{"id":1479693,"date":"2020-08-20T16:41:23","date_gmt":"2020-08-20T23:41:23","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=1479693"},"modified":"2020-08-21T10:07:48","modified_gmt":"2020-08-21T17:07:48","slug":"%e7%be%8e%e5%9b%bd%e5%8d%8e%e4%ba%ba-%e5%9c%a3%e5%9c%b0%e4%ba%9a%e5%93%a5%e5%8d%8e%e4%ba%ba-%e5%9c%a3%e5%9c%b0%e4%ba%9a%e5%93%a5%e4%b8%ad%e6%96%87%e5%aa%92%e4%bd%93-14","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/%e7%be%8e%e5%9b%bd%e5%8d%8e%e4%ba%ba-%e5%9c%a3%e5%9c%b0%e4%ba%9a%e5%93%a5%e5%8d%8e%e4%ba%ba-%e5%9c%a3%e5%9c%b0%e4%ba%9a%e5%93%a5%e4%b8%ad%e6%96%87%e5%aa%92%e4%bd%93-14\/.html","title":{"rendered":"UCSD\u5c16\u7aef\u6280\u672f\u63ed\u5f00\u4e86\u4e0e\u5e15\u91d1\u68ee\u75c5\u76f8\u5173\u7684\u86cb\u767d\u8d28(\u56fe\uff09"},"content":{"rendered":"<p>\u5e15\u91d1\u68ee\u6c0f\u75c7\u662f\u4e00\u79cd\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\uff0c\u5f71\u54cd\u4e86\u5168\u4e16\u754c\u6570\u4ee5\u767e\u4e07\u8ba1\u7684\u4eba\uff0c\u5b83\u4f1a\u9010\u6e10\u653b\u51fb\u4eba\u7684\u8fd0\u52a8\u529f\u80fd\uff0c\u5bfc\u81f4\u8fd0\u52a8\u548c\u534f\u8c03\u7b49\u65b9\u9762\u7684\u6301\u4e45\u635f\u5bb3\u3002\u800c\u4e00\u79cd\u96be\u4ee5\u6349\u6478\u7684\u86cb\u767d\u8d28\uff0c\u8bb8\u591a\u4eba\u8ba4\u4e3a\u8fd9\u662f\u5168\u9762\u4e86\u89e3\u9057\u4f20\u6027\u5e15\u91d1\u68ee\u75c5\u75c5\u56e0\u7684\u5173\u952e\uff0c\u73b0\u5728\u5b83\u5df2\u7ecf\u53d8\u5f97\u66f4\u52a0\u6e05\u6670\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-1479695\" src=\"https:\/\/www.sandiegochinesepress.com\/press\/wp-content\/uploads\/2020\/08\/UCSDre.jpg\" alt=\"\" width=\"450\" height=\"538\" \/><\/p>\n<p>\u7814\u7a76\u4eba\u5458\u5229\u7528\u6700\u5148\u8fdb\u7684\u6280\u672f\u6700\u7ec8\u63ed\u793a\u4e86\u7ec6\u80de\u5185LRRK2\u9176\u7684\u7ed3\u6784\u3002\u9996\u5148\uff0c\u4ed6\u4eec\u7528\u8367\u5149\u86cb\u767d\u627e\u5230\u5b83\uff0c\u7136\u540e\u7528\u4e00\u675f\u79bb\u5b50\u675f\u5212\u51fa\u542b\u6709LRRK2\u4e1d\u7684\u533a\u57df\uff0c\u5e76\u7528\u4f4e\u6e29\u7535\u5b50\u65ad\u5c42\u626b\u63cf\u6210\u50cf\u3002\u6700\u540e\uff0c\u4ed6\u4eec\u5bf9\u6570\u636e\u8fdb\u884c\u8ba1\u7b97\u5206\u6790\uff0c\u4ee5\u5efa\u7acb\u86cb\u767d\u8d28\u7684\u9ad8\u7ec6\u8282\u6a21\u578b\u3002<\/p>\n<p>\u5bfb\u627e\u