{"id":819012,"date":"2017-05-02T21:46:32","date_gmt":"2017-05-03T04:46:32","guid":{"rendered":"http:\/\/www.sandiegochinesepress.com\/press\/?p=819012"},"modified":"2017-05-02T23:11:28","modified_gmt":"2017-05-03T06:11:28","slug":"%e7%a5%9d%e8%b4%ba%ef%bc%81%e5%93%88%e4%bd%9b%e8%a2%81%e5%9d%87%e7%91%9b%e6%95%99%e6%8e%88%e4%bb%8a%e6%97%a5%e5%bd%93%e9%80%89%e7%be%8e%e5%9b%bd%e7%a7%91%e5%ad%a6%e9%99%a2%e9%99%a2%e5%a3%ab%e5%9b%be","status":"publish","type":"post","link":"https:\/\/www.sandiegochinesepress.com\/press\/%e7%a5%9d%e8%b4%ba%ef%bc%81%e5%93%88%e4%bd%9b%e8%a2%81%e5%9d%87%e7%91%9b%e6%95%99%e6%8e%88%e4%bb%8a%e6%97%a5%e5%bd%93%e9%80%89%e7%be%8e%e5%9b%bd%e7%a7%91%e5%ad%a6%e9%99%a2%e9%99%a2%e5%a3%ab%e5%9b%be\/.html","title":{"rendered":"\u795d\u8d3a\uff01\u54c8\u4f5b\u8881\u94a7\u745b\u6559\u6388\u4eca\u65e5\u5f53\u9009\u7f8e\u56fd\u79d1\u5b66\u9662\u9662\u58eb(\u56fe\uff09"},"content":{"rendered":"<p><strong>\u836f\u660e\u5eb7\u5fb7\/\u62a5\u9053<\/strong><\/p>\n<p>\u4eca\u5929\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\uff08National 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data-src=\"http:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/UdvecgtVRYIaMzVJVBic0Sul5wnYOquBuVhXyL4kyZQibGrNiblFvwMDbrfOUlkFQLsQnwmol1iciaoGEW1C3MEdccg\/0?wx_fmt=jpeg\" data-ratio=\"1.5\" data-w=\"1280\" data-fail=\"0\" \/><\/p>\n<p><img decoding=\"async\" class=\" img_loading\" src=\"data:image\/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVQImWNgYGBgAAAABQABh6FO1AAAAABJRU5ErkJggg==\" data-s=\"300,640\" data-type=\"jpeg\" data-src=\"http:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/UdvecgtVRYIaMzVJVBic0Sul5wnYOquBuVhXyL4kyZQibGrNiblFvwMDbrfOUlkFQLsQnwmol1iciaoGEW1C3MEdccg\/0?wx_fmt=jpeg\" data-ratio=\"1.5\" data-w=\"1280\" 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Horvitz\u6559\u6388\u8bf4\u3002\u6b64\u5916\uff0c\u8881\u94a7\u745b\u7684\u5de5\u4f5c\u5c06\u7ebf\u866b\u7684\u7ec6\u80de\u51cb\u4ea1\u57fa\u56e0\u4e0e\u4eba\u7c7b\u7684\u7ec6\u80de\u6b7b\u4ea1\u673a\u5236\u8054\u7cfb\u5230\u4e86\u4e00\u8d77\uff0c<strong>\u8fd9\u4e5f\u662f\u4eba\u4eec\u9996\u6b21\u77e5\u9053\u534a\u80f1\u5929\u51ac\u9176\uff08caspases\uff09\u8fd9\u79cd\u5728\u7ec6\u80de\u51cb\u4ea1\u4e2d\u8d77\u5230\u5173\u952e\u4f5c\u7528\u7684\u9176\u7684\u5b58\u5728<\/strong>\u3002<\/p>\n<p><img