{"id":700779,"date":"2017-04-03T22:01:58","date_gmt":"2017-04-04T05:01:58","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=700779"},"modified":"2017-04-08T10:31:12","modified_gmt":"2017-04-08T17:31:12","slug":"%e5%91%a8%e6%98%be%e6%b3%a2%ef%bc%9a%e7%b3%96%e5%b0%bf%e7%97%85%e6%97%a9%e6%9c%9f%e8%af%8a%e6%96%ad%e6%9c%80%e6%9c%89%e6%95%88%ef%bc%88%e5%9b%be%ef%bc%89","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/%e5%91%a8%e6%98%be%e6%b3%a2%ef%bc%9a%e7%b3%96%e5%b0%bf%e7%97%85%e6%97%a9%e6%9c%9f%e8%af%8a%e6%96%ad%e6%9c%80%e6%9c%89%e6%95%88%ef%bc%88%e5%9b%be%ef%bc%89\/.html","title":{"rendered":"\u5468\u663e\u6ce2\uff1a\u963f\u8328\u6d77\u9ed8\u75c7\u65e9\u671f\u8bca\u65ad\u6700\u6709\u6548\uff08\u56fe\uff09"},"content":{"rendered":"

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\u963f\u5c14\u8328\u6d77\u9ed8\u75c7(AD, \u4fd7\u79f0\u8001\u5e74\u75f4\u5446) \u662f\u4e00\u79cd\u8d77\u75c5\u9690\u533f\u3001\u8fdb\u884c\u6027\u53d1\u5c55\u3001\u81f4\u6b7b\u6027\u795e\u7ecf\u7cfb\u7edf\u9000\u884c\u6027\u75be\u75c5\u3002\u636e\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u7edf\u8ba1\uff0cAD\u662f\u6700\u5e38\u89c1\u7684\u4e00\u79cd\u5931\u667a\u75c7\uff08\u4fd7\u79f0\u75f4\u5446\u75c7\uff0cDementia\uff09\uff0c\u5360\u6240\u6709\u5931\u667a\u75c7\u768460-70%\uff0c\u4e14\u8fd9\u79cd\u5931\u667a\u4e0d\u662f\u6b63\u5e38\u8001\u5316\u7684\u4e00\u90e8\u5206\u3002<\/p>\n

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\u867d\u7136\u963f\u5c14\u8328\u6d77\u9ed8\u535a\u58eb\u65e9\u57281901\u5e74\u5c31\u63a5\u8bca\u4e86\u7b2c\u4e00\u4f8b\u786e\u8bcaAD\u75c5\u4eba\uff0c\u4f46\u60b2\u54c0\u7684\u662f\uff0c\u76ee\u524d\u5bf9\u8fd9\u4e2a\u4ee5\u4ed6\u540d\u5b57\u547d\u540d\u7684\u75be\u75c5\u7684\u8bca\u65ad\u548c\u6cbb\u7597\u4e0e\u5f53\u5e74\u4ed6\u63a5\u8bca\u7684\u7b2c\u4e00\u4e2a\u75c5\u4eba\u65f6\u76f8\u6bd4\u4e5f\u8fdb\u6b65\u751a\u5fae\u3002\u4e3b\u8981\u539f\u56e0\u5982\u4e0b\u3002<\/p>\n

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1. <\/strong>\u5230\u76ee\u524d\u4e3a\u6b62\uff0cAD\u7684\u53d1\u75c5\u673a\u5236\u4ecd\u7136\u4e0d\u660e<\/strong>\u5e76\u4e14\u6ca1\u6709\u7cbe\u51c6\u7684\u65e9\u671f\u7b5b\u67e5\u548c\u8bca\u65ad\u624b\u6bb5\uff0c\u4e5f\u6ca1\u6709\u53ef\u4ee5\u5fe0\u5b9e\u4f53\u73b0AD\u75be\u75c5\u7684\u4f53\u5916\u548c\u52a8\u7269\u6a21\u578b\uff1b<\/section>\n
<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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2. \u5168\u4e16\u754c\u5bf9AD\u7814\u7a76\u6295\u5165\u7684\u65f6\u95f4\u548c\u8d44\u91d1\u90fd\u76f8\u5bf9\u8f83\u5c11<\/strong>\u3002\u4e00\u4e2a\u5f88\u5927\u7684\u95ee\u9898\u662fAD\u7684\u75c5\u4eba\/\u5bb6\u5c5e\u7ec4\u7ec7\u7684\u5f71\u54cd\u529b\u5728\u7f8e\u56fd\u8ddf\u5176\u4ed6\u8bf8\u5982\u764c\u75c7\u6216\u827e\u6ecb\u75c5\u7684\u6ca1\u6709\u53ef\u6bd4\u6027\u3002\u56e0\u4e3a\u53d1\u75c5\u540e\u7684\u75c5\u4eba\u6ca1\u6cd5\u53bb\u7ec4\u7ec7\u6216\u53c2\u52a0\u6d3b\u52a8\uff0c\u800c\u4e14\u76ee\u524d\u4e3a\u6b62\u8be5\u75c5\u6ca1\u6709\u5e78\u5b58\u8005\uff0c\u5bb6\u4eba\u53c8\u5927\u591a\u4e0d\u613f\u610f\u627f\u8ba4\u5bb6\u91cc\u6709\u5931\u667a\u75c7\uff08\u75f4\u5446\uff09\u75c5\u4eba\u3002\u5728\u7f8e\u56fd\uff0c\u5c3d\u7ba1\u6bcf\u5e74\u56e0AD\u6b7b\u4ea1\u7684\u4eba\u6570\u51e0\u4e4e\u4e0e\u764c\u75c7\u76f8\u5f53\u5e76\u4e14\u8d39\u7528\u5de8\u5927\uff082016\u5e742590\u4ebf\u7f8e\u5143\uff09\uff0c\u4f46\u653f\u5e9c\u6bcf\u5e74\u62e8\u7ed9\u764c\u75c7\u7814\u7a76\u7684\u7ecf\u8d39\u51e0\u4e4e\u662f\u62e8\u7ed9AD\u7814\u7a76\u768410\u500d\u3002\u4ee52015\u5e74\u4e3a\u4f8b\uff0c\u7f8e\u56fd\u536b\u751f\u90e8\u7814\u53d1\u9884\u7b97\u764c\u75c7\u662f54\u4ebf\u7f8e\u5143\uff0c\u5fc3\u810f\u75c512\u4ebf\u7f8e\u5143\uff0cHIV\/\u827e\u6ecb\u75c530\u4ebf\u7f8e\u5143\uff0cAD\u53ea\u67095.66\u4ebf\u7f8e\u5143\u3002\u7f8e\u56fd\u536b\u751f\u90e8\u53ea\u662f\u8fd1\u4e24\u5e74\u624d\u589e\u52a0AD\u7814\u7a76\u9884\u7b97\u3002\u836f\u7269\u7814\u53d1\u65b9\u9762\uff0c2017\u5e741\u670813\u65e5\u7f8e\u56fd\u7684\u5b98\u65b9\u4e34\u5e8a\u8bd5\u9a8c\u767b\u5f55\u7f51\u5740Clinicaltrials.gov\u7528Alzheimer\u2019s\u53ef\u4ee5\u67e5\u5230\u67091971\u4e2aAD\u4e34\u5e8a\u7814\u7a76\uff0c\u5176\u4e2d44\u4e2a\u662f\u8fdb\u884c\u4e2d\u76843\u671f\u4e34\u5e8a\u7814\u7a76\uff1b\u7528dementia\u53ef\u4ee5\u67e5\u5230\u67092550\u4e2a\u4e34\u5e8a\u7814\u7a76\u3002\u4f5c\u4e3a\u5bf9\u6bd4\uff0c\u764c\u75c7\uff08cancer\uff09\u6216\u80bf\u7624\uff08tumor\uff09\u670958\uff0c605\u4e2a\u4e34\u5e8a\u3002\u8111\u80bf\u7624\uff08brain tumor\uff093202\uff0c\u795e\u7ecf\u80f6\u8d28\u76241802\uff01\u8fd9\u4e9b\u6570\u5b57\u5f53\u7136\u8ddf\u8bb8\u591a\u56e0\u7d20\u6709\u5173\uff0c\u4f46\u6574\u4e2a\u4e16\u754c\u5bf9AD\u7684\u91cd\u89c6\u663e\u7136\u8fdc\u8fdc\u4e0d\u591f\uff1b<\/section>\n
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3. \u6dc0\u7c89\u6837\u86cb\u767d\u75c5\u53d8\u5047\u8bf4\u7684\u5371\u5bb3<\/strong>\u3002\u76ee\u524dAD\u53d1\u75c5\u673a\u5236\u6709\u5f88\u591a\u79cd\u5047\u8bf4\uff0c\u5305\u62ec\u80c6\u78b1\u80fd\u529f\u80fd\u4f4e\u4e0b\uff0c\u03b2\u6dc0\u7c89\u6837\u86cb\u767d\uff08A\u03b2\uff09\u75c5\u53d8\uff0cTau\u86cb\u767d\u75c5\u53d8\uff0c\u795e\u7ecf\u514d\u75ab\u708e\u75c7\uff0c\u81ea\u7531\u57fa\u7b49\u7b49\u3002\u4e0a\u4e16\u7eaa90\u5e74\u4ee3\u521d\u4e16\u754c\u8303\u56f4\u5185\u7684\u5927\u836f\u4f01\u51e0\u4e4e\u5b8c\u5168\u63a5\u53d7\u4e86\u6dc0\u7c89\u6837\u86cb\u767d\u75c5\u53d8\u5047\u8bf4\u662fAD\u7684\u53d1\u75c5\u673a\u5236\uff0c\u9646\u7eed\u505c\u6b62\u4e86\u5f88\u591a\u6709\u5e0c\u671b\u6539\u5584\u75c7\u72b6\u6216\u6539\u5584\u75c5\u60c5\u8fdb\u5c55\u7684\u9776\u70b9\u836f\u7269\u7814\u7a76\uff0c\u7eb7\u7eb7\u65a5\u5de8\u8d44\u548c\u4eba\u529b\u7269\u529b\u5728A\u03b2\u9886\u57df\u505a\u4e86\u5927\u91cf\u5e0c\u671b\u63a7\u5236\u6216\u6cbb\u6108AD\u7684\u5de5\u4f5c\u3002\u5728\u521d\u671f\u7684\u51e0\u4e2a\u5de8\u59273\u671f\u5931\u8d25\u540e\uff08\u5982\u8f89\u745e\u3001\u5f3a\u751f\u548c\u793c\u6765\uff09\uff0c\u597d\u591a\u5927\u836f\u4f01\u53c8\u653e\u5f03\u6216\u524a\u51cf\u5305\u62ecAD\u5728\u5185\u7684\u4e2d\u67a2\u795e\u7ecf\u836f\u7269\u7814\u53d1(\u5982\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\uff0c\u963f\u65af\u5229\u5eb7\u548c\u845b\u5170\u7d20\u53f2\u514b)\u3002\u8fd1\u4e24\u5e74\u7684\u4e24\u4e2aA\u03b2\u6297\u4f53\u4e34\u5e8a\u8bd5\u9a8c\u53c8\u7ed9\u8fd9\u4e2a\u5047\u8bf4\u5e26\u6765\u65b0\u7684\u6d3b\u529b\u3002\u867d\u7136\u5927\u836f\u4f01\u5c24\u5176\u662f\u793c\u6765\u516c\u53f8\u5728A\u03b2\u65b9\u9762\u7684\u5192\u9669\u7cbe\u795e\u548c\u5951\u800c\u4e0d\u820d\u524d\u8d74\u540e\u7ee7\u7684\u6267\u7740\u503c\u5f97\u8d5e\u9882\uff0c\u4f46\u662f\u8fd9\u4e2a\u5047\u8bf4\u7684\u5371\u5bb3\u5728\u4e8e\u65f6\u95f4\u548c\u673a\u4f1a\u6210\u672c\u6d6a\u8d39\u592a\u5927\uff0c\u6574\u4e2a\u9886\u57df\u635f\u5931\u4e86\u81f3\u5c1110\u5e74\u4ee5\u4e0a\u65f6\u95f4!<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u7f8e\u56fd\u836f\u76d1\u5c40\u6279\u51c6\u7684\u7b2c\u4e00\u4e2a\u548c\u6700\u540e\u4e00\u4e2aAD\u65b0\u836f\u5206\u522b\u662f\u57281993\u548c2003\u5e74\uff08\u8868\u4e00\uff09<\/strong>\u3002 13\u5e74\u5df2\u5b8c\u6210\u7684\u65b0\u836f\u4e34\u5e8a\u5b9e\u9a8c\u5168\u519b\u8986\u6ca1\uff0c\u9488\u5bf9\u6dc0\u7c89\u6837\u86cb\u767d\u5047\u8bf4\u836f\u7269\u7814\u53d1\u7684\u635f\u5931\u5c24\u4e3a\u60e8\u91cd\u3002\u4f46\u7f8e\u56fd\u7ec8\u4e8e\u7387\u5148\u57282011\u5e74\u7acb\u6cd5\uff08National AD Project Act\uff09\u5bf9AD\u5ba3\u6218\uff0c\u5e76\u4e8e2012\u5e74\u63d0\u51fa\u201c2025\u5e74\u53d1\u73b0\u9884\u9632\u65b9\u6cd5\u548c\u6709\u6548AD\u7597\u6cd5\u201d\u7684\u68a6\u60f3\u822c\u7684\u5b8f\u4f1f\u76ee\u6807\u30022013\u5e7412\u6708\u4f26\u6566\u8ba4\u77e5\u75c7\u516b\u56fd\u5cf0\u4f1a\uff08G8 Dementia Summit\uff09\u662f\u7ee72005\u5e74HIV\u548cAIDS\u4e13\u9898\u75be\u75c5\u4f1a\u8bae\u4e4b\u540e\u516b\u56fd\u5cf0\u4f1a\u7684\u9996\u4e2a\u4e13\u9898\u75be\u75c5\u5cf0\u4f1a\uff0c\u5e76\u901a\u8fc7\u4e86\u201c2025\u5e74\u6cbb\u6108\u6216\u53d1\u73b0\u6709\u6548AD\u7597\u6cd5\u201d\u7684\u76ee\u6807\u3002\u867d\u7136\u5f53\u65f6\u7684AD\u7814\u53d1\u4ea7\u54c1\u94fe\u4e0d\u662f\u5f88\u4e50\u89c2\uff0c\u4f46\u9996\u8111\u4eec\u8fd8\u662f\u5e0c\u671b\u8fd9\u4e2a\u76ee\u6807\u548c\u968f\u4e4b\u7684\u52aa\u529b\u53ef\u4ee5\u50cf2005\u5e74\u7684\u5cf0\u4f1a\u5bf9AIDS\u836f\u7269\u7814\u53d1\u7684\u5f71\u54cd\u4e00\u6837\u5927\u3002\u8fd1\u5e74\u6765\u653f\u5e9c\u7814\u53d1\u673a\u6784\uff0c\u9662\u6821\uff0c\u6148\u5584\u673a\u6784\uff0c\u5927\u5c0f\u836f\u4f01\u90fd\u5728\u52aa\u529b\u7684\u7528\u5404\u79cd\u65b9\u5f0f\u5bfb\u627e\u53ef\u4ee5\u6cbb\u6108\u6216\u66f4\u597d\u6539\u5584\u75c7\u72b6\u7684\u836f\u7269\uff0c\u5982\u4e0d\u5c11\u7814\u7a76\u56e2\u961f\u8bd5\u56fe\u4ece\u8f7b\u4e2d\u5ea6AD\u5165\u624b\uff0c\u5e0c\u671b\u627e\u5230\u80fd\u591f\u9884\u9632\u3001\u51cf\u7f13\u75c5\u60c5\u53d1\u5c55\u548c\u6cbb\u6108AD\u7684\u5019\u9009\u836f\u7269\u548c\u75ab\u82d7\u3002<\/p>\n

