{"id":1496294,"date":"2026-03-13T10:50:08","date_gmt":"2026-03-13T17:50:08","guid":{"rendered":"https:\/\/www.sandiegochinesepress.com\/press\/?p=1496294"},"modified":"2026-03-13T10:50:08","modified_gmt":"2026-03-13T17:50:08","slug":"%e7%be%8e%e5%9b%bd%e5%8d%8e%e6%96%87%e7%bd%91-%e7%be%8e%e5%9b%bd%e5%8d%8e%e4%ba%ba-%e5%9c%a3%e5%9c%b0%e4%ba%9a%e5%93%a5%e5%8d%8e%e6%96%87%e7%bd%91-%e5%9c%a3%e5%9c%b0%e4%ba%9a%e5%93%a5%e5%8d%8e-2","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/%e7%be%8e%e5%9b%bd%e5%8d%8e%e6%96%87%e7%bd%91-%e7%be%8e%e5%9b%bd%e5%8d%8e%e4%ba%ba-%e5%9c%a3%e5%9c%b0%e4%ba%9a%e5%93%a5%e5%8d%8e%e6%96%87%e7%bd%91-%e5%9c%a3%e5%9c%b0%e4%ba%9a%e5%93%a5%e5%8d%8e-2\/.html","title":{"rendered":"\u52a0\u5dde\u5927\u5b66\u79d1\u5b66\u5bb6\u63ed\u793a\u67d0\u4e9b\u8111\u7ec6\u80de\u4e3a\u4f55\u80fd\u62b5\u6297\u963f\u5c14\u8328\u6d77\u9ed8\u75c5"},"content":{"rendered":"<header class=\"article-card article-card-primary article-card-featured\">\n<div class=\"article-card-body\">\n<div class=\"article-card-text\">\n<p>\u6700\u8fd1\u7531\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\u5065\u5eb7\u4e2d\u5fc3\u548c\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821\u79d1\u5b66\u5bb6\u7684\u4e00\u9879\u7814\u7a76\uff0c\u53d1\u73b0\u4e86\u4e00\u79cd\u4fdd\u62a4\u795e\u7ecf\u5143\u514d\u53d7\u6bd2\u6027tau\u86cb\u767d\u4fb5\u5bb3\u7684\u7ec6\u80de\u9632\u5fa1\u7cfb\u7edf\uff0c\u63ed\u793a\u4e86\u4e3a\u4ec0\u4e48\u67d0\u4e9b\u8111\u7ec6\u80de\u6bd4\u5176\u4ed6\u8111\u7ec6\u80de\u66f4\u80fd\u62b5\u6297\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u548c\u76f8\u5173\u75f4\u5446\u75c7\u7684\u6807\u5fd7\u6027\u6bd2\u6027\u86cb\u767d\u7684\u79ef\u7d2f\u3002<\/p>\n<p>\u8be5\u7814\u7a76\u62a5\u544a\u5df2\u7ecf\u53d1\u8868\u5728\u300a\u7ec6\u80de\u300b\uff08Cell\uff09\u6742\u5fd7\uff0c\u62a5\u544a\u8be6\u7ec6\u9610\u8ff0\u4e86\u5229\u7528\u4e00\u79cd\u57fa\u4e8eCRISPR\u6280\u672f\u7684\u65b0\u578b\u57fa\u56e0\u7b5b\u9009\u65b9\u6cd5\uff0c\u5bf9\u5b9e\u9a8c\u5ba4\u57f9\u517b\u7684\u4eba\u7c7b\u8111\u7ec6\u80de\u8fdb\u884c\u7684\u7814\u7a76\uff0c\u4ee5\u786e\u5b9a\u63a7\u5236\u5927\u8111\u4e2dtau\u86cb\u767d\u79ef\u7d2f\u7684\u7ec6\u80de\u673a\u5236\u3002\u8fd9\u4e9b\u86cb\u767d\u4f1a\u5728\u5927\u8111\u4e2d\u79ef\u805a\u6210\u6709\u6bd2\u7684\u56e2\u5757\uff0c\u6740\u6b7b\u795e\u7ecf\u5143\uff0c\u5e76\u5bfc\u81f4\u989d\u989e\u53f6\u75f4\u5446\u548c