{"id":303050,"date":"2016-11-04T11:53:45","date_gmt":"2016-11-04T18:53:45","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=303050"},"modified":"2016-11-04T12:00:39","modified_gmt":"2016-11-04T19:00:39","slug":"jak%e6%8a%91%e5%88%b6%e5%89%82%e4%b8%b4%e5%ba%8a%e6%96%b0%e8%8d%af3%e6%9c%9f%e6%88%90%e5%8a%9f%ef%bc%8c%e6%9c%89%e6%9c%9b%e6%b2%bb%e7%96%97%e9%a3%8e%e6%b9%bf%e5%85%b3%e8%8a%82%e7%82%8e","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/jak%e6%8a%91%e5%88%b6%e5%89%82%e4%b8%b4%e5%ba%8a%e6%96%b0%e8%8d%af3%e6%9c%9f%e6%88%90%e5%8a%9f%ef%bc%8c%e6%9c%89%e6%9c%9b%e6%b2%bb%e7%96%97%e9%a3%8e%e6%b9%bf%e5%85%b3%e8%8a%82%e7%82%8e\/.html","title":{"rendered":"JAK\u6291\u5236\u5242\u4e34\u5e8a\u65b0\u836f3\u671f\u6210\u529f\uff0c\u6709\u671b\u6cbb\u7597\u98ce\u6e7f\u5173\u8282\u708e"},"content":{"rendered":"

\u836f\u660e<\/strong>\u5eb7\u5fb7\/\u62a5\u9053<\/strong><\/p>\n

\u6700\u8fd1\u793c\u6765\u548cIncyte\u516c\u53f8\u5ba3\u5e03\uff0c\u5173\u952e\u60273\u671f\u4e34\u5e8a\u8bd5\u9a8cRA-BEACON\u53d6\u5f97\u826f\u597d\u6548\u679c\uff1a\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u63a5\u53d7\u4e34\u5e8a\u65b0\u836fbaricitinib\u6cbb\u7597\u7684\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\uff08RA\uff09\u60a3\u8005\u663e\u793a\u51fa\u5065\u5eb7\u76f8\u5173\u751f\u6d3b\u8d28\u91cf\uff08HRQOL\uff09\u6d4b\u91cf\u3001\u75b2\u52b3\u548c\u75bc\u75db\u65b9\u9762\u7684\u663e\u8457\u6539\u5584<\/strong>\u3002\u7814\u7a76\u7ed3\u679c\u53d1\u8868\u5728\u300aAnnals of the Rheumatic Diseases\u300b\u671f\u520a\u4e0a\u3002<\/p>\n

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\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u662f\u4e00\u79cd\u4ee5\u708e\u75c7\u548c\u5173\u8282\u8fdb\u884c\u6027\u7834\u574f\u4e3a\u7279\u5f81\u7684\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u3002\u5168\u4e16\u754c2300\u591a\u4e07\u4eba\u60a3\u6709RA\uff0c\u5176\u4e2d\u5973\u6027\u60a3\u8005\u6570\u91cf\u5927\u7ea6\u662f\u7537\u6027\u60a3\u8005\u7684\u4e09\u500d\u3002RA\u7684\u5f53\u524d\u6cbb\u7597\u5305\u62ec\u4f7f\u7528\u975e\u753e\u4f53\u6297\u708e\u836f\u3001\u53e3\u670d\u578b\u5e38\u89c4\u7684\u75be\u75c5\u7f13\u89e3\u6027\u6297\u98ce\u6e7f\u836f\uff08cDMARD\uff09\u3002\u4f8b\u5982\uff0c\u76ee\u524d\u7684\u6807\u51c6\u62a4\u7406\u65b9\u6848\u2014\u2014\u7532\u6c28\u8776\u5464\u2014\u2014\u5c31\u662f\u4e00\u79cd\u6ce8\u5c04\u578b\u7684\u751f\u7269\u6027\u75be\u75c5\u7f13\u89e3\u6027\u6297\u98ce\u6e7f\u836f\uff08bDMARD\uff09\u3002\u5c3d\u7ba1\u5b58\u5728\u4e00\u4e9b\u6cbb\u7597\u9009\u62e9\uff0c\u8bb8\u591a\u60a3\u8005\u6ca1\u6709\u8fbe\u5230\u6700\u7ec8\u6cbb\u7597\u76ee\u6807\u4ee5\u53ca\u6301\u7eed\u7f13\u89e3\uff0c\u4ecd\u6709\u989d\u5916\u7684\u6cbb\u7597\u9700\u6c42\u6765\u6574\u4f53\u6539\u5584\u60a3\u8005\u62a4\u7406<\/strong>\u3002<\/p>\n