\"\"<\/a>\u8868\u4e00\uff1a\u76ee\u524dAD\u6279\u51c6\u4e0a\u5e02\u836f\uff08\u6570\u636e\u6e90\u4e8eFDA\u548cCFDA\u7f51\u7ad9\uff09<\/p>\n

\u56de\u987e2016\u5e74\uff0cAD\u836f\u7269\u7684\u7814\u53d1\u662f\u60b2\u559c\u4ea4\u96c6\u3002<\/p>\n

\u4e00\u65b9\u9762\uff0c\u66f4\u591a3\u671f\u4e34\u5e8a\u4f20\u6765\u4e86\u60b2\u58ee\u5931\u8d25\u7684\u6d88\u606f\uff1a\u793c\u6765\u7684A\u03b2\u6297\u4f53\u836fSolanezumab\u7684\u6700\u65b0\u4e00\u8f6e\u7528PET\u7b5b\u9009\u75c5\u4eba\u7684\u4e09\u671f\u4e34\u5e8a\u8fd8\u662f\u5931\u8d25\uff08\u793c\u6765\u516c\u53f8\u7f51\u7ad9\uff09\uff1b \u7b2c\u4e00\u4e2a\u9488\u5bf9Tau\u86cb\u767d\u5047\u8bf4\u7684TauRx\u7684LMTM\u7684\u7b2c\u4e8c\u4e2a\u4e09\u671f\u4e34\u5e8a\u8fd8\u662f\u4ee5\u5931\u8d25\u544a\u7ec8\uff08TauRx\u516c\u53f8\u7f51\u7ad9\uff09\uff1b\u7075\u5317\uff08Lundbeck\uff09\u5ba3\u5e035HT6\u62ee\u6297\u5242idalopirdine(Lu AE58054)\u57281\u4e2a\u5206\u6790\u4e86\u7ed3\u679c\u76843\u4e2a\u8fdb\u884c\u4e2d\u7684\u4e34\u5e8a\u2162\u671f\u8bd5\u9a8c\u4e2d\u65e0\u6548\uff0c\u800c\u4e142017\u5e742\u6708\u5ba3\u5e03\u7684\u4e86\u5176\u4ed6\u4e24\u4e2a3\u671f\u8bd5\u9a8c\uff08\u51711463\u4e2a\u8f7b-\u4e2d\u671f\u75c5\u4eba\uff09\u7ed3\u679c\u4e5f\u662f\u65e0\u6548\u3002<\/p>\n

\u597d\u6d88\u606f\u65b9\u9762\uff0c\u6700\u6fc0\u52a8\u4eba\u5fc3\u7684\u6709\uff1a<\/p>\n

\uff081\uff09<\/strong>\u767e\u5065\u7684A\u03b2\u6297\u4f53\u836fAducanumab\u5728\u4e00\u4e9b\u75c5\u4eba\u4e2d\u770b\u5230\u4e86\u4f34\u6709\u8ba4\u77e5\u6cbb\u7597\u6548\u679c\u7684\u8001\u5e74\u6591\u6e05\u9664\uff1b<\/p>\n

\uff082\uff09<\/strong>\u7f8e\u56fd\uff089\u6708\u4efd\u8bae\u4f1a\u901a\u8fc7\u65b0\u589e$4\u4ebfAD\u7814\u53d1\u7ecf\u8d39\uff09\uff0c\u4e2d\u56fd\uff08AD\u7c7b\u75be\u75c5\u5217\u4e8e\u5341\u4e09\u4e94\u8ba1\u5212\uff09\u548c\u4e16\u754c\u8303\u56f4\u7684\u653f\u5e9c\u90fd\u5728\u589e\u5927AD\u7814\u53d1\u7ecf\u8d39\uff1b<\/p>\n

\uff083\uff09<\/strong>\u66f4\u591a\u7684\u65b0\u9776\u70b9\u548c\u65b0\u836f\u7269\u7814\u53d1\u6295\u8d44\uff0c\u5982Denali\u836f\u7269\u516c\u53f8\u7684$1.3\u4ebf\u7f8e\u5143B\u8f6e\u878d\u8d44\uff082015\u5e74\u521b\u5386\u53f2\u4e0a\u6700\u5927\u7684\u751f\u7269\u79d1\u6280\u9996\u8f6e$2.17\u4ebf\u878d\u8d44\uff09\u5e76\u5c06\u5728\u6b27\u6d32\u5f00\u59cb\u8c03\u8282\u708e\u75c7\u7684\u65b0\u9776\u70b9RIP1\u6fc0\u9176\u6291\u5236\u5242\u7684\u4e00\u671f\u4e34\u5e8a\u548cAPOE\u6297\u4f53\u836f\u7814\u53d1\u7b49\u3002<\/p>\n

