{"id":788752,"date":"2017-04-25T20:16:26","date_gmt":"2017-04-26T03:16:26","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=788752"},"modified":"2017-05-20T11:47:06","modified_gmt":"2017-05-20T18:47:06","slug":"%e5%90%8c%e6%97%b6%e6%89%a7%e6%8e%8c3%e5%ae%b6%e6%96%b0%e9%94%90%e7%9a%84%e6%98%8e%e6%98%9fceo%ef%bc%9a%e7%b2%be%e5%87%86%e5%8c%bb%e5%ad%a6%e5%b7%b2%e5%88%b0%e5%8f%91%e5%b1%95%e6%8b%90%e7%82%b9","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/%e5%90%8c%e6%97%b6%e6%89%a7%e6%8e%8c3%e5%ae%b6%e6%96%b0%e9%94%90%e7%9a%84%e6%98%8e%e6%98%9fceo%ef%bc%9a%e7%b2%be%e5%87%86%e5%8c%bb%e5%ad%a6%e5%b7%b2%e5%88%b0%e5%8f%91%e5%b1%95%e6%8b%90%e7%82%b9\/.html","title":{"rendered":"\u540c\u65f6\u6267\u638c3\u5bb6\u65b0\u9510\u7684\u660e\u661fCEO\uff1a\u7cbe\u51c6\u533b\u5b66\u5df2\u5230\u53d1\u5c55\u62d0\u70b9\uff08\u56fe\uff09"},"content":{"rendered":"

\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053<\/strong><\/p>\n

\u7f16\u8005\u6309\uff1a<\/strong>\u5728\u52a0\u5dde\u7684\u751f\u7269\u6280\u672f\u521b\u6295\u5708\uff0cTroy Wilson\u535a\u58eb\u662f\u4e00\u4e2a\u54cd\u4eae\u7684\u540d\u5b57\u3002\u4f5c\u4e3a\u4e00\u540d\u4e1a\u7ee9\u7d2f\u7d2f\u7684\u8fde\u7eed\u521b\u4e1a\u8005\uff0c\u4ed6\u5148\u540e\u53c2\u4e0e\u521b\u7acb\u4e86Ambrx\u3001Intellikine\u3001Wellspring Biosciences\u3001Avidity Biosciences\u4e0eKura Oncology\u7b49\u516c\u53f8\uff0c\u76ee\u524d\u4ecd\u540c\u65f6\u517c\u4efbWellspring\u3001Avidity\u4e0eKura\u4e09\u5bb6\u516c\u53f8\u7684\u9996\u5e2d\u6267\u884c\u5b98\u3002\u8fd9\u4e09\u5bb6\u516c\u53f8\u90fd\u5728\u4ee5\u57fa\u4e8e\u7cbe\u51c6\u533b\u5b66\u7684\u65b9\u5f0f\u5f00\u8f9f\u521b\u65b0\u9014\u5f84\u3002\u5176\u4e2d\uff0cWellspring\u4e13\u6ce8\u4e8e\u7814\u53d1\u9488\u5bf9KRAS\u7684\u836f\u7269\u3001Avidity\u7387\u5148\u5e94\u7528\u6297\u4f53-siRNA\u7f00\u5408\u7269\u6765\u514b\u670d\u5be1\u6838\u82f7\u9178\u8f93\u9001\u969c\u788d\u3001\u800cKura\u7684\u9886\u5148\u5019\u9009\u836f\u7269\u4e5f\u5df2\u5728\u9488\u5bf9HRAS<\/em>\u7a81\u53d8\u578b\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u75c7\u76842\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8868\u73b0\u51fa\u4ee4\u4eba\u9f13\u821e\u7684\u7ed3\u679c\u3002\u8fd1\u65e5\uff0c\u6211\u4eec\u4e0eWilson\u535a\u58eb\u8fdb\u884c\u4e86\u4e00\u6b21\u957f\u8c08\uff0c\u542c\u8fd9\u540d\u8fde\u7eed\u521b\u4e1a\u8005\u5206\u4eab\u4e86\u764c\u75c7\u7cbe\u51c6\u533b\u5b66\u9053\u8def\u4e0a\u7684\u524d\u666f\u4e0e\u6311\u6218\u3002<\/section>\n

<\/p>\n

\u836f\u660e\u5eb7\u5fb7\uff1a<\/strong>Wilson\u535a\u58eb\u60a8\u597d\uff0c\u6211\u4eec\u7684\u8bfb\u8005\u5bf9\u60a8\u8fde\u7eed\u521b\u4e1a\u8005\u7684\u8eab\u4efd\u975e\u5e38\u611f\u5174\u8da3\uff0c\u60a8\u80fd\u5148\u4e3a\u6211\u4eec\u7684\u8bfb\u8005\u670b\u53cb\u4eec\u4ecb\u7ecd\u4e0b\u60a8\u51fa\u4efb\u9996\u5e2d\u6267\u884c\u5b98\u7684\u4e09\u5bb6\u516c\u53f8\u5417\uff1f<\/p>\n