<\/p>\n

\u25b2\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u7684\u75c7\u72b6\uff08\u56fe\u7247\u6765\u6e90\uff1aMayo Foundation<\/strong>\uff09<\/strong><\/p>\n

Baricitinib\u76ee\u524d\u5904\u5728\u9488\u5bf9\u708e\u75c7\u548c\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u7684\u665a\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u5b83\u662f\u4e00\u79cd\u6bcf\u65e5\u4e00\u6b21\u7684\u53e3\u670d\u578b\u9ad8\u9009\u62e9\u6027\u7684JAK1\u548cJAK2\u6291\u5236\u5242\u3002\u5df2\u77e5\u7684JAK\u9176\u6709\u56db\u79cd\uff1aJAK1\u3001JAK2\u3001JAK3\u548cTYK2\u3002 JAK\u4f9d\u8d56\u6027\u7ec6\u80de\u56e0\u5b50\u6d89\u53ca\u8bb8\u591a\u708e\u75c7\u6027\u548c\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u53d1\u75c5\u673a\u7406\uff0c\u7814\u7a76\u8bc1\u660eJAK\u6291\u5236\u5242\u53ef\u7528\u4e8e\u5e7f\u6cdb\u6cbb\u7597\u708e\u6027\u75c5\u75c7<\/strong>\u3002Baricitinib\u5728\u6fc0\u9176\u6d4b\u5b9a\u4e2d\u8868\u73b0\u51fa\u7684\u9488\u5bf9JAK1\u548cJAK2\u7684\u6291\u5236\u6548\u529b\u6bd4JAK3\u8981\u7ea6\u9ad8100\u500d\u3002<\/p>\n

2009\u5e7412\u6708\uff0c\u793c\u6765\u548cIncyte\u516c\u53f8\u5ba3\u5e03\u4e86\u4e00\u9879\u72ec\u5bb6\u5168\u7403\u8bb8\u53ef\u548c\u534f\u4f5c\u534f\u8bae\uff0c\u7528\u4e8e\u5f00\u53d1\u548c\u5e02\u573a\u5316baricitinib\u548c\u4e00\u4e9b\u540e\u7eed\u7684\u708e\u75c7\u548c\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u60a3\u8005\u7684\u5316\u5408\u7269\u3002 2016\u5e74\u7b2c\u4e00\u5b63\u5ea6\uff0cBaricitinib\u5df2\u7ecf\u5728\u7f8e\u56fd\u3001\u6b27\u76df\u548c\u65e5\u672c\u5e02\u573a\u63d0\u4ea4\u4e86\u76f8\u5173\u5bfb\u6c42\u76d1\u7ba1\u90e8\u95e8\u7684\u6279\u51c6\uff0c\u7528\u4e8e\u6cbb\u7597\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\uff0c\u540c\u65f6\u8be5\u4e34\u5e8a\u65b0\u836f\u6b63\u57282\u671f\u8bd5\u9a8c\u4e2d\u7814\u7a76\u6cbb\u7597\u7279\u5e94\u6027\u76ae\u708e\u548c\u7cfb\u7edf\u6027\u7ea2\u6591\u72fc\u75ae\u3002<\/p>\n


\n\u25b2Baricitinib\u7684\u5206\u5b50\u5f0f\uff08\u56fe\u7247\u6765\u6e90\uff1aNIH<\/strong>\uff09<\/strong><\/p>\n