8be5\u75be\u75c5\u4e3b\u8981\u539f\u56e0\u7684\u7814\u7a76\u4eba\u5458\u628a\u6ce8\u610f\u529b\u96c6\u4e2d\u5728\u4e00\u79cd\u53eb\u505a\u5bcc\u542b\u4eae\u6c28\u9178\u7684\u91cd\u590d\u6fc0\u91762\uff08LRRK2\uff09\u7684\u86cb\u767d\u8d28\u7a81\u53d8\u4e0a\u3002\u7531\u4e8e\u7f3a\u4e4f\u86cb\u767d\u8d28\u7ed3\u6784\u7684\u4fe1\u606f\uff0c\u5f88\u96be\u7406\u89e3LRRK2\u662f\u5982\u4f55\u5e72\u6270\u6b63\u5e38\u529f\u80fd\u7684\u3002\u7531\u4e8eLRRK2\u662f\u4e00\u4e2a\u4e3b\u8981\u7684\u836f\u7269\u9776\u6807\uff0c\u7834\u8bd1LRRK2\u7ed3\u6784\u7684\u52aa\u529b\u751a\u81f3\u5305\u62ec\u5c06\u6837\u672c\u9001\u5165\u592a\u7a7a\uff0c\u4f5c\u4e3a\u5229\u7528\u5fae\u91cd\u529b\u6761\u4ef6\u5e2e\u52a9\u86cb\u767d\u8d28\u6837\u672c\u7ed3\u6676\u7684\u4e00\u79cd\u65b9\u6cd5\uff0c\u4f46\u6ca1\u6709\u6210\u529f\u3002<\/p>\n<p>\u6700\u8fd1\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821\uff08UCSD\uff09\u7684\u79d1\u5b66\u5bb6\u4eec\u5229\u7528\u5148\u8fdb\u7684\u6280\u672f\uff0c\u5728\u5176\u81ea\u7136\u7ec6\u80de\u73af\u5883\u4e2d\u5236\u4f5c\u4e86\u7b2c\u4e00\u4e2aLRRK2\u7684\u53ef\u89c6\u5316\u56fe\u50cf\uff0c\u4ee5\u53ca\u7b2c\u4e00\u4e2a\u86cb\u767d\u8d28\u7684\u9ad8\u5206\u8fa8\u7387\u84dd\u56fe\u3002\u4ed6\u4eec\u5229\u7528\u8fd9\u4e9b\u63cf\u8ff0\u6765\u63cf\u8ff0LRRK2\u662f\u5982\u4f55\u4e0e\u88ab\u79f0\u4e3a\u5fae\u7ba1\u7684\u7ec6\u80de\u8f68\u9053\u7ed3\u5408\u7684\uff0c\u5e76\u5bf9\u6cbf\u7740\u8fd9\u4e9b\u8f68\u9053\u8fd0\u52a8\u7684\u53d1\u52a8\u673a\u8d77\u5230\u963b\u788d\u4f5c\u7528\u3002\u8fd9\u4e00\u7814\u7a76\u53d1\u73b0\u7684\u4e24\u7bc7\u8bba\u6587\u5df2\u5206\u522b\u53d1\u8868\u5728\u300a\u7ec6\u80de\u300b\u548c\u300a\u81ea\u7136\u300b\u6742\u5fd7\u4e0a\u3002<\/p>\n<p>\u201c\u8fd9\u4e24\u7bc7\u8bba\u6587\u671d\u7740\u5f00\u53d1\u66f4\u6709\u6548\u7684\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u65b9\u5411\u8fc8\u51fa\u4e86\u5de8\u5927\u7684\u4e00\u6b65\uff0c\u5e15\u91d1\u68ee\u6c0f\u75c7\u5f71\u54cd\u4e86\u5f88\u591a\u4eba\u7684\u751f\u547d\uff0c\u201d UCSD\u751f\u7269\u79d1\u5b66\u90e8\u9662\u957f\uff0c\u5206\u5b50\u751f\u7269\u5b66\u7684\u6559\u6388Kit