decoding=\"async\" class=\" img_loading\" src=\"data:image\/gif;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAYAAAAfFcSJAAAADUlEQVQImWNgYGBgAAAABQABh6FO1AAAAABJRU5ErkJggg==\" data-s=\"300,640\" data-type=\"png\" data-src=\"http:\/\/mmbiz.qpic.cn\/mmbiz_png\/UdvecgtVRYIaMzVJVBic0Sul5wnYOquBuliapicmqnLG6ibN8PGq5h07ncHLzibQ4HWx2BDxzGnlhjvLJo9FuHg3Y0w\/0?wx_fmt=png\" data-ratio=\"0.991869918699187\" data-w=\"492\" \/><img decoding=\"async\" class=\" \" src=\"http:\/\/mmbiz.qpic.cn\/mmbiz_png\/UdvecgtVRYIaMzVJVBic0Sul5wnYOquBuliapicmqnLG6ibN8PGq5h07ncHLzibQ4HWx2BDxzGnlhjvLJo9FuHg3Y0w\/640?wx_fmt=png&amp;wxfrom=5&amp;wx_lazy=1\" data-s=\"300,640\" data-type=\"png\" data-src=\"http:\/\/mmbiz.qpic.cn\/mmbiz_png\/UdvecgtVRYIaMzVJVBic0Sul5wnYOquBuliapicmqnLG6ibN8PGq5h07ncHLzibQ4HWx2BDxzGnlhjvLJo9FuHg3Y0w\/0?wx_fmt=png\" data-ratio=\"0.991869918699187\" data-w=\"492\" data-fail=\"0\" \/><\/p>\n<p><strong>\u25b2<\/strong><strong>2002\u5e74\uff0cHorvitz\u6559\u6388\u5206\u4eab\u4e86\u5f53\u5e74\u7684\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u3002\u4ed6\u4e5f\u7279\u5730\u5f3a\u8c03\u4e86\u8881\u94a7\u745b\u6559\u6388\u505a\u51fa\u7684\u8d21\u732e<\/strong><strong>\uff08\u56fe\u7247\u6765\u6e90\uff1a\u8bfa\u8d1d\u5c14\u5956\u5b98\u65b9\u7f51\u7ad9<\/strong><strong>\uff09<\/strong><\/p>\n<p>2002\u5e74\uff0cHorvitz\u6559\u6388\u4e0e\u53e6\u5916\u4e24\u540d\u79d1\u5b66\u5bb6\u4e00\u9053\uff0c\u5206\u4eab\u4e86\u5f53\u5e74\u7684\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u3002\u8bfa\u8d1d\u5c14\u5956\u59d4\u5458\u4f1a\u7684\u8bc4\u8bed\u662f\u201c\u4ed6\u4eec\u5728\u5668\u5b98\u53d1\u80b2\u4e0e\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\u7684\u9057\u4f20\u8c03\u63a7\u4e0a\u505a\u51fa\u4e86\u91cd\u8981\u53d1\u73b0\u201d\u3002<strong>\u83b7\u5956\u540e\uff0cHorvitz\u6559\u6388\u6267\u610f\u8981\u6c42\u5df2\u662f\u54c8\u4f5b\u533b\u5b66\u9662\u6559\u6388\u7684\u8881\u94a7\u745b\u4e00\u540c\u53c2\u52a0\u665a\u5bb4\uff0c\u5e76\u5728\u83b7\u5956\u6f14\u8bf4\u4e2d\u5355\u72ec\u63d0\u5230\u8881\u5747\u745b\u6559\u6388\u5728\u7ec6\u80de\u6b7b\u4ea1\u7684\u5206\u5b50\u673a\u5236\u63a2\u7d22\u4e2d\u8d77\u5230\u7684\u5173\u952e\u8d21\u732e\u3002<\/strong><\/p>\n<p>\u7531\u4e8e\u5728Horvitz\u6559\u6388\u8bfe\u9898\u7ec4\u7684\u6770\u51fa\u5de5\u4f5c\uff0c\u535a\u58eb\u6bd5\u4e1a\u540e\uff0c\u8881\u94a7\u745b\u8fd8\u672a\u63a5\u53d7\u535a\u58eb\u540e\u7684\u8bad\u7ec3\uff0c\u5c31\u987a\u5229\u627e\u5230\u4e86\u5b66\u672f\u754c\u7684\u804c\u4f4d\u3002\u5728\u9ebb\u7701\u603b\u533b\u9662\uff08Massachusetts General