{"id":599584,"date":"2017-03-14T15:49:23","date_gmt":"2017-03-14T22:49:23","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=599584"},"modified":"2017-06-26T18:29:15","modified_gmt":"2017-06-27T01:29:15","slug":"2017%e5%b9%b4%e7%be%8e%e5%9c%a3%e5%9c%b0%e4%ba%9a%e5%93%a5%e7%94%9f%e8%8d%af%e6%8a%80%e6%9c%af%e9%a2%86%e5%9f%9f%e6%8d%b7%e6%8a%a5%e9%a2%91%e4%bc%a0%ef%bc%88%e5%9b%be%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/2017%e5%b9%b4%e7%be%8e%e5%9c%a3%e5%9c%b0%e4%ba%9a%e5%93%a5%e7%94%9f%e8%8d%af%e6%8a%80%e6%9c%af%e9%a2%86%e5%9f%9f%e6%8d%b7%e6%8a%a5%e9%a2%91%e4%bc%a0%ef%bc%88%e5%9b%be%ef%bc%89\/.html","title":{"rendered":"2017\u5e74\u7f8e\u5723\u5730\u4e9a\u54e5\u751f\u836f\u6280\u672f\u9886\u57df\u6377\u62a5\u9891\u4f20\uff08\u4e00\uff09-SABPA"},"content":{"rendered":"

\u94fe\u63a5\uff1a2017\u5e74\u7f8e\u5723\u5730\u4e9a\u54e5\u751f\u836f\u6280\u672f\u9886\u57df\u6377\u62a5\u9891\u4f20\uff08\u4e8c\uff09<\/a><\/p>\n

\u4f4d\u4e8e\u7f8e\u56fd\u5357\u52a0\u5dde\u7684\u5723\u5730\u4e9a\u54e5\u5730\u533a\u662f\u5168\u7f8e\u6700\u5927\u7684\u751f\u836f\u6280\u672f\u4ea7\u4e1a\u91cd\u5730\uff0c\u8fd9\u91cc\u805a\u96c6\u4e86\u5c06\u8fd1600\u5bb6\u751f\u7269\u533b\u836f\u516c\u53f8\uff0c\u5176\u4e2d\u7ea675%\u96c6\u4e2d\u5728\u88ab\u79f0\u4e3a\u5723\u5730\u4e9a\u54e5\u751f\u7269\u7845\u8c37\u7684\u7d22\u6717\u6258\u8c37\uff08Sorrento Valley\uff09\uff0c\u5723\u5730\u4e9a\u54e5\u7b2c52\u533a\u5468\u56f4\uff08\u89c1\u9898\u56fe\uff09\u3002<\/span><\/p>\n

\u5728\u8fd9\u6570\u767e\u5bb6\u5723\u5730\u4e9a\u54e5\u7684\u751f\u7269\u533b\u836f\u516c\u53f8\u91cc\uff0c\u4e0d\u4e4f\u6211\u4eec\u534e\u4eba\u6280\u672f\u7cbe\u82f1\u4e0e\u79d1\u5b66\u5bb6\u3002\u4ed6\u4eec\u62e5\u6709\u4e00\u4e2a\u81ea\u5df1\u7684\u4e13\u4e1a\u534f\u4f1a – \u5723\u5730\u4e9a\u54e5\u7f8e\u4e2d\u751f\u7269\u533b\u5b66\u4e0e\u836f\u5b66\u4e13\u4e1a\u534f\u4f1a(SABPA)\uff0c\u4e0b\u56fe\u4e3a\u90e8\u5206SABPA\u4f1a\u5458\u5728\u4e00\u6b21\u4e13\u4e1a\u6d3b\u52a8\u7ed3\u675f\u540e\u7684\u5408\u5f71\u3002
\n<\/span><\/p>\n

\"\"<\/a><\/p>\n

\u65e5\u524dFDA\u6279\u51c6\u4e86\u8bfa\u534e\u5236\u836f\uff08Novartis )\u4e00\u6b3e\u4e73\u817a\u764c\u65b0\u836f Kisqali\uff08ribociclib\uff09<\/span>\uff0c\u5728\u5723\u5730\u4e9a\u54e5\u8bfa\u534e\u5236\u836f\u516c\u53f8\u5de5\u4f5c\u7684\u534e\u4eba\u5458\u5de5\u95fb\u6b64\u559c\u8baf\uff0c\u5bf9\u516c\u53f8\u53d6\u5f97\u7684\u6210\u5c31\u7eb7\u7eb7\u8868\u793a\u795d\u8d3a\u5e76\u611f\u5230\u5f88\u81ea\u8c6a\u3002<\/p>\n