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7b49\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u3002tau\u86cb\u767d\u662f\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e2d\u6700\u5e38\u89c1\u7684\u805a\u96c6\u86cb\u767d\u3002\u7136\u800c\uff0c\u7814\u7a76\u4eba\u5458\u6b64\u524d\u5c1a\u672a\u786e\u5b9a\u4e3a\u4ec0\u4e48\u67d0\u4e9b\u7c7b\u578b\u7684\u795e\u7ecf\u5143\u6bd4\u5176\u4ed6\u7c7b\u578b\u7684\u795e\u7ecf\u5143\u66f4\u5bb9\u6613\u53d7\u5230\u5f71\u54cd\u3002<\/p>\n<p>\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u5f71\u54cd\u7740\u6570\u767e\u4e07\u7f8e\u56fd\u4eba\uff0c\u4f46\u76ee\u524d\u5c1a\u65e0\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6cd5\u3002<\/p>\n<p>\u201c\u6211\u4eec\u60f3\u4e86\u89e3\u4e3a\u4ec0\u4e48\u6709\u4e9b\u795e\u7ecf\u5143\u5bb9\u6613\u79ef\u7d2ftau\u86cb\u767d\uff0c\u800c\u53e6\u4e00\u4e9b\u795e\u7ecf\u5143\u5219\u66f4\u5177\u62b5\u6297\u529b\uff0c\u201d \u8be5\u7814\u7a76\u7684\u7b2c\u4e00\u4f5c\u8005\u3001 \u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\u5065\u5eb7\u4e2d\u5fc3\u795e\u7ecf\u75c5\u5b66\u52a9\u7406\u6559\u6388Avi Samelson\u535a\u58eb\u8868\u793a\uff0c\u4ed6\u66fe\u5728\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821\u8fdb\u884c\u8fc7\u8fd9\u9879\u7814\u7a76\u3002\u201c\u901a\u8fc7\u7cfb\u7edf\u5730\u7b5b\u9009\u4eba\u7c7b\u57fa\u56e0\u7ec4\u4e2d\u51e0\u4e4e\u6240\u6709\u57fa\u56e0\uff0c\u6211\u4eec\u53d1\u73b0\u4e86\u63a7\u5236\u795e\u7ecf\u5143\u4e2dtau\u86cb\u767d\u6c34\u5e73\u7684\u9884\u671f\u901a\u8def\u548c\u5b8c\u5168\u51fa\u4e4e\u610f\u6599\u7684\u901a\u8def\u3002\u201d<\/p>\n<p>\u7814\u7a76\u56e2\u961f\u5229\u7528CRISPR\u57fa\u56e0\u7f16\u8f91\u6280\u672f\uff0c\u5728\u6e90\u81ea\u4eba\u7c7b\u5e72\u7ec6\u80de\u7684\u795e\u7ecf\u5143\u4e2d\u6d4b\u8bd5\u4e86\u6572\u9664\u5355\u4e2a\u57fa\u56e0\u5982\u4f55\u5f71\u54cd\u6bd2\u6027tau\u86cb\u767d\u56e2\u5757\u7684\u79ef\u7d2f\u3002\u5728\u9274\u5b9a\u76841000\u591a\u4e2a\u57fa\u56e0\u4e2d\uff0cCRL5SOCS4\u86cb\u767d\u590d\u5408\u7269\u8131\u9896\u800c\u51fa\uff0c\u6210\u4e3a\u5173\u952e\u56e0\u5b50\uff0c\u5b83\u80fd\u5c06\u5206\u5b50\u6807\u7b7e\u9644\u52a0\u5230tau\u86cb\u767d\u4e0a\uff0c\u4f7f\u5176\u88ab\u7ec6\u80de\u7684\u964d\u89e3\u673a\u5236\u6e05\u9664\u3002<\/p>\n<p>\u91cd\u8981\u7684\u662f\uff0c\u5bf9\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u7684\u8111\u7ec4\u7ec7\u8fdb\u884c\u5206\u6790\u53d1\u73b0\uff0cCRL5SOCS4 \u6210\u5206\u7684\u9ad8\u8868\u8fbe\u4f7f\u795e\u7ecf\u5143\u66f4\u6709\u53ef\u80fd\u5b58\u6d3b\u4e0b\u6765\uff0c\u5c3d\u7ba1 tau \u86cb\u767d\u5df2\u7ecf\u79ef\u7d2f\u3002<\/p>\n<p>\u8fd9\u9879\u7814\u7a76\u8fd8\u63ed\u793a\u4e86\u7ebf\u7c92\u4f53\u529f\u80fd\u969c\u788d\u4e0etau\u86cb\u767d\u6bd2\u6027\u4e4b\u95f4\u610f\u60f3\u4e0d\u5230\u7684\u8054\u7cfb\u3002\u5f53\u7814\u7a76\u4eba\u5458\u7834\u574f\u7ec6\u80de\u80fd\u91cf\u4ea7\u751f\u4e2d\u5fc3\u2014\u2014\u7ebf\u7c92\u4f53\u65f6\uff0c\u4ed6\u4eec\u89e6\u53d1\u4e86\u4e00\u79cd\u7279\u5b9atau\u86cb\u767d\u7247\u6bb5\u7684\u4ea7\u751f\uff0c\u8be5\u7247\u6bb5\u7684\u5927\u5c0f\u7ea6\u4e3a25\u5343\u9053\u5c14\u987f\uff08\u00a0<strong class=\"Yjhzub\" data-sfc-cb=\"\" data-complete=\"true\">kDa\uff09<\/strong>\u3002\u8fd9\u79cd\u7247\u6bb5\u4e0e\u5728\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\u7684\u8840\u6db2\u548c\u8111\u810a\u6db2\u4e2d\u53d1\u73b0\u7684\u4e00\u79cd\u751f\u7269\u6807\u5fd7\u7269\u2014\u2014NTA-tau\u2014\u2014\u975e\u5e38\u76f8\u4f3c\u3002<\/p>\n<p>Samelson\u535a\u58eb\u79f0\uff1a\u201c\u8fd9\u79cdtau\u86cb\u767d\u7247\u6bb5\u4f3c\u4e4e\u662f\u5728\u7ec6\u80de\u7ecf\u5386\u6c27\u5316\u5e94\u6fc0\u65f6\u4ea7\u751f\u7684\uff0c\u800c\u6c27\u5316\u5e94\u6fc0\u5728\u8870\u8001\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e2d\u5f88\u5e38\u89c1\u3002\u6211\u4eec\u53d1\u73b0\uff0c\u8fd9\u79cd\u5e94\u6fc0\u4f1a\u964d\u4f4e\u86cb\u767d\u9176\u4f53\uff08\u7ec6\u80de\u7684\u86cb\u767d\u8d28\u56de\u6536\u673a\u5668\uff09\u7684\u6548\u7387\uff0c\u5bfc\u81f4\u5176\u65e0\u6cd5\u6b63\u786e\u5904\u7406tau\u86cb\u767d\u3002\u201d<\/p>\n<p>\u7814\u7a76\u4eba\u5458\u8bc1\u660e\uff0c\u8fd9\u79cd\u5f02\u5e38\u7684 tau \u7247\u6bb5\u4f1a\u6539\u53d8 tau \u86cb\u767d\u5728\u8bd5\u7ba1\u5b9e\u9a8c\u4e2d\u7684\u805a\u96c6\u65b9\u5f0f\uff0c\u4ece\u800c\u53ef\u80fd\u5f71\u54cd\u75be\u75c5\u7684\u8fdb\u5c55\u3002<\/p>\n<p>\u8fd9\u4e9b\u53d1\u73b0\u4e3a\u6cbb\u7597\u65b9\u6cd5\u7684\u5f00\u53d1\u63d0\u4f9b\u4e86\u51e0\u4e2a\u6709\u524d\u666f\u7684\u7ebf\u7d22\u3002\u589e\u5f3aCRL5SOCS4\u6d3b\u6027\u53ef\u80fd\u6709\u52a9\u4e8e\u795e\u7ecf\u5143\u66f4\u6709\u6548\u5730\u6e05\u9664tau\u86cb\u767d\uff0c\u800c\u7ef4\u6301\u5e94\u6fc0\u671f\u95f4\u86cb\u767d\u9176\u4f53\u529f\u80fd\u7684\u7b56\u7565\u53ef\u80fd\u6709\u52a9\u4e8e\u9632\u6b62\u6709\u6bd2tau\u86cb\u767d\u7247\u6bb5\u7684