Hospital\uff09\u505a\u4e86\u77ed\u6682\u7684\u505c\u7559\u540e\uff0c\u8881\u94a7\u745b\u56de\u5230\u4e86\u8d74\u7f8e\u7684\u7b2c\u4e00\u7ad9\u2014\u2014\u54c8\u4f5b\u5927\u5b66\uff0c\u62c5\u4efb\u52a9\u7406\u6559\u6388<strong>\u3002\u77ed\u77ed4\u5e74\uff0c\u5979\u5c31\u4ece\u7ec6\u80de\u751f\u7269\u5b66\u7684\u52a9\u7406\u6559\u6388\u5347\u5230\u4e86\u6b63\u6559\u6388<\/strong>\u3002\u5728\u90a3\u91cc\uff0c\u5979\u9ad8\u4ea7\u7684\u8bfe\u9898\u7ec4\u7ee7\u7eed\u63a2\u7d22\u7740\u7ec6\u80de\u6b7b\u4ea1\u7684\u5965\u79d8\uff0c\u5e76\u63d0\u51fa\u4e86\u4ecb\u4e8e\u7a0b\u5e8f\u6027\u7ec6\u80de\u51cb\u4ea1\uff08programmed apoptosis\uff09\u4e0e\u7ec6\u80de\u574f\u6b7b\uff08cell necrosis\uff09\u4e4b\u95f4\u7684\u7b2c\u4e09\u79cd\u7ec6\u80de\u6b7b\u4ea1\u901a\u8def\u2014\u2014<strong>\u201c\u574f\u6b7b\u6027\u51cb\u4ea1\u201d\uff08necroptosis\uff09\u3002<\/strong><\/p>\n<p><img decoding=\"async\" class=\" \" src=\"http:\/\/mmbiz.qpic.cn\/mmbiz_png\/UdvecgtVRYIaMzVJVBic0Sul5wnYOquBuF5tC7u6tmH0IgrIDKtoarsBbApxhJ8icHwjujsSiav10ibwh6fIBxIiaPg\/640?wx_fmt=png&amp;wxfrom=5&amp;wx_lazy=1\" data-s=\"300,640\" data-type=\"png\" data-src=\"http:\/\/mmbiz.qpic.cn\/mmbiz_png\/UdvecgtVRYIaMzVJVBic0Sul5wnYOquBuF5tC7u6tmH0IgrIDKtoarsBbApxhJ8icHwjujsSiav10ibwh6fIBxIiaPg\/0?wx_fmt=png\" data-ratio=\"0.6039325842696629\" data-w=\"712\" data-fail=\"0\" \/><\/p>\n<p><strong>\u25b2<\/strong><strong>2005\u5e74\u7684\u4e00\u7bc7\u91cc\u7a0b\u7891\u5f0f\u8bba\u6587\u4e0a\uff0c\u8881\u94a7\u745b\u6559\u6388\u4e0e\u56e2\u961f\u7387\u5148\u63d0\u51fa\u4e86\u201c\u574f\u6b7b\u6027\u51cb\u4ea1\u201d\u8fd9\u4e2a\u6982\u5ff5<\/strong><strong>\uff08\u56fe\u7247\u6765\u6e90\uff1a\u300aNature Chemical Biology\u300b<\/strong><strong>\uff09<\/strong><\/p>\n<p><strong>\u201c\u574f\u6b7b\u6027\u51cb\u4ea1\u201d\u7684\u53d1\u73b0\u5f7b\u5e95\u6539\u53d8\u4e86\u4eba\u7c7b\u5bf9\u7ec6\u80de\u574f\u6b7b\u7684\u8ba4\u8bc6\u3002<\/strong>\u4e4b\u524d\uff0c\u6559\u79d1\u4e66\u8ba4\u4e3a\u7ec6\u80de\u574f\u6b7b\u53ea\u662f\u4e00\u79cd\u88ab\u52a8\u7684\uff0c\u4e0d\u53d7\u8c03\u63a7\u7684\u7ec6\u80de\u6b7b\u4ea1\u3002\u4f46\u8881\u94a7\u745b\u6559\u6388\u7684\u5de5\u4f5c\u5219\u8868\u660e\uff0c\u574f\u6b7b\u6027\u51cb\u4ea1\u662f\u4e00\u79cd\u53d7\u8c03\u63a7\u7684\u7ec6\u80de\u574f\u6b7b\uff0c\u5e76\u53d1\u73b0\u4e86\u5728\u574f\u6b7b\u6027\u51cb\u4ea1\u901a\u8def\u4e2d\u8d77\u5173\u952e\u6027\u4f5c\u7528\u7684RIP1\u6fc0\u9176\u3002\u8fd9\u4e2a\u6fc0\u9176\u80fd\u6fc0\u6d3bRIP3\u