2017\u5e74\u4ee5\u6765\uff0c\u5723\u5730\u4e9a\u54e5\u751f\u836f\u6280\u672f<\/span>\u9886\u57df\u5185\u6377\u62a5\u9891\u4f20\uff0c\u4ece\u7814\u53d1\u9879\u76ee\u7684\u6210\u529f\u5230\u836f\u7269\u5728\u4e0d\u65ad\u88abFDA\u6279\u51c6\u4e0a\u5e02\u3002<\/p>\n

\u8bf7\u770b\u836f\u660e\u5eb7\u5fb7\u7684\u8be6\u7ec6\u62a5\u9053\uff1a<\/p>\n

\u4e07\u91cc\u6311\u4e00 <\/strong>\u5bfb\u627e\u6cbb\u764c\u7684\u6700\u4f73\u4e2a\u6027\u5316\u7597\u6cd5<\/strong><\/span><\/h4>\n

\u65b0\u9510\u540d\u79f0\uff1a<\/strong>CureMatch<\/p>\n

\u516c\u53f8\u5750\u6807\uff1a<\/strong>\u5723\u5730\u4e9a\u54e5\uff0c\u52a0\u5229\u798f\u5c3c\u4e9a\u5dde<\/p>\n

\u5b98\u65b9\u7f51\u7ad9\uff1a<\/strong>http:\/\/www.curematch.com\/<\/p>\n

\u7ba1\u7406\u56e2\u961f\uff1a<\/strong>Blaise Barrelet\u5148\u751f\u662f\u521b\u59cb\u4eba\u548cCEO<\/p>\n

\u4f4d\u4e8e\u7f8e\u56fd\u5723\u5730\u4e9a\u54e5\u7684\u521d\u521b\u516c\u53f8CureMatch\u6700\u8fd1\u63a8\u51fa\u4e86\u4e00\u4e2a\u7f51\u7edc\u5e73\u53f0\uff0c\u4f7f\u7528\u5176\u5f00\u53d1\u7684\u5206\u6790\u8f6f\u4ef6\u5e2e\u52a9\u80bf\u7624\u533b\u751f\u4ece\u8bb8\u591a\u79cd\u764c\u75c7\u6cbb\u7597\u65b9\u6848\u4e2d\u627e\u51fa\u6700\u9002\u5408\u60a3\u8005\u7684\u7ec4\u5408\u3002<\/p>\n

\u76ee\u524dFDA\u6279\u51c6\u7684\u6297\u764c\u836f\u7269\u5927\u7ea6\u6709300\u4e2a<\/strong>\uff0cCureMatch\u8868\u793a\u6709\u5927\u7ea6450\u4e07\u79cd<\/strong>\u4e0d\u540c\u7684\u7ec4\u5408\u65b9\u5f0f\u6765\u4f7f\u7528\u8fd9\u4e9b\u836f\u7269\u3002\u5982\u4f55\u6839\u636e\u6bcf\u4f4d\u60a3\u8005\u7684\u5b9e\u9645\u60c5\u51b5\u9009\u62e9\u6709\u53ef\u80fd\u4ea7\u751f\u6548\u679c\u7684\u7597\u6cd5\u5bf9\u4e8e\u533b\u751f\u4eec\u6765\u8bf4\u662f\u4e00\u4e2a\u5f88\u5927\u7684\u6311\u6218\u3002<\/p>\n

<\/p>\n

CureMatch\u7684\u5206\u6790\u8f6f\u4ef6\u9996\u5148\u4f7f\u7528\u60a3\u8005\u7684\u80bf\u7624\u57fa\u56e0\u6d4b\u5e8f\u7ed3\u679c\u3002\u901a\u5e38\u8fdb\u884c\u6d4b\u5e8f\u7684\u516c\u53f8\u4f1a\u63d0\u4f9b\u4e00\u4e9b\u7528\u836f\u6307\u5bfc\uff0c\u4f46\u662fCureMatch\u8ba4\u4e3a\u8fd9\u4e9b\u6307\u5bfc\u53ea\u662f\u57fa\u4e8e\u67d0\u4e2a\u7279\u5b9a\u7684\u7a81\u53d8\uff0c\u5e76\u6ca1\u6709\u771f\u6b63\u9488\u5bf9\u67d0\u4e2a\u5177\u4f53\u7684\u60a3\u8005\u7ed9\u51fa\u4e2a\u6027\u5316\u65b9\u6848\u3002CureMatch\u7684\u8f6f\u4ef6\u53ef\u4ee5\u5206\u6790\u60a3\u8005\u6240\u6709\u80bf\u7624\u4e2d\u6240\u6709\u7684\u57fa\u56e0\u7a81\u53d8\uff0c\u5bfb\u627e\u9002\u5408\u8fd9\u4e9b\u7a81\u53d8\u7684\u836f\u7269\u6216\u836f\u7269\u7ec4\u5408\u5e76\u8fdb\u884c\u6392\u5e8f\uff0c\u968f\u540e\u7ed9\u51fa\u5efa\u8bae\u3002<\/strong><\/p>\n

