\u4f4d\u4e8e\u7f8e\u56fd\u52a0\u5dde\u7ea2\u6728\u5e02\u7684\u521b\u65b0\u80bf\u7624\u836f\u7269\u516c\u53f8\uff08Revolution Medicines, Inc.\uff098\u670826\u65e5\u5ba3\u200b\u200b\u5e03\uff0c\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u5df2\u6279\u51c6\u8be5\u516c\u53f8\u7684RASONQUE™\uff08daraxonrasib\uff09\u4e0a\u5e02\uff0c\u8fd9\u662f\u9996\u4e2a\u7528\u4e8e\u6cbb\u7597\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u7684\u5e7f\u8c31RAS\u9776\u5411\u836f\u7269\uff0c\u7528\u4e8e\u6cbb\u7597\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u65e2\u5f80\u5168\u8eab\u6cbb\u7597\u6216\u4e0d\u9002\u5408\u63a5\u53d7\u591a\u836f\u8054\u5408\u5168\u8eab\u6cbb\u7597\u7684\u8f6c\u79fb\u6027\u80f0\u817a\u817a\u764c\uff08PDAC\uff09\u6210\u4eba\u60a3\u8005\uff0c\u5c5e\u4e8e\u7a81\u7834\u6027\u7684\u65b0\u578bRAS(ON)\u591a\u9009\u62e9\u6027\u548c\u7a81\u53d8\u9009\u62e9\u6027\u6291\u5236\u5242\u3002<\/p>\n
\u80f0\u817a\u764c\u662f\u6700\u96be\u6cbb\u6108\u7684\u6076\u6027\u80bf\u7624\u4e4b\u4e00\uff0c\u901a\u5e38\u8bca\u65ad\u8f83\u665a\uff0c\u751f\u7269\u5b66\u7279\u6027\u5177\u6709\u4fb5\u88ad\u6027\uff0c\u4e14\u5bf9\u4f20\u7edf\u7597\u6cd5\u7684\u53cd\u5e94\u6709\u9650\u3002RAS\u662f\u4eba\u7c7b\u7ec6\u80de\u4e2d\u5173\u952e\u7684\u751f\u957f\u8c03\u63a7\u5f00\u5173\uff0c\u4e5f\u662f\u80f0\u817a\u764c\u7684\u4e3b\u8981\u81f4\u75c5\u56e0\u7d20\uff0c\u80f0\u817a\u764c\u7684\u7279\u5f81\u662fRAS\u4fe1\u53f7\u8fc7\u5ea6\u6fc0\u6d3b\u3002RASONQUE\u83b7\u6279\u7528\u4e8e\u6cbb\u7597\u4f34\u6216\u4e0d\u4f34\u6709\u5df2\u9274\u5b9aRAS\u80bf\u7624\u7a81\u53d8\u7684\u8f6c\u79fb\u6027\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\uff08PDAC\uff09\u6210\u4eba\u60a3\u8005\uff0c\u65e0\u9700\u4f7f\u7528\u4f34\u968f\u8bca\u65ad\u68c0\u6d4b\u3002<\/p>\n
\u201cRASONQUE\u83b7\u5f97FDA\u6279\u51c6\uff0c\u5bf9\u4e8e\u80f0\u817a\u764c\u60a3\u8005\u548c\u80bf\u7624\u6cbb\u7597\u9886\u57df\u800c\u8a00\uff0c\u90fd\u662f\u4e00\u4e2a\u91cc\u7a0b\u7891\u5f0f\u7684\u8fdb\u6b65\u3002\u8fd9\u662f\u9996\u4e2a\u83b7\u6279\u7684\u9776\u5411\u836f\u7269\uff0c\u65e8\u5728\u76f4\u63a5\u6291\u5236\u80f0\u817a\u764c\u7684\u4e3b\u8981\u81f4\u75c5\u57fa\u56e0RAS\u3002RAS\u81ea\u51e0\u5341\u5e74\u524d\u88ab\u53d1\u73b0\u4ee5\u6765\uff0c\u4e00\u76f4\u662f\u6cbb\u7597\u4e2d\u6700\u68d8\u624b\u7684\u9776\u70b9\u4e4b\u4e00\u3002\u5168\u74033\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7a7a\u524d\u6210\u679c\uff0c\u4f7fRASONQUE\u6709\u671b\u6210\u4e3a\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u60a3\u8005\u7684\u65b0\u6807\u51c6\u7597\u6cd5\uff0c\u5176\u83b7\u6279\u9002\u5e94\u75c7\u4e5f\u4e3a\u771f\u5b9e\u4e16\u754c\u7684\u4e34\u5e8a\u51b3\u7b56\u63d0\u4f9b\u4e86\u652f\u6301\u3002\u6b64\u6b21\u83b7\u6279\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u4e86\u6211\u4eec\u5927\u80c6\u7684RAS(ON)\u6291\u5236\u5242\u7b56\u7565\uff0c\u8be5\u7b56\u7565\u5305\u62ec\u9488\u5bf9\u80f0\u817a\u764c\u53ca\u5176\u4ed6\u591a\u79cd\u764c\u75c7\u4e3b\u8981\u9a71\u52a8\u57fa\u56e0\u7684\u591a\u9009\u62e9\u6027\u548c\u7a81\u53d8\u9009\u62e9\u6027\u7597\u6cd5\u3002\u6211\u4eec\u5c06\u7ee7\u7eed\u4e0e\u5168\u7403\u76d1\u7ba1\u673a\u6784\u4fdd\u6301\u6c9f\u901a\uff0c\u4ee5\u671f\u6269\u5927\u548c\u52a0\u901fRASONQUE\u7684\u63a8\u5e7f\u5e94\u7528\uff0c\u201dRevolution Medicines\u9996\u5e2d\u6267\u884c\u5b98\u517c\u8463\u4e8b\u957fMark A. Goldsmith\u533b\u5b66\u535a\u58eb\u8868\u793a\u3002<\/p>\n
