{"id":261619,"date":"2016-09-04T13:58:44","date_gmt":"2016-09-04T20:58:44","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=261619"},"modified":"2016-09-04T13:58:44","modified_gmt":"2016-09-04T20:58:44","slug":"nature%e5%b0%81%e9%9d%a2%e9%9b%84%e6%96%87%ef%bc%9a%e5%85%8d%e7%96%ab%e7%96%97%e6%b3%95%e6%9c%89%e6%9c%9b%e6%94%bb%e5%85%8b%e9%98%bf%e5%85%b9%e6%b5%b7%e9%bb%98%e7%97%85%ef%bc%88%e5%9b%be%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/nature%e5%b0%81%e9%9d%a2%e9%9b%84%e6%96%87%ef%bc%9a%e5%85%8d%e7%96%ab%e7%96%97%e6%b3%95%e6%9c%89%e6%9c%9b%e6%94%bb%e5%85%8b%e9%98%bf%e5%85%b9%e6%b5%b7%e9%bb%98%e7%97%85%ef%bc%88%e5%9b%be%ef%bc%89\/.html","title":{"rendered":"Nature\u5c01\u9762\u96c4\u6587\uff1a\u514d\u75ab\u7597\u6cd5\u6709\u671b\u653b\u514b\u963f\u5179\u6d77\u9ed8\u75c5\uff08\u56fe\uff09"},"content":{"rendered":"

\u836f\u660e<\/strong>\u5eb7\u5fb7<\/strong>\/<\/strong>\u62a5\u9053<\/strong><\/p>\n

\u672c\u5468\uff0c\u767e\u5065\uff08Biogen\uff09\u516c\u53f8\u8fde\u7eed\u4f20\u6765\u559c\u8baf\u3002\u57289\u67081\u65e5\u51fa\u7248\u7684\u300a\u81ea\u7136\u300b\u6742\u5fd7\u4e0a\uff0c\u767e\u5065\u963f\u5179\u6d77\u9ed8\u75c5\u5728\u7814\u65b0\u836fAducanumab\u76841b\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u4ee5\u5c01\u9762\u6587\u7ae0\u7684\u5f62\u5f0f\u520a\u767b\u3002\u6628\u65e5\uff0cAducanumab\u53c8\u83b7\u5f97\u4e86FDA\u9881\u53d1\u7684\u65b0\u836f\u5feb\u901f\u901a\u9053\u8d44\u683c\u3002\u8fd9\u4e5f\u53cd\u6620\u4e86\u5b66\u754c\u4e0e\u4e1a\u754c\u5bf9\u8fd9\u6b3e\u521b\u65b0\u836f\u7269\u6f5c\u529b\u7684\u770b\u597d\u3002<\/p>\n

\u9898\u56fe\u4e3a<\/strong>\u672c\u9879\u91cd\u78c5\u7814\u7a76\u4f5c\u4e3a\u5c01\u9762\u6587\u7ae0\u520a\u767b\u5728\u4e86\u6700\u65b0\u4e00\u671f<\/strong>Nature<\/strong>\u4e0a\uff08\u56fe\u7247\u6765\u6e90\uff1a<\/strong>Nature<\/strong>\uff09<\/strong><\/p>\n

\u963f\u5179\u6d77\u9ed8\u75c5\u662f\u6700\u4e3a\u5e38\u89c1\u7684\u75f4\u5446\u75c7\u548c\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e4b\u4e00\uff0c\u5176\u53d1\u75c5\u7387\u968f\u5e74\u9f84\u4e0a\u5347\u800c\u8fc5\u901f\u589e\u52a0\u3002\u636e\u4f30\u8ba1\uff0c\u4e2d\u56fd\u73b0\u5728\u7ea6\u6709900\u591a\u4e07\u60a3\u8005\u3002\u968f\u7740\u793e\u4f1a\u8001\u9f84\u5316\u7a0b\u5ea6\u7684\u52a0\u5267\uff0c\u60a3\u8005\u6570\u91cf\u8fd8\u5c06\u4e0d\u65ad\u4e0a\u5347\u3002\u7531\u4e8e\u963f\u5179\u6d77\u9ed8\u75c5\u7684\u53d1\u75c5\u539f\u56e0\u81f3\u4eca\u4ecd\u7136\u4e0d\u660e\uff0c\u56e0\u6b64\u4e5f\u6ca1\u6709\u6709\u6548\u6cbb\u7597\u7684\u836f\u7269\uff0c\u76ee\u524d\u5e02\u573a\u4e0a\u53ea\u6709\u5c11\u6570\u51e0\u4e2a\u836f\u7269\u7528\u6765\u7f13\u89e3\u75c7\u72b6\u3002<\/p>\n