CureMatch\u7684\u6570\u636e\u5e93\u4e2d\u6709\u6570\u4ee5\u767e\u4e07\u8ba1\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6570\u636e\uff0c\u7814\u7a76\u6587\u732e\uff0c\u4ee5\u53ca\u836f\u7269\u4e4b\u95f4\u76f8\u4e92\u4f5c\u7528\u7684\u6570\u636e\u3002\u516c\u53f8\u7684\u8f6f\u4ef6\u53ef\u4ee5\u6839\u636e\u6bcf\u4e2a\u60a3\u8005\u7684\u5177\u4f53\u60c5\u51b5\u5728\u6570\u636e\u5e93\u4e2d\u8fdb\u884c\u6bd4\u5bf9\uff0c\u4ee5\u627e\u51fa\u6700\u4f73\u6cbb\u7597\u65b9\u6848\u3002\u8fd9\u4e2a\u8f6f\u4ef6\u4e0d\u4ec5\u8003\u8651\u60a3\u8005\u7684\u57fa\u56e0\u6d4b\u5e8f\u6570\u636e\uff0c\u8fd8\u53ef\u4ee5\u5206\u6790\u60a3\u8005\u7684\u8f6c\u5f55\u7ec4\u548c\u86cb\u767d\u8d28\u7ec4\u6570\u636e\uff0c\u4ee5\u6c42\u627e\u5230\u6700\u5408\u9002\u7684\u65b9\u6848\u3002<\/p>\n

\"\"<\/a>CureMatch\u521b\u59cb\u4ebaBlaise Barrelet\u5148\u751f<\/strong><\/p>\n

\u516c\u53f8\u7684\u521b\u59cb\u4ebaBlaise Barrelet\u5148\u751f\u4e4b\u524d\u662f\u4e92\u8054\u7f51\u4f01\u4e1a\u5bb6\uff0c\u4f46\u662f4\u5e74\u524d\u4ed6\u88ab\u8bca\u65ad\u51fa\u6162\u6027\u6dcb\u5df4\u7ec6\u80de\u767d\u8840\u75c5\u540e\u6539\u53d8\u4e86\u60f3\u6cd5\u3002<\/strong>\u4ed6\u6295\u8d44\u4e86\u8fd9\u6b3e\u6700\u65e9\u7531\u52a0\u5229\u798f\u5c3c\u4e9a\u5927\u5b66\u5723\u5730\u4e9a\u54e5\u5206\u6821\u7684Razelle Kurzrock\u535a\u58eb\u548cIgor Tsigelny\u535a\u58eb\u5f00\u53d1\u7684\u8f6f\u4ef6\uff0c\u5e76\u5c06\u5176\u63a8\u5411\u5e02\u573a\u3002<\/p>\n

Barrelet\u5148\u751f\u8ba4\u4e3a\uff0c\u5728\u6d4b\u5e8f\u6280\u672f\u5df2\u7ecf\u975e\u5e38\u53d1\u8fbe\u7684\u4eca\u5929\uff0c\u4ecd\u7136\u53ea\u6709\u5927\u7ea62%\u7684\u764c\u75c7\u60a3\u8005\u5bf9\u4ed6\u4eec\u7684\u80bf\u7624\u8fdb\u884c\u57fa\u56e0\u6d4b\u5e8f\u3002\u5176\u4e2d\u4e00\u4e2a\u91cd\u8981\u7684\u539f\u56e0\u5c31\u662f\u6ca1\u6709\u5feb\u901f\u51c6\u786e\u7684\u65b9\u6cd5\u6765\u5206\u6790\u6d4b\u5e8f\u6570\u636e\uff0c\u5e76\u5c06\u5176\u5e94\u7528\u5230\u836f\u7269\u9009\u62e9\u4e0a\u3002CureMatch\u7684\u7814\u7a76\u663e\u793a\uff0c\u901a\u8fc7\u516c\u53f8\u7684\u8f6f\u4ef6\u9009\u62e9\u6cbb\u7597\u65b9\u6848\u7684\u60a3\u8005\uff0c\u5bf9\u6cbb\u7597\u7684\u54cd\u5e94\u7387\u548c\u603b\u4f53\u5b58\u6d3b\u7387\u5747\u9ad8\u4e8e\u4f20\u7edf\u7684\u5316\u7597\u6216\u5355\u4e2a\u9776\u5411\u836f\u7269\u7597\u6cd5\u3002<\/p>\n