\u201c\u4eca\u5929\u8fd9\u9879\u5177\u6709\u91cc\u7a0b\u7891\u610f\u4e49\u7684\u6279\u51c6\u662f\u6211\u4eec\u8fc4\u4eca\u4e3a\u6b62\u5728\u5bf9\u6297\u80f0\u817a\u764c\u8fd9\u4e00\u6bc1\u706d\u6027\u75be\u75c5\u65b9\u9762\u53d6\u5f97\u7684\u6700\u91cd\u5927\u8fdb\u5c55\u3002\u6211\u76f8\u4fe1\u8fd9\u79cd\u836f\u7269\u5c06\u5f7b\u5e95\u6539\u53d8\u80f0\u817a\u764c\u7684\u6cbb\u7597\u65b9\u5f0f\uff0c\u8ba9\u60a3\u8005\u6709\u673a\u4f1a\u4e0e\u4eb2\u4eba\u5171\u5ea6\u66f4\u591a\u65f6\u5149\uff0c\u62e5\u6709\u66f4\u9ad8\u7684\u751f\u6d3b\u8d28\u91cf\uff0c\u5e76\u8ba9\u6211\u4eec\u5bf9\u6301\u7eed\u7684\u7814\u7a76\u5e26\u6765\u66f4\u5927\u7684\u8fdb\u6b65\u5145\u6ee1\u4fe1\u5fc3\uff0c\u201d\u80f0\u817a\u764c\u884c\u52a8\u7f51\u7edc\uff08PanCAN\uff09\u9996\u5e2d\u79d1\u5b66\u548c\u533b\u5b66\u5b98Anna Berkenblit\u533b\u5b66\u535a\u58eb\u8868\u793a\u3002\u201c\u6b64\u5916\uff0c\u4e0e\u4f20\u7edf\u7684\u9759\u8109\u5316\u7597\u76f8\u6bd4\uff0c\u53e3\u670d\u836f\u7269\u53ef\u4ee5\u51cf\u8f7b\u60a3\u8005\u7684\u6cbb\u7597\u8d1f\u62c5\u3002\u968f\u7740RASONQUE\u83b7\u51c6\u4e0a\u5e02\uff0cPanCAN\u5c06\u7ee7\u7eed\u4e3a\u60a3\u8005\u53ca\u5176\u7167\u62a4\u8005\u63d0\u4f9b\u6240\u9700\u7684\u8d44\u6e90\u548c\u77e5\u8bc6\uff0c\u5e2e\u52a9\u4ed6\u4eec\u4e89\u53d6\u5e94\u6709\u7684\u6cbb\u7597\u3002\u201d<\/p>\n
\u201c\u6211\u76f8\u4fe1\uff0c\u5bf9\u4e8e\u5df2\u63a5\u53d7\u8fc7\u81f3\u5c11\u4e00\u79cd\u5168\u8eab\u6cbb\u7597\u6216\u4e0d\u9002\u5408\u63a5\u53d7\u591a\u836f\u8054\u5408\u5168\u8eab\u6cbb\u7597\u7684\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u6210\u4eba\u60a3\u8005\uff0cdaraxonrasib \u6709\u671b\u6210\u4e3a\u65b0\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u3002\u51e0\u5341\u5e74\u6765\uff0c\u5c3d\u7ba1 RAS \u662f\u80f0\u817a\u764c\u7684\u4e3b\u8981\u9a71\u52a8\u56e0\u7d20\u548c\u6f5c\u5728\u7684\u836f\u7269\u9776\u70b9\uff0c\u4f46\u533b\u751f\u4eec\u4e3b\u8981\u4f9d\u8d56\u9759\u8109\u6ce8\u5c04\u7ec6\u80de\u6bd2\u6027\u5316\u7597\u6765\u6cbb\u7597\u8fd9\u79cd\u4fb5\u88ad\u6027\u75be\u75c5\u3002\u6b64\u6b21\u83b7\u6279\u8ba9\u533b\u751f\u4eec\u76f8\u4fe1\uff0c\u76f4\u63a5\u6291\u5236 RAS \u53ef\u4ee5\u4e3a\u60a3\u8005\u5e26\u6765\u663e\u8457\u7684\u7597\u6548\uff0c\u5e76\u4e3a\u8f6c\u79fb\u6027\u80f0\u817a\u764c\u60a3\u8005\u7684\u6cbb\u7597\u63d0\u4f9b\u4e86\u4e00\u79cd\u4e9f\u9700\u7684\u65b0\u65b9\u6cd5\u3002\u201d \u4e39\u5a1c-\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u6240 Hale \u5bb6\u65cf\u80f0\u817a\u764c\u7814\u7a76\u4e2d\u5fc3\u4e3b\u4efb\u3001\u54c8\u4f5b\u533b\u5b66\u9662\u533b\u5b66\u6559\u6388\u3001RASolute 302 \u8bd5\u9a8c\u7684\u4e3b\u8981\u7814\u7a76\u8005 Brian M. Wolpin \u533b\u5b66\u535a\u58eb\u3001\u516c\u5171\u536b\u751f\u7855\u58eb\u8865\u5145\u9053\u3002<\/p>\n
RASONQUE\u83b7\u5f97FDA\u6279\u51c6\u662f\u57fa\u4e8eRASolute 302\u7814\u7a76\u7684\u6570\u636e\u3002RASolute 302\u662f\u4e00\u9879\u5168\u7403\u6027\u3001\u968f\u673a3\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30RASONQUE\u4e0e\u7814\u7a76\u8005\u9009\u62e9\u7684\u7ec6\u80de\u6bd2\u6027\u5316\u7597\u65b9\u6848\u5728\u65e2\u5f80\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684\u8f6c\u79fb\u6027\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\uff08PDAC\uff09\u60a3\u8005\u4e2d\u7684\u7597\u6548\u3002\u8be5\u8bd5\u9a8c\u5728RAS G12\u7a81\u53d8\u4eba\u7fa4\u548c\u603b\u4f53\u610f\u5411\u6cbb\u7597\uff08ITT\uff09\u4eba\u7fa4\uff08\u5305\u62ec\u5df2\u68c0\u6d4b\u5230\u6216\u672a\u68c0\u6d4b\u5230\u80bf\u7624RAS\u7a81\u53d8\u7684\u60a3\u8005\uff09\u4e2d\u5747\u8fbe\u5230\u4e86\u6240\u6709\u4e3b\u8981\u7ec8\u70b9\u548c\u5173\u952e\u6b21\u8981\u7ec8\u70b9\u3002RASolute 302\u8bd5\u9a8c\u7ed3\u679c\u5df2\u00a0\u57282026\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\uff08ASCO\uff09\u5e74\u4f1a\u4e0a\u516c\u5e03\uff0c\u5e76\u540c\u65f6\u53d1\u8868\u4e8e\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\u3002<\/p>\n