4e0eMLKL\u4e24\u4e2a\u5173\u952e\u4e0b\u6e38\u86cb\u767d\u3002\u56e0\u6b64\uff0c\u5982\u679c\u80fd\u6291\u5236RIP1\uff0c\u5c31\u6709\u671b\u6291\u5236\u574f\u6b7b\u6027\u51cb\u4ea1\u5f15\u8d77\u4e86\u4e00\u7cfb\u5217\u75be\u75c5\uff0c\u8fd9\u5176\u4e2d\u5c31\u5305\u62ec\u4e86\u5f71\u54cd\u5e7f\u6cdb\u7684\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u3002<strong>\u9776\u5411\u5177\u201c\u53ef\u6210\u836f\u6027\u201d\u7684RIP1\u7684\u836f\u7269\uff0c\u4e5f\u6210\u4e86\u4eba\u7c7b\u6cbb\u7597\u8fd9\u4e9b\u75be\u75c5\u7684\u4e00\u5927\u65b9\u5411\u3002<\/strong><\/p>\n<p><strong>\u76ee\u524d\uff0c\u8881\u94a7\u745b\u6559\u6388\u7684\u8bba\u6587\u603b\u5f15\u7528\u6570\u5df2\u63a5\u8fd17\u4e07\u3002<\/strong>\u8fd1\u51e0\u5e74\u6765\uff0c\u5979\u7684\u8bfe\u9898\u7ec4\u7684\u8bba\u6587\u4e5f\u662f\u300a\u7ec6\u80de\u300b\u3001\u300a\u79d1\u5b66\u300b\u3001\u300aAutophagy\u300b\u7b49\u9886\u57df\u5185\u9876\u5c16\u671f\u520a\u7684\u5e38\u5ba2\u3002\u6b64\u5916\uff0c\u8881\u94a7\u745b\u6559\u6388\u76ee\u524d\u4e5f\u662f\u300aJournal of Cell Biology\u300b\u7684\u8d44\u6df1\u7f16\u59d4\u4f1a\u6210\u5458\u3002<\/p>\n<p><img decoding=\"async\" class=\" \" src=\"http:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/UdvecgtVRYIaMzVJVBic0Sul5wnYOquBurxERh4YDbqWgeib5GZfLtUpgF0XvTxk2APiaTjKl8jcessNcw3DuCXNA\/640?wx_fmt=jpeg&amp;wxfrom=5&amp;wx_lazy=1\" data-s=\"300,640\" data-type=\"jpeg\" data-src=\"http:\/\/mmbiz.qpic.cn\/mmbiz_jpg\/UdvecgtVRYIaMzVJVBic0Sul5wnYOquBurxERh4YDbqWgeib5GZfLtUpgF0XvTxk2APiaTjKl8jcessNcw3DuCXNA\/0?wx_fmt=jpeg\" data-ratio=\"0.73125\" data-w=\"800\" data-fail=\"0\" \/><\/p>\n<p><strong>\u25b2<\/strong><strong>\u8881\u5747\u745b\u6559\u6388\u7684\u79d1\u7814\u56e2\u961f\uff08<\/strong><strong>\u56fe\u7247\u6765\u6e90\uff1a\u8881\u94a7\u745b\u6559\u6388\u5b9e\u9a8c\u5ba4\u4e3b\u9875<\/strong><strong>\uff09<\/strong><\/p>\n<p>\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\u662f\u5168\u4e16\u754c\u6700\u5bcc\u76db\u540d\u7684\u79d1\u5b66\u9662\u4e4b\u4e00\uff0c\u7531\u5927\u91cf\u6770\u51fa\u7684\u5b66\u8005\u7ec4\u6210\u3002<strong>\u81f3\u4eca\uff0c\u8fd1500\u540d\u7f8e\u56fd\u79d1\u5b66\u9662\u9662\u58eb\u5148\u540e\u83b7\u5f97\u4e86\u8bfa\u8d1d\u5c14\u5956<\/strong>\uff0c\u79d1\u5b66\u9662\u65d7\u4e0b\u7684\u671f\u520a\u300aProceedings of the National Academy of