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\u8fd1\u65e5\uff0c\u9488\u5bf9\u65b0\u51a0\u75c5\u6bd2\u7684\u4e2d\u548c\u6297\u4f53\u7597\u6cd5\u53d7\u5230\u4e86\u5e7f\u6cdb\u5173\u6ce8\u3002\u518d\u751f\u5143\uff08Regeneron\uff09\u516c\u53f8\u548c\u793c\u6765\uff08Lilly\uff09\u516c\u53f8\u76f8\u7ee7\u516c\u5e03\u4e86\u5404\u81ea\u7684\u4e2d\u548c\u6297\u4f53\u7ec4\u5408\u7597\u6cd5\u7684\u521d\u6b65\u4e34\u5e8a\u7ed3\u679c\u3002\u6628\u65e5\uff0c\u793c\u6765\u516c\u53f8\u5ba3\u5e03\uff0c\u5df2\u7ecf\u5411\u7f8e\u56fdFDA\u9012\u4ea4\u7d27\u6025\u4f7f\u7528\u6388\u6743\uff08EUA\uff09\u7533\u8bf7\uff0c\u7533\u8bf7\u4f7f\u7528\u5728\u7814\u4e2d\u548c\u6297\u4f53\u7597\u6cd5LY-CoV555\u4f5c\u4e3a\u5355\u836f\u7597\u6cd5\uff0c\u6cbb\u7597\u9ad8\u98ce\u9669COVID-19\u60a3\u8005\u3002<\/p>\n

\u518d\u751f\u5143\u516c\u53f8\u6628\u65e5\u4e5f\u53d1\u8868\u58f0\u660e\uff0c\u5ba3\u5e03\u5728\u4e0e\u76d1\u7ba1\u673a\u6784\u8fdb\u884c\u8ba8\u8bba\u4e4b\u540e\uff0c\u8be5\u516c\u53f8\u5df2\u7ecf\u5411\u7f8e\u56fdFDA\u9012\u4ea4\u4e86\u4f7f\u7528\u5176\u4e2d\u548c\u6297\u4f53\u7ec4\u5408\u7597\u6cd5REGN-COV2\u6cbb\u7597COVID-19\u60a3\u8005\u7684EUA\u7533\u8bf7\u3002<\/p>\n

REGN-COV2\u662f\u7531\u4e24\u79cd\u9776\u5411\u65b0\u51a0\u75c5\u6bd2\u523a\u7a81\u86cb\u767d\u53d7\u4f53\u7ed3\u5408\u57df\uff08RBD\uff09\u7684\u5355\u514b\u9686\u6297\u4f53\uff08REGN10933\u548cREGN10987\uff09\u7ec4\u6210\u3002\u5b83\u4eec\u901a\u8fc7\u4e0eRBD\u7684\u4e0d\u540c\u8868\u4f4d\u7ed3\u5408\uff0c\u963b\u6b62\u65b0\u51a0\u75c5\u6bd2\u4e0e\u7ec6\u80de\u4e0a\u7684\u53d7\u4f53\u7ed3\u5408\uff0c\u4ece\u800c\u9632\u6b62\u75c5\u6bd2\u8fdb\u5165\u5e76\u611f\u67d3\u7ec6\u80de\u3002\u4e34\u5e8a\u524d\u7814\u7a76\u663e\u793a\uff0c\u5b83\u4eec\u4e0d\u4f46\u53ef\u4ee5\u6709\u6548\u52a0\u5feb\u75c5\u6bd2\u6e05\u9664\u901f\u5ea6\uff0c\u8fd8\u80fd\u591f\u4f5c\u4e3a\u9884\u9632\u6027\u7597\u6cd5\u63d0\u524d\u6ce8\u5c04\uff0c\u63d0\u9ad8\u52a8\u7269\u7684\u4fdd\u62a4\u80fd\u529b\u3002\u521d\u6b65\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u4e5f\u663e\u793a\u5728\u6cbb\u7597\u975e\u4f4f\u9662COVID-19\u60a3\u8005\u65f6\uff0c\u80fd\u591f\u964d\u4f4e\u60a3\u8005\u7684\u75c5\u6bd2\u8f7d\u91cf\u548c\u7f29\u77ed\u75c7\u72b6\u7f13\u89e3\u6240\u9700\u65f6\u95f4\u3002<\/p>\n