\u5728\u610f\u5411\u6cbb\u7597\uff08ITT\uff09\u4eba\u7fa4\u4e2d\uff0c\u4e0e\u5316\u7597\u76f8\u6bd4\uff0cRASONQUE \u4f7f\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e\u4e86 60%\uff0c\u98ce\u9669\u6bd4\uff08HR\uff09\u4e3a 0.40\uff0895% \u7f6e\u4fe1\u533a\u95f4 [CI]\uff1a0.30\u20130.53\uff1bp<0.0001\uff09\u3002RASONQUE \u7ec4\u7684\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\u4e3a 13.2 \u4e2a\u6708\uff0895% CI\uff1a10.0\u2013\u672a\u8fbe\u5230\uff09\uff0c\u800c\u5316\u7597\u7ec4\u4e3a 6.7 \u4e2a\u6708\uff0895% CI\uff1a5.8\u20138.0\uff09\u3002RASONQUE \u8fd8\u663e\u8457\u6539\u5584\u4e86\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\uff0cHR \u4e3a 0.49\uff0895% CI\uff1a0.38\u20130.64\uff1bp<0.0001\uff09\u3002RASONQUE \u7ec4\u7684\u4e2d\u4f4d PFS \u4e3a 7.2 \u4e2a\u6708\uff0895% CI\uff1a5.7\u20137.5\uff09\uff0c\u800c\u5316\u7597\u7ec4\u4e3a 3.6 \u4e2a\u6708\uff0895% CI\uff1a2.9\u20134.2\uff09\u3002 RAS G12 \u4eba\u7fa4\u7684\u7ed3\u679c\u603b\u4f53\u4e0a\u662f\u4e00\u81f4\u7684\u3002<\/p>\n
RASONQUE \u663e\u793a\u51fa\u53ef\u63a7\u7684\u5b89\u5168\u6027\u548c\u826f\u597d\u7684\u8010\u53d7\u6027\u3002\u63a5\u53d7 RASONQUE \u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u6700\u5e38\u89c1\uff08\u2265 20%\uff09\u7684\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u76ae\u75b9\u3001\u8179\u6cfb\u3001\u53e3\u8154\u708e\u3001\u6076\u5fc3\u3001\u5455\u5410\u3001\u8179\u75db\u3001\u6c34\u80bf\u3001\u98df\u6b32\u4e0b\u964d\u548c\u51fa\u8840\u3002\u8bf7\u53c2\u9605\u4e0b\u65b9\u7684 RASONQUE \u91cd\u8981\u5b89\u5168\u4fe1\u606f\u3002<\/p>\n
\u9274\u4e8e\u8f6c\u79fb\u6027\u80f0\u817a\u764c\uff08PDAC\uff09\u60a3\u8005\u75c7\u72b6\u8d1f\u62c5\u6c89\u91cd\uff0c\u8be5\u8bd5\u9a8c\u8fd8\u8bc4\u4f30\u4e86\u610f\u5411\u6cbb\u7597\uff08ITT\uff09\u4eba\u7fa4\u7684\u60a3\u8005\u62a5\u544a\u7ed3\u5c40\u3002\u4e0e\u5316\u7597\u76f8\u6bd4\uff0c\u63a5\u53d7 RASONQUE \u6cbb\u7597\u7684\u60a3\u8005\u5728\u6574\u4f53\u5065\u5eb7\u72b6\u51b5\u548c\u75bc\u75db\u6076\u5316\u65f6\u95f4\uff08TTD\uff09\u65b9\u9762\u8868\u73b0\u51fa\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u548c\u4e34\u5e8a\u610f\u4e49\u7684\u663e\u8457\u5ef6\u7f13\u3002RASONQUE \u5ef6\u957f\u4e86\u6574\u4f53\u5065\u5eb7\u72b6\u51b5\u548c\u751f\u6d3b\u8d28\u91cf\u7684\u7ef4\u6301\u65f6\u95f4\uff0c\u4e2d\u4f4d TTD \u4e3a 5.7 \u4e2a\u6708\uff0c\u800c\u5316\u7597\u7ec4\u4e3a 2.6 \u4e2a\u6708\uff08HR=0.60 [95% CI: 0.46\u20130.79]\uff1bp<0.001\uff09\u3002\u6b64\u5916\uff0cRASONQUE \u8fd8\u5ef6\u7f13\u4e86\u4e34\u5e8a\u76f8\u5173\u75bc\u75db\u7684\u6076\u5316\uff0c\u4e2d\u4f4d TTD \u4e3a 9.2 \u4e2a\u6708\uff0c\u800c\u5316\u7597\u7ec4\u4e3a 3.8 \u4e2a\u6708\uff08HR=0.51 [95% CI: 0.37\u20130.71]\uff1bp<0.001\uff09\u3002<\/p>\n
\u516c\u53f8\u540c\u65f6\u5ba3\u5e03\u63a8\u51fa (ON)\u00a0Path\u9879\u76ee\uff0c\u8fd9\u662f\u4e00\u9879\u9762\u5411\u5df2\u83b7\u5f97 RASONQUE \u5904\u65b9\u60a3\u8005\u7684\u7efc\u5408\u6027\u8ba1\u5212\u3002\u8be5\u8ba1\u5212\u53ef\u5e2e\u52a9\u60a3\u8005\u4e86\u89e3\u4fdd\u9669\u3001\u7533\u8bf7\u7ecf\u6d4e\u63f4\u52a9\u548c\u63a5\u53d7\u6cbb\u7597\u6559\u80b2\uff0c\u4ee5\u786e\u4fdd\u60a3\u8005\u80fd\u591f\u987a\u5229\u5f00\u59cb\u5e76\u575a\u6301\u670d\u836f\u3002\u66f4\u591a\u4fe1\u606f\u8bf7\u8bbf\u95eeRASONQUE.com\u3002<\/p>\n