\u4e0b\u9762\u6211\u4eec\u5c06\u6309\u9776\u70b9\/\u5047\u8bf4\u5206\u7c7b\u5217\u4e3e\u76ee\u524d\u5728\u7814\u7684AD\u9884\u9632\u548c\u6cbb\u7597\u836f\u7269\uff0c\u91cd\u70b9\u5728\u53ef\u80fd\u5b8c\u6210G8\u76842025\u5e74\u76ee\u6807\u76843\u671f\u4e34\u5e8a\u836f\u7269\uff0c\u4e0a\u5e02\u836f\u4e8c\u6b21\u5f00\u53d1\u548c\u4e00\u4e9b\u6709\u4eae\u70b9\u7684\u65b0\u9776\u70b9\u836f\u7269\uff0c\u4f46\u4e0d\u5305\u62ec\u9488\u5bf9AD\u7cbe\u795e\u75c7\u72b6\u7684\u5728\u7814\u836f\u7269\u3002\u9664\u975e\u53e6\u6709\u8bf4\u660e\uff0c\u6570\u636e\u6765\u6e90\u4e8e\u673a\u6784\/\u516c\u53f8\u7f51\u7ad9\uff0cClinicaltrials.gov\uff0cwww.alzforum.org\u548cwww.alzdiscovery.org.<\/p>\n

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\u4e00<\/p>\n
\u9884\u9632\u836f\u7269<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

AD\u65e0\u75c7\u72b6\u6f5c\u4f0f\u671f\u957f\uff0c\u4f4695-100%\u7684\u643a\u5e26APP\uff0cPS1\/2\u57fa\u56e0\u7a81\u53d8\u7684\u5bb6\u65cf\u6027\u75c5\u4eba\u572865\u5c81\u4e4b\u524d\u4f1a\u53d1\u75c5\u3002APOE e4\u7eaf\u5408\u5b50\u643a\u5e26\u8005\u4e5f\u6709\u5f88\u9ad8\u7684\u53d1\u75c5\u51e0\u7387\u3002\u9884\u9632\u6027\u6cbb\u7597\u5bf9\u8fd9\u4e9b\u4eba\u7fa4\u610f\u4e49\u91cd\u5927\u3002\u76ee\u524d\u81f3\u5c11\u67096\u4e2a\u5728\u8fdb\u884c\u4e2d\u7684\u5927\u578bAD\u9884\u9632\u4e34\u5e8a\u8bd5\u9a8c\uff0c4\u4e2a\u662f\u653f\u5e9c\/\u673a\u6784\u652f\u6301\u53d1\u8d77\u7684\uff0c2\u4e2a\u662f\u5de5\u4e1a\u754c\u53d1\u8d77\u7684\u3002\u9776\u70b9\u65b9\u9762\uff0c5\u4e2a\u9488\u5bf9\u6dc0\u7c89\u6837\u86cb\u767d\u75c5\u53d8\u5047\u8bf4\uff01\u76ee\u7684\u662f\u5ef6\u7f13\uff0c\u51cf\u6162\u6216\u9632\u6b62\u53d1\u75c5\uff0c2020\u5e74\u52302024\u5e74\u4e4b\u95f4\u53ef\u4ee5\u5f97\u51fa\u7ed3\u679c\u3002<\/p>\n

\n
1.1\u663e\u6027\u9057\u4f20AD\u7cfb\u7edf-\u4e34\u5e8a\u8bd5\u9a8c\u5355\u5143 (DIAN-TU)<\/strong><\/section>\n<\/section>\n

\u7531\u534e\u76db\u987f\u5927\u5b66\uff08\u5723\u8def\u6613\u65af\uff09Randall Bateman\u6559\u6388\u4e3b\u6301\uff0c\u7f8e\u56fd\u8001\u5e74\u6240\uff08National Institute of Aging, NIA\uff09\u548c\u5176\u4ed6\u673a\u6784\u8d44\u52a9\uff0c2012\u5e7412\u6708\u8d77\u5f00\u59cb\u5728201\u4e2a\u5c1a\u672a\u53d1\u75c5\u7684APP\uff0cPS1\/2\u57fa\u56e0\u7a81\u53d8\u643a\u5e26\u8005\u4e2d\u4f7f\u7528\u7f57\u6c0f\u516c\u53f8\u7684A\u03b2\u591a\u805a\u4f53\u7684\u6297\u4f53gantenerumab \u6216\u793c\u6765\u516c\u53f8\u7684A\u03b2\u5355\u4f53\u7684\u6297\u4f53solanezumab\u8fdb\u884c\u9884\u9632\u6027\u6cbb\u75972\/3\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5e76\u4f7f\u7528Avid\u516c\u53f8\u7684\u65b0\u578bPET\u663e\u50cf\u793a\u8e2a\u5242\u8ddf\u8e2a\u836f\u7269\u5bf9\u8001\u5e74\u6591\u7684\u6548\u679c\uff0c\u9884\u8ba12019\u5e7412\u6708\u5b8c\u6210\u3002<\/p>\n

2016\u5e7412\u6708\u5e95 DIAN-TU\u53c8\u5ba3\u5e03\u589e\u52a0\u4e86\u6768\u68ee\u7684\u4e00\u4e2aBACE\u6291\u5236\u5242\u7684\u9884\u9632\u6027\u6cbb\u7597\u5b9e\u9a8c\uff0c\u5e76\u4f1a\u4f7f\u7528General Electric (GE)Healthcare \u5728\u7814\u7684Tau\u86cb\u767dPET\u663e\u50cf\u793a\u8e2a\u5242THK-5351\u9009\u62e9\u65b0\u75c5\u4eba, \u5177\u4f53\u836f\u7269\u548c\u5176\u4ed6\u7ec6\u8282\u4e0d\u8be6\u3002\u8fd9\u4e2a\u8bd5\u9a8c\u4f1a\u505a\u81f3\u5c114\u5e74\u9884\u9632\u6027\u6cbb\u7597,\u6700\u65e9\u4e5f\u8981\u52302024\u5e74\u5e95\u624d\u80fd\u5b8c\u6210\u3002<\/p>\n

1.2TOMMORROW \u8bd5\u9a8c<\/strong><\/p>\n

2013\u5e748\u6708\u6b66\u7530\u5236\u836f\u548c\u4ed9\u7c89\u9edb\u5236\u836f\u57283500\u4e2a\u6ca1\u6709\u75c7\u72b6\u4f46\u6709\u4e9b\u662fAPOE4\u7eaf\u5408\u5b50\u643a\u5e26\u8005\u6216TOMM40\u6613\u611f\u57fa\u56e0\u643a\u5e26\u8005\u4e2d\u5f00\u59cb\u4f4e\u5242\u91cf\u7cd6\u5c3f\u75c5\u836f\u7269\u5339\u683c\u5217\u916e\uff08pioglitazone\uff0c\u6709\u6291\u5236\u708e\u75c7\u548c\u964d\u4f4eA\u03b2\u4f5c\u7528\uff09\u7684\u9884\u9632\u4e34\u5e8a\u8bd5\u9a8c\u3002\u8bd5\u9a8c\u7684\u53e6\u4e00\u4e2a\u76ee\u7684\u662f\u9a8c\u8bc1TOMM40\u6613\u611f\u57fa\u56e0\u5bf9AD\u7684\u9884\u6d4b\u6548\u679c\uff0c\u9884\u8ba12019\u5e747\u6708\u5b8c\u6210\u3002\u5f88\u4e0d\u5e78\u7684\u662f\u4ed9\u7c89\u9edb\u5236\u836f\u7684\u53d1\u8d77\u4ebaAllen Roses\u535a\u58eb2016\u5e749\u6708\u53bb\u4e16\u3002 Roses\u535a\u58eb\u662f\u8457\u540d\u7684\u6dc0\u7c89\u6837\u86cb\u767d\u75c5\u53d8\u5047\u8bf4\u6311\u6218\u8005\uff0c\u4f46\u4ed6\u65e0\u6cd5\u4eb2\u773c\u770b\u5230\u4ed6\u7684\u201c\u5f71\u54cd\u8461\u8404\u7cd6\u548c\u6c27\u4ee3\u8c22\u7684\u7ebf\u7c92\u4f53\u75c5\u53d8\u662fAD\u53d1\u75c5\u4e3b\u8981\u539f\u56e0\u4e4b\u4e00\u201d\u7684\u7406\u8bba\u662f\u5426\u53ef\u4ee5\u88ab\u9a8c\u8bc1\u4e86\u3002<\/p>\n

1.3AD\u9884\u9632\u8ba1\u5212\u7684\u5e38\u67d3\u8272\u4f53\u663e\u6027\u9057\u4f20AD\u8bd5\u9a8c\uff0cAPI-ADAD Trial<\/strong><\/p>\n

\u7531\u4e9a\u5229\u6851\u90a3\u5dde\u51e4\u51f0\u57ce\u7684Banner AD\u7814\u7a76\u6240\u53d1\u8d77\uff0c\u57fa\u56e0\u6cf0\u514b\u516c\u53f8\u8d44\u52a9\uff0c\u7075\u611f\u6765\u6e90\u4e8e\u4e00\u4e2a\u643a\u5e26PSEN1\u57fa\u56e0\u7a81\u53d8\u7684\u54e5\u4f26\u6bd4\u4e9aantioquia\u7701\u7684\u65e9\u53d1AD\u5bb6\u7cfb\uff08~5000\u4eba\uff09\uff0c\u8be5\u5bb6\u7cfb\u662f\u4e16\u754c\u4e0a\u6700\u5927\u7684\u5bb6\u65cf\u6027\u6216\u65e9\u53d1AD\u7684\u53d7\u96be\u8005\u30022013\u5e7412\u6708\u5f00\u59cb\u5bf9\u8be5\u5bb6\u7cfb\u4e2d\u672a\u53d1\u75c5\u7684~300\u4eba\u7528Genentech\u516c\u53f8\u7684 A\u03b2\u6297\u4f53crenezumab\u8fdb\u884c\u9884\u9632\u6027\u6cbb\u7597\uff0c\u9884\u8ba12020\u5e749\u6708\u5b8c\u6210\u3002<\/p>\n

1.4\u65e0\u75c7\u72b6\u671fAD\u60a3\u8005\u7684\u6297\u6dc0\u7c89\u6837\u86cb\u767d\u6cbb\u7597\uff08A4\u8bd5\u9a8c\uff09<\/strong><\/p>\n

\u8457\u540d\u7684A4\u8bd5\u9a8c\uff0c\u7531\u793c\u6765\u516c\u53f8\u8d44\u52a9\uff0cAD\u5408\u4f5c\u7814\u7a76\u7ec4\u7ec7\uff08ADCS\uff09\u4e3b\u6301\u4e0b\u5c55\u5f00\u30022014\u5e742\u6708\u5f00\u59cb\u57281150\u540d\u8ba4\u77e5\u6b63\u5e38\u4f46 A\u03b2PET\u663e\u793a\u4e0d\u6b63\u5e38A\u03b2\u8001\u5e74\u6591\u768465-85\u5c81\u4eba\u7fa4\u4e2d\u4f7f\u7528\u793c\u6765\u516c\u53f8\u7684A\u03b2\u6297\u4f53solanezumab\u505a\u5e72\u9884\u7684AD\u9884\u9632\u6027\u7814\u7a76\uff0c\u9884\u8ba12020\u5e7410\u6708\u5b8c\u6210\u3002<\/p>\n

