{"id":663374,"date":"2017-03-24T16:43:12","date_gmt":"2017-03-24T23:43:12","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=663374"},"modified":"2017-03-25T09:35:15","modified_gmt":"2017-03-25T16:35:15","slug":"2017%e5%b9%b4%e7%be%8e%e5%9c%a3%e5%9c%b0%e4%ba%9a%e5%93%a5%e7%94%9f%e8%8d%af%e6%8a%80%e6%9c%af%e9%a2%86%e5%9f%9f%e6%8d%b7%e6%8a%a5%e9%a2%91%e4%bc%a0%ef%bc%88%e4%ba%8c%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/2017%e5%b9%b4%e7%be%8e%e5%9c%a3%e5%9c%b0%e4%ba%9a%e5%93%a5%e7%94%9f%e8%8d%af%e6%8a%80%e6%9c%af%e9%a2%86%e5%9f%9f%e6%8d%b7%e6%8a%a5%e9%a2%91%e4%bc%a0%ef%bc%88%e4%ba%8c%ef%bc%89\/.html","title":{"rendered":"2017\u5e74\u7f8e\u5723\u5730\u4e9a\u54e5\u751f\u836f\u6280\u672f\u9886\u57df\u6377\u62a5\u9891\u4f20\uff08\u4e8c\uff09"},"content":{"rendered":"

\u94fe\u63a5\uff1a2017\u5e74\u7f8e\u5723\u5730\u4e9a\u54e5\u751f\u836f\u6280\u672f\u9886\u57df\u6377\u62a5\u9891\u4f20\uff08\u4e00\uff09<\/a><\/p>\n

\u9ed8\u514b\u8f89\u745e\u6297PD-L1\u836f\u7269\u83b7\u7f8e\u56fdFDA\u6279\u51c6\uff0c\u6cbb\u7597\u76ae\u80a4\u764c<\/span><\/h4>\n

\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053<\/strong><\/p>\n

\u7f8e\u56fdFDA\u65e5\u524d\u5ba3\u5e03\uff0c\u52a0\u901f\u6279\u51c6\u7531\u5fb7\u56fd\u9ed8\u514b\u516c\u53f8\u4e0e\u8f89\u745e\u5171\u540c\u7814\u53d1\u7684\u514d\u75ab\u7597\u6cd5\u65b0\u836fBavencio\uff08avelumab\uff09\u4e0a\u5e02\uff0c\u6cbb\u7597\u7f79\u60a3\u8f6c\u79fb\u6027\u6885\u514b\u5c14\u7ec6\u80de\u764c\uff08metastatic Merkel cell carcinoma\uff09\u7684\u6210\u4eba\u4e0e12\u5c81\u4ee5\u4e0a\u513f\u7ae5\uff0c\u672a\u7ecf\u5148\u524d\u5316\u7597\u6cbb\u7597\u7684\u60a3\u8005\u4e5f\u540c\u6837\u9002\u7528\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0cavelumab\u662fFDA\u6279\u51c6\u7684\u9996\u4e2a\u6cbb\u7597\u8fd9\u4e00\u75be\u75c5\u7684\u7597\u6cd5\uff0c\u540c\u65f6\u4e5f\u662f\u7b2c\u4e8c\u4e2a\u5f97\u5230\u7f8e\u56fdFDA\u6279\u51c6\u7684\u6297PD-L1\u6297\u4f53\u836f\u7269\u3002<\/strong><\/p>\n