Sciences\u300b\u4e5f\u662f\u5168\u7403\u6027\u7684\u9876\u5c16\u5b66\u672f\u520a\u7269\u3002\u5176\u79d1\u7814\u6c34\u5e73\u4e4b\u4f18\u5f02\uff0c\u7531\u6b64\u53ef\u89c1\u4e00\u6591\u3002\u56e0\u6b64\uff0c\u80fd\u591f\u5f53\u9009\u7f8e\u56fd\u79d1\u5b66\u9662\u9662\u58eb\uff0c\u662f\u5bf9\u79d1\u5b66\u5bb6\u672c\u8eab\u5b66\u672f\u80fd\u529b\u6781\u9ad8\u7684\u80af\u5b9a\u3002<\/p>\n<p>\u6211\u4eec\u5f88\u9ad8\u5174\u80fd\u5728\u4eca\u65e5\u7f8e\u56fd\u79d1\u5b66\u9662\u65b0\u589e\u9662\u58eb\u7684\u540d\u5355\u4e2d\u770b\u5230\u8881\u94a7\u745b\u6559\u6388\u7684\u540d\u5b57\uff0c\u5e76\u5bf9\u8881\u94a7\u745b\u6559\u6388\u53d6\u5f97\u7684\u6210\u5c31\u8868\u793a\u795d\u8d3a\uff01<\/p>\n<p>\u53c2\u8003\u8d44\u6599\uff1a<\/p>\n<p>[1] National Academy of Sciences Members and Foreign Associates Elected<\/p>\n<p>[2] Necroptosis in health and diseases<\/p>\n<p>[3] Junying Yuan \u2013 ASCB<\/p>\n<p>[4] \u8881\u94a7\u745b\u6559\u6388\u5b9e\u9a8c\u5ba4\u4e3b\u9875<\/p>\n<p><strong><img decoding=\"async\" class=\" \" src=\"http:\/\/mmbiz.qpic.cn\/mmbiz_png\/UdvecgtVRYLDccuDdZTyZ1SDccPDl3sYW1gk1x5ZkcyN0G5k41dicnIiaXkTjKIzOzuekdv4ib6ic5qIwbjFDQibCBQ\/640?wx_fmt=png&amp;wxfrom=5&amp;wx_lazy=1\" data-ratio=\"0.3375\" data-s=\"300,640\" data-src=\"http:\/\/mmbiz.qpic.cn\/mmbiz_png\/UdvecgtVRYLDccuDdZTyZ1SDccPDl3sYW1gk1x5ZkcyN0G5k41dicnIiaXkTjKIzOzuekdv4ib6ic5qIwbjFDQibCBQ\/640?wx_fmt=png\" data-type=\"png\" data-w=\"640\" data-fail=\"0\" \/><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4eca\u5929\u7f8e\u56fd\u56fd\u5bb6\u79d1\u5b66\u9662\uff08National Academy of Sciences\uff09\u4f20\u6765\u559c\u8baf\uff1a\u54c8\u4f5b\u533b\u5b66\u9662\uff08Harvard Medical School\uff09\u7684\u8881\u94a7\u745b\u6559\u6388\u6210\u529f\u5f53\u9009\u79d1\u5b66\u9662\u9662\u58eb&#8230;&#8230;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16],"tags":[],"class_list":["post-819012","post","type-post","status-publish","format-standard","hentry","category-science_technology_education"],"_links":{"self":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/819012","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/comments?post=819012"}],"version-history":[{"count":0,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/posts\/819012\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/media?parent=819012"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/categories?post=819012"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sandiegochinesepress.com\/press\/wp-json\/wp\/v2\/tags?post=819012"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}