1.5\u65e0\u75c7\u72b6\u671fAD\u60a3\u8005\u7684\u6297\u6dc0\u7c89\u6837\u86cb\u767d\u6cbb\u7597\uff08EARLY\u6216A5\u8bd5\u9a8c\uff09<\/strong><\/p>\n

2015\u5e7410\u6708\u6768\u68ee\u5f00\u59cb\u57281650\u4e2a\u8ba4\u77e5\u6b63\u5e38\u4f46 A\u03b2PET\u663e\u793a\u4e0d\u6b63\u5e38A\u03b2\u8001\u5e74\u6591\u768460-85\u5c81\u4eba\u7fa4\u4e2d\u4f7f\u7528BACE\u6291\u5236\u5242JNJ-54861911\u505aAD\u9884\u9632\u6027\u7814\u7a76\uff0c\u9884\u8ba12023\u5e745\u6708\u5b8c\u6210\u3002<\/p>\n

1.6AD\u9884\u9632\u8ba1\u5212\u7684\u4ee3\u4ee3\u76f8\u4f20\u7814\u7a76 API Generation Study<\/strong><\/p>\n

\u7531\u4e9a\u5229\u6851\u90a3\u5dde\u51e4\u51f0\u57ce\u7684Banner AD\u7814\u7a76\u6240\u53d1\u8d77\uff0c\u4e0e\u8bfa\u534e\/\u5b89\u8fdb\u5408\u4f5c\uff0c2015\u5e7411\u6708\u5f00\u59cb\u57281340\u540d\u8ba4\u77e5\u6b63\u5e38\u5065\u5eb7\u768460-75\u5c81APOE e4\u7eaf\u5408\u5b50\u643a\u5e26\u8005\u4e2d\u8fdb\u884cCAD106\u75ab\u82d7\uff08\u4e3b\u52a8\u514d\u75abA\u03b21-6\uff0c \u8bfa\u534e\uff09\u6216BACE\u6291\u5236\u5242CNP520\uff08\u8bfa\u534e\/\u5b89\u8fdb\uff09\u8fdb\u884c\u9884\u9632\u6027\u6cbb\u7597\uff0c\u76ee\u7684\u662f\u5ef6\u7f13\u6216\u9632\u6b62AD\u75c7\u72b6\u7684\u53d1\u751f\uff0c\u9884\u8ba12023\u5e748\u6708\u5b8c\u6210\u3002<\/p>\n

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\u4e8c<\/section>\n<\/section>\n<\/section>\n
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\u6cbb\u7597<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u6cbb\u7597\u836f\u7269\u65b9\u9762\uff0c\u65e9\u53d1\u73b0\u65e9\u6cbb\u7597AD\u76ee\u524d\u88ab\u5927\u591a\u6570\u4eba\u63a5\u53d7\u4e3a\u6700\u6709\u53ef\u80fd\u6709\u6548\u5e2e\u52a9\u7684AD\u75c5\u4eba\u7684\u7b56\u7565\u3002\u968f\u7740A\u03b2 PET\u663e\u50cf\u793a\u8e2a\u5242\u7f8e\u56fd\u836f\u76d1\u5c40\u6279\u51c6\u4e0a\u5e02\u548cTau PET\u663e\u50cf\u793a\u8e2a\u5242\u7684\u6279\u51c6\u4e34\u5e8a\u7814\u7a76\uff0c\u5927\u836f\u4f01\u5f00\u59cb\u4f7f\u7528\u8fd9\u4e24\u4e2a\u751f\u7269\u6807\u5fd7\u7269\u7b5b\u9009\u75c5\u4eba\u5165\u7ec4\u6216\u8005\u4f5c\u4e3a\u7597\u6548\u6d4b\u8bd5\u6307\u6807\u3002<\/p>\n

2.1 \u80c6\u78b1\u80fd\u7cfb\u7edf<\/strong><\/p>\n

\u80c6\u78b1\u916f\u9176\u662fAD\u836f\u7269\u7814\u53d1\u6700\u4e3a\u6210\u529f\u7684\u9776\u70b9\uff0c\u7f8e\u56fd\u836f\u76d1\u5c40\u76ee\u524d\u4e3a\u6b62\u53ea\u6279\u51c6\u4e865\u4e2aAD\u65b0\u836f(NCE)\uff0c\u5176\u4e2d4\u4e2a\u662f\u80c6\u78b1\u916f\u9176\u6291\u5236\u5242\uff08\u8868\u4e00\uff09\u3002\u8fd9\u4e2a\u9886\u57df\u76ee\u524d\u5728\u7814\u65b0\u4ea7\u54c1\u4e0d\u591a\uff0c\u53ef\u4ee5\u67e5\u5230\u8fdb\u884c\u4e2d\u4e34\u5e8a\u8bd5\u9a8c\u53ea\u67092\u4e2a\uff1b\u4e00\u4e2a1\u671f\u4e34\u5e8a\u836f\u7269\u4ee5\u53ca\u4e00\u4e2a\u77f3\u886b\u78b1\u7532\u76844\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n

2.1.1 VU0467319<\/strong><\/p>\n

\u8303\u5fb7\u5821\u5927\u5b66\u7814\u53d1\u7684\u6bd2\u8548\u78b1\u578b\u4e59\u9170\u80c6\u78b1\u53d7\u4f53\uff08mAchR1\uff09\u6b63\u5411\u522b\u6784\u8c03\u8282\u5242\uff08positive allosteric modulator\uff09\uff0c\u5373PAM\u6fc0\u52a8\u5242\uff0c\u9884\u8ba1\u4eca\u5e74\u4e0a\u534a\u5e74\u5f00\u59cb\u4e00\u671f\u4e34\u5e8a\uff082\uff09\u3002\u8fd9\u4e2a\u9776\u70b9\u4e00\u5ea6\u5f88\u53d7\u91cd\u89c6\uff0c\u4f46\u56e0\u4f20\u7edf\u6fc0\u52a8\u5242\u5bf9\u5916\u5468\u7cfb\u7edf\u7684\u6bd2\u526f\u4f5c\u7528\u548cA\u03b2\u5047\u8bf4\u7684\u91cd\u89c6\u5f71\u54cd\u4e86\u8fd9\u4e2a\u9776\u70b9\u7684\u8fdb\u7a0b\u3002<\/p>\n

2.1.2\u77f3\u886b\u78b1\u7532<\/strong><\/p>\n

\u4e0a\u6d77\u5e02\u7cbe\u795e\u536b\u751f\u4e2d\u5fc32016\u5e7411\u6708\u5f00\u59cb\u505a\u7684\u77f3\u886b\u78b1\u7532\u76844\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5728300\u4e2aMCI\u671fAD\u75c5\u4eba\u4e2d\u505a\u4e3a\u671f52\u5468\u7684MCI\u5230AD\u8f6c\u5316\u7387\u7684\u5b9e\u9a8c\uff0c\u9884\u8ba12018\u5e7412\u6708\u5b8c\u6210\uff082017\u5e7412\u6708\u5b8c\u6210\u6570\u636e\u91c7\u96c6\uff09\u3002<\/p>\n

2.2 \u6dc0\u7c89\u6837\u86cb\u767d\u75c5\u53d8<\/strong><\/p>\n

\u8fd9\u4e2a\u673a\u5236\u76ee\u524d\u5728\u7814\u7684\u836f\u7269\u6700\u591a\uff0c\u4e5f\u51fa\u73b0\u4e86\u8bb8\u591a\u5931\u8d25\u7684\u60c5\u51b5\u3002\u5728\u7814\u836f\u7269\u5305\u62ec\u5c0f\u5206\u5b50\uff0c\u6297\u4f53\u548c\u75ab\u82d7\u3002\u76ee\u524d\uff0c2\/3\u548c3\u671f\u4e34\u5e8a\u8bd5\u9a8c\u7684\u836f\u7269\u9884\u8ba12019\u5e74\u5f00\u59cb\u4f1a\u6709\u7ed3\u679c\uff0c\u8fd9\u4e2a\u5047\u8bf4\u662f\u5426\u53ef\u4ee5\u5f71\u54cdAD\u75c5\u60c5\u57282020-2023\u5e74\u4e4b\u95f4\u4f30\u8ba1\u53ef\u4ee5\u5f97\u51fa\u5b9a\u8bba\u3002\u5982\u679c\u5b89\u5168\u5e76\u53ef\u4ee5\u964d\u4f4eA\u03b2\u6591\u5757\uff08\u800c\u4e14\u4f34\u6709\u4e00\u5b9a\u8ba4\u77e5\u6548\u679c\uff09\uff0c\u8fd9\u65b9\u9762\u7684\u836f\u7269\u5c06\u53ef\u80fd\u88abFDA\u6279\u51c6\uff0c\u8ddf\u964d\u80c6\u56fa\u9187\u7684\u836f\u9884\u9632\u5fc3\u810f\u75c5\u4e00\u6837\uff0c\u5728A\u03b2\u5f02\u5e38\u589e\u9ad8\u7684\u4eba\u7fa4\u4e2d\u4f7f\u7528\u3002<\/p>\n

2.2.1\u5c0f\u5206\u5b50\u836f\u7269<\/strong><\/p>\n

\u9488\u5bf9\u6dc0\u7c89\u6837\u86cb\u767d\u75c5\u53d8\u5047\u8bf4\u7684\u5c0f\u5206\u5b50\u9776\u70b9\u4e3b\u8981\u662fA\u03b2\u9884\u86cb\u767dAPP\u4ee3\u8c22\u901a\u9053\u7684\u4e09\u4e2a\u5185\u6ccc\u9176\uff08secretase\uff09\uff1a\u03b1, \u03b2\u548c\u03b3\u5185\u6ccc\u9176\u3002\u5176\u4e2d\u7814\u7a76\u6700\u591a\u7684\u662f\u03b2\u5185\u6ccc\u9176\uff0cBACE\u3002\u53e6\u5916\u6709\u8bb8\u591a\u9776\u70b9\u53ef\u4ee5\u95f4\u63a5\u7684\u5f71\u54cd\u6dc0\u7c89\u6837\u86cb\u767d\u75c5\u53d8\u3002<\/p>\n