Troy Wilson\u535a\u58eb\uff1a<\/strong>\u6211\u5148\u8bf4\u4e00\u4e0bKura Oncology\u5427\u3002Kura\u7684\u9886\u5148\u5728\u7814\u836f\u7269tipifarnib\u662f\u4e00\u6b3e\u6cd5\u5462\u57fa\u8f6c\u79fb\u9176\uff08\u7b80\u79f0FT\uff09\u7684\u9009\u62e9\u6027\u5f3a\u6548\u6291\u5236\u5242\u3002FT\u662f20\u4e16\u7eaa90\u5e74\u4ee3\u6700\u65e9\u7814\u7a76\u7684\u764c\u75c7\u5206\u5b50\u9776\u70b9\u4e4b\u4e00\uff0c\u4eba\u4eec\u76f8\u4fe1\u901a\u8fc7\u9776\u5411FT\uff0c\u53ef\u4ee5\u6291\u5236RAS\u7a81\u53d8\u5bfc\u81f4\u7684\u80bf\u7624\u3002\u7136\u800c\u5f53\u65f6\u7684\u65f6\u673a\u5e76\u4e0d\u662f\u5f88\u597d\uff0c\u4eba\u4eec\u8fd8\u5904\u5728\u764c\u75c7\u7ec6\u80de\u4fe1\u53f7\u4f20\u5bfc\u7684\u751f\u7269\u5b66\u7814\u7a76\u521d\u671f\uff0c\u4e0b\u4e00\u4ee3\u6d4b\u5e8f\uff08NGS\uff09\u7b49\u6280\u672f\u4e5f\u5c1a\u672a\u666e\u53ca\u3002\u4ece\u672c\u8d28\u4e0a\u8bf4\uff0c\u5f53\u65f6\u4eba\u4eec\u867d\u7136\u8bd5\u56fe\u5f00\u53d1\u7cbe\u51c6\u533b\u5b66\u7684\u836f\u7269\uff0c\u4f46\u5374\u4e0d\u5177\u5907\u76f8\u5173\u7684\u6280\u672f\u5de5\u5177\u548c\u8ba4\u8bc6\u3002\u51fa\u4e8e\u8fd9\u4e9b\u539f\u56e0\uff0c\u5230\u4e862006\u5e74\uff0c\u8bb8\u591a\u5927\u516c\u53f8\u90fd\u653e\u5f03\u4e86FT\u6291\u5236\u5242\u9879\u76ee\u3002<\/p>\n

\u4f46\u6211\u4eec\u5728tipifarnib\u4e0a\u770b\u5230\u4e86\u51e0\u4e2a\u5f15\u4eba\u6ce8\u76ee\u7684\u7279\u5f81\uff0c\u5b83\u5728\u4e00\u4e9b\u60a3\u8005\u8eab\u4e0a\u663e\u793a\u51fa\u6301\u4e45\u7684\u6297\u764c\u6d3b\u6027\uff0c\u526f\u4f5c\u7528\u53ef\u88ab\u63a7\u5236\uff0c\u5b89\u5168\u6027\u6570\u636e\u6db5\u76d6\u4e86\u591a\u8fbe5000\u591a\u540d\u60a3\u8005\uff0c\u8fd9\u90fd\u8ba9\u5b83\u6709\u671b\u6210\u4e3a\u4e00\u6b3e\u51fa\u8272\u7684\u5019\u9009\u836f\u7269\u3002\u5f53\u65f6\u7684\u6311\u6218\u5728\u4e8e\u7814\u7a76\u4eba\u5458\u9700\u8981\u4e86\u89e3tipifarnib\u7684\u5206\u5b50\u673a\u5236\u548c\u9002\u7528\u7684\u60a3\u8005\u4eba\u7fa4\u3002\u6211\u4eec\u76f8\u4fe1\u6211\u4eec\u80fd\u9610\u660e\u6cd5\u5462\u57fa\u8f6c\u79fb\u9176\u7684\u751f\u7269\u5b66\u673a\u5236\uff0c\u5e76\u79ef\u6781\u53c2\u8003\u4e34\u5e8a\u89c2\u5bdf\u7ed3\u679c\u548cNGS\u7b49\u6280\u672f\uff0c\u9009\u62e9\u5408\u9002\u7684\u60a3\u8005\u3002\u56e0\u6b64\uff0c\u6211\u4eec\u83b7\u5f97\u4e86\u8fd9\u6b3e\u836f\u7269\u7684\u4e13\u5229\u8bb8\u53ef\uff0c\u5e76\u4f7f\u7528\u7cbe\u51c6\u533b\u5b66\u7684\u624b\u6bb5\u5bf9\u5b83\u7ee7\u7eed\u5f00\u53d1\u3002\u76ee\u524d\uff0c\u8fd9\u6b3e\u836f\u7269\u5728EGFR\uff0cALK\uff0cBRAF\u548cTRK\u7b49\u591a\u79cd\u764c\u75c7\u9776\u6807\u4e0a\u90fd\u663e\u793a\u51fa\u4e86\u4e00\u5b9a\u7684\u6210\u6548\u3002\u6211\u5f53\u65f6\u5f00\u73a9\u7b11\u8bf4tipifarnib\u662f\u201c\u9886\u5148\u4e8e\u65f6\u4ee3\u7684\u836f\u7269\u201d\uff0c\u4f46\u6211\u4e50\u89c2\u5730\u8ba4\u4e3a\uff0c\u76ee\u524d\u5c5e\u4e8e\u5b83\u7684\u6b63\u786e\u65f6\u673a\u6b63\u5728\u6765\u4e34\u3002<\/strong><\/p>\n