\u80f0\u817a\u817a\u764c\uff08PDAC\uff09\u662f\u80f0\u817a\u764c\u4e2d\u6700\u5e38\u89c1\u7684\u7c7b\u578b\uff0c\u4e5f\u662f\u6700\u96be\u6cbb\u7597\u7684\u6076\u6027\u80bf\u7624\u4e4b\u4e00\u3002\u5728\u7f8e\u56fd\uff0c\u6bcf\u5e74\u7ea6\u670955,000\u4eba\u88ab\u8bca\u65ad\u51fa\u60a3\u6709PDAC\uff0c\u8d85\u8fc750,000\u4eba\u6b7b\u4e8e\u8be5\u75be\u75c5\uff0c\u800c\u76ee\u524d\u7684\u6cbb\u7597\u6807\u51c6\u5c1a\u65e0\u6cd5\u6709\u6548\u63a7\u5236\u75c5\u60c5\u3002<sup> 2,3<\/sup>\u7531\u4e8e\u65e9\u671f\u80f0\u817a\u764c\u901a\u5e38\u75c7\u72b6\u8f7b\u5fae\u6216\u65e0\u75c7\u72b6\uff0c\u7ea680%\u7684\u60a3\u8005\u5728\u786e\u8bca\u65f6\u5df2\u53d1\u751f\u8f6c\u79fb\uff0c\u6b64\u65f6\u6cbb\u7597\u9009\u62e9\u66f4\u4e3a\u6709\u9650\u3002\u5bf9\u4e8e\u8f6c\u79fb\u6027PDAC\u60a3\u8005\uff0c\u7f8e\u56fd\u7684\u4e94\u5e74\u76f8\u5bf9\u751f\u5b58\u7387\u7ea6\u4e3a3%\u3002<\/p>\n
RASONQUE \u662f\u4e00\u79cd\u53e3\u670d\u7684 RAS(ON) \u591a\u9009\u62e9\u6027\u975e\u5171\u4ef7\u4e09\u590d\u5408\u7269\u6291\u5236\u5242\uff0c\u65e8\u5728\u9776\u5411\u6cbb\u7597\u7531\u591a\u79cd\u5e38\u89c1 RAS \u57fa\u56e0\u578b\u9a71\u52a8\u7684\u764c\u75c7\uff0c\u5305\u62ec\u80f0\u817a\u817a\u764c (PDAC)\u3001\u975e\u5c0f\u7ec6\u80de\u80ba\u764c (NSCLC) \u548c\u7ed3\u76f4\u80a0\u764c\u3002RASONQUE \u901a\u8fc7\u6291\u5236\u91ce\u751f\u578b\u548c\u7a81\u53d8\u578b RAS(ON) \u86cb\u767d\u53ca\u5176\u4e0b\u6e38\u6548\u5e94\u5206\u5b50\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\u6765\u6291\u5236 RAS \u4fe1\u53f7\u4f20\u5bfc\u3002<\/p>\n
\u8be5\u836f\u7269\u4e3a\u53e3\u670d\u7247\u5242\uff0c\u7528\u4e8e\u6cbb\u7597\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u79cd\u5168\u8eab\u6cbb\u7597\u6216\u4e0d\u9002\u5408\u63a5\u53d7\u591a\u836f\u5168\u8eab\u6cbb\u7597\u7684\u8f6c\u79fb\u6027\u80f0\u817a\u817a\u764c\u6210\u5e74\u60a3\u8005\uff0c\u76ee\u524d\u6b63\u5728\u8fdb\u884c\u4e00\u9879\u9488\u5bf9 PDAC \u548c\u8f6c\u79fb\u6027 RAS \u7a81\u53d8 NSCLC \u60a3\u8005\u7684\u5168\u7403 3 \u671f\u6ce8\u518c\u7814\u7a76\u3002<\/p>\n
RASONQUE\u5165\u9009\u4e86\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08FDA\uff09\u5c40\u957f\u7684\u56fd\u5bb6\u4f18\u5148\u8bd5\u70b9\u9879\u76ee\uff0c\u8be5\u9879\u76ee\u65e8\u5728\u52a0\u901f\u5ba1\u6279\u9488\u5bf9\u56fd\u5bb6\u91cd\u70b9\u536b\u751f\u95ee\u9898\u7684\u836f\u7269\u3002RASONQUE\u7684\u65b0\u836f\u7533\u8bf7\u4e5f\u7eb3\u5165\u4e86FDA\u7684\u201c\u5965\u6bd4\u65af\u8ba1\u5212\u201d\uff08Project Orbis\uff09\uff0c\u8be5\u8ba1\u5212\u4e3a\u53c2\u4e0e\u7684\u56fd\u9645\u673a\u6784\u540c\u6b65\u5ba1\u67e5\u80bf\u7624\u836f\u7269\u7533\u8bf7\u63d0\u4f9b\u4e86\u4e00\u4e2a\u6846\u67b6\u3002FDA\u6388\u4e88RASONQUE\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u548c\u5b64\u513f\u836f\u8ba4\u5b9a\uff0c\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684\u8f6c\u79fb\u6027\u80f0\u817a\u5bfc\u7ba1\u817a\u764c\uff08PDAC\uff09\u60a3\u8005\uff1b\u540c\u65f6\u6388\u4e88\u5176\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff0c\u7528\u4e8e\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u94c2\u7c7b\u5316\u7597\u548c\u6297PD-(L)1\u6297\u4f53\u6cbb\u7597\u3001\u643a\u5e26\u9664G12C\u7a81\u53d8\u4ee5\u5916\u7684KRAS\u57fa\u56e0\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u6210\u4eba\u60a3\u8005\u3002<\/p>\n