\"\"<\/a><\/p>\n

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Avelumab\u6b63\u662f\u4e00\u6b3e\u80fd\u6cbb\u7597\u8fd9\u79cd\u7f55\u89c1\u4e14\u9ad8\u4fb5\u88ad\u6027\u764c\u75c7\u7684\u65b0\u836f\u3002\u4f5c\u4e3a\u4e00\u79cd\u5168\u4eba\u6e90\u5316\u7684\u6297PD-L1\u5355\u514b\u9686\u6297\u4f53<\/strong>\uff0cavelumab\u80fd\u6291\u5236PD-L1\u4e0ePD-1\u7684\u7ed3\u5408\uff0c\u4ece\u800c\u6fc0\u6d3bT\u7ec6\u80de\u4e0e\u83b7\u5f97\u6027\u514d\u75ab\u7cfb\u7edf\uff0c\u5bf9\u764c\u7ec6\u80de\u5c55\u5f00\u653b\u51fb\u3002\u6b64\u5916\uff0c\u7531\u4e8e\u4fdd\u7559\u4e86\u5929\u7136\u7684Fc\u533a\u57df\uff0c\u7814\u53d1\u4eba\u5458\u4e5f\u8ba4\u4e3aavelumab\u80fd\u53c2\u4e0e\u5230\u5148\u5929\u6027\u514d\u75ab\u7cfb\u7edf\u7684\u8fd0\u4f5c\u4e2d\uff0c\u5e76\u53ef\u80fd\u8bf1\u53d1\u6297\u4f53\u4f9d\u8d56\u6027\u7ec6\u80de\u5a92\u4ecb\u7ec6\u80de\u6bd2\u6027\u4f5c\u7528\uff08antibody-dependent cell-mediated cytotoxicity\uff0cADCC\uff09\u30022014\u5e7411\u6708\uff0c\u9ed8\u514b\u4e0e\u8f89\u745e\u5ba3\u5e03\u8fbe\u6210\u6218\u7565\u8054\u76df\uff0c\u5171\u540c\u5f00\u53d1\u8fd9\u6b3e\u836f\u7269\u3002\u5148\u524d\uff0cFDA\u66fe\u6388\u4e88\u5b83\u5b64\u513f\u836f\u8d44\u683c\u3001\u7a81\u7834\u6027\u7597\u6cd5\u8ba4\u5b9a\u53ca\u4f18\u5148\u5ba1\u8bc4\u8d44\u683c\u3002<\/strong><\/p>\n

\"\"<\/a><\/p>\n

\u5728\u4e00\u9879\u5355\u81c2\u8bd5\u9a8c\u4e2d\uff0cavelumab\u7684\u7597\u6548\u5f97\u5230\u4e86\u9a8c\u8bc1\u3002\u8fd9\u9879\u8bd5\u9a8c\u62db\u52df\u4e8688\u540d\u7f79\u60a3\u8f6c\u79fb\u6027\u6885\u514b\u5c14\u7ec6\u80de\u764c\u7684\u60a3\u8005\uff0c\u4ed6\u4eec\u5148\u524d\u81f3\u5c11\u63a5\u53d7\u4e86\u4e00\u6b21\u5316\u7597\u6cbb\u7597\u3002\u800c\u8fd9\u9879\u8bd5\u9a8c\u7684\u76ee\u7684\u662f\u4e3a\u4e86\u68c0\u9a8c\u5728avelumab\u7684\u6cbb\u7597\u4e0b\uff0c\u60a3\u8005\u7684\u603b\u4f53\u54cd\u5e94\u7387\uff08\u80bf\u7624\u5b8c\u5168\u6216\u90e8\u5206\u7f29\u51cf\uff09\u3002\u6b64\u5916\uff0c\u7814\u7a76\u4eba\u5458\u4e5f\u60f3\u4e86\u89e3\u5728\u51fa\u73b0\u54cd\u5e94\u7684\u60a3\u8005\u4e2d\uff0c\u54cd\u5e94\u65f6\u957f\u6709\u591a\u4e45\u3002\u8bd5\u9a8c\u53d1\u73b0\uff0c\u572888\u540d\u60a3\u8005\u4e2d\uff0c\u670933%\u7684\u60a3\u8005\u7684\u80bf\u7624\u51fa\u73b0\u5b8c\u5168\u6216\u90e8\u5206\u7f29\u51cf<\/strong>\u3002\u5728\u51fa\u73b0\u54cd\u5e94\u7684\u60a3\u8005\u4e2d\uff0c\u54cd\u5e94\u8d85\u8fc7\u534a\u5e74\u7684\u60a3\u8005\u6bd4\u4f8b\u9ad8\u8fbe86%\uff0c\u54cd\u5e94\u8d85\u8fc7\u4e00\u5e74\u7684\u60a3\u8005\u8fbe\u5230\u4e8645%\u3002\u57fa\u4e8e\u8fd9\u4e9b\u4f18\u79c0\u6570\u636e\uff0c\u7f8e\u56fdFDA\u6279\u51c6\u4e86avelumab\u4e0a\u5e02\u3002<\/p>\n