<\/p>\n

\u25b2Tipifarnib\u8fd9\u6b3e\u201c\u9886\u5148\u4e8e\u65f6\u4ee3\u7684\u836f\u7269\u201d\uff0c\u6b63\u8fce\u6765\u5b83\u7684\u6b63\u786e\u65f6\u673a<\/strong>\uff08\u56fe\u7247\u6765\u6e90\uff1aSelleck Chemicals<\/strong>\uff09<\/strong><\/p>\n

\u836f\u660e\u5eb7\u5fb7\uff1a<\/strong>Tipifarnib\u76ee\u524d\u7684\u7814\u53d1\u8fdb\u5c55\u600e\u6837\uff1f<\/p>\n

Troy Wilson\u535a\u58eb\uff1a<\/strong>\u76ee\u524d\u6211\u4eec\u6b63\u5728\u56db\u4e2a\u4e0d\u540c\u7684\u9002\u5e94\u75c7\u4e0a\u5f00\u5c55tipifarnib\u76842\u671f\u4e34\u5e8a\u8bd5\u9a8c\u3002\u5728HRAS<\/em>\u7a81\u53d8\u578b\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u75c7\u60a3\u8005\u7684\u6cbb\u7597\u4e2d\uff0c tipifarnib\u5df2\u7ecf\u663e\u793a\u51fa\u4e86\u4ee4\u4eba\u9f13\u821e\u7684\u7ed3\u679c\u3002\u4e8b\u5b9e\u4e0a\uff0c\u6211\u4eec\u80fd\u5f88\u5feb\u786e\u8ba4HRAS<\/em>\u7a81\u53d8\u578b\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u764c\u75c7\u8fd9\u4e00\u9002\u5e94\u75c7\uff0c\u672c\u8eab\u4e5f\u53cd\u6620\u4e86\u57fa\u4e8e\u7cbe\u51c6\u533b\u5b66\u7684\u836f\u7269\u7814\u53d1\u624b\u6bb5\u4e4b\u5f3a\u5927\u3002\u76ee\u524d\uff0c\u6211\u4eec\u6b63\u5728\u62db\u52df\u66f4\u591a\u60a3\u8005\uff0c\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u6211\u4eec\u7684\u521d\u6b65\u53d1\u73b0\u3002\u6b64\u5916\uff0c\u6211\u4eec\u4e5f\u6b63\u5728\u5f00\u5c55\u53e6\u59163\u98792\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u6570\u636e\u5c06\u4e8e\u660e\u5e74\u516c\u5e03\u3002<\/p>\n

\u5bf9\u4e8e\u8fd9\u4e00\u8fdb\u5ea6\uff0c\u6211\u4eec\u611f\u5230\u975e\u5e38\u6ee1\u610f\u3002\u5c3d\u7ba1\u6240\u6709\u7684\u4e34\u5e8a\u524d\u6570\u636e\u90fd\u663e\u793aHRAS<\/em>\u662f\u4e00\u79cd\u201c\u53ef\u6210\u836f\u201d\u7684\u81f4\u764c\u57fa\u56e0\uff0c\u4f46\u4e34\u5e8a\u524d\u6570\u636e\u5e76\u4e0d\u603b\u80fd\u8f6c\u5316\u4e3a\u4e34\u5e8a\u7ed3\u679c\u3002\u80fd\u770b\u5230tipifarnib\u5728HRAS<\/em>\u7a81\u53d8\u578b\u5934\u9888\u90e8\u9cde\u72b6\u7ec6\u80de\u6076\u6027\u80bf\u7624\u60a3\u8005\u4e2d\u663e\u793a\u51fa\u5145\u6ee1\u6f5c\u529b\u7684\u4e34\u5e8a\u6d3b\u6027\uff0c\u6211\u4eec\u611f\u5230\u975e\u5e38\u9ad8\u5174\u3002\u76ee\u524d\u6211\u4eec\u7684\u6570\u636e\u53ea\u6d89\u53ca\u4e09\u540d\u60a3\u8005\uff0c\u7814\u7a76\u8fd8\u662f\u5f88\u65e9\u671f\uff0c\u4f46\u5b83\u7684\u6301\u7eed\u6548\u679c\u7ed9\u6211\u4eec\u7559\u4e0b\u4e86\u5f88\u6df1\u7684\u5370\u8c61\u3002\u8fd9\u4e09\u540d\u60a3\u8005\u4e2d\uff0c\u6709\u4e24\u540d\u60a3\u8005\u7684\u8bd5\u9a8c\u6301\u7eed\u4e86<\/strong>16\u4e2a\u6708<\/strong>\u548c10\u4e2a\u6708\uff0c\u8fd9\u975e\u540c\u5bfb\u5e38\uff0c\u4ee4\u4eba\u5174\u594b\u3002<\/strong><\/p>\n

\u836f\u660e\u5eb7\u5fb7\uff1a<\/strong>\u80fd\u8bf4\u8bf4\u53e6\u5916\u4e24\u5bb6\u516c\u53f8\u5417\uff1fAvidity\u4eca\u5e74\u4e00\u6708\u521a\u5b8c\u62101600\u4e07\u7f8e\u5143\u7684B\u8f6e\u878d\u8d44\uff0cWellspring\u5219\u8fd8\u4fdd\u6301\u7740\u795e\u79d8\u3002\u8fd9\u4e24\u5bb6\u516c\u53f8\u4f1a\u5728\u4eca\u5e74\u8fce\u6765\u600e\u6837\u7684\u8fdb\u5c55\uff1f<\/p>\n