\u5728\u7f8e\u56fd\u4ee5\u5916\uff0cdaraxonrasib \u662f\u4e00\u79cd\u7814\u7a76\u6027\u836f\u7269\uff0c\u5c1a\u672a\u83b7\u5f97\u4efb\u4f55\u76d1\u7ba1\u673a\u6784\u7684\u6279\u51c6\u3002\u6b27\u6d32\u836f\u54c1\u7ba1\u7406\u5c40 (EMA) \u4eba\u7528\u836f\u54c1\u59d4\u5458\u4f1a\u5df2\u542f\u52a8\u5bf9 daraxonrasib \u7684\u5206\u9636\u6bb5\u5ba1\u67e5\uff0c\u4ee5\u4fbf\u5728\u63d0\u4ea4\u5b8c\u6574\u7684\u4e0a\u5e02\u8bb8\u53ef\u7533\u8bf7\u4e4b\u524d\uff0c\u5bf9\u73b0\u6709\u6570\u636e\u8fdb\u884c\u8bc4\u4f30\u3002daraxonrasib \u56e0\u5176\u6709\u671b\u6ee1\u8db3\u4e00\u9879\u91cd\u5927\u672a\u6ee1\u8db3\u7684\u533b\u7597\u9700\u6c42\uff0c\u5df2\u88ab\u6388\u4e88\u80f0\u817a\u764c\u5b64\u513f\u836f\u8d44\u683c\uff0c\u5e76\u5728 EMA \u7684\u764c\u75c7\u836f\u7269\u63a2\u8def\u8005\u9879\u76ee\u4e2d\u83b7\u5f97\u9ad8\u4f18\u5148\u7ea7\u5730\u4f4d\u3002<\/p>\n
\u5173\u4e8e RASolute 302 \u4e34\u5e8a\u8bd5\u9a8c<\/p>\n
RASolute 302 (\u00a0NCT06625320\u00a0) \u662f\u4e00\u9879\u5168\u7403\u6027\u3001\u968f\u673a\u3001III\u671f\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u65e8\u5728\u8bc4\u4f30 RASONQUE \u5355\u836f\u6cbb\u7597\u65e2\u5f80\u63a5\u53d7\u8fc7\u6cbb\u7597\u7684\u8f6c\u79fb\u6027\u80f0\u817a\u817a\u764c (PDAC) \u60a3\u8005\u7684\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u8bd5\u9a8c\u4e2d\uff0c\u60a3\u8005\u88ab\u968f\u673a\u5206\u914d\u63a5\u53d7\u6bcf\u65e5\u4e00\u6b21\u53e3\u670d 300 mg RASONQUE \u6216\u7531\u7814\u7a76\u8005\u9009\u62e9\u7684\u56db\u79cd\u4e0d\u540c\u7684\u7ec6\u80de\u6bd2\u6027\u5316\u7597\u65b9\u6848\uff0c\u8fd9\u4e9b\u65b9\u6848\u4ee3\u8868\u4e86\u5168\u7403\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u3002\u8be5\u8bd5\u9a8c\u7eb3\u5165\u4e86\u643a\u5e26\u591a\u79cd RAS \u53d8\u5f02\u7684\u8f6c\u79fb\u6027 PDAC \u60a3\u8005\uff0c\u5305\u62ec\u643a\u5e26 RAS G12 \u7a81\u53d8\uff08\u5982 G12D\u3001G12V \u548c G12R\uff09\u7684\u60a3\u8005\uff0c\u4ee5\u53ca\u672a\u68c0\u6d4b\u5230\u80bf\u7624 RAS \u7a81\u53d8\uff08\u91ce\u751f\u578b\uff09\u7684\u60a3\u8005\u3002<\/p>\n
RASolute 302\u8bd5\u9a8c\u7684\u4e3b\u8981\u7ec8\u70b9\u662f\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\uff0c\u7531\u72ec\u7acb\u4e2d\u5fc3\u5ba1\u67e5\u59d4\u5458\u4f1a\u6839\u636eRECIST 1.1\u6807\u51c6\u8fdb\u884c\u8bc4\u4f30\uff0c\u4ee5\u53ca\u643a\u5e26RAS G12\u7a81\u53d8\u80bf\u7624\u60a3\u8005\u7684\u603b\u751f\u5b58\u671f\uff08OS\uff09\u3002\u6b21\u8981\u7ec8\u70b9\u5305\u62ec\u6240\u6709\u5165\u7ec4\u60a3\u8005\uff08\u610f\u5411\u6cbb\u7597\u4eba\u7fa4\uff09\u7684PFS\u548cOS\uff0c\u6db5\u76d6\u4e86\u5df2\u9274\u5b9a\u80bf\u7624RAS\u7a81\u53d8\u548c\u672a\u9274\u5b9a\u80bf\u7624RAS\u7a81\u53d8\u7684\u60a3\u8005\uff0c\u4ee5\u53ca\u5ba2\u89c2\u7f13\u89e3\u7387\u3001\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\u548c\u60a3\u8005\u81ea\u8ff0\u751f\u6d3b\u8d28\u91cf\u3002<\/p>\n
RASONQUE \u9002\u7528\u4e8e\u6cbb\u7597\u81f3\u5c11\u63a5\u53d7\u8fc7\u4e00\u6b21\u5168\u8eab\u6cbb\u7597\u6216\u4e0d\u9002\u5408\u63a5\u53d7\u591a\u836f\u5168\u8eab\u6cbb\u7597\u7684\u8f6c\u79fb\u6027\u80f0\u817a\u817a\u764c\u6210\u5e74\u60a3\u8005\u3002<\/p>\n
\u5b89\u5168\u4e8b\u9879<\/p>\n
RASONQUE \u53ef\u5f15\u8d77\u76ae\u80a4\u6bd2\u6027\uff0c\u4e14\u53ef\u80fd\u8f83\u4e3a\u4e25\u91cd\u3002\u4e34\u5e8a\u8868\u73b0\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\u76ae\u75b9\u3001\u7619\u75d2\u3001\u7532\u6c9f\u708e\u3001\u76ae\u80a4\u5e72\u71e5\u548c\u76ae\u80a4\u76b2\u88c2\u3002\u5728\u80f0\u817a\u817a\u764c\u60a3\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u63a5\u53d7 RASONQUE \u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u6709 86% \u51fa\u73b0\u76ae\u80a4\u6bd2\u6027\uff0c\u5176\u4e2d 10% \u4e3a 3 \u7ea7\u3002<\/p>\n