Pogliano\u535a\u58eb\u8bf4\u3002\u7ed3\u5408\u51b7\u51bb\u7535\u5b50\u663e\u5fae\u955c\u548c\u6d3b\u7ec6\u80de\u6210\u50cf\u6280\u672f\uff0c\u7814\u7a76\u4eba\u5458\u53ef\u4ee5\u770b\u5230\u7ec6\u80de\u5185\u7684\u86cb\u767d\u8d28\uff0c\u5e76\u66f4\u5feb\u5730\u786e\u5b9a\u6f5c\u5728\u836f\u7269\u5982\u4f55\u5f71\u54cd\u5176\u529f\u80fd\u3002\u8fd9\u5c06\u52a0\u901f\u836f\u7269\u7684\u53d1\u73b0\uff0c\u5e76\u4e3a\u90a3\u4e9b\u60a3\u6709\u8fd9\u79cd\u4f7f\u4eba\u8870\u5f31\u7684\u75be\u75c5\u7684\u4eba\u5e26\u6765\u65b0\u7684\u5e0c\u671b\u3002<\/p>\n<p><strong>LRRK2\uff1a\u5e15\u91d1\u68ee\u75c5\u7684\u5173\u952e\u6cbb\u7597\u9776\u70b9<\/strong><\/p>\n<p>LRRK2\u88ab\u79f0\u4e3a\u6fc0\u9176\uff0c\u662f\u4e00\u79cd\u5411\u5176\u4ed6\u86cb\u767d\u8d28\u6dfb\u52a0\u78f7\u9178\u76d0\u5316\u5b66\u6807\u7b7e\uff0c\u5f71\u54cd\u5176\u529f\u80fd\u7684\u4e00\u79cd\u9176\u3002LRRK2\u7a81\u53d8\u662f\u9057\u4f20\u6027\u5e15\u91d1\u68ee\u6c0f\u75c7\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u4f46\u7814\u7a76\u4eba\u5458\u8fd8\u4e0d\u5b8c\u5168\u4e86\u89e3\u8fd9\u79cd\u9176\u5728\u75be\u75c5\u72b6\u6001\u4e0b\u7684\u6b63\u5e38\u529f\u80fd\u3002<\/p>\n<p>\u5bf9\u8fd9\u4e9b\u95ee\u9898\u7684\u7b54\u6848\u4e00\u76f4\u5728\u79ef\u6781\u5bfb\u6c42\uff0c\u7279\u522b\u662f\u56e0\u4e3a\u6fc0\u9176\u662f\u6cbb\u7597\u5b66\u4e2d\u6700\u786e\u5b9a\u7684\u836f\u7406\u5b66\u9776\u70b9\u4e4b\u4e00\u3002\u81ea\u4eceLRRK2\u57fa\u56e0\u57282004\u5e74\u9996\u6b21\u88ab\u514b\u9686\u4ee5\u6765\uff0c\u4eba\u4eec\u4e00\u76f4\u81f4\u529b\u4e8e\u5c06\u5176\u7528\u4e8e\u5e15\u91d1\u68ee\u75c5\u7684\u6cbb\u7597\u3002<\/p>\n<p>Susan Taylor\u535a\u58eb\u662f\u4e16\u754c\u8457\u540d\u7684\u6fc0\u9176\u6743\u5a01\uff0c\u5979\u8ba4\u4e3a\u52a0\u5927\u5723\u5730\u4e9a\u54e5\u5206\u6821\u7684\u4e13\u4e1a\u77e5\u8bc6\u6c34\u5e73\u975e\u5e38\u9002\u5408\u89e3\u51b3\u8fd9\u4e2a\u95ee\u9898\u3002\u56e0\u800c\u83b7\u5f97<a href=\"https:\/\/www.michaeljfox.org\">\u8fc8\u514b\u5c14\u00b7J\u00b7\u798f\u514b\u65af\u57fa\u91d1\u4f1a<\/a>\u652f\u6301\u7684\uff0c\u5305\u62ec\u52a0\u5927\u5723\u5730\u4e9a\u54e5\u5206\u6821\u4eba\u5458\u5728\u5185\u7684\u56fd\u9645\u7814\u7a76\u56e2\u961f\uff0c\u5f00\u59cb\u5229\u7528\u65b0\u6280\u672f\u7814\u7a76LRRK2\u3002<\/p>\n<p><strong>LRRK2\u5728\u5fae\u7ba1\u4e0a\u7684\u7ec6\u80de\u84dd\u56fe<\/strong><\/p>\n<p>\u6b63\u5982\u5728\u300a\u7ec6\u80de\u7684\u300b\u8bba\u6587\u4e2d\u6240\u63cf\u8ff0\u7684\uff0c\u5728\u52a0\u5927\u5723\u5730\u4e9a\u54e5\u5206\u6821\uff0c\u7531Elizabeth