\u03b1-\u5185\u6ccc\u9176\u662f\u4e2a\u5f88\u597d\u7684\u9776\u70b9\uff0c\u9700\u8981\u6fc0\u6d3b\u5242\uff0c\u867d\u7136\u76ee\u524d\u9176\u6fc0\u6d3b\u5242\u672c\u8eab\u7684\u7814\u53d1\u8fd8\u6ca1\u6709\u592a\u597d\u529e\u6cd5\uff0c\u4f46\u53ef\u4ee5\u901a\u8fc7\u4fe1\u53f7\u901a\u8def\u6fc0\u6d3b\u3002\u6bd4\u5982\u4e0a\u9762\u63d0\u5230\u7684\u6bd2\u8548\u78b1\u578b\u4e59\u9170\u80c6\u78b1\u53d7\u4f53\u6fc0\u52a8\u5242\u7684\u53ef\u4ee5 \u901a\u8fc7\u8c03\u8282\u86cb\u767dK\u6fc0\u9176\uff08PKC\uff09\u6d3b\u6027\u6765\u589e\u52a0\u03b1-\u5185\u6ccc\u9176\u6d3b\u6027\u3002\u53e6\u5916\u4ece\u82d4\u9c9c\u52a8\u7269\u8349\u82d4\u866b(Bugula neritina)\u4e2d\u63d0\u53d6\u51fa\u7684\u4e00\u79cd\u5927\u73af\u5185\u916f\u7c7b\u7269\u8d28Bryostatin 1\uff08\u82d4\u85d3\u866b\u7d20\uff09\u4e5f\u88ab\u53d1\u73b0\u6709PKC\u8c03\u8282\u4f5c\u7528\uff0c\u5e76\u5bf91\u4f8b\u4e25\u91cd\u5bb6\u65cf\u6027AD\u75c5\u4eba\u6709\u6548\u679c\uff0c\u76ee\u524dNeurotrope\u6b63\u5728\u8fdb\u884c2\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u540c\u65f6Aphios\u516c\u53f8\u4e5f\u5728\u8fdb\u884cBryostatin\u884d\u751f\u7269\u7684\u7814\u7a76\uff0cAPH-0703\u5728\u5df4\u54c8\u9a6c\u505a\u4e86\u4e00\u4f8bAD\u75c5\u4eba,\uff0c\u516c\u53f8\u7f51\u7ad9\u79f0\u7ed3\u679c\u201c\u663e\u8457\u3001\u9f13\u821e\u4eba\u5fc3\u201d\uff0c\u76ee\u524d\u8be5\u516c\u53f8\u6b63\u5728\u7814\u53d1\u6bd4APH-0703\u6d3b\u6027\u66f4\u597d\u7684\u5728\u9884\u4e34\u5e8a\u9636\u6bb5\u7684\u884d\u751f\u7269APH-104\u3002<\/p>\n

\u03b3-\u5185\u6ccc\u9176\u4e00\u5ea6\u6709\u5f88\u591a\u516c\u53f8\u5728\u7814\u53d1\uff0c\u4f46\u5e95\u7269\u975e\u7279\u5f02\u6291\u5236\u5242\u4e34\u5e8a\u8bc1\u660e\u6291\u5236\u03b3-\u5185\u6ccc\u9176\u4e0d\u4f46\u4e0d\u80fd\u5e2e\u52a9AD\u75c5\u4eba\u53cd\u800c\u53ef\u4ee5\u52a0\u91cd\u75c5\u60c5(5)\uff0c\u516c\u8ba4\u7684\u539f\u56e0\u662f\u03b3-\u5185\u6ccc\u9176\u6709\u597d\u591aAPP\u4ee5\u5916\u7684\u5e95\u7269\u5982Wnt, \u6291\u5236\u8fd9\u4e9b\u5e95\u7269\u7684\u6d3b\u6027\u5bfc\u81f4\u6bd2\u526f\u4f5c\u7528\u3002\u76ee\u524d\u9009\u62e9\u6027\u03b3-\u5185\u6ccc\u9176\u8c03\u8282\u5242\u7684\u7814\u7a76\u5728\u8fdb\u884c\u4e2d\uff0c\u8f89\u745e\u7684PF-06648671\u5df2\u7ecf\u8fdb\u5165\u4e34\u5e8a\u671f\u3002<\/p>\n

2.2.1.1 BACE\u6291\u5236\u5242<\/strong><\/p>\n

\u76ee\u524d\u5728\u7814\u76842-3\u671f\u4e34\u5e8a\u7684BACE\u6291\u5236\u5242\u5171\u67096\u4e2a\u836f\u7269\uff0c\u4e0a\u9762\u63d0\u5230\u7684\u6768\u68ee\u7684JNJ-54861911\u548c\u8bfa\u534e\/\u5b89\u8fdb\u7684CNP520\u5728\u505a\u9884\u9632\u6027\u8bd5\u9a8c\uff081.5\uff0c1.6\uff09\u3002\u5176\u4ed64\u4e2a\u89c1\u8868\u4e8c\uff0c\u5176\u4e2d\u4e24\u4e2a\u83b7\u5f97\u7f8e\u56fd\u836f\u76d1\u5c40\u7684\u7eff\u8272\u901a\u9053\u8eab\u4efd\uff08Fast Track designation\uff09\u3002\u8fd9\u4e2a\u9776\u70b9\u662f\u5426\u6709\u65482019\u5e74\u5e952020\u5e74\u521d\u53ef\u4ee5\u77e5\u9053\u521d\u6b65\u7ed3\u679c\u3002\u4e0d\u8fc7\u9ed8\u6c99\u4e1c\u521a\u5ba3\u5e03\u7684Verubecestat\u76843\u671f\u4e34\u5e8a\u5931\u8d25\uff08\u8868\u4e8c\uff0c\u7ea2\u989c\u8272\uff09\uff0c\u4e3a\u8fd9\u4e2a\u9776\u70b9\u5e26\u6765\u4e25\u91cd\u5371\u673a\uff0c\u4f46\u793c\u6765\/\u963f\u65af\u5229\u5eb7\u4eca\u5e743\u6708\u5f00\u59cb1400\u75c5\u4eba\u7684\u73b0\u5728\u8fdb\u884c\u5b9e\u9a8c\u7684\u5ef6\u7eed\uff08\u8868\u4e8c\uff0c\u7eff\u989c\u8272\uff09\uff0c\u4e5f\u8868\u660e\u4e86\u8fd9\u4e24\u5bb6\u5927\u836f\u4f01\u5bf9BACE\u9776\u70b9\u7684\u4fe1\u5fc3\uff01<\/p>\n

\"\"<\/a>\u8868\u4e8c\uff1a2-3\u671f\u5728\u7814BACE\u6291\u5236\u5242\uff08\u6570\u636e\u6765\u6e90\uff1aclinicaltrials.gov; yahoo.com\u641c\u7d22\u548cEisai.com\uff09<\/p>\n

2.2.1.2 \u5176\u4ed6\u5f71\u54cdA\u03b2\u7684\u5728\u7814\u5c0f\u5206\u5b50\u836f\u7269<\/strong><\/p>\n

\u6587\u732e\u4e2d\u7684\u53ef\u4ee5\u901a\u8fc7\u4e0d\u540c\u9014\u5f84\u5f71\u54cd\u6216\u6e05\u9664A\u03b2\u7684\u5c0f\u5206\u5b50\u6709\u5f88\u591a\u3002\u9664\u4e86\u4e0a\u9762\u63d0\u5230\u7684\u8f89\u745e\u7684\u03b3-\u5185\u6ccc\u9176\u8c03\u8282\u5242\uff0c\u4e0b\u9762\u662f4\u4e2a\u4e0d\u540c\u673a\u5236\u7684\u5728\u7814\u7684\u5176\u4ed6\u5f71\u54cdA\u03b2\u7684\u5c0f\u5206\u5b50\u836f\u7269\uff0c\u6700\u65e9\u76842018\u5e74\u53ef\u4ee5\u77e5\u9053\u7ed3\u679c\u3002<\/p>\n

2.2.1.2.1 Azeliragon (TTP488, PF-04494700)<\/strong><\/p>\n

RAGE\u53d7\u4f53\u6291\u5236\u5242\uff0c\u6297\u6c27\u5316\u5e76\u6709\u6e05\u9664A\u03b2\u4f5c\u7528\u3002vTv \u836f\u7269\u516c\u53f82013\u5e74\u83b7\u5f97FDA\u7eff\u8272\u901a\u9053\uff0c2015\u5e744\u6708\u5f00\u59cb\u5728800\u4e2a\u8f7b\u5ea6AD\u75c5\u4eba\u4e2d\u505a\u4e00\u4e2a\u53ebSTEADFAST\u76843\u671f\u4e34\u5e8a\uff0c\u9884\u8ba12019\u5e741\u6708\u5b8c\u6210\u3002<\/p>\n

2.2.1.2.2 ALZT-OP1\uff08\u8272\u7518\u9178\u9f3b\u55b7\u5242Cromolyn\u548c\u5e03\u6d1b\u82acIbuprofen\uff09<\/strong><\/p>\n

\u8001\u836f\u65b0\u7528\u8054\u5408\u65b0\u7528\uff0c\u5e03\u6d1b\u82ac\u6297\u708e\u75c7\uff0c\u8272\u7518\u9178\u6709\u6297A\u03b2\u805a\u96c6\u548c\u964d\u4f4eA\u03b2\u4f5c\u7528\u3002 AZTherapies\u516c\u53f82015\u5e749\u6708\u5f00\u59cb\u5728600\u4e2a\u65e9\u671f\u75c5\u4eba\u4e2d\u505a\u4e00\u4e2a\u53ebCOGNITE\u76843\u671f\u4e34\u5e8a\uff0c\u9884\u8ba12018\u5e743\u6708\u5b8c\u6210\u3002<\/p>\n

2.2.1.2.3CT1812<\/strong><\/p>\n

Sigma-2\/PGRMC1\u53d7\u4f53\u7ed3\u5408\u5242\uff0c\u53ef\u4ee5\u6291\u5236A\u03b2\u4e0eSigma-2\/PGRMC1\u53d7\u4f53\u7ed3\u5408\u3002CogRx\u516c\u53f82015\u5e749\u6708\u5f00\u59cb\u5728114\u4e2a\u5065\u5eb7\u5fd7\u613f\u8005\u8fdb\u884c1\u671f\u4e34\u5e8a\uff0c2016\u5e745\u6708\u5b8c\u6210\u30022016\u5e749\u67081\/2\u671f\u4e34\u5e8a\u5f00\u59cb\u572816\u4e2a\u65e9\u4e2d\u671fAD\u75c5\u4eba\u5728\u6fb3\u5927\u5229\u4e9a\u7684\u51e0\u4e2a\u4e2d\u5fc3\u8fdb\u884c\u3002<\/p>\n