Barrelet\u5148\u751f\u8868\u793a\uff1a\u201c \u968f\u7740\u764c\u75c7\u7814\u7a76\u548c\u836f\u7269\u7814\u53d1\u8d8a\u6765\u8d8a\u590d\u6742\uff0c\u6211\u4eec\u5e0c\u671b\u5411\u533b\u751f\u63d0\u4f9b\u65b0\u7684\u77e5\u8bc6\u548c\u89c1\u89e3\u3002\u201d<\/p>\n

\u6211\u4eec\u5e0c\u671bCureMatch\u7684\u8f6f\u4ef6\u80fd\u591f\u83b7\u5f97\u66f4\u5e7f\u6cdb\u7684\u5e94\u7528\uff0c\u5e2e\u52a9\u764c\u75c7\u60a3\u8005\u627e\u5230\u6700\u4f73\u4e2a\u6027\u5316\u6cbb\u7597\u65b9\u6848\u3002<\/p>\n

\u53c2\u8003\u8d44\u6599\uff1a
\n[1] CureMatch Uses Analytics to Rank Best Options for Cancer Treatment
\n[2] CureMatch\u5b98\u65b9\u7f51\u7ad9<\/p>\n

\u8111\u764c\u57fa\u56e0\u7597\u6cd5\u516c\u53f8\u7533\u8bf7\u4e0a\u5e02\uff0c\u9884\u671f\u7b79\u96c68600\u4e07\u7f8e\u5143<\/span><\/h4>\n

\u8fd1\u65e5\uff0c\u4f4d\u4e8e\u52a0\u5dde\u5723\u5730\u4e9a\u54e5\u7684\u751f\u7269\u6280\u672f\u516c\u53f8Tocagen\u5ba3\u5e03\u6b63\u5728\u7533\u8bf7IPO\uff0c\u9884\u671f\u7b79\u96c6\u9ad8\u8fbe8600\u4e07\u7f8e\u5143\u7684\u8d44\u91d1\uff0c\u63a8\u8fdb\u5176\u8111\u764c\u57fa\u56e0\u6cbb\u7597\u7ec4\u54082\/3\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7b2c\u4e00\u90e8\u5206<\/strong>\u3002\u8be5\u516c\u53f8\u5e0c\u671b\u5728\u660e\u5e74\u4e0a\u534a\u5e74\u63d0\u4f9b\u6765\u81ea2\u671f\u9636\u6bb5\u7684\u6570\u636e\uff0c\u800c\u4e14\u4eca\u5e74\u4e0a\u4e2a\u6708\u5df2\u7ecf\u5b8c\u6210\u4e86\u76f8\u5173\u75c5\u4eba\u62db\u52df\u3002\u4e0a\u8ff0\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8bc4\u4f30\u57fa\u56e0\u7597\u6cd5Toca 511\u548c\u524d\u836fToca FC\u7ec4\u5408\u65b9\u6848\u7684\u7597\u6548\uff0c\u9488\u5bf9\u53d1\u751f\u7b2c\u4e00\u6216\u7b2c\u4e8c\u6b21\u590d\u53d1\u7684\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\uff08glioblastoma\uff09\u60a3\u8005\u6216\u8005\u6b63\u63a5\u53d7\u5207\u9664\u624b\u672f\u7684\u95f4\u53d8\u6027\u661f\u5f62\u7ec6\u80de\u7624\uff08anaplastic astrocytoma\uff09\u60a3\u8005\u3002<\/p>\n

\"\"<\/a><\/p>\n

\u503c\u5f97\u4e00\u63d0\u7684\u662f\uff0c2017\u5e742\u6708\uff0c\u7f8e\u56fdFDA\u5df2\u6388\u4e88\u5176\u5728\u7814\u7597\u6cd5Toca 511 & Toca FC\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u8d44\u683c\uff0c\u7528\u4e8e\u6cbb\u7597\u590d\u53d1\u6027\u9ad8\u7ea7\u522b\u80f6\u8d28\u7624\uff08high grade glioma\uff09\u3002<\/strong><\/p>\n