\u963f\u5179\u6d77\u9ed8\u75c5\u60a3\u8005\u5927\u8111\u5185\u7684\u03b2\u6dc0\u7c89\u6837\u86cb\u767d\u548cTau\u86cb\u767d\u6709\u671b\u6210\u4e3a\u6cbb\u7597\u7684\u7a81\u7834\u53e3\u3002\u8fd9\u4e24\u79cd\u86cb\u767d\u7684\u975e\u6b63\u5e38\u5806\u79ef\u5747\u4f1a\u5f71\u54cd\u795e\u7ecf\u5143\u7684\u6b63\u5e38\u529f\u80fd\uff0c\u5e76\u5bfc\u81f4\u795e\u7ecf\u7ec6\u80de\u7684\u51cb\u4ea1\u3002\u56e0\u6b64\uff0c\u5c06\u8fd9\u4e24\u79cd\u6c89\u79ef\u86cb\u767d\u6e05\u9664\u51fa\u5927\u8111\u4fbf\u6210\u4e3a\u4e86\u76ee\u524d\u7814\u7a76\u7684\u91cd\u70b9\u3002\u76ee\u524d\uff0c\u4e00\u79cd\u6fc0\u6d3b\u673a\u4f53\u81ea\u8eab\u514d\u75ab\u7cfb\u7edf\uff0c\u5c06\u6c89\u79ef\u86cb\u767d\u89c6\u4e3a\u5165\u4fb5\u8005\u8fdb\u884c\u6e05\u7406\u7684\u65b9\u6cd5\u5df2\u5728\u52a8\u7269\u6a21\u578b\u4e2d\u5f97\u5230\u4e86\u9a8c\u8bc1\u3002<\/p>\n

\"d_08_cl_alz_1a\"<\/a>\u25b2\u03b2<\/strong>\u6dc0\u7c89\u6837\u86cb\u767d\u6709\u671b\u6210\u4e3a\u6cbb\u7597\u963f\u5179\u6d77\u9ed8\u75c5\u7684\u7a81\u7834\u53e3\uff08\u56fe\u7247\u6765\u6e90\uff1a<\/strong>McGill<\/strong>\u5927\u5b66\uff09<\/strong><\/p>\n

\u767e\u5065\u516c\u53f8\u7684Aducanumab\u5229\u7528\u4e86\u540c\u6837\u7684\u539f\u7406\u3002\u5b83\u662f\u4e00\u4e2a\u7279\u5f02\u9488\u5bf9\u03b2\u6dc0\u7c89\u6837\u86cb\u767d\u7684\u5355\u514b\u9686\u6297\u4f53\u3002\u5728\u8fdb\u5165\u4eba\u4f53\u540e\uff0c\u5b83\u53ef\u4ee5\u9009\u62e9\u6027\u548c\u8111\u5185\u7684\u6dc0\u7c89\u6837\u6591\u5757\u7ed3\u5408\uff0c\u7136\u540e\u6fc0\u6d3b\u514d\u75ab\u7cfb\u7edf\uff0c\u5c06\u6c89\u79ef\u86cb\u767d\u6e05\u7406\u51fa\u5927\u8111\u3002<\/p>\n

\u8fd9\u4e2a\u521b\u65b0\u60f3\u6cd5\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u6536\u83b7\u4e86\u5de8\u5927\u6210\u529f\u3002\u5728\u4e3a\u671f1\u5e74\u7684Ib\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c165\u4f4d50-90\u5c81\u7684\u963f\u5179\u6d77\u9ed8\u60a3\u8005\u88ab\u968f\u673a\u5206\u5165\u4e86\u5bf9\u7167\u7ec4\u548c\u591a\u4e2a\u4e0d\u540c\u5242\u91cf\u7684\u836f\u7269\u7ec4\u3002\u60a3\u8005\u6bcf\u4e2a\u6708\u63a5\u53d7\u4e00\u6b21Aducanumab\u7684\u9759\u8109\u6ce8\u5c04\uff0c\u5e76\u901a\u8fc7\u6b63\u7535\u5b50\u53d1\u5c04\u626b\u63cf\u6210\u50cf\uff08PET\uff09\u6765\u76d1\u6d4b\u8111\u5185\u7684\u6dc0\u7c89\u6837\u6591\u5757\u6c34\u5e73\u3002\u540c\u65f6\uff0c\u4ed6\u4eec\u4e5f\u9700\u8981\u63a5\u53d7\u4e34\u5e8a\u667a\u529b\u548c\u8bb0\u5fc6\u529b\u8bc4\u4f30\u3002<\/p>\n