2.2.1.2.4 PF-05251749<\/strong><\/p>\n

\u6ca1\u6709\u900f\u9732\u5177\u4f53\u673a\u5236\u7684\u7b2c\u4e8c\u4e2a1\u671f\u68c0\u6d4b\u8111\u810a\u6db2A\u03b2\u3002\u8f89\u745e2016\u5e7411\u6708\u516c\u53f8\u4ea7\u54c1\u94fe\u5217\u4e3e\u6b64\u5316\u5408\u7269\u4e3aAD\u5728\u7814\u4ea7\u54c1\uff0c\u5df2\u5b8c\u62101\u4e2a\u4e00\u671f\u4e34\u5e8a\u3002\u5e76\u57282016\u5e746\u6708\u5728\u6bd4\u5229\u65f654\u4e2a\u5065\u5eb7\u548c\u5065\u5eb7\u8001\u4eba\u4e2d\u5f00\u59cb\u7b2c\u4e8c\u4e2a\u4e00\u671f\u4e34\u5e8a\u3002<\/p>\n

2.2.2 \u6297\u4f53\u836f\u7269<\/strong><\/p>\n

\u9488\u5bf9A\u03b2\u7684\u6297\u4f53\u662f\u8fd9\u4e2a\u9886\u57df\u505a\u7684\u6700\u591a\u7684\uff0c\u4e5f\u662f\u5931\u8d25\u6700\u591a\u7684\u3002\u5728\u4e94\u4e2a\u4e34\u5e8a\u6570\u636e\u6700\u591a\u7684A\u03b2\u6297\u4f53\u4e2d\uff0c\u8f89\u745e\u7684Ponezumab\u548c\u8f89\u745e\/\u6768\u68ee\u7684Bapineuzumab\u5df2\u7ecf\u88ab\u653e\u5f03\uff0c\u4f46\u7f57\u6c0f\/\u57fa\u56e0\u6cf0\u514b\u7684Crenezumab (MABT510A)\uff081.3\uff0c\u8868\u4e09\uff09\uff0c\u7f57\u6c0f\/\u57fa\u56e0\u6cf0\u514b\/\u4e2d\u5916\u5236\u836f\u7684Gantenerumab (RG1450)\uff081.1\uff0c\u8868\u4e09\uff09\u548c\u793c\u6765\u7684Solanezumab\uff081.1\uff0c1.4\uff09\u90fd\u83b7\u5f97\u4e86\u65b0\u751f\u3002\u867d\u7136\u793c\u6765\u7684\u65b0\u603b\u88c1\u521a\u521a\u5ba3\u5e03\u7ec8\u6b62\u4e86\u521a\u5f00\u59cb\u7684SolanezumabExpediton PRO3\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff086\uff0c \u8868\u4e09\u7ea2\u989c\u8272\uff09\u4f46\u7f57\u6c0f\u521a\u5ba3\u5e03\u5f00\u5c55\u4e00\u4e2a\u65b0\u7684Crenezumab3\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff08\u8868\u4e09\uff0c\u7eff\u989c\u8272\uff09\u3002\u76ee\u524d\u4e1a\u5185\u6700\u770b\u597d\u7684\u662f\u767e\u5065\u7684Aducanumab (BIIB 037\uff0c\u8868\u4e09)\u3002\u5c3d\u7ba12016\u5e74\u516c\u5e03\u7684Aducanumab\u76841\u671f\u4e34\u5e8a\u6570\u636e\u63ed\u793a\u80fd\u591f\u6709\u6548\u51cf\u7f13\u65e9\u671fAD\u75c5\u4eba\u7684\u8ba4\u77e5\u529f\u80fd\u51cf\u9000\uff0c\u4f46\u5982\u4f55\u63a7\u5236\u526f\u4f5c\u7528\u548c\u8fdb\u884c\u4e2d\u76842\u4e2a3\u671f\u4e34\u5e8a\u662f\u5426\u80fd\u91cd\u590d\u8fd9\u4e2a\u6837\u672c\u5f88\u5c0f\u4f46\u5230\u76ee\u524d\u4e3a\u6b62A\u03b2\u9886\u57df\u6700\u597d\u7684\u7ed3\u679c\u53ea\u6709\u65f6\u95f4\u53ef\u4ee5\u56de\u7b54\u3002\u5e0c\u671b2020\u5e74\u53ef\u4ee5\u6709\u597d\u6d88\u606f\u3002<\/p>\n

\"\"<\/a>\u8868\u4e09\uff1a\u5728\u7814A\u03b2\u6297\u4f53\u836f\u7269<\/p>\n

2.2.3 \u75ab\u82d7<\/strong><\/p>\n

\u75ab\u82d7\u662f\u4e2a\u975e\u5e38\u6709\u524d\u666f\u7684\u65b9\u5411\uff0c\u4f46\u5305\u62ec\u8111\u819c\u8111\u708e\u5728\u5185\u7684\u6bd2\u526f\u4f5c\u7528\u662f\u4e2a\u4e9f\u5f85\u89e3\u51b3\u7684\u96be\u70b9\u3002\u76ee\u524dA\u03b2\u9886\u57df\u81f3\u5c11\u67096\u4e2a\u4e34\u5e8a\u671f\u75ab\u82d7\u3002<\/p>\n

2.2.3.1<\/strong>\u8bfa\u534e\u7684CAD106\u75ab\u82d7\u5728\u505a2\/3\u671f\u9884\u9632\u4e34\u5e8a\u8bd5\u9a8c\uff081.6\uff09\u8d70\u5728\u6700\u524d\u6cbf\u3002<\/p>\n

2.2.3.2<\/strong>AC Immune\u516c\u53f8\u7684ACI-24\u75ab\u82d7\u5728\u505a\u4e24\u4e2a\u4e34\u5e8a\u8bd5\u9a8c\uff1a2009\u5e74\u5f00\u59cb\u5728\u6b27\u6d32\u4e0d\u8d85\u8fc7198\u4e2aAD\u75c5\u4eba\u4e2d\u8fdb\u884c 1\/2\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u4f55\u65f6\u5b8c\u6210\u4e0d\u8be6\u548c2016\u5e743\u6708\u5f00\u59cb\u5728\u7f8e\u56fd24\u4e2a\u5510\u6c0f\u7efc\u5408\u75c7\u75c5\u4eba\u4e2d\u8fdb\u884c1\u671f\u4e34\u5e8a\uff0c\u9884\u8ba12019\u5e748\u6708\u5b8c\u6210\u3002<\/p>\n

2.2.3.3<\/strong>Araclon\u7684ABvac 40\u548cABvac42\u75ab\u82d7\u6ca1\u6709\u5728\u4e16\u754c\u536b\u751f\u7ec4\u7ec7\u6216Clinicaltrials.gov\u4e0a\u767b\u5f55\uff0c\u4f46\u516c\u53f8\u7f51\u7ad9\u663e\u793a\u5df2\u57282015\u5e74\u5206\u522b\u8fdb\u51651\u671f\u548c2\u671f\u4e34\u5e8a\u3002<\/p>\n

2.2.3.4<\/strong>AFFiRiS\u516c\u53f82010\u5e749\u6708\u52302013\u5e742\u6708\u5728\u6b27\u6d32\u505a\u4e86332\u4e2aAD\u75c5\u4eba\u7684AFFITOPE AD02\u75ab\u82d72\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u7ed3\u679c\u53d1\u73b0\u75ab\u82d7\u6ca1\u6709\u6548\u679c\u3002\u4f46\u6709\u610f\u601d\u7684\u662f\u8f85\u52a9\u514d\u75ab\u914d\u65b9\uff08\u540e\u6765\u88ab\u8be5\u516c\u53f8\u547d\u540d\u4e3aAD04\uff09\u5bf9\u7167\u7ec4\uff08~50\u75c5\u4eba\uff09\u6709\u7ea6\u4e00\u534a\u75c5\u4eba\u7684\u75c5\u60c5\u5f97\u5230\u7f13\u89e3\u3002AFFiRiS\u516c\u53f8\u8fd8\u5728\u601d\u8003\u4e0b\u4e00\u6b65\u5982\u4f55\u8fdb\u884c\u30022.4.5United\u795e\u7ecf\u79d1\u5b66\u516c\u53f8\u7684UB-311\u75ab\u82d72015\u5e7410\u6708\u5f00\u59cb\u5728\u53f0\u6e7e\u768445\u4e2a\u8f7b\u5ea6\u75c5\u4eba\u4e2d\u8fdb\u884c2\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u9884\u8ba12017\u5e7412\u6708\u5b8c\u6210\u30022.4.6\u7075\u53172015\u5e743\u6708\u5f00\u59cb\u572835\u4e2a\u8f7b\u5ea6\u75c5\u4eba\u4e2d\u5f00\u59cbLu AF20513\u75ab\u82d7\u76841\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u9884\u8ba12017\u5e745\u6708\u5b8c\u6210\u3002<\/p>\n

2.3 Tau\u86cb\u767d\u75c5\u53d8<\/strong><\/p>\n

\u9488\u5bf9Tau\u86cb\u767d\u75c5\u53d8\u7684\u5728\u7814\u836f\u7269\u4e0d\u591a\uff0c\u53ef\u4ee5\u67e5\u5230\u7684\u4e34\u5e8a\u7814\u53d1\u836f\u7269\u67096\u4e2a\uff1a2\u4e2a\u5c0f\u5206\u5b50\uff0c2\u4e2a\u6297\u4f53\u548c2\u4e2a\u75ab\u82d7\u3002<\/p>\n

2.3.1\u5c0f\u5206\u5b50\u836f\u7269<\/strong><\/p>\n

2.3.1.1LMTM\uff0c\u4e9a\u7532\u84dd\uff08Methylene blue\uff09\u884d\u751f\u7269<\/strong><\/p>\n