\u9ad8\u7ea7\u522b\u80f6\u8d28\u7624\u662f\u6700\u4e3a\u5e38\u89c1\u548c\u4fb5\u88ad\u6027\u7684\u539f\u53d1\u6027\u8111\u764c\u4e4b\u4e00\uff0c\u9884\u8ba1\u57282017\u5e74\u5728\u5168\u4e16\u754c\u5c06\u6709\u8fd116\u4e07\u65b0\u786e\u8bca\u60a3\u8005\u3002\u9ad8\u7ea7\u522b\u80f6\u8d28\u7624\u7684\u4e24\u79cd\u6700\u5e38\u89c1\u7684\u5f62\u5f0f\u662f\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\u548c\u95f4\u53d8\u6027\u661f\u5f62\u7ec6\u80de\u7624\u3002\u65b0\u786e\u8bca\u60a3\u8005\u7684\u6807\u51c6\u6cbb\u7597\u5305\u62ec\u624b\u672f\u5207\u9664\uff0c\u7136\u540e\u8fdb\u884c\u653e\u7597\u548c\u5316\u7597\u3002\u7136\u800c\uff0c\u5927\u591a\u6570\u60a3\u8005\u5373\u4fbf\u5728\u63a5\u53d7\u6700\u5927\u9650\u5ea6\u6cbb\u7597\u540e\u4ecd\u4f1a\u590d\u53d1\uff0c\u590d\u53d1\u540e\u7684\u4e2d\u4f4d\u751f\u5b58\u671f\u901a\u5e38\u4e3a7\u81f39\u4e2a\u6708\u3002<\/p>\n

Tocagen\u7684\u8fd9\u4e00\u5728\u7814\u7597\u6cd5\u662fToca 511\uff08vocimagene amiretrorepvec\uff09\u548cToca FC\u7684\u7ec4\u5408\u3002Toca 511\u662f\u4e00\u79cd\u7528\u4e8e\u6ce8\u5c04\u7684\u9006\u8f6c\u5f55\u75c5\u6bd2\u590d\u5236\u8f7d\u4f53\uff08RRV\uff09\uff0c\u5176\u7f16\u7801\u53ef\u5c06\u524d\u836f\u6fc0\u6d3b\u7684\u80de\u5627\u5576\u8131\u6c28\u9176\uff08CD\uff09\uff0c\u540e\u8005\u6e90\u81ea\u9175\u6bcd\uff0c\u4e0d\u89c1\u4e8e\u4eba\u4f53\u5185\u3002\u5728\u88ab\u9009\u62e9\u6027\u9012\u9001\u81f3\u764c\u7ec6\u80de\u540e\uff0c\u611f\u67d3\u7684\u764c\u7ec6\u80de\u643a\u5e26\u6709CD\u57fa\u56e0\u5e76\u53ef\u4ea7\u751fCD\u9176\u3002Toca FC\u5219\u53ef\u53e3\u670d\uff0c\u4e3a5-\u6c1f\u80de\u5627\u5576\uff085-FC\uff09\u7684\u7f13\u91ca\u5236\u5242\uff0c\u662f\u6297\u764c\u836f\u72695-\u6c1f\u5c3f\u5627\u5576\uff085-FU\uff09\u7684\u65e0\u6d3b\u6027\u524d\u836f\u3002\u5728\u4f7f\u7528\u65f6\uff0c\u53e3\u670d\u7ed9\u4e88\u7684Toca FC\u88ab\u5438\u6536\u8fdb\u5165\u8840\u6db2\u5faa\u73af\uff0c\u5e76\u5f88\u5bb9\u6613\u7a7f\u8fc7\u8840\u8111\u5c4f\u969c\u800c\u6269\u6563\u5230\u8111\u90e8\u7684\u764c\u7ec6\u80de\u4e2d\u30025-FC\u5728\u7531Toca 511\u611f\u67d3\u7684\u764c\u7ec6\u80de\u5185\u88abCD\u9176\u8f6c\u5316\u4e3a5-FU\u3002<\/p>\n

\"\"<\/a>\u25b2<\/strong>Toca 511 & Toca FC<\/strong>\u4f5c\u7528\u673a\u7406<\/strong>\uff08\u56fe\u7247\u6765\u6e90\uff1a<\/strong>Tocagen<\/strong>\u5b98\u7f51\uff09<\/strong><\/p>\n