\"effect\"<\/a>\u25b2<\/strong>\u968f\u7740\u7ed9\u836f\u6d53\u5ea6\u7684\u589e\u52a0\uff0c\u60a3\u8005\u8111\u5185\u7684\u6dc0\u7c89\u6837\u6591\u5757\u9010\u6e10\u51cf\u5c11\uff08\u56fe\u7247\u6765\u6e90\uff1a<\/strong>Nature<\/strong>\uff09<\/strong><\/p>\n

\u4e00\u5e74\u4e4b\u540e\uff0c\u836f\u7269\u7ec4\u7684\u75c5\u4eba\u8111\u5185\u7684\u6dc0\u7c89\u6837\u6591\u5757\u5927\u5c0f\u548c\u6570\u91cf\u660e\u663e\u4e0b\u964d\uff0c\u5e76\u4e14\u4e0b\u964d\u7a0b\u5ea6\u4e0e\u5242\u91cf\u663e\u8457\u76f8\u5173\u3002\u5728\u6700\u9ad8\u5242\u91cf\u7ec4\uff0810\u6beb\u514b\/\u516c\u65a4 \uff09\u75c5\u4eba\u8111\u5185\uff0c\u6dc0\u7c89\u6837\u6591\u5757\u7684\u542b\u91cf\u4e0b\u964d\u6700\u591a\uff0cPET\u6210\u50cf\u663e\u793a\u8fd9\u90e8\u5206\u75c5\u4eba\u8111\u5185\u7684\u6dc0\u7c89\u6837\u6591\u5757\u6c34\u5e73\u4e0b\u964d\u5230\u4e86\u63a5\u8fd1\u5065\u5eb7\u4eba\u7fa4\u7684\u6c34\u5e73\u3002\u540c\u65f6\uff0c\u7b80\u77ed\u667a\u80fd\u6d4b\u9a8c\uff08MMSE\uff09\u548c\u4e34\u5e8a\u75f4\u5446\u75c7\u8bc4\u4f30\uff08CDR-SB\uff09\u8fd9\u4e24\u9879\u6d4b\u8bd5\u53d1\u73b0\uff0c\u836f\u7269\u7ec4\u75c5\u4eba\u7684\u8bb0\u5fc6\u529b\u8870\u9000\u660e\u663e\u6bd4\u5bf9\u7167\u7ec4\u8981\u6162\uff0c\u8fd9\u79cd\u5bf9\u8bb0\u5fc6\u529b\u7684\u4fdd\u62a4\u80fd\u529b\u4e5f\u4e0e\u5242\u91cf\u76f8\u5173\u3002\u6b64\u5916\uff0cAducanumab\u4e5f\u663e\u793a\u51fa\u4e86\u826f\u597d\u7684\u5b89\u5168\u6027\u3002\u8fd9\u4e9b\u79ef\u6781\u7ed3\u679c\u4f7fAducanumab\u83b7\u5f97\u4e86FDA\u5feb\u901f\u901a\u9053\u8ba4\u5b9a\u3002<\/p>\n

\"1449163736346\"<\/a>\u25b2<\/strong>\u767e\u5065\u516c\u53f8\u6267\u884c\u526f\u603b\u88c1\u517c\u9996\u5e2d\u533b\u5b66\u5b98<\/strong>Alfred Sandrock<\/strong>\u535a\u58eb\uff08\u56fe\u7247\u6765\u6e90\uff1a\u767e\u5065\uff09<\/strong><\/p>\n