\u5bc6\u5207\u76d1\u6d4b\u63a5\u53d7 RASONQUE \u6cbb\u7597\u671f\u95f4\u51fa\u73b0\u76ae\u80a4\u6216\u8f6f\u7ec4\u7ec7\u6bd2\u6027\u53cd\u5e94\u7684\u60a3\u8005\u3002\u5728\u9996\u6b21\u4f7f\u7528 RASONQUE \u524d\uff0c\u5e94\u91c7\u53d6\u9884\u9632\u63aa\u65bd\uff08\u4f8b\u5982\uff0c\u5916\u7528\u76ae\u8d28\u7c7b\u56fa\u9187\u3001\u6da6\u80a4\u971c\u3001\u9632\u6652\u971c\u3001\u53e3\u670d\u6297\u751f\u7d20\uff09\uff0c\u4ee5\u964d\u4f4e\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u76ae\u80a4\u53cd\u5e94\u7684\u98ce\u9669\u3002\u5efa\u8bae\u60a3\u8005\u5728\u670d\u7528 RASONQUE \u671f\u95f4\u9650\u5236\u65e5\u6652\u3002\u6839\u636e\u4e34\u5e8a\u6307\u5f81\u91c7\u53d6\u652f\u6301\u6027\u6cbb\u7597\uff08\u4f8b\u5982\uff0c\u53e3\u670d\u76ae\u8d28\u7c7b\u56fa\u9187\uff09\uff0c\u5e76\u8003\u8651\u54a8\u8be2\u76ae\u80a4\u79d1\u533b\u751f\u3002\u6839\u636e\u75c5\u60c5\u4e25\u91cd\u7a0b\u5ea6\uff0c\u6682\u505c\u4f7f\u7528\u3001\u964d\u4f4e\u5242\u91cf\u6216\u6c38\u4e45\u505c\u7528 RASONQUE\u3002<\/p>\n
\u53e3\u8154\u708e\u548c\u53e3\u8154\u75be\u75c5<\/p>\n
RASONQUE \u53ef\u5f15\u8d77\u53e3\u8154\u708e\uff0c\u5305\u62ec\u53e3\u8154\u6e83\u75a1\u548c\u53e3\u8154\u9ecf\u819c\u708e\u3002\u5728\u80f0\u817a\u817a\u764c\u60a3\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c57% \u7684\u60a3\u8005\u51fa\u73b0\u53e3\u8154\u708e\uff0c\u5176\u4e2d 9% \u4e3a 3 \u7ea7\u3002<\/p>\n
\u60a3\u8005\u63a5\u53d7 RASONQUE \u6cbb\u7597\u671f\u95f4\uff0c\u5e94\u5bc6\u5207\u76d1\u6d4b\u53e3\u8154\u708e\u7684\u4f53\u5f81\u548c\u75c7\u72b6\u3002\u4e00\u65e6\u53d1\u73b0\u53e3\u8154\u708e\uff0c\u5e94\u7acb\u5373\u4f7f\u7528\u542b\u7c7b\u56fa\u9187\u7684\u6f31\u53e3\u6c34\u8fdb\u884c\u6cbb\u7597\uff0c\u5e76\u6839\u636e\u4e34\u5e8a\u9700\u8981\u7ed9\u4e88\u5176\u4ed6\u5c40\u90e8\u6cbb\u7597\uff08\u4f8b\u5982\uff0c\u6c2f\u5df1\u5b9a\u6f31\u53e3\u6c34\u30012% \u5229\u591a\u5361\u56e0\u51dd\u80f6\uff09\u3002\u6839\u636e\u75c5\u60c5\u4e25\u91cd\u7a0b\u5ea6\uff0c\u53ef\u6682\u505c\u4f7f\u7528\u3001\u51cf\u5c11\u5242\u91cf\u6216\u6c38\u4e45\u505c\u7528 RASONQUE\u3002<\/p>\n
\u8179\u6cfb<\/p>\n
RASONQUE \u53ef\u5f15\u8d77\u8179\u6cfb\u3002\u5728\u80f0\u817a\u817a\u764c\u60a3\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c63% \u7684\u60a3\u8005\u51fa\u73b0\u8179\u6cfb\uff0c\u5176\u4e2d 6% \u4e3a 3 \u7ea7\u8179\u6cfb\u3002<\/p>\n
\u5982\u679c\u51fa\u73b0\u8179\u6cfb\uff0c\u5e94\u6839\u636e\u4e34\u5e8a\u6307\u5f81\u7ed9\u4e88\u6b62\u6cfb\u6cbb\u7597\u3002\u6839\u636e\u75c5\u60c5\u4e25\u91cd\u7a0b\u5ea6\uff0c\u53ef\u6682\u505c\u4f7f\u7528\u3001\u51cf\u5c11\u5242\u91cf\u6216\u6c38\u4e45\u505c\u7528 RASONQUE\u3002<\/p>\n
\u80c3\u80a0\u9053\u7a7f\u5b54<\/p>\n
RASONQUE \u53ef\u5f15\u8d77\u80c3\u80a0\u9053\u7a7f\u5b54\u3002\u5728\u80f0\u817a\u817a\u764c\u60a3\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u63a5\u53d7 RASONQUE \u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u6709 0.9% \u53d1\u751f\u80c3\u80a0\u9053\u7a7f\u5b54\uff0c\u5176\u4e2d 0.5% \u4e3a 3 \u7ea7\uff0c1 \u4f8b\u4e3a 4 \u7ea7\uff0c1 \u4f8b\u4e3a\u6b7b\u4ea1\u3002<\/p>\n
\u76d1\u6d4b\u60a3\u8005\u662f\u5426\u53d1\u751f\u80c3\u80a0\u9053\u7a7f\u5b54\u3002\u5982\u679c\u6000\u7591\u53d1\u751f\u80c3\u80a0\u9053\u7a7f\u5b54\uff0c\u5e94\u6682\u505c\u4f7f\u7528RASONQUE\u3002\u5982\u679c\u672a\u53d1\u73b0\u5176\u4ed6\u53ef\u80fd\u5bfc\u81f4\u80c3\u80a0\u9053\u7a7f\u5b54\u7684\u539f\u56e0\uff0c\u5219\u5e94\u51cf\u5c11\u5242\u91cf\u6216\u6c38\u4e45\u505c\u7528RASONQUE\u3002<\/p>\n