\u793c\u6765\u548cIncyte\u516c\u53f8\u5728\u4e2d\u5ea6\u81f3\u91cd\u5ea6\u6d3b\u52a8\u6027\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u60a3\u8005\u4e2d\u8fdb\u884c\u4e864\u9879\u5173\u952e\u6027\u7684baricitinib\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4ee5\u652f\u6301\u5728\u5927\u591a\u6570\u56fd\u5bb6\u7684\u76d1\u7ba1\u63d0\u4ea4\u3002\u6b64\u5916\uff0c\u4e24\u5bb6\u516c\u53f8\u8fd8\u542f\u52a8\u4e86\u53e6\u4e00\u4e2a3\u671f\u7814\u7a76\uff0c\u4ee5\u652f\u6301\u5728\u4e2d\u56fd\u7684\u4e34\u5e8a\u53d1\u5c55<\/strong>\u3002\u8fd9\u4e9b\u4e34\u5e8a\u8bd5\u9a8c\u8ba1\u5212\u5305\u62ec\u4e86\u90a3\u4e9b\u5bf9\u7532\u6c28\u8776\u5464\u65e0\u53cd\u5e94\u3001\u5bf9\u7532\u6c28\u8776\u5464\u53cd\u5e94\u4e0d\u8db3\u3001\u5bf9cDMARD\u53cd\u5e94\u4e0d\u8db3\u6216\u5bf9TNF\u6291\u5236\u5242\u7684\u53cd\u5e94\u4e0d\u8db3\u7684\u5e7f\u6cdb\u7684\u60a3\u8005\u7fa4\u4f53\u3002\u52a0\u5165\u5b8c\u62105\u4e2a3\u671f\u7814\u7a76\u4e2d\u4efb\u4e00\u4e2a\u7684\u60a3\u8005\u53ef\u4ee5\u53c2\u52a0\u957f\u671f\u5ef6\u4f38\u7814\u7a76\u3002<\/p>\n

\u4e0a\u8ff0RA-BEACON\u7814\u7a76\u5305\u62ec\u5bf9bDMARDs\u6cbb\u7597\uff08\u5305\u62ec\u80bf\u7624\u574f\u6b7b\u56e0\u5b50\uff08TNF\uff09\u6291\u5236\u5242\uff09\u53cd\u5e94\u4e0d\u8db3\u6216\u4e0d\u8010\u53d7\u7684\u60a3\u8005\u3002RA-BEACON\u7814\u7a76\u603b\u5171\u62db\u52df\u4e86527\u540d\u5148\u524d\u81f3\u5c11\u5728\u4e00\u79cdTNF\u6291\u5236\u5242\u6cbb\u7597\u4e2d\u5931\u8d25\u7684\u60a3\u8005\uff0c\u5e76\u4e14\u5305\u62ec199\u540d\u4e5f\u63a5\u53d7\u8fc7\u4e00\u79cd\u6216\u591a\u79cd\u975e\u6297TNF\u751f\u7269\u5242\u6cbb\u7597\u7684\u60a3\u8005\u3002\u9664\u4e86\u5176\u73b0\u6709\u7684\u80cc\u666f\u7597\u6cd5\u5916\uff0c\u60a3\u8005\u6bcf\u5929\u63a5\u53d74\u6beb\u514b\uff08n=177\uff09\u30012\u6beb\u514b\uff08n=174\uff09baricitinib\u6216\u5b89\u6170\u5242\uff08n=176\uff09\u6cbb\u759724\u5468\u3002 RA-BEACON\u7814\u7a76\u7684\u4e34\u5e8a\u6548\u679c\u548c\u5b89\u5168\u6027\u7ed3\u679c\u4eca\u5e74\u65e9\u4e9b\u65f6\u5019\u5728\u300a\u65b0\u82f1\u683c\u5170\u533b\u5b66\u6742\u5fd7\u300b\u4e0a\u53d1\u8868\u3002\u5728\u8fd9\u4e9b\u60a3\u8005\u4e2d\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u4f7f\u7528baricitinib\u6cbb\u759724\u5468\u663e\u8457\u6539\u5584\u4e86\u5927\u591a\u6570\u60a3\u8005\u81ea\u6211\u62a5\u544a\u7684\u7ed3\u679c\uff0c\u800c\u63a5\u53d74\u6beb\u514bbaricitinib\u5242\u91cf\u7684\u60a3\u8005\u6bd42\u6beb\u514b\u5242\u91cf\u663e\u793a\u51fa\u6700\u5feb\u548c\u6700\u5927\u7684\u6539\u5584<\/strong>\u3002<\/p>\n

