\u80fd\u7ef4\u6301\u7ec8\u751f\u3002<\/section>\n
\u00a0<\/section>\n
\u5f88\u591a\u76f8\u5173\u62a5\u9053\u6307\u51fa\uff0c\u8fd9\u4e2a\u53d1\u73b0\u6709\u671b\u5e26\u6765\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u57fa\u56e0\u7597\u6cd5\u3002\u8003\u8651\u5230\u5e15\u91d1\u68ee\u75c5\u9886\u57df\u76ee\u524d\u7684\u6cbb\u7597\u624b\u6bb5\u591a\u4e3a\u201c\u6cbb\u6807\u4e0d\u6cbb\u672c\u201d\uff0c\u8fd9\u79cd\u80fd\u591f\u8ba9\u795e\u7ecf\u5143\u91cd\u65b0\u751f\u957f\u7684\u6280\u672f\uff0c\u6709\u671b\u5e26\u6765\u771f\u6b63\u7684\u98a0\u8986\u4e0e\u53d8\u9769\u3002<\/strong>\u4f46\u5728\u8fd9\u79cd\u6280\u672f\u5e94\u7528\u4e8e\u4eba\u4f53\u524d\uff0c\u6211\u4eec\u4e5f\u9700\u8981\u786e\u8ba4\u5b83\u80fd\u5426\u5728\u8001\u5e74\u4eba\u7fa4\u4e2d\u540c\u6837\u6fc0\u6d3b\u795e\u7ecf\u5143\u518d\u751f\u3002\u5018\u82e5\u8fd9\u79cd\u6280\u672f\u65e0\u8bba\u5e74\u9f84\uff0c\u5747\u53ef\u8d77\u6548\uff0c\u90a3\u672a\u6765\u7684\u5e94\u7528\u524d\u666f\u5c06\u6781\u4e3a\u5bbd\u5e7f\u3002<\/section>\n
\u00a0<\/section>\n
\u6211\u4eec\u671f\u5f85\u65e9\u65e5\u89c1\u8bc1\u5e15\u91d1\u68ee\u75c5\u57fa\u56e0\u7597\u6cd5\u7684\u8bde\u751f\uff01<\/section>\n
\u00a0<\/section>\n

\u53c2\u8003\u8d44\u6599\uff1a<\/p>\n

[1] Qian, H., Kang, X., Hu, J. et al. Reversing a model of Parkinson\u2019s disease with in situ converted nigral neurons. Nature 582, 550\u2013556 (2020). https:\/\/doi.org\/10.1038\/s41586-020-2388-4<\/p>\n

[2] One-time treatment generates new neurons, eliminates Parkinson’s disease in mice, Retrieved June 24, 2020, from https:\/\/www.eurekalert.org\/pub_releases\/2020-06\/uoc–otg061820.php<\/p>\n

[3] A preliminary new method could restore the brain cells Parkinson\u2019s disease patients lost, Retrieved June 24, 2020, from https:\/\/www.statnews.com\/2020\/06\/24\/brain-cells-parkinsons-method\/<\/p>\n

\u9898\u56fe\u6765\u6e90\uff1aPixabay<\/section>\n
<\/section>\n
\u53c2\u8003\u8d44\u6599\uff1a<\/section>\n
[1] Better sleep? Prebiotics could help. Retrieved June 22, 2020, from https:\/\/www.colorado.edu\/today\/2020\/03\/03\/better-sleep-prebiotics-could-help<\/section>\n
[2]\u00a0 60 minutes of endurance training is enough to shift body clock in mice. Retrieved June 22, 2020, from https:\/\/medicalxpress.com\/news\/2020-06-minutes-shift-body-clock-mice.html<\/section>\n
[3] Office lighting experiment suggests workers sleep longer when exposed to more daylight. Retrieved June 22, 2020, from https:\/\/medicalxpress.com\/news\/2020-06-office-workers-longer-exposed-daylight.html<\/section>\n","protected":false},"excerpt":{"rendered":"

\u836f\u660e\u5eb7\u5fb7\u5185\u5bb9\u56e2\u961f\u7f16\u53d1\u62a5\u9053\uff1a\u4eca\u5929\uff0c\u9876\u5c16\u5b66\u672f\u671f\u520a\u300a\u81ea\u7136\u300b\u6742\u5fd7\u53d1\u8868\u4e86\u6700\u65b0\u4e00\u6279\u7814\u7a76\u8bba\u6587\uff0c\u5176\u4e2d\u7531\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821\uff08U … \u7ee7\u7eed\u9605\u8bfbUCSD\u4ed8\u5411\u4e1c\u6559\u6388\u79d1\u7814\u7ec4\u53d1\u73b0\u6cbb\u7597\u5e15\u91d1\u68ee\u65b0\u7b56\u7565(\u56fe\uff09<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":1478044,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-1478043","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science_technology_education"],"_links":{"self":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1478043","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/comments?post=1478043"}],"version-history":[{"count":0,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1478043\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media\/1478044"}],"wp:attachment":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media?parent=1478043"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/categories?post=1478043"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/tags?post=1478043"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}