\u524d\u9762\u63d0\u5230TauRx\u516c\u53f82016\u5e74\u5ba3\u5e03LMTM \u7684\u7b2c\u4e8c\u4e2a3\u671f\u4e34\u5e8a\u5931\u8d25\uff0c\u4f46TauRX\u58f0\u79f0LMTM\u5728\u5b8c\u6210\u7684\u4e24\u4e2a3\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2dLMTM\u5355\u72ec\u4f7f\u7528\u7ec4\u8ddfLMTM\u4e0eAricept\u8054\u5408\u7528\u836f\u7ec4\u5bf9\u7167\u6709\u660e\u663e\u7597\u6548\uff0c\u867d\u7136\u5728\u6d4b\u8bd5\u8fc7\u7684\u5242\u91cf\u4e2d\u6ca1\u6709\u91cf\u6548\u5173\u7cfb\u3002TauRx\u516c\u53f8\u7684\u8fd9\u4e2a\u5206\u6790\u65b9\u5f0f\u906d\u5230\u5f88\u591a\u975e\u8bae\u56e0\u4e3a\u5355\u72ec\u7528\u836f\u7ec4\u6ca1\u6709\u76f8\u5e94\u5b89\u6170\u5242\u5bf9\u7167\u7ec4\uff0c\u4f46\u516c\u53f8\u51c6\u5907\u7ee7\u7eedLMTM\u7684\u7814\u53d1\uff0c\u6b63\u5728\u7b79\u5907LMTM\u5355\u72ec\u7528\u836f\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n

2.3.1.2 TPI 287<\/strong><\/p>\n

Cortice\u516c\u53f8\u7684\u53ef\u4ee5\u5f71\u54cdTau\u75c5\u53d8\u7684\u7684\u6297\u764c\u836f\u3002\u52a0\u5dde\u5927\u5b66\u65e7\u91d1\u5c71\u5206\u68212013\u5e7411\u6708\u5f00\u59cb\u572833\u4e2a\u8f7b\u5230\u4e2d\u5ea6\u75c5\u4eba\u4e2d\u8fdb\u884c1\u671f\u4e34\u5e8a\uff0c\u9884\u8ba12017\u5e7411\u6708\u5b8c\u6210\u3002<\/p>\n

2.3.2 \u6297\u4f53\u836f\u7269<\/strong><\/p>\n

2.3.2.1 ABBV-8E12\uff08C2N 8E12\uff09<\/strong><\/p>\n

AbbVie\u516c\u53f82015\u5e743\u6708\u4eceC2N\u516c\u53f8\u8f6c\u8ba9\u800c\u6765\u7684Tau\u6297\u4f53\uff0c2016\u5e7410\u6708\u5f00\u59cb\u5728400\u4e2a\u65e9\u671fAD\u75c5\u4eba\u4e2d\u8fdb\u884c2\u671f\u4e34\u5e8a\uff0c\u9884\u8ba12020\u5e744\u6708\u5b8c\u6210\u3002\u516c\u53f8\u58f0\u79f0\u53ef\u4ee5\u5c3d\u5feb\u5728\u4e0d\u540c\u7684\u9002\u5f53\u65f6\u673a\u77e5\u9053\u8bd5\u9a8c\u7ed3\u679c\uff0c\u6700\u5927\u7a0b\u5ea6\u63a8\u8fdb\u7814\u53d1\u901f\u5ea6\u3002<\/p>\n

2.3.2.2 RO 7105705\uff08RG 6100\uff09<\/strong><\/p>\n

\u57fa\u56e0\u6cf0\u514b\u548cAC Immune\u516c\u53f8\u8054\u5408\u5f00\u53d1\u7684Tau\u6297\u4f53\u3002\u57fa\u56e0\u6cf0\u514b2016\u5e746\u6708\u5f00\u59cb\u572871\u4e2a\u5065\u5eb7\u4eba\u548c\u8f7b\u5ea6\u5230\u4e2d\u5ea6AD\u75c5\u4eba\u4e2d\u8fdb\u884c1\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u9884\u8ba12017\u5e745\u6708\u5b8c\u6210\u3002<\/p>\n

2.3.3\u75ab\u82d7<\/strong><\/p>\n

2.3.3.1<\/strong><\/p>\n

AADvac-1\u662fAxon \u795e\u7ecf\u79d1\u5b66\u516c\u53f8\u9488\u5bf9Tau\u6c28\u57fa\u9178294\u5230305\u7684\u75ab\u82d7\uff0c2016\u5e743\u6708\u5f00\u59cb\u5728185\u4e2a\u8f7b\u5ea6AD\u75c5\u4eba\u4e2d\u8fdb\u884c2\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u9884\u8ba12019\u5e742\u6708\u5b8c\u6210\u3002<\/p>\n

2.3.3.2<\/strong><\/p>\n

ACI-35\u662fAC Immune\u516c\u53f8\u7814\u53d1\u7684\u9488\u5bf9\u78f7\u9178\u5316Tau\u86cb\u767d\u7684\u75ab\u82d7\uff0c2013\u5e7412\u6708\u5f00\u59cb\u572824\u4e2a\u8f7b\u5ea6\u5230\u4e2d\u5ea6\u7684AD\u75c5\u4eba\u4e2d\u5f00\u59cb1\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c 2015\u5e74\u8f6c\u8ba9\u7ed9\u5f3a\u68ee\u516c\u53f8\uff0c\u76ee\u524d\u8fdb\u5c55\u4e0d\u8be6\u3002<\/p>\n

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\u80f0\u5c9b\u7d20\u548c\u80f0\u5c9b\u7d20\u4fe1\u53f7\u4f20\u5bfc\u7cfb\u7edf<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u80f0\u5c9b\u7d20\u7684\u8131\u654f\uff0cII\u578b\u7cd6\u5c3f\u75c5\u548c\u4ee3\u8c22\u75c5\u662fAD\u6613\u611f\u56e0\u7d20\u3002\u80f0\u5c9b\u7d20\u53ef\u80fd\u4fdd\u62a4A\u03b2\u6bd2\u6027\uff0c\u80f0\u5c9b\u7d20\u7f3a\u4e4f\u6216\u529f\u80fd\u4f4e\u4e0b\u8ddfTau\u75c5\u53d8\uff0c\u708e\u75c7\u548cAD\u7684\u5176\u4ed6\u75c5\u53d8\u90fd\u6709\u5173\u8054\u3002\u4e00\u4e2a\u5c0f\u89c4\u6a21\u7684\u4e34\u5e8a\u8bd5\u9a8c\u5728\u5065\u5eb7\u4eba\u4e2d\u53d1\u73b0\u9f3b\u8154\u5438\u5165\u7684\u80f0\u5c9b\u7d20\u53ef\u4ee5\u589e\u5f3a\u8bb0\u5fc6\u3002\u76ee\u524d\u9664\u4e86\u4e0a\u9762\u63d0\u5230\u7684\u4f4e\u5242\u91cf\u7cd6\u5c3f\u75c5\u836f\u7269\u5339\u683c\u5217\u916e\uff0c\u8fd8\u6709\u51e0\u4e2a\u8fdb\u884c\u4e2d\u7684\u80f0\u5c9b\u7d20AD\u4e34\u5e8a\u8bd5\u9a8c\u3002\u5176\u4e2d\u5357\u52a0\u5dde\u5927\u5b66\u548c\u7f8e\u56fd\u8001\u5e74\u6240\uff0cAD\u836f\u7269\u7814\u7a76\u6240\u53ca\u7ef4\u514b\u68ee\u6797\u5927\u5b66\u5408\u4f5c\u57282013\u5e749\u6708\u5728240\u4e2aaMCI\u6216\u8f7b\u5ea6AD\u75c5\u4eba\u4e2d\u8fdb\u884c\u7684\u80f0\u5c9b\u7d20\uff08\u9f3b\u8154\u7ed9\u836f\uff092\/3\u671f\u4e34\u5e8a\u89c4\u6a21\u8f83\u5927\uff0c\u9884\u8ba1\u4e8e2017\u5e742\u6708\u5b8c\u6210\u3002<\/p>\n

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\u56db<\/section>\n<\/section>\n<\/section>\n<\/section>\n
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\u5176\u4ed6-\u514d\u75ab\uff0c\u795e\u7ecf\uff0c\u708e\u75c7\uff0c\u6297\u6c27\u5316\uff0c5-HT6\u548c\u65b0\u9776\u70b9<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n

\u8fd1\u5e74\u6765\u968f\u7740A\u03b2\u5047\u8bf4\u836f\u7269\u4e34\u5e8a\u8bd5\u9a8c\u7684\u5931\u8d25\uff0c\u6d8c\u73b0\u51fa\u8d8a\u6765\u8d8a\u591a\u7684\u65b0\u9896\u9776\u70b9\uff08\u8868\u56db-\u516d\uff09\uff0c\u5305\u62ec\u8001\u836f\u65b0\u7528\u548c\u88ab\u4ee5\u4e3a\u6709\u6297\u708e\u75c7\u6216\u6c27\u5316\u7684\u529f\u80fd\u6027\u98df\u54c1\uff08\u8868\u56db\uff09\uff0c\u5176\u4e2d\u597d\u591a\u836f\u7269\u5df2\u7ecf\u8fdb\u51652\/3\u671f\u4e34\u5e8a\u9636\u6bb5\uff08\u8868\u4e94\uff09\u3002\u8868\u516d\u5217\u4e3e\u4e861\u671f\u4e34\u5e8a\u548c\u9884\u4e34\u5e8a\u9636\u6bb5\u7684\u7814\u53d1\u836f\u7269\u548c\u9879\u76ee\u3002<\/p>\n

\u4e0a\u5e02\u836f\u4e8c\u6b21\u5f00\u53d1\u76ee\u524d\u5728\u7814\u4ea7\u54c1\u5305\u62ec\u673a\u5236\u5e7f\u6cdb\uff0c2019-2020\u5e74\u5de6\u53f3\u5305\u62ec\u80f0\u5c9b\u7d20\uff0c\u5339\u683c\u5217\u916e\uff08pioglitazone\uff09\u7684\u5927\u578b\u9884\u9632\u8bd5\u9a8c\uff08TOMORROW\uff09\u548cALZT-OP1\u7684\u4e09\u671f\u4e34\u5e8a\u90fd\u4f1a\u5b8c\u6210\uff0c\u671f\u5f85\u6709\u7a81\u7834\u3002<\/p>\n