Troy Wilson\u535a\u58eb\uff1a<\/strong>Avidity\u6709\u671b\u80fd\u89e3\u51b3siRNA\u548c\u5176\u4ed6\u5be1\u6838\u82f7\u9178\u836f\u7269\u8f93\u9001\u7684\u4f20\u7edf\u969c\u788d\u3002\u867d\u7136\u57fa\u4e8esiRNA\u7684\u6cbb\u7597\u65b9\u6cd5\u5df2\u7ecf\u663e\u793a\u51fa\u91cd\u8981\u7684\u4e34\u5e8a\u548c\u5546\u4e1a\u524d\u666f\uff0c\u4f46\u5927\u90e8\u5206\u5e38\u89c4\u65b9\u6cd5\u90fd\u9650\u4e8e\u9776\u5411\u809d\u810f\u3002Avidity\u6b63\u5728\u505a\u4e00\u4e9b\u5b8c\u5168\u4e0d\u540c\u7684\u4e8b\u60c5\u3002Avidity\u7684\u6297\u4f53-siRNA\u7f00\u5408\u7269\uff08ASCs\uff09\u5728\u808c\u8089\uff0c\u514d\u75ab\u7ec6\u80de\u548c\u80bf\u7624\u7b49\u591a\u79cd\u7ec4\u7ec7\u4e2d\u5c55\u73b0\u4e86\u524d\u6240\u672a\u6709\u7684\u57fa\u56e0\u963b\u65ad\u6c34\u5e73\uff0c\u56e0\u6b64\u6709\u6f5c\u529b\u7528\u4e8e\u808c\u8089\u75be\u75c5\u3001\u708e\u75c7\u548c\u80bf\u7624\u7b49\u5e7f\u6cdb\u7684\u6cbb\u7597\u9886\u57df\u3002Avidity\u6b63\u5728\u4e0e\u4e00\u4e9b\u9886\u5148\u7684\u751f\u7269\u6280\u672f\u548c\u5236\u836f\u516c\u53f8\u5408\u4f5c\uff0c\u7814\u7a76\u4e00\u7cfb\u5217\u9776\u5411\u9057\u4f20\u56e0\u7d20\u7684ASCs\u836f\u7269\u3002\u5176\u4e2d\u4e24\u4e2a\u5408\u4f5c\u5173\u7cfb\u6b63\u5728\u8fdb\u884c\u4e4b\u4e2d\uff0c\u6211\u9884\u8ba1\u672a\u6765\u8fd8\u4f1a\u6709\u66f4\u591a\u7684\u5408\u4f5c\u3002<\/p>\n

\u5173\u4e8eWellspring\u548c\u5b83\u7684\u7814\u53d1\u9879\u76ee\uff0c\u6211\u8fd8\u4e0d\u80fd\u900f\u9732\u592a\u591a\u3002\u8fd9\u91cc\u6211\u53ea\u80fd\u8bf4\uff0c\u76ee\u524d\u6211\u4eec\u7684\u56e2\u961f\u6b63\u5728\u7528\u5f00\u521b\u6027\u7684\u65b9\u6cd5\u6765\u7814\u7a76\u9776\u5411KRAS G12C\u7a81\u53d8\u81f4\u764c\u86cb\u767d\u7684\u836f\u7269\uff0c\u4e5f\u5df2\u7ecf\u53d1\u8868\u4e86\u4e00\u4e9b\u4ee4\u4eba\u5370\u8c61\u6df1\u523b\u7684\u8bba\u6587\u3002\u4ece\u8fd9\u4e9b\u8bba\u6587\u53ef\u4ee5\u770b\u51fa\uff0c\u6211\u4eec\u7684\u5316\u5408\u7269\u6b63\u53d8\u5f97\u66f4\u5f3a\u6548\uff0c\u66f4\u6709\u7279\u5f02\u6027\uff0c\u66f4\u50cf\u836f\u7269\u3002\u8bb8\u591a\u5e74\u6765\uff0c\u4eba\u4eec\u4e00\u76f4\u8bf4\u201cRAS\u65e0\u6210\u836f\u6027\u201d\uff0c\u4f46\u5728\u73b0\u5728\u7684\u5b66\u672f\u4f1a\u8bae\u4e0a\uff0c\u5df2\u7ecf\u6709\u58f0\u97f3\u8ba4\u4e3a\uff0cKRAS G12C\u53ef\u80fd\u662f\u7b2c\u4e00\u4e2a\u83b7\u5f97\u6210\u529f\u7684KRAS\u764c\u86cb\u767d\u836f\u7269\u9776\u70b9\u3002<\/strong>\u76ee\u524dWellspring\u56e2\u961f\u6b63\u5728\u52aa\u529b\u5de5\u4f5c\uff0c\u7acb\u5fd7\u505a\u51fa\u9996\u4e2a\u9776\u5411KRAS\u7684\u836f\u7269\u3002<\/p>\n

<\/p>\n

\u25b2Wellspring\u7acb\u5fd7\u7814\u53d1\u51fa\u9996\u4e2a\u9776\u5411KRAS\u7684\u836f\u7269<\/strong>\uff08\u56fe\u7247\u6765\u6e90\uff1aWellspring\u5b98\u65b9\u7f51\u7ad9<\/strong>\uff09<\/strong><\/p>\n