\"\"<\/a>\u25b2\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u5728\u672a\u6765\u5c06\u7ee7\u7eed\u8d77\u5230\u91cd\u8981\u7684\u4f5c\u7528\uff08\u56fe\u7247\u6765\u6e90\uff1a\u9ed8\u514b\u5b98\u7f51<\/strong>\uff09<\/strong><\/p>\n

\u201c\u76ae\u80a4\u764c\u662f\u6700\u5e38\u89c1\u7684\u764c\u75c7\u4e4b\u4e00\u3002\u5148\u524d\uff0c\u7f79\u60a3\u6885\u514b\u5c14\u7ec6\u80de\u764c\u8fd9\u79cd\u7f55\u89c1\u76ae\u80a4\u764c\u7684\u60a3\u8005\u4e00\u76f4\u6ca1\u6709\u83b7\u6279\u7684\u7597\u6cd5\u53ef\u7528\uff0c\u201dFDA\u836f\u7269\u8bc4\u4f30\u4e0e\u7814\u7a76\u4e2d\u5fc3\u8840\u6db2\u5b66\u4e0e\u80bf\u7624\u4ea7\u54c1\u529e\u516c\u5ba4\u8d1f\u8d23\u4ebaRichard Pazdur\u535a\u58eb\u8bf4\u9053\uff1a\u201c\u79d1\u5b66\u754c\u5c06\u7ee7\u7eed\u5229\u7528\u4eba\u4f53\u7684\u514d\u75ab\u7cfb\u7edf\uff0c\u6cbb\u7597\u591a\u79cd\u764c\u75c7\u3002\u5373\u4fbf\u662f\u90a3\u4e9b\u76ee\u524d\u7f3a\u5c11\u6216\u7f3a\u5931\u7597\u6cd5\u7684\u7f55\u89c1\u764c\u75c7\uff0c\u4e5f\u80fd\u4ece\u8fd9\u4e9b\u8fdb\u5c55\u4e2d\u6536\u83b7\u5168\u65b0\u7684\u7597\u6cd5\u3002<\/strong>\u201d<\/p>\n

\u6211\u4eec\u795d\u8d3a\u9ed8\u514b\u4e0e\u8f89\u745e\u53d6\u5f97\u7684\u6210\u7ee9\uff0c\u5e76\u795d\u613f\u514d\u75ab\u7597\u6cd5\u80fd\u7ee7\u7eed\u5927\u653e\u5f02\u5f69\uff0c\u4e3a\u8bf8\u591a\u764c\u75c7\u60a3\u8005\u5e26\u6765\u751f\u7684\u5e0c\u671b\u3002<\/p>\n

\u53c2\u8003\u8d44\u6599\uff1a<\/p>\n

[1] FDA approves first treatment for rare form of skin cancer<\/p>\n

[2] Avelumab \u2013 Pfizer<\/p>\n

[3] \u9ed8\u514b\u5b98\u65b9\u7f51\u7ad9<\/p>\n

\u836f\u660e\u5eb7\u5fb7\u6b63\u5f0f\u542f\u52a8A\u80a1IPO\u00a0 \u521b\u7acb<\/span>\u6700\u8d35\u65b0\u836f\u7814\u53d1\u516c\u53f8<\/span><\/span><\/h4>\n