\u518d\u751f\u5143\u6307\u51fa\uff0c\u76ee\u524d\u8be5\u516c\u53f8\u62e5\u6709\u80fd\u591f\u6cbb\u7597\u63a5\u8fd150000\u540d\u60a3\u8005\u7684\u4e2d\u548c\u6297\u4f53\u7597\u6cd5\u5e93\u5b58\u3002\u9884\u8ba1\u5728\u672a\u6765\u51e0\u4e2a\u6708\u91cc\uff0c\u8be5\u516c\u53f8\u5c06\u751f\u4ea7\u51fa\u80fd\u591f\u6cbb\u759730\u4e07\u540d\u60a3\u8005\u7684\u4e2d\u548c\u6297\u4f53\u7597\u6cd5\u3002<\/p>\n

JAK\u6291\u5236\u5242\/\u745e\u5fb7\u897f\u97e6\u7ec4\u5408\u964d\u4f4eCOVID-19\u60a3\u8005\u6b7b\u4ea1\u7387<\/strong><\/p>\n

\u793c\u6765\u548cIncyte\u516c\u53f8\u4eca\u65e5\u516c\u5e03\u4e86JAK\u6291\u5236\u5242baricitinib\u4e0e\u745e\u5fb7\u897f\u97e6\u8054\u7528\uff0c\u5728\u6cbb\u7597COVID-19\u60a3\u8005\u7684ACTT-2\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u7684\u6700\u65b0\u7ed3\u679c\u3002\u6b64\u524d\u5df2\u7ecf\u516c\u5e03\u7684\u7ed3\u679c\u663e\u793a\uff0cbaricitinib\u8fbe\u5230\u8bd5\u9a8c\u7684\u4e3b\u8981\u7ec8\u70b9\uff0c\u4e0e\u745e\u5fb7\u897f\u97e6\u76f8\u6bd4\uff0c\u7f29\u77ed\u60a3\u8005\u6062\u590d\u6240\u9700\u65f6\u95f4\u3002<\/p>\n

Baricitinib\u7684\u5546\u54c1\u540d\u4e3aOlumiant\uff0c\u662f\u4e00\u79cd\u6bcf\u65e5\u53e3\u670d\u4e00\u6b21\u7684JAK1\/2\u6291\u5236\u5242\uff0c\u5b83\u5df2\u7ecf\u83b7\u5f97FDA\u6279\u51c6\u6cbb\u7597\u4e2d\u91cd\u5ea6\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u60a3\u8005\u3002JAK1\/2\u86cb\u767d\u4ecb\u5bfc\u591a\u79cd\u708e\u75c7\u6027\u53cd\u5e94\u3002\u6291\u5236JAK1\/2\u53ef\u80fd\u964d\u4f4eCOVID-19\u60a3\u8005\u56e0\u7ec6\u80de\u56e0\u5b50\u98ce\u66b4\u800c\u4ea7\u751f\u7684\u8fc7\u5ea6\u708e\u75c7\u53cd\u5e94\u3002<\/p>\n

\u6700\u65b0\u516c\u5e03\u7684\u6570\u636e\u663e\u793a\uff0cbaricitinib\u4e0e\u745e\u5fb7\u897f\u97e6\u8054\u7528\uff0c\u4e0e\u745e\u5fb7\u897f\u97e6\u76f8\u6bd4\uff0c\u5728\u63a5\u53d7\u6cbb\u7597\u540e29\u5929\u65f6\u5c06\u60a3\u8005\u7684\u6b7b\u4ea1\u7387\u964d\u4f4e\u4e8635%\uff085.1%\u6bd47.8%\uff0cHR=0.65\uff0c95% CI\uff1a0.39\uff0c1.08\uff0cp=0.09\uff09\u3002\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c\u5728\u9700\u8981\u63a5\u53d7\u8f85\u52a9\u6c27\u6c14\u652f\u6301\uff0c\u6216\u8005\u9700\u8981\u9ad8\u6d41\u91cf\u6c27\u7597\/\u65e0\u521b\u901a\u6c14\u7684\u4e25\u91cdCOVID-19\u60a3\u8005\u4e2d\uff0c\u7ec4\u5408\u7597\u6cd5\u63d0\u4f9b\u66f4\u591a\u76ca\u5904\u3002\u5728\u9700\u8981\u63a5\u53d7\u8f85\u52a9\u6c27\u6c14\u652f\u6301\u7684\u60a3\u8005\u4e9a\u7fa4\u4e2d\uff0c\u7ec4\u5408\u7597\u6cd5\u5c06\u6b7b\u4ea1\u7387\u964d\u4f4e60%\uff1b\u5728\u9700\u8981\u9ad8\u6d41\u91cf\u6c27\u7597\/\u65e0\u521b\u901a\u6c14\u7684\u60a3\u8005\u4e9a\u7fa4\u4e2d\uff0c\u7ec4\u5408\u7597\u6cd5\u5c06\u6b7b\u4ea1\u7387\u964d\u4f4e43%\u3002<\/p>\n