\u836f\u660e\u5eb7\u5fb7\uff1a<\/strong>\u201c\u65e0\u6210\u836f\u6027\u201d\u7684\u9776\u5411\u836f\u5f88\u96be\u7814\u53d1\uff0c\u60a8\u4e3a\u4f55\u4f1a\u9009\u62e9\u8fd9\u4e00\u9053\u8def\u5462\uff1f<\/p>\n

Troy Wilson\u535a\u58eb\uff1a<\/strong>\u5728\u6211\u5f00\u59cb\u521b\u4e1a\u540e\u4e0d\u4e45\uff0c\u6211\u7684\u6bcd\u4eb2\u56e0\u4e3a\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u53bb\u4e16\u4e86\u3002 \u5728\u5979\u751f\u547d\u7684\u6700\u540e\u4e00\u5e74\u91cc\uff0c\u6211\u82b1\u4e86\u5f88\u591a\u65f6\u95f4\u7167\u987e\u5979\uff0c\u8fd9\u6bb5\u7ecf\u5386\u771f\u7684\u8ba9\u6211\u610f\u8bc6\u5230\u764c\u75c7\u60a3\u8005\u627f\u62c5\u7684\u75db\u82e6\uff0c\u6211\u4eec\u6781\u5ea6\u9700\u8981\u66f4\u597d\u7684\u6cbb\u7597\u65b9\u6cd5\u300220\u5e74\u540e\u770b\uff0c\u6211\u4eec\u73b0\u5728\u6b63\u5904\u4e8e\u80bf\u7624\u5b66\u7684\u9ec4\u91d1\u65f6\u4ee3\uff0c\u6211\u60f3\u5c3d\u5168\u529b\u628a\u764c\u75c7\u53d8\u6210\u4e00\u4e2a\u53ef\u4ee5\u957f\u671f\u7ba1\u7406\u7684\u6162\u6027\u75be\u75c5\uff0c\u50cf\u827e\u6ecb\u75c5\uff0c\u809d\u708e\u6216\u67d0\u4e9b\u7f55\u89c1\u75be\u75c5\u4e00\u6837\u3002\u6211\u76f8\u4fe1\u6211\u4eec\u4f1a\u5b9e\u73b0\u8fd9\u4e2a\u76ee\u6807\u3002<\/p>\n

\u836f\u660e\u5eb7\u5fb7\uff1a<\/strong>\u540c\u65f6\u8fd0\u8425\u4e09\u5bb6\u751f\u7269\u6280\u672f\u65b0\u9510\uff0c\u4e00\u5b9a\u5f88\u6709\u6311\u6218\u5427\uff1f<\/p>\n

Troy Wilson\u535a\u58eb\uff1a<\/strong>\u7684\u786e\u6709\u6311\u6218\u3002\u8fd0\u8425\u4e09\u5bb6\u516c\u53f8\uff0c\u6211\u4eec\u9700\u8981\u8bbe\u7acb\u6709\u6311\u6218\u4f46\u53ef\u53ca\u7684\u76ee\u6807\uff0c\u62db\u52df\u6770\u51fa\u4eba\u624d\uff0c\u521b\u9020\u4e00\u4e2a\u5145\u6ee1\u6fc0\u60c5\u3001\u521b\u9020\u529b\u548c\u594b\u6597\u7cbe\u795e\u7684\u5de5\u4f5c\u6c1b\u56f4\u6765\u6fc0\u52b1\u5458\u5de5\u3002\u4f46\u6211\u60f3\u597d\u5904\u66f4\u663e\u800c\u6613\u89c1\u3002\u9996\u5148\uff0c\u6211\u4eec\u80fd\u83b7\u5f97\u5927\u91cf\u7684\u79d1\u5b66\u6570\u636e\u3002\u6211\u662f\u4e00\u4e2a\u6570\u636e\u72c2\uff0c\u65e0\u8bba\u662f\u5b9e\u9a8c\u6570\u636e\u8fd8\u662f\u4e34\u5e8a\u6570\u636e\uff0c\u6211\u90fd\u559c\u6b22\u3002\u6211\u8ba4\u4e3a\u4e0e\u6570\u636e\u4fdd\u6301\u63a5\u8fd1\u975e\u5e38\u91cd\u8981\u3002\u5b89\u8fdb\u516c\u53f8\u7b2c\u4e00\u4efb\u9996\u5e2d\u6267\u884c\u5b98George Rathmann\u535a\u58eb\u66fe\u7ecf\u8bf4\u8fc7\uff0c\u201c\u5982\u679c\u6211\u4e0e\u79d1\u5b66\u8d70\u5f97\u5f88\u8fd1\uff0c\u90a3\u6bcf\u4e2a\u4eba\u90fd\u4f1a\u4e0e\u79d1\u5b66\u8d70\u5f97\u5f88\u8fd1\u201d<\/strong>\u3002\u6211\u975e\u5e38\u540c\u610f\u8fd9\u70b9\u3002\u6211\u7684\u51e0\u5bb6\u516c\u53f8\u91cc\u7684\u6bcf\u4e2a\u4eba\u90fd\u5728\u548c\u6700\u57fa\u7840\u7684\u79d1\u5b66\u95ee\u9898\u6253\u4ea4\u9053\u3002\u6211\u4eec\u662f\u4ee5\u79d1\u5b66\u4e3a\u5bfc\u5411\u7684\uff0c\u9700\u8981\u4fdd\u6301\u4e0e\u79d1\u5b66\u7684\u63a5\u8fd1\u3002\u8fd0\u8425\u4e09\u5bb6\u516c\u53f8\u7684\u7b2c\u4e8c\u4e2a\u597d\u5904\u662f\u56e2\u961f\u3002\u80fd\u4e0e\u8bb8\u591a\u6709\u521b\u9020\u6027\u548c\u5929\u8d4b\u7684\u4eba\u624d\u4e00\u8d77\u5de5\u4f5c\u662f\u6211\u7684\u5e78\u8fd0\u3002\u6211\u7684\u8bb8\u591a\u540c\u4e8b\u5df2\u7ecf\u548c\u6211\u5408\u4f5c\u4e86\u591a\u5e74\uff0c\u6211\u76f8\u4fe1\u4ed6\u4eec\u80fd\u521b\u9020\u5947\u8ff9\u3002\u7b2c\u4e09\u4e2a\u597d\u5904\u662f\u6211\u7684\u6700\u7231\u2014\u2014\u6211\u4eec\u6709\u6f5c\u529b\u4e3a\u60a3\u8005\u7684\u751f\u6d3b\u5e26\u6765\u5b9e\u9645\u5f71\u54cd\u3002<\/p>\n