Villa\u535a\u58eb\u548c\u5979\u7684\u540c\u4e8b\u4eec\u7ec4\u6210\u7684\u7814\u7a76\u5c0f\u7ec4\uff0c\u5229\u7528\u4e86\u4e00\u79cd\u65b0\u7684\u7a81\u7834\u6027\u6280\u672f\u2014\u4f4e\u6e29\u7535\u5b50\u65ad\u5c42\u6444\u5f71\u672f\uff08cryo-ET\uff09\u3002\u8fd9\u662f\u4e00\u79cd\u4f4e\u6e29\u7535\u5b50\u663e\u5fae\u955c\uff08cryo-EM\uff09\u7684\u5f62\u5f0f\uff0c\u5728\u7ec6\u80de\u5185\u89c2\u5bdfLRRK2\u7684\u81ea\u7136\u73af\u5883\uff0c\u5e76\u63cf\u8ff0\u5176\u7ed3\u6784\u5728\u4ee5\u524d\u4ece\u672a\u89c1\u8fc7\u7684\u6c34\u5e73\u4e4b\u4e0a\u3002<\/p>\n<p>\u5728\u8bb8\u591a\u60c5\u51b5\u4e0b\uff0c\u5f53\u7814\u7a76\u4eba\u5458\u8bd5\u56fe\u786e\u5b9a\u4e00\u79cd\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u65f6\uff0c\u4ed6\u4eec\u9996\u5148\u5c06\u86cb\u767d\u8d28\u4ece\u7ec6\u80de\u5916\u5206\u79bb\u51fa\u6765\u3002\u5f53\u4f7f\u7528\u4f4e\u6e29\u7535\u5b50\u663e\u5fae\u955c\u65f6\uff0c\u79d1\u5b66\u5bb6\u4eec\u5c06\u8fd9\u4e9b\u5206\u5b50\u51bb\u7ed3\u5728\u4e00\u5c42\u8584\u51b0\u4e2d\uff0c\u4fdd\u5b58\u5b83\u4eec\u7684\u7ed3\u6784\uff0c\u5e76\u4ee5\u9ad8\u5206\u8fa8\u7387\u786e\u5b9a\u5b83\u4eec\u7684\u7ed3\u6784\u3002\u76f8\u53cd\uff0c\u7ef4\u62c9\u7684\u7814\u7a76\u5c0f\u7ec4\u7528\u4e0d\u540c\u89d2\u5ea6\u62cd\u6444\u542b\u6709\u7814\u7a76\u4e2d\u5206\u5b50\u7684\u51b0\u51bb\u7ec6\u80de\u56fe\u50cf\uff0c\u6709\u70b9\u50cfCAT\u626b\u63cf\u3002<\/p>\n<p>Villa\u535a\u58eb\u8bf4\uff1a\u201c\u6211\u4eec\u6380\u5f00\u5f15\u64ce\u76d6\uff0c\u89c2\u5bdf\u7ec6\u80de\u5185\u4e0d\u540c\u4f4d\u7f6e\u7684\u51b0\u51bb\u5206\u5b50\u5728\u76f8\u4e92\u4f5c\u7528\u8fc7\u7a0b\u4e2d\u88ab\u6355\u83b7\u7684\u60c5\u51b5\u3002\u201d 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loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-1479694\" src=\"https:\/\/www.sandiegochinesepress.com\/press\/wp-content\/uploads\/2020\/08\/UCSDre1.jpg\" alt=\"\" width=\"450\" height=\"300\" \/><\/p>\n<p>\u52a0\u5927\u5723\u5730\u4e9a\u54e5\u5206\u6821\u7684\u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0cLRRK2\u7ed3\u5408\u5fae\u7ba1\uff0c\u5e76\u5236\u9020\u969c\u788d\u7269\uff0c\u963b\u6b62\u9a71\u52a8\u7ec6\u80de\u8d27\u7269\u8fd0\u8f93