\u5f62\u6210\u3002<\/p>\n<p>Samelson\u535a\u58eb\u8bf4\uff1a\u201c\u8fd9\u9879\u7814\u7a76\u7684\u7279\u522b\u4e4b\u5904\u5728\u4e8e\uff0c\u6211\u4eec\u4f7f\u7528\u4e86\u643a\u5e26\u771f\u6b63\u81f4\u75c5\u7a81\u53d8\u7684\u4eba\u7c7b\u795e\u7ecf\u5143\u3002\u8fd9\u4e9b\u7ec6\u80de\u5728tau\u86cb\u767d\u52a0\u5de5\u8fc7\u7a0b\u4e2d\u81ea\u7136\u5b58\u5728\u5dee\u5f02\uff0c\u8fd9\u8ba9\u6211\u4eec\u786e\u4fe1\uff0c\u6211\u4eec\u53d1\u73b0\u7684\u673a\u5236\u4e0e\u4eba\u7c7b\u75be\u75c5\u76f8\u5173\u3002\u201d<\/p>\n<p>\u8fd9\u9879\u7814\u7a76\u8fd8\u51f8\u663e\u4e86\u7cfb\u7edf\u6027\u57fa\u56e0\u7b5b\u67e5\u5728\u63ed\u793a\u75be\u75c5\u673a\u5236\u65b9\u9762\u7684\u5f3a\u5927\u4f5c\u7528\u3002\u7814\u7a76\u56e2\u961f\u53d1\u73b0\u4e86\u4e00\u4e9b\u610f\u60f3\u4e0d\u5230\u7684\u901a\u8def\uff0c\u5305\u62ec\u4e00\u79cd\u540d\u4e3aUFMylation\u7684\u86cb\u767d\u8d28\u4fee\u9970\u7cfb\u7edf\u4ee5\u53ca\u53c2\u4e0e\u6784\u5efa\u7ec6\u80de\u819c\u951a\u5b9a\u7684\u9176\uff0c\u8fd9\u4e9b\u901a\u8def\u6b64\u524d\u5e76\u672a\u88ab\u8ba4\u4e3a\u4e0etau\u86cb\u767d\u8c03\u63a7\u6709\u5173\u3002<\/p>\n<p>Tau\u86cb\u767d\u662f\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e2d\u6700\u5e38\u89c1\u7684\u805a\u96c6\u86cb\u767d\u3002\u7136\u800c\uff0c\u7814\u7a76\u4eba\u5458\u5c1a\u672a\u786e\u5b9a\u4e3a\u4ec0\u4e48\u67d0\u4e9b\u7c7b\u578b\u7684\u795e\u7ecf\u5143\u6bd4\u5176\u4ed6\u7c7b\u578b\u7684\u795e\u7ecf\u5143\u66f4\u5bb9\u6613\u53d7\u5230\u5f71\u54cd\u3002<\/p>\n<p>\u8be5\u7814\u7a76\u53d1\u73b0\u4e86\u4e00\u79cd\u540d\u4e3aCRL5SOCS4\u7684\u86cb\u767d\u8d28\u590d\u5408\u7269\uff0c\u5b83\u80fd\u6807\u8bb0tau\u86cb\u767d\u4ee5\u8fdb\u884c\u964d\u89e3\u3002\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u589e\u5f3a\u8fd9\u79cd\u5929\u7136\u9632\u5fa1\u673a\u5236\u53ef\u80fd\u4ee3\u8868\u4e00\u79cd\u6cbb\u7597\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u65b0\u7b56\u7565\u3002<\/p>\n<p>\u589e\u5f3a CRL5SOCS4 \u6d3b\u6027\u53ef\u4ee5\u5e2e\u52a9\u795e\u7ecf\u5143\u66f4\u6709\u6548\u5730\u6e05\u9664 tau \u86cb\u767d\uff0c\u800c\u7ef4\u6301\u538b\u529b\u671f\u95f4\u86cb\u767d\u9176\u4f53\u529f\u80fd\u7684\u7b56\u7565\u53ef\u80fd\u4f1a\u9632\u6b62\u6709\u6bd2 tau \u86cb\u767d\u7247\u6bb5\u7684\u5f62\u6210\u3002<\/p>\n<p>\u8be5\u7814\u7a76\u7684\u65b0\u53d1\u73b0\u4e3a\u6cbb\u7597\u6216\u7597\u6cd5\u63d0\u4f9b\u65b0\u7684\u9776\u70b9\uff0c\u4e3a\u65b0\u7684\u6cbb\u7597\u65b9\u6cd5\u6253\u5f00\u4e86\u4e00\u4e2a\u65b0\u5927\u95e8\u3002\u7814\u7a76\u53d1\u73b0\u4ee4\u4eba\u9f13\u821e\uff0c\u4f46\u76f8\u5173\u7814\u7a76\u4eba\u5458\u5f3a\u8c03\uff0c\u8981\u5c06\u8fd9\u4e9b\u53d1\u73b0\u8f6c\u5316\u4e3a\u6cbb\u7597\u65b9\u6cd5\uff0c\u8fd8\u9700\u8981\u8fdb\u884c\u66f4\u591a\u7814\u7a76\u3002<\/p>\n<p>\u8be5\u7814\u7a76\u7531 Rainwater Charitable Foundation\/Tau Consortium\u3001\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u548c\u5176\u4ed6\u673a\u6784\u8d44\u52a9\u3002<\/p>\n<p>\u6765\u6e90\uff1a\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\uff0c\u65e7\u91d1\u5c71\u5206\u6821\u3002<\/p>\n<p>\uff08\u7f8e\u56fd\u534e\u6587\u7f51\u7f16\u53d1\uff09<\/p>\n<\/div>\n<\/div>\n<\/header>\n","protected":false},"excerpt":{"rendered":"<p>\u6700\u8fd1\u7531\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\u5065\u5eb7\u4e2d\u5fc3\u548c\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u6821\u79d1\u5b66\u5bb6\u7684\u4e00\u9879\u7814\u7a76\uff0c\u53d1\u73b0\u4e86\u4e00\u79cd\u4fdd\u62a4\u795e\u7ecf\u5143\u514d\u53d7\u6bd2\u6027tau\u86cb\u767d\u4fb5\u5bb3\u7684\u7ec6\u80de\u9632\u5fa1\u7cfb\u7edf\uff0c\u63ed\u793a\u4e86\u4e3a\u4ec0\u4e48\u67d0\u4e9b\u8111\u7ec6\u80de\u6bd4\u5176\u4ed6\u8111\u7ec6\u80de\u66f4\u80fd\u62b5\u6297\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u548c\u76f8\u5173\u75f4\u5446\u75c7\u7684\u6807\u5fd7\u6027\u6bd2\u6027\u86cb\u767d\u7684\u79ef\u7d2f&#8230;&#8230;<\/p>\n","protected":false},"author":3,"featured_media":1496296,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-1496294","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-us_today"],"_links":{"self":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1496294","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/comments?post=1496294"}],"version-history":[{"count":2,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1496294\/revisions"}],"predecessor-version":[{"id":1496299,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1496294\/revisions\/1496299"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media\/1496296"}],"wp:attachment":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media?parent=1496294"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/categories?post=1496294"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/tags?post=1496294"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}