\u836f\u660e\u5eb7\u5fb7\uff1a<\/strong>\u518d\u8bf4\u8bf4\u60a8\u4e2a\u4eba\u5427\u3002\u60a8\u8ba4\u4e3a\u4ece\u4e00\u540d\u79d1\u5b66\u5bb6\u6210\u529f\u8f6c\u578b\u4e3a\u4f01\u4e1a\u5bb6\uff0c\u6700\u91cd\u8981\u7684\u662f\u4ec0\u4e48\uff1f<\/p>\n

Troy Wilson\u535a\u58eb\uff1a<\/strong>\u4f5c\u4e3a\u4e00\u540d\u79d1\u5b66\u5bb6\uff0c\u6211\u4e13\u6ce8\u4e8e\u63d0\u9ad8\u5bf9\u79d1\u5b66\u7684\u7406\u89e3\u3002\u5f53\u6211\u6210\u4e3a\u4f01\u4e1a\u5bb6\u65f6\uff0c\u6211\u610f\u8bc6\u5230\u5c3d\u7ba1\u79d1\u5b66\u4f9d\u7136\u5f88\u91cd\u8981\uff0c\u4e0d\u8fc7\u4e00\u65e6\u5f53\u4f60\u4ece\u6295\u8d44\u8005\u90a3\u91cc\u83b7\u5f97\u8d44\u91d1\uff0c\u4e00\u5207\u90fd\u6539\u53d8\u4e86\u3002\u4ece\u6295\u8d44\u8005\u8eab\u4e0a\u62ff\u94b1\u662f\u4e00\u4e2a\u91cd\u5927\u8d23\u4efb\uff0c\u60f3\u8981\u8f6c\u53d8\u6210\u529f\u7684\u79d1\u5b66\u5bb6\u90fd\u9700\u8981\u5bf9\u8fd9\u79cd\u8d23\u4efb\u6709\u5f88\u597d\u7684\u7406\u89e3\u3002<\/p>\n

\u836f\u660e\u5eb7\u5fb7\uff1a<\/strong>\u4f5c\u4e3a\u8fde\u7eed\u521b\u4e1a\u5bb6\uff0c\u60a8\u8ba4\u4e3a\u4eca\u5929\u7684\u521b\u4e1a\u73af\u5883\u4e0e\u5341\u5e74\u524d\u6709\u4f55\u4e0d\u540c\uff1f\u8fd9\u4e00\u8def\u4e0a\u6709\u4ec0\u4e48\u7ecf\u9a8c\u53ef\u4ee5\u548c\u8bfb\u8005\u4eec\u5206\u4eab\u7684\u5417\uff1f<\/p>\n

Troy Wilson\u535a\u58eb\uff1a<\/strong>\u6709\u4e00\u70b9\u6beb\u65e0\u7591\u95ee\uff0c\u5373\u4f7f\u662f\u5728\u8fc7\u53bb\u4e94\u5e74\u91cc\uff0c\u521b\u7acb\u4e00\u5bb6\u751f\u7269\u6280\u672f\u516c\u53f8\u4ee3\u4ef7\u4e5f\u53d8\u5f97\u8d8a\u6765\u8d8a\u9ad8\u3002\u597d\u6d88\u606f\u662f\uff0c\u73b0\u5728\u8d44\u91d1\u6765\u6e90\u66f4\u591a<\/strong>\uff0c\u4f60\u80fd\u4ece\u98ce\u9669\u6295\u8d44\u516c\u53f8\uff0c\u8de8\u56fd\u516c\u53f8\u548c\u516c\u5171\u6295\u8d44\u8005\uff0c\u6218\u7565\u6295\u8d44\u8005\uff0c\u57fa\u91d1\u4f1a\uff0c\u751a\u81f3\u4f17\u7b79\u7b49\u65b9\u9762\u62ff\u5230\u8d44\u91d1\u3002\u4f46\u8d44\u91d1\u662f\u4e00\u65b9\u9762\uff0c\u521d\u521b\u516c\u53f8\u7684\u5173\u952e\u662f\u521b\u65b0\u2014\u2014\u4f5c\u4e3a\u4e00\u4e2a\u4f01\u4e1a\u5bb6\uff0c\u4f60\u5fc5\u987b\u50cf\u5728\u505a\u79d1\u7814\u4e00\u6837\u5728\u5546\u4e1a\u65b9\u9762\u8fdb\u884c\u521b\u65b0\u3002<\/p>\n