\u7684\u5206\u5b50\u673a\u5668\u3002\u4ed6\u4eec\u8fd8\u8868\u660e\uff0c\u4e00\u4e9b\u9776\u5411LRRK2\u6fc0\u9176\u7684\u836f\u7269\u589e\u5f3a\u4e86\u8fd9\u79cd\u4f5c\u7528\uff0c\u800c\u5176\u4ed6\u836f\u7269\u5219\u51cf\u5f31\u4e86\u8fd9\u79cd\u4f5c\u7528\u3002<\/p>\n<p>Villa\u535a\u58eb\u8bf4\uff1a\u201c\u8fd9\u79cd\u5f3a\u6709\u529b\u7684\u65b0\u6280\u672f\u7684\u7ed3\u5408\u5728\u8fd9\u9879\u7814\u7a76\u4e2d\u662f\u7b2c\u4e00\u6b21\u88ab\u5e94\u7528\uff0c\u5e76\u4f7f\u4eba\u4eec\u80fd\u591f\u7b2c\u4e00\u6b21\u770b\u5230\u7a81\u53d8\u578bLRRK2\u7684\u7ed3\u6784\uff0c\u540c\u65f6\u4e5f\u5f97\u76ca\u4e8e\u5b83\u7684\u7ec6\u80de\u73af\u5883\u3002\u201d\u3002\u201c\u636e\u6211\u4eec\u6240\u77e5\uff0c\u8fd9\u662f\u4eba\u7c7b\u86cb\u767d\u8d28\u7684\u6700\u9ad8\u5206\u8fa8\u7387\u7ed3\u6784\uff0c\u5728\u4f7f\u7528\u5e38\u89c4\u751f\u5316\u5de5\u5177\u4e4b\u524d\uff0c\u5b83\u662f\u5728\u7ec6\u80de\u5185\u6d4b\u5b9a\u7684\u3002\u6211\u4eec\u6b63\u5728\u5c06\u7ed3\u6784\u5f15\u5165\u7ec6\u80de\u751f\u7269\u5b66\u3002\u201d<\/p>\n<p><strong>LRRK2\u5206\u5b50\u84dd\u56fe<\/strong><\/p>\n<p>\u4e3a\u4e86\u4e86\u89e3LRRK2\u5728\u5316\u5b66\u6c34\u5e73\u4e0a\u7684\u5de5\u4f5c\u539f\u7406\u548c\u8bbe\u8ba1\u6cbb\u7597\u65b9\u6cd5\uff0c\u9700\u8981\u66f4\u9ad8\u5206\u8fa8\u7387\u7684\u7ed3\u6784\u6765\u63ed\u793a\u539f\u5b50\u7684\u4f4d\u7f6e\u4ee5\u53ca\u5b83\u4eec\u4e0e\u6f5c\u5728\u836f\u7269\u7684\u76f8\u4e92\u4f5c\u7528\u3002\u5728\u300a\u81ea\u7136\u300b\u7684\u7814\u7a76\u4e2d\uff0c\u8054\u5408\u8d44\u6df1\u4f5c\u8005Samara Reck-Peterson\u535a\u58eb\u548cAndres Leschziner\u535a\u58eb\u6df1\u5165\u7814\u7a76\u4e86LRRK2\u7684\u7ed3\u6784\u548c\u529f\u80fd\uff0c\u5e76\u4e0e\u7ef4\u62c9\u7684\u7814\u7a76\u5c0f\u7ec4\u5408\u4f5c\uff0c\u4ee5\u786e\u5b9aLRRK2\u5982\u4f55\u4e0e\u5fae\u7ba1\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n<p>\u5229\u7528cryo-EM\uff0cReck-Peterson\u548cLeschziner\u7684\u56e2\u961f\u6355\u6349\u5230\u4e86\u8fc4\u4eca\u4e3a\u6b62LRRK2\u7ed3\u6784\u7684\u6700\u8be6\u7ec6\u56fe\u50cf\uff0c\u4e00\u76f4\u5230\u539f\u5b50\u6c34\u5e73\u3002\u5fb7\u56fd\u6cd5\u5170\u514b\u798f\u6b4c\u5fb7\u5927\u5b66\u6559\u6388 Stefan