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\u836f\u660e<\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/strong><\/p>\n

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KEYTRUDA\u662f\u4e00\u6b3e\u4eba\u6e90\u5316\u7684PD-1\u6297\u4f53\uff0c\u80fd\u963b\u65adT\u7ec6\u80de\u8868\u9762PD-1\u53d7\u4f53\u4e0e\u5176\u914d\u4f53\u7684\u7ed3\u5408\uff0c\u8d77\u5230\u6fc0\u6d3bT\u7ec6\u80de\uff0c\u8ba9\u5176\u5bf9\u80bf\u7624\u5c55\u5f00\u653b\u51fb\u7684\u4f5c\u7528\u3002\u4eca\u5e749\u6708\uff0c\u5b83\u83b7\u5f97\u4e86\u7531FDA\u9881\u53d1\u7684\u7b2c6\u9879\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\uff0c\u7528\u4e8e\u665a\u671f\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u7684\u6cbb\u7597\uff0c\u5e76\u83b7\u5f97\u4e86\u4f18\u5148\u5ba1\u8bc4\u8d44\u683c\u3002<\/p>\n

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\u25b2KEYNOTE-024\u7684\u4f18\u79c0\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\uff08\u56fe\u7247\u6765\u6e90\uff1a\u9ed8\u6c99\u4e1c\u5b98\u7f51\uff09<\/strong><\/p>\n

\u672c\u6b21FDA\u6279\u51c6KEYTRUDA\u4e0a\u5e02\u662f\u57fa\u4e8eKEYNOTE-024\u7684\u4f18\u79c0\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\u3002\u5728\u8fd9\u9879\u968f\u673a\u3001\u516c\u5f00\u6807\u6ce8\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u68c0\u9a8c\u4e86KEYTRUDA\u4f5c\u4e3a\u5355\u4e00\u7597\u6cd5\u6cbb\u7597\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u521d\u6cbb\u60a3\u8005\u7684\u7597\u6548\uff0c\u8fd9\u4e9b\u60a3\u8005\u7684PD-L1\u8868\u8fbe\u91cf\u90fd\u8d85\u8fc7\u4e8650%\u3002\u4e0e\u6807\u51c6\u7684\u542b\u94c2\u5316\u7597\u76f8\u6bd4\uff0c\u4f7f\u7528KEYTRUDA\u7684\u60a3\u8005\u5176\u65e0\u8fdb\u5c55\u751f\u5b58\u671f(HR, 0.50 [95% CI, 0.37, 0.68]; p<0.001)\u4e0e\u603b\u4f53\u751f\u5b58\u7387(HR, 0.60 [95% CI, 0.41, 0.89]; p=0.005)\u90fd\u5f97\u5230\u4e86\u663e\u8457\u7684\u6539\u5584\uff0c\u5206\u522b\u62b5\u8fbe\u4e86\u4e3b\u8981\u4e0e\u6b21\u8981\u4e34\u5e8a\u7ec8\u70b9<\/strong>\u3002\u56e0\u6b64\uff0c\u8fd9\u9879\u8bd5\u9a8c\u4e5f\u5728\u4eca\u5e746\u6708\u63d0\u524d\u7ec8\u6b62\uff0c\u8ba9\u5316\u7597\u7ec4\u7684\u60a3\u8005\u80fd\u591f\u7b2c\u4e00\u65f6\u95f4\u63a5\u53d7KEYTRUDA\u7684\u6cbb\u7597\u3002<\/p>\n

<\/p>\n

\u25b2\u9ed8\u6c99\u4e1c\u7814\u7a76\u5b9e\u9a8c\u5ba4\u7684\u603b\u88c1Roger M. Perlmutter\u535a\u58eb\uff08\u56fe\u7247\u6765\u6e90\uff1a\u9ed8\u6c99\u4e1c\u5b98\u7f51\uff09<\/strong><\/p>\n

\u201c\u5728\u80bf\u7624\u8868\u8fbe\u9ad8\u6c34\u5e73PD-L1\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u8eab\u4e0a\uff0cKEYTRUDA\u4e0e\u5e38\u89c4\u5316\u7597\u76f8\u6bd4\u80fd\u591f\u63d0\u9ad8\u751f\u5b58\u7387\uff0c\u201d\u9ed8\u6c99\u4e1c\u7814\u7a76\u5b9e\u9a8c\u5ba4\u7684\u603b\u88c1Roger Perlmutter\u535a\u58eb\u8bf4\u9053\uff1a\u201cKEYTRUDA\u83b7\u6279\u7528\u4e8e\u4e00\u7ebf\u6cbb\u7597\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u6709\u671b\u5f7b\u5e95\u6539\u53d8\u8fd9\u4e9b\u60a3\u8005\u7684\u6cbb\u7597\u60c5\u51b5\u3002\u201d<\/p>\n

 <\/p>\n

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\u6211\u4eec\u795d\u8d3a\u9ed8\u6c99\u4e1c\u53d6\u5f97\u4f73\u7ee9\uff0c\u4e5f\u795d\u613f\u66f4\u591a\u60a3\u8005\u80fd\u4eceKEYTRUDA\u7684\u6cbb\u7597\u4e2d\u53d7\u76ca\u3002\uff08\u64b0\u7a3f\uff1a\u987e\u65b9\u4e3a\uff09<\/p>\n

\u53c2\u8003\u8d44\u6599\uff1a<\/p>\n

[1] FDA Approves Merck\u2019s KEYTRUDA\u00ae (pembrolizumab) in Metastatic NSCLC for First-Line Treatment of Patients Whose Tumors Have High PD-L1 Expression (Tumor Proportion Score [TPS] of 50 Percent or More) With No EGFR or ALK Genomic Tumor Aberrations<\/p>\n

[2] \u9ed8\u6c99\u4e1c\u5b98\u65b9\u7f51\u7ad9<\/p>\n

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