\u7f8e\u56fd\u79d1\u5b66\u5bb6\u8fd1\u671f\u5173\u4e8e\u5496\u5561\u4e0e\u4eba\u7c7b\u5065\u5eb7\u7684\u6700\u65b0\u7814\u7a76\u4e3b\u8981\u805a\u7126\u4e8e\u7ec6\u80de\u6297\u8870\u8001\u673a\u5236\u4e0e\u957f\u671f\u5927\u8111\u8ba4\u77e5\u4fdd\u62a4\u3002<\/p>\n
\u7f8e\u56fd\u5fb7\u514b\u8428\u65af\u519c\u5de5\u5927\u5b66\u517d\u533b\u4e0e\u751f\u7269\u533b\u5b66\u79d1\u5b66\u5b66\u9662\uff08VMBS\uff09\u4e00\u9879\u6700\u65b0\u7814\u7a76\u6210\u679c\u63ed\u793a\u4e86\u5496\u5561\u4e0e\u5065\u5eb7\u8001\u9f84\u5316\u548c\u964d\u4f4e\u75be\u75c5\u98ce\u9669\u53cd\u590d\u76f8\u5173\u7684\u4e00\u4e2a\u91cd\u8981\u7684\u53ef\u80fd\u6027\uff0c\u58f0\u79f0\u5496\u5561\u4e2d\u7684\u5316\u5408\u7269\u53ef\u80fd\u4f1a\u6fc0\u6d3b\u4e00\u79cd\u53ebNR4A1\u7684\u4fdd\u62a4\u6027\u53d7\u4f53\uff0c\u5e2e\u52a9\u4eba\u7684\u8eab\u4f53\u51cf\u8f7b\u708e\u75c7\u3001\u4fee\u590d\u635f\u4f24\u5e76\u62b5\u5fa1\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u75be\u75c5\uff0c\u800c\u5f53\u53bb\u9664\u8be5\u53d7\u4f53\u540e\uff0c\u8fd9\u4e9b\u4fdd\u62a4\u4f5c\u7528\u4fbf\u51cf\u9000\uff0c\u4ece\u800c\u5f3a\u5316\u4e86\u4e8c\u8005\u4e4b\u95f4\u7684\u8054\u7cfb\u3002\u4ee4\u4eba\u60ca\u8bb6\u7684\u662f\uff0c\u5496\u5561\u9178\u7b49\u690d\u7269\u6027\u5316\u5408\u7269\u7684\u6d3b\u6027\u4f3c\u4e4e\u8fdc\u9ad8\u4e8e\u5496\u5561\u56e0\u672c\u8eab\u3002\u8be5\u9879\u7814\u7a76\u6210\u679c\u8fd1\u671f\u5df2\u53d1\u8868\u5728\u300a\u8425\u517b\u5143\u7d20\uff08Nutrients<\/em>\uff09<\/em>\u300b\u6742\u5fd7\u3002<\/p>\n \u5496\u5561\u4e00\u76f4\u88ab\u8ba4\u4e3a\u4e0e\u5ef6\u957f\u5bff\u547d\u548c\u964d\u4f4e\u591a\u79cd\u6162\u6027\u75be\u75c5\u98ce\u9669\u6709\u5173\u3002\u5373\u4fbf\u5982\u6b64\uff0c\u79d1\u5b66\u5bb6\u4eec\u5c1a\u672a\u5b8c\u5168\u4e86\u89e3\u53ef\u80fd\u89e3\u91ca\u8fd9\u4e9b\u76ca\u5904\u7684\u751f\u7269\u5b66\u8fc7\u7a0b\u3002<\/p>\n \u4e3b\u8981\u4f5c\u8005\uff0cVMBS\u517d\u533b\u5b66\u9662\u517d\u533b\u751f\u7406\u4e0e\u836f\u7406\u5b66\u7cfb\u6770\u51fa\u6559\u6388\u517c\u897f\u5fb7\u00b7\u51ef\u5c14\u517d\u533b\u6bd2\u7406\u5b66\u8bb2\u5e2d\u6559\u6388Stephen Safe\u535a\u58eb\u79f0\uff0c\u201c \u5496\u5561\u5177\u6709\u4f17\u6240\u5468\u77e5\u7684\u5065\u5eb7\u4fc3\u8fdb\u529f\u6548\uff0c\u5176\u4e2d\u4e00\u4e9b\u529f\u6548\u53ef\u80fd\u4e0e\u5496\u5561\u5316\u5408\u7269\u5982\u4f55\u4e0e\u8fd9\u79cd\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528\u6709\u5173\uff0c\u800c\u8fd9\u79cd\u53d7\u4f53\u53c2\u4e0e\u4fdd\u62a4\u8eab\u4f53\u514d\u53d7\u5e94\u6fc0\u5f15\u8d77\u7684\u635f\u4f24\u3002\u201d<\/p>\n NR4A1<\/strong>\u5982\u4f55\u5e2e\u52a9\u4fdd\u62a4\u8eab\u4f53\uff1f<\/strong><\/p>\n NR4A1 \u5c5e\u4e8e\u6838\u53d7\u4f53\u7ec4\uff0c\u5f53\u8eab\u4f53\u53d7\u5230\u538b\u529b\u6216\u7ec4\u7ec7\u635f\u4f24\u65f6\uff0c\u6838\u53d7\u4f53\u7ec4\u6709\u52a9\u4e8e\u63a7\u5236\u57fa\u56e0\u6d3b\u6027\u3002<\/p>\n \u5728\u65e9\u671f\u7684\u7814\u7a76\u4e2d\uff0cSafe \u548c\u4ed6\u7684\u5408\u4f5c\u8005\u5c06 NR4A1 \u63cf\u8ff0\u4e3a\u201c\u8425\u517b\u4f20\u611f\u5668\u201d\uff0c\u8fd9\u610f\u5473\u7740\u5b83\u53ef\u4ee5\u5bf9\u81b3\u98df\u5316\u5408\u7269\u505a\u51fa\u53cd\u5e94\uff0c\u5e76\u6709\u52a9\u4e8e\u8eab\u4f53\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u4fdd\u6301\u5065\u5eb7\u3002<\/p>\n \u201c\u5982\u679c\u4f60\u635f\u4f24\u4e86\u51e0\u4e4e\u4efb\u4f55\u7ec4\u7ec7\uff0cNR4A1\u90fd\u4f1a\u505a\u51fa\u53cd\u5e94\u6765\u51cf\u8f7b\u8fd9\u79cd\u635f\u4f24\uff0c\u201d Safe\u8bf4\u3002\u201c\u5982\u679c\u4f60\u79fb\u9664\u8fd9\u79cd\u53d7\u4f53\uff0c\u635f\u4f24\u4f1a\u66f4\u4e25\u91cd\u3002\u201d<\/p>\n \u7814\u7a76\u8868\u660e\uff0cNR4A1\u4e0e\u708e\u75c7\u3001\u4ee3\u8c22\u548c\u7ec4\u7ec7\u4fee\u590d\u5bc6\u5207\u76f8\u5173\u3002\u8fd9\u4e9b\u8fc7\u7a0b\u90fd\u4e0e\u591a\u79cd\u5e74\u9f84\u76f8\u5173\u75be\u75c5\u5bc6\u5207\u76f8\u5173\uff0c\u5305\u62ec\u764c\u75c7\u3001\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u548c\u4ee3\u8c22\u7d0a\u4e71\u3002<\/p>\n \u5496\u5561\u76ca\u5904\u80cc\u540e\u7684\u53ef\u80fd\u673a\u5236<\/strong><\/p>\n \u5927\u578b\u89c2\u5bdf\u6027\u7814\u7a76\u8868\u660e\uff0c\u996e\u7528\u5496\u5561\u4e0e\u964d\u4f4e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u3001\u5e15\u91d1\u68ee\u75c5\u548c\u4ee3\u8c22\u6027\u75be\u75c5\u7684\u98ce\u9669\u76f8\u5173\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u7814\u7a76\u901a\u5e38\u53ea\u63ed\u793a\u4e86\u4e8c\u8005\u4e4b\u95f4\u7684\u5173\u8054\uff0c\u800c\u6ca1\u6709\u5177\u4f53\u89e3\u91ca\u5496\u5561\u5982\u4f55\u4ea7\u751f\u4fdd\u62a4\u4f5c\u7528\u3002<\/p>\n Safe \u548c\u4ed6\u7684\u56e2\u961f\u63d0\u51fa\uff0cNR4A1 \u53ef\u80fd\u662f\u8fd9\u79cd\u89e3\u91ca\u7684\u4e00\u90e8\u5206\u3002<\/p>\n \u7814\u7a76\u4eba\u5458\u53d1\u73b0\uff0c\u5496\u5561\u4e2d\u7684\u51e0\u79cd\u5316\u5408\u7269\u53ef\u4ee5\u4e0eNR4A1\u7ed3\u5408\u5e76\u6539\u53d8\u5176\u6d3b\u6027\u3002\u5176\u4e2d\u6d3b\u6027\u6700\u5f3a\u7684\u5316\u5408\u7269\u5305\u62ec\u591a\u7f9f\u57fa\u5316\u5408\u7269\u548c\u591a\u915a\u7c7b\u5316\u5408\u7269\uff0c\u4f8b\u5982\u5496\u5561\u9178\u3002<\/p>\n \u201c\u6211\u4eec\u60f3\u8bf4\u7684\u662f\uff0c\u5496\u5561\u81f3\u5c11\u6709\u4e00\u90e8\u5206\u5065\u5eb7\u76ca\u5904\u53ef\u80fd\u6765\u81ea\u4e8e\u4e0e\u8fd9\u79cd\u53d7\u4f53\u7ed3\u5408\u5e76\u6fc0\u6d3b\u5b83\uff0c\u201d Safe\u8bf4\u3002<\/p>\n \u5728\u5b9e\u9a8c\u5ba4\u6a21\u578b\u4e2d\uff0c\u8fd9\u4e9b\u5316\u5408\u7269\u8fd8\u80fd\u4ee5\u4e0e\u75be\u75c5\u9632\u62a4\u76f8\u5173\u7684\u65b9\u5f0f\u6539\u53d8\u7ec6\u80de\u884c\u4e3a\u3002\u5b83\u4eec\u80fd\u51cf\u5c11\u7ec6\u80de\u635f\u4f24\u5e76\u51cf\u7f13\u764c\u7ec6\u80de\u7684\u751f\u957f\u3002<\/p>\n \u5f53\u7814\u7a76\u4eba\u5458\u4ece\u7ec6\u80de\u4e2d\u53bb\u9664NR4A1\u540e\uff0c\u8fd9\u4e9b\u4fdd\u62a4\u4f5c\u7528\u5c31\u6d88\u5931\u4e86\u3002\u8fd9\u4e00\u7ed3\u679c\u8fdb\u4e00\u6b65\u8bc1\u660e\uff0c\u8be5\u53d7\u4f53\u81f3\u5c11\u6709\u52a9\u4e8e\u4ecb\u5bfc\u5496\u5561\u7684\u90e8\u5206\u751f\u7269\u5b66\u6548\u5e94\u3002<\/p>\n \u5496\u5561\u7684\u76ca\u5904\u53ef\u80fd\u4e0d\u4ec5\u9650\u4e8e\u5496\u5561\u56e0\u3002<\/p>\n \u5496\u5561\u56e0\u662f\u5496\u5561\u4e2d\u542b\u91cf\u6700\u9ad8\u7684\u5355\u4e00\u6210\u5206\uff0c\u4f46\u7814\u7a76\u8868\u660e\uff0c\u5b83\u53ef\u80fd\u5e76\u975e\u5496\u5561\u5177\u6709\u4fdd\u62a4\u4f5c\u7528\u7684\u4e3b\u8981\u6765\u6e90\u3002<\/p>\n \u76f8\u53cd\uff0c\u8bb8\u591a\u6c34\u679c\u548c\u852c\u83dc\u4e2d\u4e5f\u5b58\u5728\u7684\u5929\u7136\u5316\u5408\u7269\u4f3c\u4e4e\u5bf9 NR4A1 \u6709\u66f4\u5f3a\u7684\u5f71\u54cd\u3002\u201c\u5496\u5561\u56e0\u80fd\u4e0e\u53d7\u4f53\u7ed3\u5408\uff0c\u4f46\u5728\u6211\u4eec\u7684\u6a21\u578b\u4e2d\u4f5c\u7528\u4e0d\u5927\uff0c\u201dSafe\u8bf4\u3002\u201c\u591a\u7f9f\u57fa\u5316\u5408\u7269\u548c\u591a\u915a\u7c7b\u5316\u5408\u7269\u7684\u6d3b\u6027\u8981\u9ad8\u5f97\u591a\u3002\u201d<\/p>\n \u8fd9\u4e00\u53d1\u73b0\u6216\u8bb8\u53ef\u4ee5\u89e3\u91ca\u4e3a\u4ec0\u4e48\u5927\u578b\u4eba\u53e3\u7814\u7a76\u5c06\u542b\u5496\u5561\u56e0\u5496\u5561\u548c\u4e0d\u542b\u5496\u5561\u56e0\u5496\u5561\u90fd\u4e0e\u7c7b\u4f3c\u7684\u5065\u5eb7\u76ca\u5904\u8054\u7cfb\u8d77\u6765\u3002<\/p>\n \u4f17\u591a\u9014\u5f84\u4e4b\u4e00<\/strong><\/p>\n Safe\u63d0\u9192\u8bf4\uff0c\u5496\u5561\u7684\u5316\u5b66\u6210\u5206\u5f88\u590d\u6742\uff0c\u53ef\u80fd\u4f1a\u901a\u8fc7\u591a\u79cd\u751f\u7269\u9014\u5f84\u5f71\u54cd\u4eba\u4f53\u3002\u4ed6\u8bf4\uff1a\u201c\u8fd9\u91cc\u6d89\u53ca\u8bb8\u591a\u53d7\u4f53\u548c\u673a\u5236\u3002\u6211\u4eec\u6b63\u5728\u8bc1\u660e\uff0c\u8fd9\u53ef\u80fd\u662f\u5176\u4e2d\u4e00\u6761\u91cd\u8981\u7684\u901a\u8def\u3002\u201d<\/p>\n \u8fd9\u9879\u7814\u7a76\u65e8\u5728\u63a2\u7a76\u751f\u7269\u5b66\u673a\u5236\uff0c\u4f46\u5e76\u672a\u5efa\u7acb\u4eba\u4f53\u5185\u76f4\u63a5\u7684\u56e0\u679c\u5173\u7cfb\uff0c\u4e5f\u672a\u8bc1\u660e\u996e\u7528\u5496\u5561\u53ef\u4ee5\u9884\u9632\u75be\u75c5\u3002<\/p>\n \u201c\u8fd8\u6709\u5f88\u591a\u5de5\u4f5c\u8981\u505a\uff0c\u201dSafe\u8bf4\u3002\u201c\u6211\u4eec\u5df2\u7ecf\u5efa\u7acb\u4e86\u8054\u7cfb\uff0c\u4f46\u6211\u4eec\u9700\u8981\u66f4\u597d\u5730\u7406\u89e3\u8fd9\u79cd\u8054\u7cfb\u7684\u91cd\u8981\u6027\u3002\u201d<\/p>\n \u7814\u7a76\u7ed3\u679c\u652f\u6301\u8d8a\u6765\u8d8a\u591a\u7684\u7814\u7a76\uff0c\u8fd9\u4e9b\u7814\u7a76\u8868\u660e\u996e\u98df\uff0c\u7279\u522b\u662f\u690d\u7269\u6027\u5316\u5408\u7269\uff0c\u53ef\u4ee5\u5f71\u54cd\u4e0e\u8870\u8001\u548c\u75be\u75c5\u76f8\u5173\u7684\u751f\u7269\u9014\u5f84\u3002<\/p>\n \u7531\u4e8eNR4A1\u5728\u591a\u79cd\u75be\u75c5\u4e2d\u53d1\u6325\u4f5c\u7528\uff0c\u8fd9\u4e9b\u53d1\u73b0\u4e5f\u53ef\u80fd\u6709\u52a9\u4e8e\u672a\u6765\u7684\u836f\u7269\u7814\u53d1\u3002<\/p>\n Safe\u7684\u56e2\u961f\u6b63\u5728\u7814\u7a76\u6bd4\u5929\u7136\u81b3\u98df\u7269\u8d28\u66f4\u80fd\u6709\u6548\u9776\u5411\u8be5\u53d7\u4f53\u7684\u5408\u6210\u5316\u5408\u7269\uff0c\u65e8\u5728\u5f00\u53d1\u6cbb\u7597\u764c\u75c7\u548c\u5176\u4ed6\u75be\u75c5\u7684\u6f5c\u5728\u7597\u6cd5\u3002<\/p>\n \u8fd9\u9879\u7814\u7a76\u4e5f\u7a81\u663e\u4e86\u65e5\u5e38\u996e\u98df\u9009\u62e9\u7684\u6f5c\u5728\u91cd\u8981\u6027\u3002<\/p>\n 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