Knapp\u548c\u4ed6\u7684\u56e2\u961f\u5728\u786e\u5b9a\u5982\u4f55\u4f7fLRRK2\u9002\u7528\u4e8e\u7ed3\u6784\u5de5\u7a0b\u65f6\u4e5f\u53d1\u6325\u4e86\u91cd\u8981\u4f5c\u7528\u3002\u8fd9\u4e2a\u7ed3\u6784\u7ec4\u6210\u4e86\u86cb\u767d\u8d28\u7684\u5546\u4e1a\u7aef\uff0c\u5305\u62ec\u7528\u78f7\u9178\u76d0\u6807\u8bb0\u5176\u4ed6\u86cb\u767d\u8d28\u7684\u90e8\u5206\u3002\u6240\u6709\u5bfc\u81f4\u5e15\u91d1\u68ee\u6c0f\u75c7\u7684\u4e3b\u8981\u7a81\u53d8\u70b9\u90fd\u5728\u8fd9\u4e2a\u7ed3\u6784\u4e2d\u3002<\/p>\n<p>\u63a5\u4e0b\u6765\uff0cReck-Peterson\u548cLeschziner\u7684\u56e2\u961f\u5c06\u4ed6\u4eec\u7684\u7ed3\u6784\u4e0e\u7ef4\u62c9\u7684\u7ed3\u5408\u8d77\u6765\uff0c\u63d0\u51fa\u4e86\u4e00\u4e2a\u89e3\u91caLRRK2\u5982\u4f55\u4e0e\u5fae\u7ba1\u7ed3\u5408\u7684\u6a21\u578b\u3002<\/p>\n<p>\u201c\u4f60\u53ef\u4ee5\u628aLRRK2\u7684\u6fc0\u9176\u90e8\u5206\u60f3\u8c61\u6210\u6709\u70b9\u50cfPacman\uff0c\u5b83\u53ef\u4ee5\u662f\u5f00\u653e\u7684\uff0c\u4e5f\u53ef\u4ee5\u662f\u5c01\u95ed\u7684\uff0c\u201d\u52a0\u5927\u5723\u5730\u4e9a\u54e5\u533b\u5b66\u9662\u548c\u751f\u7269\u79d1\u5b66\u90e8\u6559\u6388Leschziner\u8bf4\u3002\u201c\u6211\u4eec\u7684\u6a21\u578b\u8868\u660e\uff0c\u5f53\u4e0e\u5fae\u7ba1\u7ed3\u5408\u65f6\uff0c\u6fc0\u9176\u9700\u8981\u5904\u4e8e\u5c01\u95ed\u72b6\u6001\uff0c\u8fd9\u8868\u660e\u6fc0\u9176\u7684\u5f62\u72b6\u53ef\u80fd\u8c03\u8282LRRK2\u4e0e\u5fae\u7ba1\u7684\u7ed3\u5408\u3002\u6211\u4eec\u4e0eReck Peterson\u5b9e\u9a8c\u5ba4\u5408\u4f5c\uff0c\u51b3\u5b9a\u76f4\u63a5\u6d4b\u8bd5\u6b64\u6a21\u578b\u3002\u201d<\/p>\n<p><strong>LRRK2\u662f\u5206\u5b50\u9a6c\u8fbe\u7684\u969c\u788d<\/strong><\/p>\n<p>\u5fae\u7ba1\u662fReck-Peterson\u535a\u58eb\u7684\u4e13\u957f\u3002\u5979\u548c\u5979\u7684\u56e2\u961f\u5bf9\u6cbf\u7740\u5fae\u7ba1\u8fd0\u8f93\u8d27\u7269\u7684\u5206\u5b50\u9a6c\u8fbe\u4ee5\u53ca\u8fd9\u79cd\u8fd0\u8f93\u4e2d\u7684\u7f3a\u9677\u5982\u4f55\u5bfc\u81f4\u4eba\u7c7b\u795e\u7ecf\u53d1\u80b2\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u611f\u5174\u8da3\u3002Reck