\u767e\u5065\u516c\u53f8\u6267\u884c\u526f\u603b\u88c1\u517c\u9996\u5e2d\u533b\u5b66\u5b98Alfred Sandrock\u535a\u58eb\u8868\u793a\uff1a\u201c\u8fd9\u9879\u65e9\u671f\u8bd5\u9a8c\u7ed3\u679c\u5c55\u73b0\u4e86Aducanumab\u6e05\u9664\u60a3\u8005\u8111\u5185\u6dc0\u7c89\u6837\u6591\u5757\u7684\u80fd\u529b\u4ee5\u53ca\u51cf\u7f13\u60a3\u8005\u8bb0\u5fc6\u529b\u8870\u9000\u7684\u6f5c\u529b\u3002\u80fd\u591f\u5728\u300a\u81ea\u7136\u300b\u6742\u5fd7\u53d1\u8868\u8bd5\u9a8c\u7ed3\u679c\u662f\u4e00\u9879\u4e86\u4e0d\u8d77\u7684\u6210\u5c31\uff0c\u4e5f\u662f\u5bf9\u6240\u6709\u53c2\u4e0e\u8bd5\u9a8c\u7684\u79d1\u7814\u4eba\u5458\uff0c\u533b\u52a1\u4eba\u5458\u548c\u75c5\u4eba\u5fd7\u613f\u8005\u4eec\u7684\u80af\u5b9a\u3002\u6211\u4eec\u5e0c\u671b\u901a\u8fc7\u4e0eFDA\u5feb\u901f\u901a\u9053\u9879\u76ee\u7684\u5408\u4f5c\uff0c\u80fd\u591f\u5c3d\u5feb\u4e3a\u963f\u5179\u6d77\u9ed8\u75c5\u60a3\u8005\u5e26\u6765\u6709\u6548\u7684\u836f\u7269\u3002\u201d<\/p>\n

\"title\"<\/a><\/p>\n

\u767e\u5065\u516c\u53f8\u5df2\u7ecf\u4e8e2015\u5e74\u5f00\u59cb\u4e86\u4e24\u9879Aducanumab\u7684III\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5171\u8ba1\u5212\u5728\u5168\u7403\u8303\u56f4\u5185\u62db\u52df2700\u540d\u5fd7\u613f\u8005\u53c2\u52a0\uff0c\u8bd5\u9a8c\u7ed3\u679c\u9884\u8ba1\u5c06\u57282022\u5e74\u516c\u5e03\u3002\u4e00\u65e6\u6210\u529f\uff0c\u5b83\u5c06\u6709\u671b\u6210\u4e3a\u9996\u4e2a\u80fd\u591f\u963b\u6b62\u6216\u9006\u8f6c\u963f\u5179\u6d77\u9ed8\u75c5\u8fdb\u7a0b\u7684\u836f\u7269\u3002\u6211\u4eec\u8877\u5fc3\u795d\u613f\u8fd9\u4e24\u9879III\u671f\u4e34\u5e8a\u83b7\u5f97\u826f\u597d\u7ed3\u679c\uff0c\u4ece\u800c\u4e3a\u963f\u5179\u6d77\u9ed8\u75c5\u60a3\u8005\u63d0\u4f9b\u6709\u6548\u7684\u6cbb\u7597\u624b\u6bb5\u3002<\/p>\n

\"083116_LS_alzheimers_main\"<\/a>\u8f6c\u81ea\u836f\u660e\u5eb7\u5fb7<\/p>\n","protected":false},"excerpt":{"rendered":"

\u672c\u5468\uff0c\u767e\u5065\uff08Biogen\uff09\u516c\u53f8\u8fde\u7eed\u4f20\u6765\u559c\u8baf\u3002\u57289\u67081\u65e5\u51fa\u7248\u7684\u300a\u81ea\u7136\u300b\u6742\u5fd7\u4e0a\uff0c\u767e\u5065\u963f\u5179\u6d77\u9ed8\u75c5\u5728\u7814\u65b0\u836fAducanumab\u76841b\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u4ee5\u5c01\u9762\u6587\u7ae0\u7684\u5f62\u5f0f\u520a\u767b……<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-261619","post","type-post","status-publish","format-standard","hentry","category-science_technology_education"],"_links":{"self":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/261619","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/comments?post=261619"}],"version-history":[{"count":0,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/261619\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media?parent=261619"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/categories?post=261619"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/tags?post=261619"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}