\u8bf4\u5230\u7ecf\u9a8c\uff0c\u6211\u9075\u5faa\u4e00\u4e2a\u7ecf\u6211\u4e0d\u65ad\u603b\u7ed3\u548c\u5b8c\u5584\u7684\u7b80\u5355\u516c\u5f0f\uff1a\u4f60\u9700\u8981\u6709\u4e00\u4e2a\u5927\u80c6\u7684\u8bbe\u60f3\u3001\u89e3\u51b3\u90a3\u4e9b\u56f0\u96be\u4e14\u91cd\u8981\u7684\u95ee\u9898\u3001\u62db\u6700\u51fa\u8272\u7684\u4eba\u5e76\u8d4b\u4e88\u4ed6\u4eec\u6210\u529f\u6240\u9700\u7684\u8d44\u6e90\u3001\u5bfb\u627e\u90a3\u4e9b\u548c\u4f60\u76ee\u6807\u4e00\u81f4\uff0c\u4e14\u80fd\u4e3a\u4f60\u63d0\u4f9b\u8d44\u6e90\u7684\u6295\u8d44\u8005\u548c\u5408\u4f5c\u4f19\u4f34\u3002<\/strong>\u6700\u91cd\u8981\u7684\u662f\uff0c\u4f60\u5fc5\u987b\u6311\u6218\u4f60\u548c\u4f60\u7684\u56e2\u961f\u53bb\u505a\u4f1f\u5927\u7684\u4e8b\u60c5\u3002\u5f53\u6211\u521b\u7acbWellspring\u7814\u53d1KRAS\u836f\u7269\uff0c\u521b\u7acbAvidity\u89e3\u51b3RNA\u836f\u7269\u9012\u9001\u95ee\u9898\u7684\u65f6\u5019\uff0c\u4eba\u4eec\u90fd\u8ba4\u4e3a\u6211\u75af\u4e86\u3002\u540e\u6765\uff0c\u6211\u521b\u7acbKura\u60f3\u8ba9tipifarnib\u8d77\u6b7b\u56de\u751f\uff0c\u6709\u4e9b\u4eba\u5219\u4e0d\u65ad\u6447\u5934\u3002\u4f46\u6211\u4eec\u505a\u5230\u4e86\u2014\u2014\u6211\u4eec\u4e0d\u65ad\u6311\u6218\u81ea\u5df1\uff0c\u5efa\u7acb\u4e86\u4e09\u4e2a\u84ec\u52c3\u53d1\u5c55\u7684\u516c\u53f8\u3002<\/p>\n

\u836f\u660e\u5eb7\u5fb7\uff1a<\/strong>\u518d\u8c08\u8c08\u672a\u6765\u5427\u3002\u5728\u60a8\u770b\u6765\uff0c\u57282017\u5e74\uff0c\u533b\u836f\u884c\u4e1a\u53d1\u5c55\u65b9\u9762\u6709\u4ec0\u4e48\u4ee4\u4eba\u503c\u5f97\u671f\u5f85\u7684\u5730\u65b9\uff1f<\/p>\n

Troy Wilson\u535a\u58eb\uff1a<\/strong>\u6211\u671f\u5f85\u5f88\u5feb\u770b\u5230\u5be1\u6838\u82f7\u9178\u4e0e\u5c0f\u5206\u5b50\uff0c\u86cb\u767d\u8d28\/\u6297\u4f53\u548c\u591a\u80bd\u4e00\u6837\uff0c\u6210\u4e3a\u4e3b\u8981\u7684\u6cbb\u7597\u65b9\u6cd5\u3002<\/strong>\u770b\u770bFDA\u6700\u8fd1\u5341\u5e74\u6279\u51c6\u7684\u80bf\u7624\u836f\u7269\u5c31\u77e5\u9053\uff0c\u533b\u836f\u884c\u4e1a\u5728\u5f00\u53d1\u5c0f\u5206\u5b50\u7cbe\u51c6\u836f\u7269\u65b9\u9762\u53d6\u5f97\u4e86\u975e\u51e1\u7684\u8fdb\u6b65\uff0c\u4f46\u4ecd\u7136\u6709\u8bb8\u591a\u201c\u65e0\u6210\u836f\u6027\u201d\u7684\u9776\u6807\u5b58\u5728\u3002\u5728\u57fa\u56e0\u7597\u6cd5\u9886\u57df\uff0c\u6211\u4eec\u5df2\u7ecf\u770b\u5230\u4e86\u4e00\u4e9b\u975e\u51e1\u7684\u8d8b\u52bf\uff0c\u5b83\u6b63\u5728\u4e0d\u65ad\u52a0\u901f\u3002\u76ee\u524d\uff0c\u5df2\u7ecf\u6709\u4e00\u79cd\u6cbb\u7597\u810a\u9ad3\u6027\u808c\u8089\u840e\u7f29\u7684\u836f\u7269\u83b7\u5f97\u6279\u51c6\uff0c\u5e76\u4e14\u8fd8\u6709\u4e00\u4e9b\u5176\u4ed6\u7684\u5019\u9009\u836f\u7269\u5728\u665a\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u3002\u6211\u76f8\u4fe1\u57fa\u56e0\u7597\u6cd5\uff0c\u53cd\u4e49\u5be1\u6838\u82f7\u9178\u7597\u6cd5\u548cRNA\u5e72\u6270\u7b49\u4f1a\u5e26\u6765\u4ee4\u4eba\u5174\u594b\u7684\u7ed3\u679c\u3002<\/p>\n