\u793c\u6765\u516c\u53f8\u8868\u793a\uff0c\u5176\u5408\u4f5c\u4f19\u4f34\u7f8e\u56fd\u56fd\u5bb6\u8fc7\u654f\u548c\u4f20\u67d3\u75c5\u7814\u7a76\u6240\uff08NIAID\uff09\u7684\u7814\u7a76\u4eba\u5458\u6b63\u5728\u5b8c\u6210\u8fd9\u4e00\u7814\u7a76\u7684\u6700\u7ec8\u6570\u636e\u5206\u6790\uff0c\u7814\u7a76\u7ed3\u679c\u5c06\u4e8e\u8fd1\u65e5\u5728\u540c\u884c\u8bc4\u8bae\u7684\u671f\u520a\u4e0a\u53d1\u8868\u3002\u540c\u65f6\uff0c\u8be5\u516c\u53f8\u5c06\u7ee7\u7eed\u4e0e\u7f8e\u56fdFDA\u8ba8\u8bba\u7533\u8bf7EUA\u7684\u53ef\u80fd\u3002<\/p>\n

\u8d85\u514d\u75ab\u7403\u86cb\u767d\u7597\u6cd53\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5165\u7ec4\u9996\u4f8b\u60a3\u8005<\/strong><\/p>\n

\u4eca\u65e5\uff0c\u7531\u4e16\u754c\u4e0a\u591a\u5bb6\u5f00\u53d1\u8840\u6d46\u4ea7\u54c1\u7684\u9886\u5148\u533b\u836f\u516c\u53f8\u7ec4\u6210\u7684CoVIg-19\u8840\u6d46\u8054\u76df\uff08The CoVIg-19 Plasma Alliance\uff09\u5ba3\u5e03\uff0c\u7531\u7f8e\u56fd\u56fd\u5bb6\u8fc7\u654f\u548c\u4f20\u67d3\u75c5\u7814\u7a76\u6240\uff08NIAID\uff09\u8d5e\u52a9\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8cITAC\u5df2\u7ecf\u5f00\u59cb\u6ce8\u518c\u60a3\u8005\u3002\u8fd9\u4e00\u4e34\u5e8a\u8bd5\u9a8c\u5c06\u8bc4\u4f30\u6297\u65b0\u51a0\u75c5\u6bd2\u7684\u8d85\u514d\u75ab\u7403\u86cb\u767d\uff08hyperimmune immunoglobulin\uff0cH-Ig\uff09\u7597\u6cd5\u5728\u6cbb\u7597\u6709\u98ce\u9669\u51fa\u73b0\u4e25\u91cd\u5e76\u53d1\u75c7\u7684\u4f4f\u9662COVID-19\u60a3\u8005\u65f6\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u7597\u6548\u3002\u5982\u679c\u8bd5\u9a8c\u83b7\u5f97\u6210\u529f\uff0c\u8d85\u514d\u75ab\u7403\u86cb\u767d\u7597\u6cd5\u53ef\u80fd\u6210\u4e3a\u4f4f\u9662COVID-19\u60a3\u8005\u6700\u65e9\u7684\u6cbb\u7597\u9009\u62e9\u4e4b\u4e00\u3002<\/p>\n