\u95f4\u8d28\u6027\u80ba\u75c5\uff08ILD\uff09\/\u80ba\u708e<\/p>\n
RASONQUE \u53ef\u5f15\u8d77\u95f4\u8d28\u6027\u80ba\u75c5\u6216\u80ba\u708e\u3002\u5728\u80f0\u817a\u817a\u764c\u60a3\u8005\u7684\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u63a5\u53d7 RASONQUE \u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u6709 2.4% \u53d1\u751f\u95f4\u8d28\u6027\u80ba\u75c5\/\u80ba\u708e\uff0c\u5176\u4e2d 0.9% \u4e3a 3 \u7ea7\uff0c\u4e14\u6709\u4e00\u4f8b\u6b7b\u4ea1\u3002<\/p>\n
\u5bc6\u5207\u76d1\u6d4b\u60a3\u8005\u80ba\u90e8\u75c7\u72b6\u662f\u5426\u51fa\u73b0\u65b0\u7684\u6216\u52a0\u91cd\u3002\u5982\u679c\u6000\u7591\u662f\u95f4\u8d28\u6027\u80ba\u75c5\/\u80ba\u708e\uff0c\u5e94\u6682\u505c\u4f7f\u7528RASONQUE\u3002\u5982\u679c\u672a\u53d1\u73b0\u5176\u4ed6\u53ef\u80fd\u5bfc\u81f4\u95f4\u8d28\u6027\u80ba\u75c5\/\u80ba\u708e\u7684\u539f\u56e0\uff0c\u5219\u5e94\u51cf\u5c11\u5242\u91cf\u6216\u6c38\u4e45\u505c\u7528RASONQUE\u3002<\/p>\n
\u80da\u80ce-\u80ce\u513f\u6bd2\u6027<\/p>\n
\u6839\u636e\u52a8\u7269\u5b9e\u9a8c\u7ed3\u679c\uff0cRASONQUE \u5bf9\u5b55\u5987\u4f7f\u7528\u53ef\u80fd\u9020\u6210\u80ce\u513f\u635f\u5bb3\u3002\u5efa\u8bae\u6709\u751f\u80b2\u80fd\u529b\u7684\u5973\u6027\u5728 RASONQUE \u6cbb\u7597\u671f\u95f4\u4ee5\u53ca\u672b\u6b21\u7ed9\u836f\u540e 1 \u5468\u5185\u91c7\u53d6\u6709\u6548\u7684\u907f\u5b55\u63aa\u65bd\u3002\u5efa\u8bae\u4f34\u4fa3\u4e3a\u6709\u751f\u80b2\u80fd\u529b\u5973\u6027\u7684\u7537\u6027\u5728 RASONQUE \u6cbb\u7597\u671f\u95f4\u4ee5\u53ca\u672b\u6b21\u7ed9\u836f\u540e 1 \u5468\u5185\u91c7\u53d6\u6709\u6548\u7684\u907f\u5b55\u63aa\u65bd\u3002<\/p>\n
\u4e0d\u826f\u53cd\u5e94<\/p>\n
\u63a5\u53d7 RASONQUE \u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u6709 30% \u51fa\u73b0\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u3002\u63a5\u53d7 RASONQUE \u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u53d1\u751f\u7387 \u2265 2% \u7684\u4e25\u91cd\u4e0d\u826f\u53cd\u5e94\u5305\u62ec\u8179\u6cfb (3.7%)\u3001\u53d1\u70ed (3.3%)\u3001\u8d25\u8840\u75c7 (2.9%)\u3001\u75b2\u4e4f (2.1%) \u548c\u51fa\u8840 (2.1%)\u3002<\/p>\n
2.9% \u7684\u60a3\u8005\u51fa\u73b0\u4e0d\u826f\u53cd\u5e94\uff0c\u5bfc\u81f4\u6c38\u4e45\u505c\u6b62\u4f7f\u7528 RASONQUE\uff0c\u5176\u4e2d\u5305\u62ec 2 \u4f8b\u56e0\u76ae\u75b9\u800c\u505c\u6b62\u4f7f\u7528\u7684\u60a3\u8005 (0.8%)\u3002<\/p>\n
\u63a5\u53d7 RASONQUE \u6cbb\u7597\u7684\u60a3\u8005\u4e2d\u6700\u5e38\u89c1\u7684\uff08\u2265 20%\uff09\u4e0d\u826f\u53cd\u5e94\u662f\u76ae\u75b9\u3001\u8179\u6cfb\u3001\u53e3\u8154\u708e\u3001\u6076\u5fc3\u3001\u75b2\u52b3\u3001\u5455\u5410\u3001\u8179\u75db\u3001\u6c34\u80bf\u3001\u98df\u6b32\u4e0b\u964d\u548c\u51fa\u8840\u3002<\/p>\n
\u836f\u7269\u76f8\u4e92\u4f5c\u7528<\/p>\n
\u5f3a\u6548 CYP3A \u6291\u5236\u5242\u4e0e P-gp \u6291\u5236\u5242\uff1a\u907f\u514d\u540c\u65f6\u4f7f\u7528\u3002
\n\u5f3a\u6548 CYP3A \u6291\u5236\u5242\uff08\u4e0d\u6291\u5236 P-gp\uff09\uff1a\u51cf\u5c11 RASONQUE \u5242\u91cf\u3002
\n\u4e2d\u5ea6 CYP3A \u6291\u5236\u5242\uff08\u4f34\u6216\u4e0d\u4f34 P-gp \u6291\u5236\uff09\uff1a\u51cf\u5c11 RASONQUE \u5242\u91cf\u3002
\nP-gp\u6291\u5236\u5242\uff1a\u51cf\u5c11RASONQUE\u5242\u91cf\u3002
\n\u73af\u5b62\u7d20A\uff1a\u907f\u514d\u540c\u65f6\u4f7f\u7528\u3002
\n\u5f3a\u6548CYP3A\u8bf1\u5bfc\u5242\uff1a\u907f\u514d\u540c\u65f6\u4f7f\u7528\u3002\u5982\u679c\u65e0\u6cd5\u907f\u514d\u540c\u65f6\u4f7f\u7528\uff0c\u5219\u589e\u52a0RASONQUE\u7684\u5242\u91cf\u3002
\n\u4e2d\u5ea6 CYP3A \u8bf1\u5bfc\u5242\uff1a\u589e\u52a0 RASONQUE \u5242\u91cf\u3002