\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u65e9\u5728\u7b2c4\u5468\uff0c\u4e24\u4e2a\u5242\u91cf\u7684baricitinib\uff082\u6beb\u514b\u548c4\u6beb\u514b\uff09\u4e5f\u663e\u8457\u6539\u5584\u75b2\u52b3\uff0c\u5e76\u4e14\u5728\u6574\u4e2a\u7814\u7a76\u4e2d\u7ef4\u6301\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\u66f4\u4f73\u7684\u6539\u5584\u3002\u8be5\u7814\u7a76\u8fd8\u663e\u793a\uff0c\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u65e9\u671f\u7b2c1\u5468\uff084\u6beb\u514b\u5242\u91cf\uff09baricitinib\u6cbb\u7597\u5bfc\u81f4\u65e9\u6668\u5173\u8282\u50f5\u76f4\u7684\u6301\u7eed\u65f6\u95f4\u663e\u8457\u51cf\u77ed\uff0c\u5e76\u4e14\u5728\u6574\u4e2a\u7814\u7a76\u4e2d\u7ef4\u6301\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\u66f4\u4f73\u7684\u6539\u5584\u3002\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u5728\u7b2c12\u5468\u548c\u7b2c24\u5468\uff0c\u5728baricitinib\u6cbb\u7597\u7ec4\u4e2d\u60a3\u8005\u7684\u8eab\u4f53\u529f\u80fd\u548c\u75bc\u75db\u4e5f\u6709\u663e\u8457\u6539\u5584\u3002<\/p>\n

<\/p>\n

\u25b2\u793c\u6765\u9ad8\u7ea7\u533b\u5b66\u4e3b\u4efbTerence Rooney\u535a\u58eb\uff08\u56fe\u7247\u6765\u6e90\uff1aLinkedIn<\/strong>\uff09<\/strong><\/p>\n

\u201cRA-BEACON\u7814\u7a76\u53d6\u5f97\u4e86\u79ef\u6781\u7ed3\u679c\uff0cbaricitinib\u6cbb\u7597\u663e\u8457\u6539\u5584\u4e86\u5065\u5eb7\u76f8\u5173\u7684\u751f\u6d3b\u8d28\u91cf\u3001\u75b2\u52b3\u548c\u75bc\u75db\uff0c\u518d\u6b21\u5f3a\u8c03\u4e86\u4f7f\u7528baricitinib\u6cbb\u7597\u53ef\u89e3\u51b3\u4ee5\u524d\u7528\u751f\u7269\u5236\u5242\u6cbb\u7597\u5931\u8d25\u7684\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u60a3\u8005\u7684\u672a\u6ee1\u8db3\u7684\u9700\u6c42\uff0c\u201d \u793c\u6765\u8d1f\u8d23baricitinib\u7684\u9ad8\u7ea7\u533b\u5b66\u4e3b\u4efbTerence Rooney\u535a\u58eb\u8bf4\u9053\uff1a \u201c\u5982\u679c\u83b7\u5f97\u6279\u51c6\uff0cbaricitinib\u53ef\u80fd\u6709\u52a9\u4e8e\u89e3\u51b3\u4e00\u4e9b\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u60a3\u8005\u5728\u8fdb\u884c\u65e5\u5e38\u6d3b\u52a8\u65f6\u75be\u75db\uff0c\u76ee\u524d\u7684\u751f\u7269\u6cbb\u7597\u65e0\u6cd5\u8fbe\u5230\u7f13\u89e3\u6216\u964d\u4f4e\u75be\u75c5\u75c7\u72b6\u3002\u201d<\/p>\n

\u53c2\u8003\u8d44\u6599\uff1a<\/p>\n

[1] Eli Lilly (LLY) Release: New Data From Pivotal RA-BEACON Study Show Significant Improvement In Patient-Reported Outcomes In Rheumatoid Arthritis Patients Treated With Baricitinib Compared To Placebo<\/p>\n

[2] Baricitinib in Patients with Refractory Rheumatoid Arthritis, New England Journal of Medicine<\/p>\n

[3] Rheumatoid arthritis, Lancet<\/p>\n

<\/p>\n

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