\u524d\u9762\u63d0\u5230\u7684\u5927\u836f\u4f01\u805a\u7126\u5728\u6dc0\u7c89\u6027\u86cb\u767d\u75c5\u53d8\u7684\u5047\u8bf4\u7684\u5371\u5bb3\u5728\u4e8e\u975e\u5927\u836f\u4f01\u51fa\u8d44\u7684\u4e34\u5e8a\u8bd5\u9a8c\u90fd\u5f88\u96be\u6709\u89c4\u6a21\uff0c\u800c\u4e14\u5c0f\u516c\u53f8\u7684\u4e34\u5e8a\u7814\u53d1\u7ecf\u9a8c\u8ddf\u5927\u836f\u4f01\u6ca1\u6709\u53ef\u6bd4\u6027\u3002\u53e6\u5916\uff0c\u6dc0\u7c89\u6027\u86cb\u767d\u75c5\u53d8\u7684\u805a\u7126\u5bfc\u81f4\u6ca1\u6709\u66f4\u591a\u65b0\u836f\u83b7\u6279\uff0c\u76ee\u524d\u6279\u51c6\u836f\u4e4b\u5916\u7684\u8054\u5408\u7528\u836f\u4e34\u5e8a\u8bd5\u9a8c\u4e5f\u6ca1\u6cd5\u5f00\u5c55\u3002\u76ee\u524d\u5728\u7814\u7684AD\u836f\u7269\u8d85\u8fc71000\u4eba\u7684\u4e09\u671f\u4e34\u5e8a\u57fa\u672c\u4e0a\u90fd\u662f\u5927\u836f\u4f01\u5728\u505a\uff0c \u552f\u4e00\u7684\u4f8b\u5916\u662f\u4e00\u4e2a\u8d44\u672c\u8fd0\u4f5c\u9ad8\u624b\u6210\u7acb\u7684Roxvant\u7684\u4e24\u4e2a5HT6\u62ee\u6297\u5242RVT-101\u7684\u4e09\u671f\u4e34\u5e8a\uff08\u8868\u4e94\uff09\u3002\u867d\u7136\u7075\u5317\u6700\u8fd1\u5ba3\u5e03\u51765HT6\u62ee\u6297\u5242idalopirdine\u7684\u5927\u578b\u4e09\u671f\u4e34\u5e8a\u5931\u8d25\uff0c\u5e0c\u671b\u90a3\u662f\u56e0\u4e3aidalopirdine\u5242\u91cf\u548c\u4e34\u5e8a\u8bbe\u8ba1\u95ee\u9898\u800c\u4e0d\u662f\u9776\u70b9\u672c\u8eab\u3002 Roxvant\u7684\u7b2c\u4e00\u4e2a\u4e09\u671f\u4e34\u5e8a\u4eca\u5e74\u5e74\u5e95\u5b8c\u6210\u3002<\/p>\n

\"\"<\/a>\u8868\u56db\uff1a\u4e0a\u5e02\u836f\u548c\u4fdd\u5065\u54c1\u4e8c\u6b21\u5f00\u53d1\"\"<\/a>\u8868\u4e94:2-3\u671f\u4e34\u5e8aAD\u5728\u7814\u836f\u7269<\/p>\n

\u6211\u4eec\u770b\u597d\u7684\u65b0\u9896\u9776\u70b9\u5305\u62ec\uff1a<\/strong><\/p>\n

\uff081\uff09\u795e\u7ecf\u514d\u75ab\u548c\u708e\u75c7\u3002<\/strong>\u80f6\u8d28\u7ec6\u80de\u3001\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u5728AD \u53d1\u75c5\u4e2d\u7684\u91cd\u8981\u6027\u65e5\u65e5\u53d7\u5230\u91cd\u89c6\uff0c\u5e76\u4e14\u5f15\u53d1\u51fa\u5f88\u591a\u65b0\u9896\u3001\u5df2\u6210\u836f\u548c\u53ef\u6210\u836f\u9776\u70b9\uff1b<\/p>\n

\uff082\uff09\u8868\u89c2\u9057\u4f20\u8c03\u63a7\u3002<\/strong>\u7ec4\u86cb\u767d\u5bc6\u7801(Histone code)\u5047\u8bf4\u5df2\u7ecf\u5f62\u6210\u591a\u5e74\uff0c\u5927\u91cf\u7814\u7a76\u8868\u660e\u7ec4\u86cb\u767d\u8131\u4e59\u9170\u57fa\u9176(HDAC)\u5728\u8ba4\u77e5\u5b66\u4e60\u4e2d\u8d77\u91cd\u8981\u4f5c\u7528\u3002Oryzon\u7684ORY-2001\u662f\u7b2c\u4e00\u4e2a\u8fdb\u5165\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u4e34\u5e8a\u7684\u8868\u89c2\u9057\u4f20\u836f\u7269\uff0c2016\u5e74\u5f00\u59cb\u4e34\u5e8a\u8bd5\u9a8c \uff08\u8868\u516d\uff09\u3002Rodin\u7684HDAC2\u548cRegenacy\u7684HDAC1\/2\uff0c HDAC6\u9879\u76ee\u90fd\u5df2\u7ecf\u53d6\u5f97\u5f88\u5927\u8fdb\u5c55\u3002Rodin2016\u5e74\u8ddf\u767e\u5065\u7b7e\u7f72\u4e86\u6700\u9ad8\u53ef\u4ee5\u591a\u59274.85\u4ebf\u7684\u5408\u4f5c\u534f\u8bae\u3002Regenacy\u662fAcetylon\u7684HDAC\u80bf\u7624\u9879\u76ee\u88ab\u65b0\u57fa(Celgene)\u6536\u8d2d\u540e\u65b0\u6210\u7acb\u7684\u805a\u7126HDAC\u6291\u5236\u5242\u5728\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7684\u516c\u53f8\uff08\u8868\u516d\uff09\uff1b<\/p>\n

\uff083\uff09\u5f71\u54cd\u795e\u7ecf\u73af\u8def(neural circuit)\u7684\u9776\u70b9\u3002<\/strong>\u6b64\u7c7b\u9776\u70b9\u5982\u78f7\u9178\u4e8c\u916f\u9176\uff08PDE\uff09\u901a\u5e38\u4e0d\u9488\u5bf9AD\uff0c \u800c\u662f\u901a\u8fc7\u5f71\u54cd\u4e00\u4e2a\u8fdb\u5316\u8fc7\u7a0b\u4e2d\u5171\u4eab\u7684\u6bd4\u55bb\u8bb0\u5fc6\u5f62\u6210\u673a\u5236\u8d77\u4f5c\u7528\u3002PDE4\u6291\u5236\u5242\u662f\u7814\u7a76\u5728\u589e\u5f3a\u8bb0\u5fc6\u9886\u57df\u7814\u7a76\u8f83\u591a\u7684\u4e00\u4e2a\u9776\u70b9\u3002Dart \u795e\u7ecf\u79d1\u5b66\u7684HT-0712\u57282005\u5e74\u8fdb\u5165\u4e34\u5e8a\uff0c2015\u5e74\u5728119\u4e2a\u5e74\u9f84\u76f8\u5173\u8ba4\u77e5\u969c\u788d\u75c5\u4eba\uff08AAMI\uff09\u4e2d\u5b8c\u6210\u76842\u671f\u4e34\u5e8a\uff08PRIME\uff09\u53d1\u73b0\u4e00\u4e2a\u5242\u91cf\u53ef\u4ee5\u63d0\u9ad8\u5355\u8bcd\u590d\u8ff0\u3002Tetra Discovery\u7684PDE4D\u9009\u62e9\u6027\u8d1f\u5411\u522b\u6784\u8c03\u8282\u5242\uff08NAM\uff09BPN14770\u4eca\u5e74\u8fdb\u5165\u4e00\u671f\u4e34\u5e8a\uff0c\u76ee\u7684\u662f\u907f\u5f00PDE4\u6291\u5236\u5242\u7684\u5455\u5410\u526f\u4f5c\u7528(\u8868\u516d)\u3002\u53e6\u5916\uff0c\u54e5\u4f26\u6bd4\u4e9a\u5927\u5b66\u7684Arancio\u6559\u6388\u5728\u5f00\u53d1\u53ef\u4ee5\u901a\u8fc7\u8840\u8111\u5c4f\u969c\u7684PDE5\u6291\u5236\u5242\u3002<\/p>\n

\"\"<\/a>\u8868\u516d:1\u671f\u4e34\u5e8a\u548c\u9884\u4e34\u5e8aAD\u5728\u7814\u836f\u7269\u548c\u9879\u76ee<\/p>\n

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\u4e2d\u836f\u6210\u5206\u590d\u6742\uff0c\u53ef\u4ee5\u5e94\u5bf9\u591a\u9776\u70b9\uff0c\u6709\u53ef\u80fd\u662f\u4e2a\u53d1\u73b0\u6709\u6548AD\u7597\u6cd5\u7684\u597d\u6e90\u6cc9\u3002\u67e5\u8be2\u6587\u732e\u4e2d\u6709\u590d\u65b9\u5236\u5242\u53ef\u4ee5\u6cbb\u7597AD\u7684\u62a5\u5bfc\uff0c\u4f46\u7f3a\u4e4f\u5927\u578b\u591a\u4e2d\u5fc3\u968f\u673a\u53cc\u76f2\u8bd5\u9a8c\u6765\u9a8c\u8bc1\u7597\u6548\u3002<\/p>\n

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\u836f\u7269\u7814\u53d1\u662f\u4e00\u4e2a\u591a\u65b9\u5206\u5de5\u5408\u4f5c\u3001\u5145\u6ee1\u6311\u6218\u548c\u4e50\u8da3\u7684\u8fc7\u7a0b\u3002\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u662f\u76ee\u524d\u5236\u836f\u754c\u6700\u5927\u7684\u6311\u6218\u4e4b\u4e00\uff0c\u8054\u5408\u7528\u836f\u662f\u76ee\u524d\u7684\u4e3b\u6d41\u65b9\u5411\uff0c\u4f46\u4e5f\u9700\u8981\u6709\u6548\u7684\u836f\u7269\u3002\u8f89\u745e\u597d\u50cf\u6b63\u5728\u6084\u6084\u4e3a\u5c06\u6765\u7684\u8054\u5408\u7528\u836f\u5e03\u5c40\uff0c\u6211\u4eec\u4e5f\u5728\u4e3a\u8054\u5408\u7528\u836f\u505a\u51c6\u5907\u3002\u7eb5\u89c2\u76ee\u524d\u5728\u7814\u7684AD\u836f\u7269\uff0c\u77ed\u671f\u5185\u9664\u975eA\u03b2\u7684\u9884\u9632\u6027\u4e34\u5e8a\u8bd5\u9a8c\u6709\u91cd\u5927\u7a81\u7834\uff0c\u5176\u4ed6\u9776\u70b9\u90fd\u9700\u8981\u65f6\u95f4\u3002\u73b0\u5728\u662f\u5e03\u5c40\u548c\u52a0\u5165AD\u836f\u7269\u7814\u53d1\u7684\u597d\u65f6\u5019\u3002<\/p>\n

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