\u4ee5\u8fd9\u79cd\u65b9\u5f0f\u4ea7\u751f\u76845-FU\u5177\u6709\u53cc\u91cd\u4f5c\u7528\u673a\u5236\uff1a\u76f4\u63a5\u6740\u6b7bRRV\u611f\u67d3\u7684\u764c\u7ec6\u80de\u548c\u76f8\u90bb\u7684\u672a\u611f\u67d3\u764c\u7ec6\u80de\uff0c\u5e76\u4e14\u8fd8\u6740\u6b7b\u514d\u75ab\u6291\u5236\u6027\u7ec6\u80de\uff0c\u4f8b\u5982\u9ad3\u6e90\u6027\u6291\u5236\u7ec6\u80de\uff08MDSC\uff09\uff0c\u540e\u8005\u662f\u80bf\u7624\u4e2d\u4e3b\u8981\u7684\u514d\u75ab\u6291\u5236\u56e0\u7d20\uff0c\u5c06\u5176\u53bb\u9664\u53ef\u4fc3\u8fdb\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u3002\u6b64\u5916\uff0c\u514d\u75ab\u7cfb\u7edf\u8fd8\u4f1a\u88ab\u80bf\u7624\u76f8\u5173\u6297\u539f\u548c\u4ece\u6b7b\u4ea1\u764c\u7ec6\u80de\u91ca\u653e\u7684\u75c5\u6bd2\u86cb\u767d\u8fdb\u4e00\u6b65\u6d3b\u5316\u3002\u8fd9\u79cd\u65b9\u6cd5\u9009\u62e9\u6027\u5730\u6740\u6b7b\u4f53\u5185\u7684\u764c\u7ec6\u80de\uff0c\u540c\u65f6\u4fdd\u6301\u5065\u5eb7\u7684\u7ec6\u80de\u4e0d\u53d7\u4f24\u5bb3\u3002<\/p>\n

\u57281\u671f\u9636\u6bb5\u63a5\u53d7\u8f83\u9ad8\u5242\u91cfToca 511\u5e76\u7b26\u54082\/3\u671f\u7eb3\u5165\u6807\u51c6\u768424\u540d\u60a3\u8005\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u89c2\u5bdf\u5230\u4e863\u4f8b\u5b8c\u5168\u53cd\u5e94\u548c2\u4f8b\u90e8\u5206\u53cd\u5e94\u3002\u5728\u6700\u540e\u4e00\u6b21\u6570\u636e\u66f4\u65b0\u65f6\uff0c\u5e94\u7b54\u8005\u5728\u8fdb\u5165\u7814\u7a76\u540e24\u81f343\u4e2a\u6708\u5185\u4ecd\u7136\u5b58\u6d3b\u300224\u4f8b\u60a3\u8005\u83b7\u5f97\u4e86\u4e2d\u4f4d\u751f\u5b58\u671f\u4e3a14.3\u4e2a\u6708\u7684\u826f\u597d\u7ed3\u679c\u3002<\/p>\n

\u6211\u4eec\u8877\u5fc3\u795d\u613fTocagen\u516c\u53f8\u6b63\u5728\u8fdb\u884c\u7684\u590d\u53d1\u6027\u9ad8\u7ea7\u522b\u80f6\u8d28\u7624\u4e34\u5e8a\u7814\u7a76\u548c\u76f8\u5173\u4e0a\u5e02\u7533\u8bf7\u987a\u5229\uff0c\u65e9\u65e5\u9020\u798f\u9971\u53d7\u8be5\u81f4\u547d\u75be\u60a3\u82e6\u695a\u7684\u5168\u4e16\u754c\u60a3\u8005\u3002<\/p>\n

\u53c2\u8003\u8d44\u6599\uff1a<\/p>\n

[1] Tocagen seeks $86M IPO to fund cancer gene therapy trial
\n[2] Tocagen Receives Breakthrough Therapy Designation from U.S. Food and Drug Administration for Toca 511 & Toca FC in Recurrent High Grade Glioma
\n[3] Tocagen\u516c\u53f8\u5b98\u7f51
\n[4] \u81f4\u547d\u8111\u7624\u57fa\u56e0\u7597\u6cd5\u83b7FDA\u7a81\u7834\u6027\u7597\u6cd5\u8d44\u683c\u8ba4\u5b9a<\/p>\n

FDA\u6279\u51c6\u8bfa\u534e\u4e73\u817a\u764c\u65b0\u836fKisqali\uff08ribociclib\uff09<\/strong><\/span><\/h4>\n