\u53d7\u5230\u65b0\u51a0\u75c5\u6bd2\u611f\u67d3\u5e76\u4e14\u5eb7\u590d\u7684\u60a3\u8005\u7684\u8840\u6db2\u4e2d\u5305\u542b\u7740\u9488\u5bf9\u65b0\u51a0\u75c5\u6bd2\u7684\u4e2d\u548c\u6297\u4f53\u3002\u56e0\u6b64\uff0c\u5eb7\u590d\u8005\u8840\u6d46\u53ef\u4ee5\u6210\u4e3a\u4e00\u79cd\u6cbb\u7597COVID-19\u60a3\u8005\u7684\u9009\u62e9\u3002\u800c\u8d85\u514d\u75ab\u7403\u86cb\u767d\u4e0e\u5eb7\u590d\u8005\u8840\u6d46\u76f8\u6bd4\u66f4\u8fdb\u4e00\u6b65\u3002\u751f\u4ea7\u5382\u5bb6\u5c06\u4ece\u8bb8\u591a\u5eb7\u590d\u60a3\u8005\u4e2d\u6536\u96c6\u7684\u8840\u6d46\u6c47\u96c6\u5728\u4e00\u8d77\uff0c\u901a\u8fc7\u4e25\u683c\u7684\u7a0b\u5e8f\u706d\u6d3b\u5176\u4e2d\u7684\u75c5\u6bd2\uff0c\u5e76\u4e14\u5bf9\u5176\u4e2d\u7684\u6297\u4f53\u8fdb\u884c\u5bcc\u96c6\u3002\u4e0e\u5eb7\u590d\u8005\u8840\u6d46\u76f8\u6bd4\uff0c\u8d85\u514d\u75ab\u7403\u86cb\u767d\u5177\u6709\u4ee5\u4e0b\u51e0\u4e2a\u4f18\u52bf\uff1a<\/p>\n

\u8d85\u514d\u75ab\u7403\u86cb\u767d\u7684\u4fdd\u8d28\u671f\u957f\u8fbe24-36\u4e2a\u6708\uff0c\u56e0\u6b64\u66f4\u5bb9\u6613\u5206\u914d\u548c\u50a8\u5b58\uff0c\u53ef\u7528\u4e8e\u5728\u672a\u6765\u7684\u75be\u75c5\u7206\u53d1\u4e2d\u4f7f\u7528\u3002
\n\u6240\u6709\u8d85\u514d\u75ab\u7403\u86cb\u767d\u4ea7\u54c1\u90fd\u7ecf\u8fc7\u81f3\u5c113\u4e2a\u4e13\u95e8\u706d\u6d3b\u6216\u53bb\u9664\u75c5\u6bd2\u7684\u6b65\u9aa4\uff0c\u800c\u4e14\u60a3\u8005\u4e0d\u9700\u8981\u8840\u578b\u5339\u914d\u5c31\u53ef\u4ee5\u4f7f\u7528\u3002
\n\u8d85\u514d\u75ab\u7403\u86cb\u767d\u5728\u5236\u9020\u8fc7\u7a0b\u4e2d\u5f97\u5230\u7eaf\u5316\u548c\u5bcc\u96c6\uff0c\u80fd\u591f\u4fdd\u8bc1\u6bcf\u4e00\u5242\u4ea7\u54c1\u4e2d\u90fd\u5305\u542b\u4e00\u81f4\u7684\u9ad8\u6297\u4f53\u6c34\u5e73\u3002<\/p>\n

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\u53c2\u8003\u8d44\u6599\uff1a
\n[1] Statement on REGN-COV2 Emergency Use Authorization Request. Retrieved October 8, 2020, from https:\/\/newsroom.regeneron.com\/static-files\/6feab76b-176d-402d-bf30-d40462e68b7b
\n[2] Baricitinib has Significant Effect on Recovery Time, Most Impactful in COVID-19 Patients Requiring Oxygen. Retrieved October 8, 2020, from https:\/\/investor.lilly.com\/news-releases\/news-release-details\/baricitinib-has-significant-effect-recovery-time-most-impactful
\n[3] First Patient Enrolled in NIH Phase 3 Trial to Evaluate Potential COVID-19 Hyperimmune Medicine. Retrieved October 8, 2020, from https:\/\/www.prnewswire.com\/news-releases\/first-patient-enrolled-in-nih-phase-3-trial-to-evaluate-potential-covid-19-hyperimmune-medicine-301148902.html<\/p>\n","protected":false},"excerpt":{"rendered":"

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