\nP-gp \u5e95\u7269\uff1a\u4e0e RASONQUE \u81f3\u5c11\u95f4\u9694 4 \u5c0f\u65f6\u670d\u7528\u3002<\/p>\n
\u9884\u9632\u63aa\u65bd<\/p>\n
\u5728\u5f00\u59cb\u4f7f\u7528 RASONQUE \u6cbb\u7597\u671f\u95f4\u4ee5\u53ca\u6574\u4e2a\u6cbb\u7597\u8fc7\u7a0b\u4e2d\uff0c\u5efa\u8bae\u4f7f\u7528\u9884\u9632\u6027\u836f\u7269\u548c\u4f34\u968f\u7528\u836f\uff0c\u4ee5\u964d\u4f4e\u76ae\u80a4\u53cd\u5e94\u7684\u98ce\u9669\uff1a<\/p>\n
\u4f7f\u7528\u5c40\u90e8\u76ae\u8d28\u7c7b\u56fa\u9187\uff08\u6d82\u62b9\u4e8e\u9762\u90e8\u548c\u80f8\u90e8\uff09\u548c\u6da6\u80a4\u971c\uff0c\u5efa\u8bae\u60a3\u8005\u9650\u5236\u65e5\u6652\uff0c\u5e76\u4f7f\u7528\u5e7f\u8c31\u9632\u6652\u971c\uff08SPF 30 \u6216\u66f4\u9ad8\uff09\uff0c\u8003\u8651\u9884\u9632\u6027\u53e3\u670d\u6297\u751f\u7d20\uff08\u4f8b\u5982\uff0c\u591a\u897f\u73af\u7d20\u6216\u7c73\u8bfa\u73af\u7d20\uff09\u3002<\/p>\n
Revolution Medicines\u662f\u4e00\u5bb6\u5168\u7403\u6027\u7684\u5546\u4e1a\u5316\u9636\u6bb5\u80bf\u7624\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u53d1\u73b0\u3001\u5f00\u53d1\u548c\u63d0\u4f9b\u521b\u65b0\u836f\u7269\uff0c\u4ee5\u6cbb\u7597RAS\u4f9d\u8d56\u6027\u764c\u75c7\u60a3\u8005\u3002\u51ed\u501f\u5176\u72ec\u7279\u7684RAS(ON)\u4e09\u590d\u5408\u7269\u6291\u5236\u5242\u5e73\u53f0\uff0c\u8be5\u516c\u53f8\u6b63\u5728\u63a8\u8fdb\u4e00\u7cfb\u5217\u5e7f\u6cdb\u7684\u53e3\u670dRAS(ON)\u6291\u5236\u5242\u4ea7\u54c1\u7ec4\u5408\uff0c\u65e8\u5728\u76f4\u63a5\u9776\u5411RAS\u7684\u6d3b\u6027\u72b6\u6001\uff0c\u5373\u9a71\u52a8\u764c\u75c7\u53d1\u751f\u7684\u72b6\u6001\u3002Revolution Medicines\u79c9\u6301\u4e25\u8c28\u7684\u79d1\u5b66\u63a2\u7d22\u7cbe\u795e\u548c\u6311\u6218\u4f20\u7edf\u89c2\u5ff5\u7684\u610f\u613f\uff0c\u81f4\u529b\u4e8e\u6539\u53d8\u5168\u7403RAS\u4f9d\u8d56\u6027\u764c\u75c7\u60a3\u8005\u7684\u75be\u75c5\u8fdb\u7a0b\u3002<\/p>\n
\u65b0\u95fb\u7a3f\u6765\u6e90\uff1aRevolution Medicines<\/p>\n
\uff08\u7f8e\u56fd\u534e\u6587\u7f51\u7f16\u53d1\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"
Revolution Medicines\u662f\u4e00\u5bb6\u5168\u7403\u6027\u7684\u5546\u4e1a\u5316\u9636\u6bb5\u80bf\u7624\u516c\u53f8\uff0c\u81f4\u529b\u4e8e\u53d1\u73b0\u3001\u5f00\u53d1\u548c\u63d0\u4f9b\u521b\u65b0\u836f\u7269\uff0c\u4ee5\u6cbb\u7597RAS\u4f9d\u8d56\u6027\u764c\u75c7\u60a3\u8005\u3002\u51ed\u501f\u5176\u72ec\u7279\u7684RAS(ON)\u4e09\u590d\u5408\u7269\u6291\u5236\u5242\u5e73\u53f0\uff0c\u8be5\u516c\u53f8\u6b63\u5728\u63a8\u8fdb\u4e00\u7cfb\u5217\u5e7f\u6cdb\u7684\u53e3\u670dRAS(ON)\u6291\u5236\u5242\u4ea7\u54c1\u7ec4\u5408…..<\/p>\n","protected":false},"author":3,"featured_media":1496675,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[40],"tags":[],"class_list":["post-1496674","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-us_news"],"_links":{"self":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1496674","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/comments?post=1496674"}],"version-history":[{"count":1,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1496674\/revisions"}],"predecessor-version":[{"id":1496676,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/1496674\/revisions\/1496676"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media\/1496675"}],"wp:attachment":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media?parent=1496674"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/categories?post=1496674"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/tags?post=1496674"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}