\"\"<\/a><\/p>\n

\u65e5\u524d\uff0c\u7f8e\u56fdFDA\u6279\u51c6\u4e86\u8bfa\u534e\u516c\u53f8\u65b0\u836fKisqali\uff08ribociclib\uff0c\u4ee5\u524d\u79f0\u4e3aLEE011\uff09\u4e0e\u82b3\u9999\u9176\u6291\u5236\u5242\u8054\u5408\u4f5c\u4e3a\u521d\u59cb\u5185\u5206\u6ccc\u7c7b\u6cbb\u7597\u65b9\u6848\uff0c\u7528\u4e8e\u7edd\u7ecf\u540e\u6fc0\u7d20\u53d7\u4f53\u9633\u6027\u3001\u4eba\u7c7b\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53-2\u9634\u6027\uff08HR+\/HER2-\uff09\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u5973\u6027\u60a3\u8005<\/strong>\u3002<\/p>\n

\u4e73\u817a\u764c\u662f\u7f8e\u56fd\u5987\u5973\u7b2c\u4e8c\u5e38\u89c1\u7684\u764c\u75c7\u3002\u636e\u7f8e\u56fd\u764c\u75c7\u5b66\u4f1a\u4f30\u8ba1\uff0c2017\u5e74\u7ea6\u670925\u4e07\u591a\u5987\u5973\u5c06\u88ab\u8bca\u65ad\u4e3a\u6d78\u6da6\u6027\u4e73\u817a\u764c\uff0c\u800c\u4e14\u9ad8\u8fbe\u4e09\u5206\u4e4b\u4e00\u7684\u65e9\u671f\u4e73\u817a\u764c\u60a3\u8005\u5c06\u968f\u540e\u53d1\u5c55\u6210\u8f6c\u79fb\u6027\u75be\u75c5\u9636\u6bb5\u3002<\/p>\n

\"\"<\/a>\u25b2Ribociclib\u7684\u5206\u5b50\u5f0f<\/strong>\uff08\u56fe\u7247\u6765\u6e90\uff1a\u7ef4\u57fa\u767e\u79d1\uff09<\/strong><\/p>\n

Kisqali\u662f\u4e00\u79cdCDK4\/6\u6291\u5236\u5242\uff0c\u57fa\u4e8e\u4f18\u79c0\u76843\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\uff0c\u8be5\u7814\u7a76\u63d0\u65e9\u8fbe\u5230\u5176\u4e3b\u8981\u7ec8\u70b9\u3002\u7b2c\u4e00\u6b21\u9884\u5148\u8ba1\u5212\u7684\u4e2d\u671f\u5206\u6790\u663e\u793a\uff0c\u4e0e\u6765\u66f2\u5511\uff08letrozole\uff09\u5355\u72ec\u4f7f\u7528\u65f6\u76f8\u6bd4\uff0cKisqali\u6cbb\u7597\u5728\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u4e0a\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\u663e\u8457\u6539\u5584\u3002Kisqali\u66fe\u7ecf\u83b7\u5f97FDA\u9881\u53d1\u7684\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u548c\u4f18\u5148\u5ba1\u8bc4\u8d44\u683c<\/strong>\u3002<\/p>\n

\"\"<\/a>\u25b2Ribociclib\u662f\u4e00\u79cdCDK4\/6\u6291\u5236\u5242<\/strong>\uff08\u56fe\u7247\u6765\u6e90\uff1a\u300aNature Reviews\u300b\uff09<\/strong><\/p>\n