Peterson\u548c\u5979\u7684\u56e2\u961f\u60f3\u77e5\u9053LRRK2\u4e0e\u5fae\u7ba1\u7684\u76f8\u4e92\u4f5c\u7528\u662f\u5426\u4f1a\u5bf9\u5728\u5fae\u7ba1\u4e0a\u79fb\u52a8\u5e76\u5728\u7ec6\u80de\u4e2d\u4ece\u4e00\u4e2a\u5730\u65b9\u8fd0\u9001\u91cd\u8981\u8d27\u7269\u7684\u5206\u5b50\u673a\u5668\u6709\u5bb3\u3002<\/p>\n<p>\u5979\u7684\u7814\u7a76\u5c0f\u7ec4\u53d1\u73b0\uff0cLRRK2\u5236\u9020\u4e86\u963b\u6b62\u8fd9\u4e9b\u5206\u5b50\u673a\u5668\u7684\u8def\u969c\u3002\u4ed6\u4eec\u8fd8\u8868\u660e\uff0c\u4e00\u4e9b\u9776\u5411LRRK2\u6fc0\u9176\u7684\u836f\u7269\u589e\u5f3a\u4e86\u8fd9\u79cd\u4f5c\u7528\uff0c\u800c\u5176\u4ed6\u836f\u7269\u5219\u51cf\u5f31\u4e86\u8fd9\u79cd\u4f5c\u7528\u3002\u867d\u7136Leschziner\u548cReck-Peterson\u8fd8\u4e0d\u786e\u5b9a\u8def\u969c\u662f\u5426\u5728\u5e15\u91d1\u68ee\u75c5\u4e2d\u8d77\u4f5c\u7528\uff0c\u4f46\u4ed6\u4eec\u7684\u53d1\u73b0\u5df2\u7ecf\u5bf9\u901a\u8fc7\u6291\u5236LRRK2\u53d1\u6325\u4f5c\u7528\u7684\u6cbb\u7597\u836f\u7269\u7684\u8bbe\u8ba1\u4ea7\u751f\u4e86\u5f71\u54cd\u3002\u4ed6\u4eec\u7684\u5de5\u4f5c\u6307\u51fa\uff0c\u5173\u95edLRRK2\u6fc0\u9176\u7ed3\u6784\u57df\u7684\u6fc0\u9176\u6291\u5236\u5242\u53ef\u80fd\u4f1a\u5bfc\u81f4\u963b\u788d\u5206\u5b50\u9a6c\u8fbe\u8fd0\u52a8\u7684\u6709\u5bb3\u6548\u5e94\u3002<\/p>\n<p>\u52a0\u5927\u5723\u5730\u4e9a\u54e5\u533b\u5b66\u9662\u548c\u751f\u7269\u79d1\u5b66\u90e8\u6559\u6388\u3001\u970d\u534e\u5fb7\u4f11\u65af\u533b\u5b66\u9662\u7684\u7814\u7a76\u5458Reck-Peterson\u535a\u58eb\u8bf4\uff1a\u201c\u76ee\u524d\u8fd8\u4e0d\u6e05\u695aLRRK2\u5fae\u7ba1\u7ed3\u5408\u5728\u5e15\u91d1\u68ee\u75c5\u4e2d\u7684\u4f5c\u7528\u3002\u201d\u3002\u201c\u4f46\u662f\uff0c\u6211\u4eec\u73b0\u5728\u62e5\u6709\u7684\u662f\u7ec6\u80de\u548c\u5206\u5b50\u84dd\u56fe\uff0c\u8fd9\u5c31\u662f\u7814\u7a76LRRK2\u7684\u4f5c\u7528\u548c\u5fae\u8c03\u9488\u5bf9LRRK2\u7684\u6cbb\u7597\u836f\u7269\u6240\u9700\u8981\u7684\u3002\u201d<\/p>\n<p>\u7ec6\u80de\u7814\u7a76\u7684\u5408\u8457\u8005\uff1aColin K. Deniston, David M. Snead, Indarjit Lahiri, Reika Watanabe, Jan B\u00f6hning, Elizabeth Villa, Samara L. Reck-Peterson, and Andres E. Leschziner\uff0c \u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821\uff1bKeren Lasker\uff0c\u65af\u5766\u798f\u5927\u5b66\u3002<\/p>\n<p>\u7ec6\u80de\u7814\u7a76\u7684\u8d44\u91d1\u6765\u6e90\uff1a\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u9662\u957f\u65b0\u521b\u65b0\u8005\u5956\u3001\u8fc8\u514b\u5c14J.