\u6839\u636e\u7b2c\u4e00\u8d22\u7ecf\u8bb0\u8005\u83b7\u5f97\u7684\u6700\u65b0\u6d88\u606f\uff0c\u8d77\u6e90\u5730\u5728\u7f8e\u5723\u5730\u4e9a\u54e5\u7684\u836f\u660e\u5eb7\u5fb7\u5df2\u6b63\u5f0f\u542f\u52a8A\u80a1IPO\u6d41\u7a0b\uff0c\u4e0e\u8fc7\u5f80\u731c\u6d4b\u7684\u4e0d\u540c\uff0c\u6b64\u6b21\u767b\u9646A\u80a1\uff0c\u836f\u660e\u5eb7\u5fb7\u5e76\u672a\u91c7\u53d6\u6b64\u524d\u4f20\u8a00\u7684\u201c\u501f\u58f3\u201d\u5f62\u5f0f\u3002<\/p>\n

3\u670823\u65e5\u665a\u95f4\uff0c\u65e0\u9521\u836f\u660e\u5eb7\u5fb7\u65b0\u836f\u5f00\u53d1\u80a1\u4efd\u6709\u9650\u516c\u53f8\u6b63\u5f0f\u53d1\u5e03\u4e0a\u5e02\u8f85\u5bfc\u516c\u544a\uff1a\u62df\u9996\u6b21\u516c\u5f00\u53d1\u884c\u4eba\u6c11\u5e01\u666e\u901a\u80a1\u5e76\u4e0a\u5e02\uff0c\u73b0\u6b63\u63a5\u53d7\u534e\u6cf0\u8054\u5408\u8bc1\u5238\u6709\u9650\u8d23\u4efb\u516c\u53f8\u7684\u8f85\u5bfc\u3002<\/p>\n

\u6839\u636e\u516c\u544a\uff0c\u6b64\u6b21\u4e0a\u5e02\u7684\u7684\u4e3b\u8981\u53d1\u8d77\u4eba\u4e3aGlorious Moonlight Limited\u3001SUMMER BLOOM INVESTMENTS (I) PTE. LTD\u3001G&C VI Limited\u3001WuXi AppTec (BVI) Inc.\u3001ABG-WX HOLDING (HK) LIMITED\u3001\u5609\u4e16\u5eb7\u6052(\u5929\u6d25)\u6295\u8d44\u5408\u4f19\u4f01\u4e1a(\u6709\u9650\u5408\u4f19)\u3001HCFII WX (HK) Holdings Limited\u3001G&C IV Hong Kong Limited\u548c\u4e0a\u6d77\u91d1\u836f\u6295\u8d44\u7ba1\u7406\u6709\u9650\u516c\u53f8\u7b49\uff0c\u516c\u53f8\u6cd5\u5b9a\u4ee3\u8868\u4eba\u4e3a\u674e\u9769\u3002<\/p>\n

<\/p>\n

\u6392\u961f\u4e0a\u5e02\uff0c\u8fd9\u4e0e\u6b64\u524d\u4e00\u76f4\u4f20\u8a00\u7684\u501f\u58f3\u4e0a\u5e02\u7684\u8bf4\u6cd5\u4ea7\u751f\u4e86\u51fa\u5165\uff0c\u7b2c\u4e00\u8d22\u7ecf\u8bb0\u8005\u5728\u91c7\u8bbf\u63a5\u8fd1\u6b64\u6b21\u4ea4\u6613\u7684\u4eba\u58eb\u540e\u83b7\u6089\uff0c\u201c\u7531\u4e8e\u653f\u7b56\u6536\u7d27\uff0c\u501f\u58f3\u73b0\u5728\u5f88\u96be\u6279\u590d\uff0c\u56e0\u6b64\u8f6c\u9053\u2018\u6392\u961f\u2019\uff0c\u800c\u73b0\u5728A\u80a1\u6392\u961f\u5ba1\u8bc4\u901f\u5ea6\u52a0\u5feb\uff0c\u6240\u4ee5IPO\u6392\u961f\u4e5f\u7528\u4e0d\u4e86\u592a\u4e45\u3002\u201d<\/p>\n

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