\u6b64\u6b21FDA\u7684\u6279\u51c6\u662f\u57fa\u4e8e\u5173\u952e\u60273\u671fMONALEESA-2\u8bd5\u9a8c\u7684\u826f\u597d\u6570\u636e\uff0c\u4e0e\u5355\u72ec\u4f7f\u7528\u6765\u66f2\u5511\u76f8\u6bd4\uff0cKisqali+\u6765\u66f2\u5511\u7684\u8054\u5408\u65b9\u6848\u663e\u793a\u4e86\u4f18\u8d8a\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u8be5\u8bd5\u9a8c\u62db\u52df\u4e86668\u540d\u7edd\u7ecf\u540eHR +\/HER2-\u665a\u671f\u6216\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u5987\u5973\uff0c\u5979\u4eec\u672a\u63a5\u53d7\u8fc7\u9488\u5bf9\u665a\u671f\u4e73\u817a\u764c\u7684\u5168\u8eab\u6027\u6cbb\u7597\u3002\u76f8\u6bd4\u8f83\u4e8e\u5355\u72ec\u4f7f\u7528\u6765\u66f2\u551114.7\u4e2a\u6708\uff0895\uff05CI\uff1a13.0-16.5\u4e2a\u6708\uff09\uff0cKisqali\u52a0\u4e0a\u82b3\u9999\u9176\u6291\u5236\u5242\u6765\u66f2\u5511\u53ef\u5c06\u8fdb\u5c55\u6216\u6b7b\u4ea1\u7684\u98ce\u9669\u964d\u4f4e44\uff05<\/strong> (95% CI: 19.3 months-not reached)\uff1bHR=0.556 \uff0895\uff05CI\uff1a0.429-0.720\uff09; p <0.0001\u3002\u540c\u65f6\uff0cKisqali+\u6765\u66f2\u5511\u663e\u793a\u4e8653\uff05\u7684\u603b\u54cd\u5e94\u7387\u7684\u80bf\u7624\u8d1f\u8377\u51cf\u5c11<\/strong>\u3002Kisqali +\u6765\u66f2\u5511\u65b9\u6848\u8fd8\u663e\u793a\u4e86\u9488\u5bf9\u6240\u6709\u60a3\u8005\u4e9a\u7ec4\u7684\u6cbb\u7597\u76ca\u5904<\/strong>\uff0c\u65e0\u8bba\u75be\u75c5\u8d1f\u62c5\u6216\u80bf\u7624\u4f4d\u7f6e\u3002<\/p>\n

\u4e00\u534a\u4ee5\u4e0a\u7684\u60a3\u8005\u670d\u7528Kisqali+\u6765\u66f2\u5511\u5728\u4e2d\u671f\u5206\u6790\u65f6\u4ecd\u7136\u5b58\u6d3b\u548c\u65e0\u8fdb\u5c55\uff0c\u56e0\u6b64\u65e0\u6cd5\u786e\u5b9a\u4e2d\u4f4dPFS\u3002\u5728\u968f\u540e\u768411\u4e2a\u6708\u968f\u8bbf\u548c\u8fdb\u5c55\u5206\u6790\u4e2d\uff0c\u89c2\u5bdf\u5230Kisqali\u52a0\u6765\u66f2\u5511\u7684\u4e2d\u4f4dPFS\u4e3a25.3\u4e2a\u6708\uff0c\u6765\u66f2\u5511\u5355\u72ec\u4f7f\u7528\u4ec5\u4e3a16.0\u4e2a\u6708\u3002\u603b\u751f\u5b58\u671f\u6570\u636e\u5c1a\u672a\u6210\u719f\uff0c\u5c06\u5728\u4ee5\u540e\u63d0\u4f9b\u3002<\/p>\n

<\/p>\n

\u25b2<\/strong>Novartis Oncology\u7684\u9996\u5e2d\u6267\u884c\u5b98Bruno Strigini\u535a\u58eb\uff08\u56fe\u7247\u6765\u6e90\uff1aNovartis\u5b98\u7f51\uff09<\/strong><\/p>\n

Novartis Oncology\u7684\u9996\u5e2d\u6267\u884c\u5b98Bruno Strigini\u535a\u58eb\u8bf4\u9053\uff1a\u201cKisqali\u8c61\u5f81\u7740\u8bfa\u534e\u516c\u53f8\u7ee7\u7eed\u4e3aHR+\/HER2-\u8f6c\u79fb\u6027\u4e73\u817a\u764c\u60a3\u8005\u5e26\u6765\u521b\u65b0\u3002\u6211\u4eec\u8bfa\u534e\u516c\u53f8\u4e3aKisqali\u7684\u7efc\u5408\u4e34\u5e8a\u8ba1\u5212\u611f\u5230\u81ea\u8c6a\uff0c\u8fd9\u9020\u5c31\u4e86\u4eca\u5929\u7684\u83b7\u6279\u4ee5\u53ca\u8fd9\u79cd\u836f\u5bf9\u60a3\u8005\u548c\u5bb6\u4eba\u7684\u65b0\u5e0c\u671b\u3002\u201d<\/p>\n

\u76f8\u5173\u9605\u8bfb\uff1a<\/strong>2017\u6709\u671b\u4e0a\u5e02\u768415\u79cd\u91cd\u78c5\u836f\u7269<\/a><\/span><\/h5>\n

\uff08\u7a3f\u6e90\uff1a\u836f\u660e\u5eb7\u5fb7\uff09<\/p>\n

\"\"\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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