\u798f\u514b\u65af\u57fa\u91d1\u4f1a\u3001\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u666e\u901a\u533b\u5b66\u7814\u7a76\u6240\u3001\u5e03\u5170\u592b\u66fc\u5bb6\u5ead\u57fa\u91d1\u4f1a\u5956\u3001\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821\u53ef\u89c1\u5206\u5b50\u7ec6\u80de\u8054\u5408\u4f1a\u535a\u58eb\u540e\u5956\u5b66\u91d1\u548c\u53f0\u6e7e\u6559\u80b2\u90e8\u8054\u8c0a\u4f1a\u3002<\/p>\n<p>\u300a\u81ea\u7136\u300b\u7814\u7a76\u7684\u5408\u8457\u8005\uff1aColin K.Deniston\uff0cDavid M.Snead\uff0cIndarjit Lahiri\uff0cReika Watanabe\uff0cJan B\u00f6hning\uff0cElizabeth Villa\uff0cSamara L.Reck Peterson\u548cAndres E.Leschziner\uff0c\u52a0\u5dde\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821\uff1bJohn Salogiannis\uff0cOscar Donosa\uff0cHoward Hughes UCSD\u533b\u5b66\u9662\uff1bSebastian Mathea\uff0cStefan Knapp\uff0c\u6b4c\u5fb7\u5927\u5b66\uff1bAndrew K.Shiau\uff0c\u8def\u5fb7\u7ef4\u683c\u764c\u75c7\u7814\u7a76\u6240\u3002<\/p>\n<p>\u56fe\u6587\u6765\u6e90\uff1a\u52a0\u5927\u5723\u5730\u4e9a\u54e5\u5206\u6821<\/p>\n<h5><span style=\"color: #000080;\"><strong>\u51fa\u95e8\u6234\u53e3\u7f69\uff0c\u52ff\u53bb\u624e\u4eba\u5806\uff01<\/strong><\/span><\/h5>\n<div><\/div>\n<p><strong>\u6709\u5173\u672c\u5730COVID-19\u6d4b\u8bd5\u95ee\u9898\u54a8\u8be2\u548c<\/strong><strong>\u8054\u7cfb\u7684\u5b98\u65b9\u7f51\u9875\uff1a<\/strong><a href=\"https:\/\/www.sandiegocounty.gov\/content\/sdc\/hhsa\/programs\/phs\/community_epidemiology\/dc\/2019-nCoV\/testing.html\">https:\/\/www.sandiegocounty.gov\/content\/sdc\/hhsa\/programs\/phs\/community_epidemiology\/dc\/2019-nCoV\/testing.html<\/a><\/p>\n<div>\n<p><a href=\"https:\/\/www.cdph.ca.gov\/Programs\/CID\/DCDC\/Pages\/Face-Coverings-Guidance.aspx\"><strong>\u52a0\u5dde\u516c\u5171\u536b\u751f\u90e8\u53d1\u5e03\u7684\u5173\u4e8e\u4f7f\u7528\u5e03\u9762\u8986\u76d6\u7269\u9632\u6b62\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2COVID-19\u4f20\u64ad\u7684\u6307\u5357\u94fe\u63a5\u3002<\/strong><\/a>https:\/\/www.cdph.ca.gov\/Programs\/CID\/DCDC\/Pages\/Face-Coverings-Guidance.aspx<\/p>\n<p><a href=\"https:\/\/www.coronainusa.com\/\"><strong>\u67e5\u67e5\u60a8\u4f4f\u7684\u9644\u8fd1\u6709\u6ca1\u6709COVID-19\u75c5\u4f8b By \u8f93\u5165\u4f60\u7684Zip Code\uff01https:\/\/www.coronainusa.com\/&gt;<\/strong><\/a><\/p>\n<\/div>\n<p><a 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