<\/p>\n

\u25b2\u7cbe\u51c6\u533b\u5b66\u7684\u53d1\u5c55\u5df2\u7ecf\u5230\u4e86\u4e00\u4e2a\u62d0\u70b9<\/strong>\uff08\u56fe\u7247\u6765\u6e90\uff1aUniversity of Pennsylvania<\/strong>\uff09<\/strong><\/p>\n

\u836f\u660e\u5eb7\u5fb7\uff1a<\/strong>\u60a8\u7684\u51e0\u5bb6\u516c\u53f8\u90fd\u91c7\u7528\u4e86\u7cbe\u51c6\u533b\u5b66\u7684\u601d\u8def\u5728\u7814\u53d1\u65b0\u836f\u3002\u60a8\u8ba4\u4e3a\u7cbe\u51c6\u533b\u5b66\u7684\u53d1\u5c55\u5df2\u7ecf\u5230\u4e86\u4e00\u4e2a\u62d0\u70b9\u5417\uff1f<\/p>\n

Troy Wilson\u535a\u58eb\uff1a<\/strong>\u7edd\u5bf9\u662f\u7684\u3002\u6211\u4eec\u5df2\u7ecf\u770b\u5230\uff0c\u50cf\u963f\u65af\u5229\u5eb7\u7684Tagrisso<\/a>\u8fd9\u6837\u7684\u836f\u7269\uff0c\u4ece\u7b2c\u4e00\u4e2a\u60a3\u8005\u5165\u7ec4\u5230FDA\u6279\u51c6\u975e\u5e38\u5feb\u901f\u3002\u8fd9\u5e94\u8be5\u662f\u6211\u4eec\u8ffd\u6c42\u7684\u6807\u51c6\u3002\u963f\u65af\u5229\u5eb7\u7684\u7814\u53d1\u901f\u5ea6\u57fa\u4e8e\u4ed6\u4eec\u7684\u836f\u7269\u5728EGFR T790M\u7a81\u53d8\u578b\u80ba\u764c\u4e2d\u7684\u9ad8\u6d3b\u6027\uff0c\u4ee5\u53ca\u4ed6\u4eec\u4e86\u89e3\u836f\u7269\u9002\u7528\u7684\u60a3\u8005\u7fa4\u4f53\u3002\u5728\u514d\u75ab\u7597\u6cd5\u4e2d\uff0c\u6211\u4eec\u770b\u5230\u4e86\u540c\u6837\u7684\u4e3b\u9898\u2014\u2014\u5173\u6ce8\u751f\u7269\u6807\u5fd7\u7269\u548c\u60a3\u8005\u9009\u62e9\u3002<\/strong>\u7cbe\u51c6\u533b\u5b66\u662f\u80bf\u7624\u836f\u7269\u5f00\u53d1\u4e2d\u6700\u91cd\u8981\u7684\u4e3b\u9898\u4e4b\u4e00\uff0c\u5b83\u5c06\u6c38\u8fdc\u5b58\u5728\u4e0b\u53bb\u3002<\/p>\n

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Troy Wilson\u535a\u58eb\uff1a<\/strong>\u6211\u60f3\u8bf4\uff0c\u6211\u4eec\u5e94\u5f53\u521b\u9020\u80fd\u4e0d\u65ad\u6fc0\u52b1\u521b\u65b0\u7684\u4f53\u7cfb<\/strong>\uff0c\u5e76\u964d\u4f4e\u4eff\u5236\u836f\u7814\u53d1\u7684\u5438\u5f15\u529b\u3002\u7814\u53d1\u4eff\u5236\u836f\u53ea\u4f1a\u8ba9\u4eba\u4eec\u8d70\u6377\u5f84\uff0c\u8fd9\u4e0d\u662f\u771f\u6b63\u7684\u521b\u65b0\uff0c\u4e5f\u4e0d\u4f1a\u6539\u5584\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf\u3002\u4e0d\u4e45\u524d\uff0cFDA\u764c\u75c7\u5353\u8d8a\u4e2d\u5fc3\u4e3b\u4efbRichard Pazdur\u535a\u58eb\u547c\u5401\u533b\u836f\u884c\u4e1a\u628a\u6ce8\u610f\u529b\u96c6\u4e2d\u5728\u524d\u6cbf\uff0c\u5728\u764c\u75c7\u7814\u53d1\u7ba1\u7ebf\u4e2d\u907f\u514d\u4eff\u5236\u836f\u3002\u4ed6\u662f\u5bf9\u7684\u3002\u521b\u65b0\u96be\u5ea6\u9ad8\uff0c\u98ce\u9669\u5927\uff0c\u4f46\u5bf9\u6211\u4eec\u884c\u4e1a\u7684\u957f\u671f\u5065\u5eb7\u53d1\u5c55\u81f3\u5173\u91cd\u8981\u3002<\/p>\n

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